Immune Regulation

Our immune system is a precisely balanced protective wall that recognizes and combats pathogenic intruders. Similar to ourselves the immune system sometimes can be led astray and, by mistake, attacks parts of the own body. Furthermore, parallel infections with different pathogens massively challenge our immune system. Learn more about how scientists investigate the balance of the immune system in those extreme situations.


Selected Publications

Bruder D, Probst-Kepper M, Westendorf AM, Geffers R, Beissert S, Loser K, von Boehmer H, Buer J, Hansen W (2004) Neuropilin-1: a surface marker of regulatory T cells. Eur J Immunol 34:623-30. 

Bruder D, Westendorf AM, Geffers R, Gruber AD, Gereke M, Enelow RI, Buer J (2004) CD4 T Lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions. Am J Respir Crit Care Med 170:1145-52

Bruder D, Westendorf AM, Hansen W, Prettin S, Gruber AD, Qian Y, von Boehmer H, Mahnke K, Buer J (2005) On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes. Diabetes 54:3395-401. 

Gereke M, Jung S, Buer J, Bruder D (2009) Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med 179:344-55 

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L (2011) “Senescence surveillance” suppresses carcinogenesis in the liver and involves an adaptive immune response against premalignant senescent hepatocytes. Nature 479:547-51 


  • Authors: Stegemann-Koniszewski,S.; Behrens,S.; Boehme,J.D.; Hochnadel,I.; Riese,P.; Guzmán,C.A.; Kröger,A.; Schreiber,J.; Gunzer,M.; Bruder,D.; ( Year: 2018). Title: Respiratory influenza A virus infection triggers local and systemic natural killer cell activation via toll-like receptor 7. Journal: Frontiers in Immunology Volume: 9 Issue: FEB, S-Page: Article 245 DOI: 10.3389/fimmu.2018.00245 WEBURLS
  • Authors: Mracsko,E.; Stegemann-Koniszewski,S.; Na,S.Y.; Dalpke,A.; Bruder,D.; Lasitschka,F.; Veltkamp,R.; ( Year: 2017). Title: A Mouse Model of Post-Stroke Pneumonia Induced by Intra-Tracheal Inoculation with Streptococcus pneumoniae. Journal: Cerebrovasc.Dis. Volume: 43 Issue: 3-4, S-Page: 99- E-Page: 109 DOI: 10.1159/000452136 PubMed
  • Authors: Boehme,J.D.; Stegemann-Koniszewski,S.; Autengruber,A.; Peters,N.; Wissing,J.; Jänsch,L.; Jeron,A.; Bruder,D.; ( Year: 2017). Title: Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance. Journal: Sci.Rep. Volume: 7 Issue: 1, S-Page: 4972 DOI: 10.1038/s41598-017-05212-4 PubMed
  • Authors: Boehme,J.D.; Bruder,D.; ( Year: 2017). Title: IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity. Journal: Cell Mol.Immunol. Volume: 14 Issue: 11, S-Page: 875- E-Page: 877 DOI: 10.1038/cmi.2017.53 PubMed
  • Authors: Frede,A.; Neuhaus,B.; Knuschke,T.; Wadwa,M.; Kollenda,S.; Klopfleisch,R.; Hansen,W.; Buer,J.; Bruder,D.; Epple,M.; Westendorf,A.M.; ( Year: 2017). Title: Local delivery of siRNA-loaded calcium phosphate nanoparticles abates pulmonary inflammation. Journal: Nanomedicine. Volume: 13 Issue: 8, S-Page: 2395- E-Page: 2403 DOI: 10.1016/j.nano.2017.08.001 PubMed
  • Authors: Volckmar,J.; Gereke,M.; Ebensen,T.; Riese,P.; Philipsen,L.; Lienenklaus,S.; Wohlleber,D.; Klopfleisch,R.; Stegemann-Koniszewski,S.; Muller,A.J.; Gruber,A.D.; Knolle,P.; Guzmán,C.A.; Bruder,D.; ( Year: 2017). Title: Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver. Journal: Sci Rep. Volume: 7 Issue: Mar, S-Page: 43985 DOI: 10.1038/srep43985 HZI repository PubMed
