Immune Regulation

Our immune system is a precisely balanced protective wall that recognizes and combats pathogenic intruders. Similar to ourselves the immune system sometimes can be led astray and, by mistake, attacks parts of the own body. Furthermore, parallel infections with different pathogens massively challenge our immune system. Learn more about how scientists investigate the balance of the immune system in those extreme situations.

Publications

  • Rolle,A.M.; Hasenberg,M.; Thornton,C.R.; Solouk-Saran,D.; M S nn,L.; Weski,J.; Maurer,A.; Fischer,E.; Spycher,P.R.; Schibli,R.; Boschetti,F.; Stegemann-Koniszewski,S.; Bruder,D.; Severin,G.W.; Autenrieth,S.E.; Krappmann,S.; Davies,G.; Pichler,B.J.; Gunzer,M.; Wiehr,S.; (2016). ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo. Proceedings of the National Academy of Sciences of the United States of America: 113 8, E1026-E103300278424 DOI: Article WEBURLS
  • Rolle,A.M.; Hasenberg,M.; Thornton,C.R.; Solouk-Saran,D.; Mann,L.; Weski,J.; Maurer,A.; Fischer,E.; Spycher,P.R.; Schibli,R.; Boschetti,F.; Stegemann-Koniszewski,S.; Bruder,D.; Severin,G.W.; Autenrieth,S.E.; Krappmann,S.; Davies,G.; Pichler,B.J.; Gunzer,M.; Wiehr,S.; (2016). ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo. 113 8, E1026-E1033 PubMed
  • Boehme,J.D.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; (2015). Erratum to: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. 193, 955 PubMed
  • Yeruva,S.; Chodisetti,G.; Luo,M.; Chen,M.; Cinar,A.; Ludolph,L.; Lünnemann,M.; Goldstein,J.; Singh,A.K.; Riederer,B.; Bachmann,O.; Bleich,A.; Gereke,M.; Bruder,D.; Hagen,S.; He,P.; Yun,C.; Seidler,U.; (2015). Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis. 467 8, 1795-180700316768 DOI: 10.1007/s00424-014-1608-x HZI repository PubMed
  • Tschernig,T.; Hartwig,C.; Jeron,A.; Dinh,Q.T.; Gereke,M.; Bruder,D.; (2015). First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma. 2015, 638032 DOI: 10.1155/2015/638032 HZI repository PubMed
  • Biswas,A.; Bruder,D.; Wolf,S.A.; Jeron,A.; Mack,M.; Heimesaat,M.M.; Dunay,I.R.; (2015). Ly6Chigh monocytes control cerebral toxoplasmosis. Journal of Immunology: 194 7, 3223-323500221767 WEBURLS
  • Boianelli,A.; Nguyen,V.K.; Ebensen,T.; Schulze,K.; Wilk,E.; Sharma,N.; Stegemann-Koniszewski,S.; Bruder,D.; Toapanta,F.R.; Guzm b n,C.A.; Meyer-Hermann,M.; Hernandez-Vargas,E.A.; (2015). Modeling influenza virus infection: A roadmap for influenza research. Viruses: 7 10, 5274-530419994915 WEBURLS
  • Désiréé Boehme,J.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; (2015). Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. 193 6, 947-95303412040 DOI: 10.1007/s00408-015-9797-4 HZI repository PubMed
  • Sakthivel,P.; Grunewald,J.; Eklund,A.; Bruder,D.; Wahlstrom,J.; (2015). Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution. 183, 294-306 PubMed
  • Sakthivel,P.; Gereke,M.; Breithaupt,A.; Fuchs,D.; Gigliotti,L.; Gruber,A.D.; Dianzani,U.; Bruder,D.; (2014). Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells. PLoS ONE: 9 7, e100970 PubMed
  • Sakthivel,Priya; Gereke,Marcus; Breithaupt,A.; Fuchs,D.; Gigliotti,L.; Gruber,A.D.; Dianzani,U.; Bruder,Dunja; (2014). Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells. PLoS ONE: 9 7, e10097019326203 DOI: 10.1371/journal.pone.0100970 HZI repository PubMed
  • Petzold,C.; Steinbronn,N.; Gereke,M.; Strasser,R.H.; Sparwasser,T.; Bruder,D.; Geffers,R.; Schallenberg,S.; Kretschmer,K.; (2014). Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin. European Journal of Immunology: 44 12, 3632-364500142980 DOI: Article WEBURLS