  • Authors: Pieler,M.M.; Frentzel,S.; Bruder,D.; Wolff,M.W.; Reichl,U.; ( Year: 2016). Title: A cell culture-derived whole virus influenza A vaccine based on magnetic sulfated cellulose particles confers protection in mice against lethal influenza A virus infection. Journal: Vaccine Volume: 34 Issue: 50, S-Page: 6367- E-Page: 6374 DOI: 10.1016/j.vaccine.2016.10.041 HZI repository PubMed
  • Authors: Sakthivel,P.; Sharma,N.; Klahn,P.; Gereke,M.; Bruder,D.; ( Year: 2016). Title: Abscisic acid: A phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications. Journal: Curr.Med.Chem. Volume: 23 Issue: 15, S-Page: 1549- E-Page: 1570 DOI: 10.2174/0929867323666160405113129 WEBURLS
  • Authors: Parzmair,G.P.; Gereke,M.; Haberkorn,O.; Annemann,M.; Podlasly,L.; Kliche,S.; Reinhold,A.; Schraven,B.; Bruder,D.; ( Year: 2016). Title: ADAP plays a pivotal role in CD4+ T cell activation but is only marginally involved in CD8+ T cell activation, differentiation, and immunity to pathogens. Journal: J Leukoc.Biol. Volume: 101 Issue: 2, S-Page: 407- E-Page: 419 DOI: 10.1189/jlb.1A0216-090RR PubMed
  • Authors: Stegemann-Koniszewski,S.; Jeron,A.; Gereke,M.; Geffers,R.; Kroger,A.; Gunzer,M.; Bruder,D.; ( Year: 2016). Title: Alveolar Type II Epithelial Cells Contribute to the Anti-Influenza A Virus Response in the Lung by Integrating Pathogen- and Microenvironment-Derived Signals. Journal: MBio. Volume: 7 Issue: 3 DOI: 10.1128/mBio.00276-16 HZI repository PubMed
  • Authors: Duvigneau,S.; Sharma-Chawla,N.; Boianelli,A.; Stegemann-Koniszewski,S.; Nguyen,V.K.; Bruder,D.; Hernandez-Vargas,E.A.; ( Year: 2016). Title: Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection. Journal: Sci Rep. Volume: 6, S-Page: 37045 DOI: 10.1038/srep37045 HZI repository PubMed
  • Authors: Rolle,A.M.; Hasenberg,M.; Thornton,C.R.; Solouk-Saran,D.; M S nn,L.; Weski,J.; Maurer,A.; Fischer,E.; Spycher,P.R.; Schibli,R.; Boschetti,F.; Stegemann-Koniszewski,S.; Bruder,D.; Severin,G.W.; Autenrieth,S.E.; Krappmann,S.; Davies,G.; Pichler,B.J.; Gunzer,M.; Wiehr,S.; ( Year: 2016). Title: ImmunoPET/MR imaging allows specific detection of Aspergillus fumigatus lung infection in vivo. Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 113 Issue: 8, S-Page: E1026- E-Page: E1033 DOI: 10.1073/pnas.1518836113 WEBURLS
  • Authors: Sharma-Chawla,N.; Sender,V.; Kershaw,O.; Gruber,A.D.; Volckmar,J.; Henriques-Normark,B.; Stegemann-Koniszewski,S.; Bruder,D.; ( Year: 2016). Title: Influenza A virus infection predisposes hosts to secondary infection with different Streptococcus pneumoniae serotypes with similar outcome but serotype-specific manifestation. Journal: Infection and Immunity Volume: 84 Issue: 12, S-Page: 3445- E-Page: 3457 DOI: 10.1128/IAI.00422-16 HZI repository PubMed
  • Authors: Sakthivel,P.; Bruder,D.; ( Year: 2016). Title: Mechanism of granuloma formation in sarcoidosis. Journal: Curr Opin.Hematol. Volume: 24 Issue: 1, S-Page: 59- E-Page: 65 PubMed
  • Authors: Boianelli,A.; Sharma-Chawla,N.; Bruder,D.; Hernandez-Vargas,E.A.; ( Year: 2016). Title: Oseltamivir PK/PD Modeling and Simulation to Evaluate Treatment Strategies against Influenza-Pneumococcus Coinfection. Journal: Front Cell Infect.Microbiol. Volume: 6, S-Page: 60 DOI: 10.3389/fcimb.2016.00060 HZI repository PubMed
  • Authors: Sakthivel,P.; Breithaupt,A.; Gereke,M.; Copland,D.A.; Schulz,C.; Gruber,A.D.; Dick,A.D.; Schreiber,J.; Bruder,D.; ( Year: 2016). Title: Soluble CD200 Correlates With Interleukin-6 Levels in Sera of COPD Patients: Potential Implication of the CD200/CD200R Axis in the Disease Course. Journal: Lung Volume: 159, S-Page: 59- E-Page: 68 DOI: 10.1007/s00408-016-9962-4 HZI repository PubMed