  • Kominsky,D.J.; Campbell,E.L.; Ehrentraut,S.F.; Wilson,K.E.; Kelly,C.J.; Glover,L.E.; Collins,C.B.; Bayless,A.J.; Saeedi,B.; Dobrinskikh,E.; Bowers,B.E.; Macmanus,C.F.; Muller,W.; Colgan,S.P.; Bruder,Dunja; (2014). IFN-gamma-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia. Journal of Immunology: 192 3, 1267-1276 PubMed
  • Nair,Sharmila; Michaelsen-Preusse,K.; Finsterbusch,Katja; Stegemann-Koniszewski,Sabine; Bruder,Dunja; Grashoff,Martina; Korte,Martin; Köster,Mario; Kalinke,Ulrich; Hauser,Hansjörg; Kröger,Andrea; (2014). Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. PLoS Pathogens: 10 3, e1003999 DOI: 10.1371/journal.ppat.1003999 HZI repository PubMed
  • Hasenberg,M.; Stegemann-Koniszewski,S.; Gunzer,Matthias*; (2013). Cellular immune reactions in the lung. Immunological Reviews: 251 1, 189-214 DOI: 10.1111/imr.12020 HZI repository PubMed
  • Telieps,T.; Ewald,F.; Gereke,Marcus; Annemann,Michaela; Rauter,Yvonne; Schuster,Marc; Ueffing,N.; von,Smolinski D.; Gruber,A.D.; Bruder,Dunja; Schmitz,Ingo; (2013). Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection. European Journal of Immunology: 43 6, 1499-1510 WEBURLS
  • Martinez,J.P.; Perez-Vilaro,G.; Muthukumar,Y.; Scheller,N.; Hirsch,Tatjana; Diestel,R.; Steinmetz,Heinrich; Jansen,Rolf; Frank,Ronald; Sasse,Florenz; Meyerhans,A.; Diez,J.; (2013). Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology. RNA Biology: 10 11, 1661-1669 Full text
  • Tosiek,M.J.; Bader,S.R.; Gruber,A.D.; Buer,J.; Gereke,M.; Bruder,Dunja; (2012). CD8+ T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity. American Journal of Respiratory Cell and Molecular Biology: 47 6, 869-878 DOI: 10.1165/rcmb.2011-0387OC PubMed
  • Jeron,Aandreas; Hansen,W.; Ewert,F.; Buer,J.; Geffers,Robert; Bruder,Dunja; (2012). ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells. BMC GENOMICS: 13 1, 705 PubMed
  • König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; (2012). First insight into the kinome of human regulatory T cells. PLoS ONE: 7 7, e40896 DOI: 10.1371/journal.pone.0040896 HZI repository PubMed
  • Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; (2012). Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies. Journal of Visualized Experiments: JoVE: 701940087X DOI: 4322. WEBURLS
  • Albrecht,M.; Arnhold,M.; Lingner,S.; Mahapatra,S.; Bruder,Dunja; Hansen,G.; Dittrich,A.M.; (2012). IL-4 Attenuates Pulmonary Epithelial Cell-Mediated Suppression of T Cell Priming. PLoS ONE: 7 9, e45916 DOI: 10.1371/journal.pone.0045916 PubMed
  • Autengruber,Andrea; Gereke,Marcus; Hansen,G.; Hennig,C.; Bruder,Dunja; (2012). Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function. European Journal of Microbiology and Immunology: 2 2, 112-120 DOI: 10.1556/EuJMI.2.2012.2.3
  • Sakthivel,Priya; Gereke,Marcus; Bruder,Dunja; (2012). Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction. Review on Recent Clinical Trials: 7 1, 10-23 PubMed
  • Stegemann-Koniszewski,S.; Gereke,M.; Orrskog,S.; Lienenklaus,S.; Pasche,B.; Bader,S.R.; Gruber,A.D.; Akira,S.; Weiss,Siegfried; Henriques-Normark,B.; Bruder,Dunja; Gunzer,M.; (2012). TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection. Journal of Innate Immunity: 5 1, 84-96 DOI: 10.1159/000345112 HZI repository PubMed
  • Tosiek,M.J.; Gruber,A.D.; Bader,S.; Hoymann,H.G.; Mauel,S.; Tschwernig,T.; Buer,J.; Gereke,M.; Bruder,Dunja*; (2011). CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung inflammation. Journal of Immunology: 186 11, 6106-6118