  • Authors: Boehme,J.D.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; ( Year: 2015). Title: Erratum to: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. Journal: Lung Volume: 193, S-Page: 955 PubMed
  • Authors: Yeruva,S.; Chodisetti,G.; Luo,M.; Chen,M.; Cinar,A.; Ludolph,L.; Lünnemann,M.; Goldstein,J.; Singh,A.K.; Riederer,B.; Bachmann,O.; Bleich,A.; Gereke,M.; Bruder,D.; Hagen,S.; He,P.; Yun,C.; Seidler,U.; ( Year: 2015). Title: Evidence for a causal link between adaptor protein PDZK1 downregulation and Na+/H+ exchanger NHE3 dysfunction in human and murine colitis. Journal: Pflug.Arch.Eur.J.Physiol. Volume: 467 Issue: 8, S-Page: 1795- E-Page: 1807 DOI: 10.1007/s00424-014-1608-x HZI repository PubMed
  • Authors: Tschernig,T.; Hartwig,C.; Jeron,A.; Dinh,Q.T.; Gereke,M.; Bruder,D.; ( Year: 2015). Title: First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma. Journal: Int.J Genomics Volume: 2015, S-Page: 638032 DOI: 10.1155/2015/638032 HZI repository PubMed
  • Authors: Biswas,A.; Bruder,D.; Wolf,S.A.; Jeron,A.; Mack,M.; Heimesaat,M.M.; Dunay,I.R.; ( Year: 2015). Title: Ly6Chigh monocytes control cerebral toxoplasmosis. Journal: Journal of Immunology Volume: 194 Issue: 7, S-Page: 3223- E-Page: 3235 WEBURLS
  • Authors: Boianelli,A.; Nguyen,V.K.; Ebensen,T.; Schulze,K.; Wilk,E.; Sharma,N.; Stegemann-Koniszewski,S.; Bruder,D.; Toapanta,F.R.; Guzm b n,C.A.; Meyer-Hermann,M.; Hernandez-Vargas,E.A.; ( Year: 2015). Title: Modeling influenza virus infection: A roadmap for influenza research. Journal: Viruses Volume: 7 Issue: 10, S-Page: 5274- E-Page: 5304 DOI: 10.3390/v7102875 HZI repository PubMed
  • Authors: Désiréé Boehme,J.; Pietkiewicz,S.; Lavrik,I.; Jeron,A.; Bruder,D.; ( Year: 2015). Title: Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. Journal: Lung Volume: 193 Issue: 6, S-Page: 947- E-Page: 953 DOI: 10.1007/s00408-015-9797-4 HZI repository PubMed
  • Authors: Sakthivel,P.; Grunewald,J.; Eklund,A.; Bruder,D.; Wahlstrom,J.; ( Year: 2015). Title: Pulmonary sarcoidosis is associated with high-level ICOS expression on lung regulatory T cells - possible implications for the ICOS/ICOS-L axis in disease course and resolution. Journal: Clin.Exp.Immunol. Volume: 183, S-Page: 294- E-Page: 306 PubMed
  • Authors: Sakthivel,P.; Gereke,M.; Breithaupt,A.; Fuchs,D.; Gigliotti,L.; Gruber,A.D.; Dianzani,U.; Bruder,D.; ( Year: 2014). Title: Attenuation of immune-mediated influenza pneumonia by targeting the inducible co-stimulator (ICOS) molecule on T cells. Journal: PLoS ONE Volume: 9 Issue: 7, S-Page: e100970 DOI: 10.1371/journal.pone.0100970 HZI repository PubMed
  • Authors: Petzold,C.; Steinbronn,N.; Gereke,M.; Strasser,R.H.; Sparwasser,T.; Bruder,D.; Geffers,R.; Schallenberg,S.; Kretschmer,K.; ( Year: 2014). Title: Fluorochrome-based definition of naturally occurring Foxp3+ regulatory T cells of intra- and extrathymic origin. Journal: European Journal of Immunology Volume: 44 Issue: 12, S-Page: 3632- E-Page: 3645 DOI: Article WEBURLS
  • Authors: Kominsky,D.J.; Campbell,E.L.; Ehrentraut,S.F.; Wilson,K.E.; Kelly,C.J.; Glover,L.E.; Collins,C.B.; Bayless,A.J.; Saeedi,B.; Dobrinskikh,E.; Bowers,B.E.; Macmanus,C.F.; Muller,W.; Colgan,S.P.; Bruder,Dunja; ( Year: 2014). Title: IFN-gamma-Mediated Induction of an Apical IL-10 Receptor on Polarized Intestinal Epithelia. Journal: Journal of Immunology Volume: 192 Issue: 3, S-Page: 1267- E-Page: 1276 DOI: 10.4049/jimmunol.1301757 HZI repository PubMed
  • Authors: Nair,Sharmila; Michaelsen-Preusse,K.; Finsterbusch,Katja; Stegemann-Koniszewski,Sabine; Bruder,Dunja; Grashoff,Martina; Korte,Martin; Köster,Mario; Kalinke,Ulrich; Hauser,Hansjörg; Kröger,Andrea; ( Year: 2014). Title: Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. Journal: PLoS Pathogens Volume: 10 Issue: 3, S-Page: e1003999 DOI: 10.1371/journal.ppat.1003999 HZI repository PubMed