  • Hasenberg,M.; Köhler,A.; Jeron,Andreas*; Bonifatius,S.; Gunzer,M.; (2011). Direct observation of phagocytosis and NET formation by neutrophils in infected lungs using 2-photon microscopy3332. Journal of Visualized Experiments: 52 art. no. e2659 DOI: 10.3791/2659
  • Alberts,R.; Chen,H.; Pommerenke,C.; Smit,A.B.; Spijker,S.; Williams,R.W.; Geffers,Robert*; Bruder,Dunja*; Schughart,Klaus*; (2011). Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease1. BMC GENOMICS: 12, 610 PubMed
  • Ukena,S.N.; Velaga,S.; Geffers,Robert*; Grosse,J.; Baron,U.; Buchholz,S.; Stadler,M.; Bruder,Dunja*; Ganser,A.; Franzke,A.; (2011). Human regulatory T cells in allogeneic stem cell transplantation. Blood: 118 13, e82-e92 PubMed
  • Liesz,A.; Zhou,W.; Mracskó,E.; Karcher,S.; Doerr,H.; Schwarting,S.; Sun,L.; Bruder,Dunja*; Stegemann,S.; Cerwenka,A.; Sommer,C.; Dalpke,A.; Veltkamp,R.; (2011). Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain: 134 3, 704-720
  • Cappuccini,F.; Eldh,T.; Bruder,Dunja*; Gereke,M.; Jastrow,H.; Schulze-Osthoff,K.; Fischer,U.; Kohler,D.; Stuschke,M.; Jendrossek,V.; (2011). New insights into the molecular pathology of radiation-induced pneumopathy. Radiotherapy and Oncology: 101 1, 86-92 DOI: 10.1016/j.radonc.2011.05.064 HZI repository PubMed
  • Kang,T.W.; Yevsa,T.; Woller,N.; Hoenicke,L.; Wuestefeld,T.; Dauch,D.; Hohmeyer,A.; Gereke,M.; Rudalska,R.; Potapova,A.; Iken,M.; Vucur,M.; Weiss,Siegfried*; Heikenwalder,M.; Khan,S.; Gil,J.; Bruder,Dunja*; Manns,M.; Schirmacher,P.; Tacke,F.; Ott,M.; Luedde,T.; Longerich,T.; Kubicka,S.; Zender,Lars*; (2011). Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature: 479 7374, 547-551 PubMed
  • Bar-On,L.; Birnberg,T.; Lewis,K.L.; Edelson,B.T.; Bruder,Dunja*; Hildner,K.; Buer,J.; Murphy,K.M.; Reizis,B.; Jung,S.; (2010). CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Proceedings of the National Acadamy of Sciences of the United States of America: 107 33, 14745-14750 PubMed
  • Bruns,S.; Kniemeyer,O.; Hasenberg,M.; Aimanianda,V.; Nietzsche,S.; Thywissen,A.; Jeron,Andreas*.; Latge,J.P.; Brakhage,A.A.; Gunzer,Matthias*; (2010). Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathogens: 6 4, e1000873 DOI: 10.1371/journal.ppat.1000873 HZI repository PubMed
  • Gereke,M.; Jung,S.; Buer,J.; Bruder,Dunja*; (2009). Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. American Journal of Respiratory and Critical Care Medicine: 179 5, 344-355 PubMed
  • De Buhr,M.F.; Hedrich,H.J.; Westendorf,Astrid M.*; Obermeier,F.; Hofmann,C.; Zschemisch,N.H.; Buer,J.; Bumann,D.; Goyert,S.M.; Bleich,A.; (2009). Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflammatory Bowel Diseases: 15 12, 1824-1836 DOI: 10.1002/ibd.21030 HZI repository PubMed
  • Westendorf,A.M.; Fleissner,D.; Gröbe,Lothar*; Jung,S.; Gruber,A.D.; Hansen,W.; Buer,J.; (2009). CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. GUT: 58 2, 211-219 PubMed
  • Jeron,A.; Pfoertner,S.; Bruder,Dunja*; Geffers,Robert*; Hammerer,P.; Hofmann,R.; Buer,J.; Schrader,A.J.; (2009). Frequency and Gene Expression Profile of Regulatory T Cells in Renal Cell Carcinoma. Tumor Biology: 30 3, 160-170 PubMed
  • Probst-Kepper,M.; Geffers,Robert*; Kroger,A.; Viegas,N.; Erck,C.; Hecht,Hans-Jürgen*; Lünsdorf,Heinrich*; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,Andreas*; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,Rudi*; Hauser,Hansjörg*; Buer,J.; Weiss,Siegfried*; (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine: 13 9, 3343-3357 PubMed
  • Stegemann,S.; Dahlberg,S.; Kroger,A.; Gereke,M.; Bruder,Dunja*; Henriques-Normark,B.; Gunzer,Matthias*; (2009). Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. PLoS ONE: 4 3, e4840 DOI: 10.1371/journal.pone.0004840 HZI repository PubMed
  • Lienenklaus,S.; Cornitescu,M.; Zietara,N.; Lyszkiewicz,M.; Gekara,N.; Jablonska,J.; Edenhofer,F.; Rajewsky,K.; Bruder,Dunja*; Hafner,M.; Staeheli,P.; Weiss,Siegfried*; (2009). Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. Journal of Immunology: 183 5, 3229-3236 PubMed
  • Barth,K.; Weinhold,K.; Guenther,A.; Linge,A.; Gereke,Marcus*; Kasper,M.; (2008). Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells. International Journal of Biochemistry and Cell Biology: 40 10, 2230-2239 DOI: 10.1016/j.biocel.2008.03.001 PubMed
  • Hansen,W.; Westendorf,A.M.; Reinwald,S.; Bruder,Dunja*; Deppenmeier,S.; Gröbe,Lothar*; Probst-Kepper,Michael*; Gruber,A.D.; Geffers,Robert*; Buer,Jan*; (2007). Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 - CD25 - regulatory T cells 1. Journal of Immunology: 179, 8059-8068
  • Gereke,M.; Gröbe,Lothar*; Prettin,S.; Kasper,M.; Deppenmeier,S.; Gruber,A.D.; Enelow,R.I.; Buer,Jan*; Bruder,Dunja*; (2007). Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation. Respiratory research: 8, 47 DOI: 10.1186/1465-9921-8-47 HZI repository PubMed
  • Ukena,S.N.; Singh,A.; Dringenberg,U.; Engelhardt,R.; Seidler,U.; Hansen,W.; Bleich,A.; Bruder,Dunja*; Franzke,A.; Rogler,G.; Suerbaum,S.; Buer,Jan*; Gunzer,F.; Westendorf,Astrid .M.*; (2007). Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS ONE: 2 12, e1308 DOI: 10.1371/journal.pone.0001308 HZI repository PubMed
  • Westendorf,Astrid M.*; Fleissner,D.; Deppenmeier,S.; Gruber,A.D.; Bruder,Dunja*; `Hansen,H.; Liblau,R.; Buer,Jan*; (2006). Autoimmune-mediated intestinal inflammation - impact and regulation of antigen specific CD8+ T cells. Gastroenterology: 131 2, 510-524
  • Bruder,Dunja*; Srikiatkhachorn,A.; Enelow,R.I.; (2006). Cellular immunity and lung injury in respiratory virus infection. Viral Immunology: 26, 318-327
  • Hansen,W.; Loser,K.; Westendorf,Astrid M.*; Bruder,Dunja*; Pförtner,S.; Siewert,C.; Huehn,J.; Beissert,S.; Buer,Jan*; (2006). GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. Journal of Immunology: 177, 209-215
  • Westendorf,Astrid M.*; Bruder,Dunja*; Hansen,Wiebke*; Buer,Jan*; (2006). Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model. Annals of the New York Academy of Sciences: 1072, 401-406
  • Ramana,C.V.; Chintapalli,J.; Xu,L.; Alia,C.; Bruder,Dunja*; Enelow,R.I.; (2006). Lung epithelial Stat1 and NF- B signalling in response to CD8+ T cell antigen recognition. Journal of Interferon and Cytokine Research: 26, 318-327
  • Bruder,Dunja*; Nussbaum,A.K.; Gakamsky,D.M.; Schirle,M.; Stevanovic,S.; Singh-Jasuja,H.; Darji,A.; Chakraborty,T.; Schild,H.; Pecht,I.; Weiss,Siegfried*; (2006). Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O. International immunology: 18, 89-100 DOI: 10.1093/intimm/dxh352 HZI repository PubMed
  • Pfoertner,Susanne*; Jeron,A.; Probst-Kepper,M.; Guzmán,Carlos A.*; Hansen,W.; Westendorf,A.M.; Toepfer,T.; Schrader,A.J.; Franzke,A.; Buer,Jan*; Geffers,Robert*; (2006). Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biology: 7, R54 DOI: 10.1186/gb-2006-7-7-r54 HZI repository PubMed

Leader

  • Prof Dunja Bruder

    Dunja Bruder

    Head of the Research Group Immunregulation

    +49 531 6181-3051

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