  • Authors: Hasenberg,M.; Stegemann-Koniszewski,S.; Gunzer,Matthias*; ( Year: 2013). Title: Cellular immune reactions in the lung. Journal: Immunological Reviews Volume: 251 Issue: 1, S-Page: 189- E-Page: 214 DOI: 10.1111/imr.12020 HZI repository PubMed
  • Authors: Telieps,T.; Ewald,F.; Gereke,Marcus; Annemann,Michaela; Rauter,Yvonne; Schuster,Marc; Ueffing,N.; von,Smolinski D.; Gruber,A.D.; Bruder,Dunja; Schmitz,Ingo; ( Year: 2013). Title: Cellular-FLIP, Raji isoform (c-FLIPR) modulates cell death induction upon T-cell activation and infection. Journal: European Journal of Immunology Volume: 43 Issue: 6, S-Page: 1499- E-Page: 1510 WEBURLS
  • Authors: Martinez,J.P.; Perez-Vilaro,G.; Muthukumar,Y.; Scheller,N.; Hirsch,Tatjana; Diestel,R.; Steinmetz,Heinrich; Jansen,Rolf; Frank,Ronald; Sasse,Florenz; Meyerhans,A.; Diez,J.; ( Year: 2013). Title: Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology. Journal: RNA Biology Volume: 10 Issue: 11, S-Page: 1661- E-Page: 1669 Fulltext
  • Authors: Tosiek,M.J.; Bader,S.R.; Gruber,A.D.; Buer,J.; Gereke,M.; Bruder,Dunja; ( Year: 2012). Title: CD8+ T Cells Responding to Alveolar Self-Antigen Lack CD25 Expression and Fail to Precipitate Autoimmunity. Journal: American Journal of Respiratory Cell and Molecular Biology Volume: 47 Issue: 6, S-Page: 869- E-Page: 878 DOI: 10.1165/rcmb.2011-0387OC PubMed
  • Authors: Jeron,Aandreas; Hansen,W.; Ewert,F.; Buer,J.; Geffers,Robert; Bruder,Dunja; ( Year: 2012). Title: ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells. Journal: BMC GENOMICS Volume: 13 Issue: 1, S-Page: 705 PubMed
  • Authors: König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; ( Year: 2012). Title: First insight into the kinome of human regulatory T cells. Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e40896 DOI: 10.1371/journal.pone.0040896 HZI repository PubMed
  • Authors: Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; ( Year: 2012). Title: Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies. Journal: Journal of Visualized Experiments: JoVE Issue: 70 DOI: 4322. WEBURLS
  • Authors: Albrecht,M.; Arnhold,M.; Lingner,S.; Mahapatra,S.; Bruder,Dunja; Hansen,G.; Dittrich,A.M.; ( Year: 2012). Title: IL-4 Attenuates Pulmonary Epithelial Cell-Mediated Suppression of T Cell Priming. Journal: PLoS ONE Volume: 7 Issue: 9, S-Page: e45916 DOI: 10.1371/journal.pone.0045916 PubMed
  • Authors: Autengruber,Andrea; Gereke,Marcus; Hansen,G.; Hennig,C.; Bruder,Dunja; ( Year: 2012). Title: Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function. Journal: European Journal of Microbiology and Immunology Volume: 2 Issue: 2, S-Page: 112- E-Page: 120 DOI: 10.1556/EuJMI.2.2012.2.3
  • Authors: Sakthivel,Priya; Gereke,Marcus; Bruder,Dunja; ( Year: 2012). Title: Therapeutic intervention in cancer and chronic viral infections: antibody mediated manipulation of PD-1/PD-L1 interaction. Journal: Review on Recent Clinical Trials Volume: 7 Issue: 1, S-Page: 10- E-Page: 23 PubMed
  • Authors: Stegemann-Koniszewski,S.; Gereke,M.; Orrskog,S.; Lienenklaus,S.; Pasche,B.; Bader,S.R.; Gruber,A.D.; Akira,S.; Weiss,Siegfried; Henriques-Normark,B.; Bruder,Dunja; Gunzer,M.; ( Year: 2012). Title: TLR7 Contributes to the Rapid Progression but Not to the Overall Fatal Outcome of Secondary Pneumococcal Disease following Influenza A Virus Infection. Journal: Journal of Innate Immunity Volume: 5 Issue: 1, S-Page: 84- E-Page: 96 DOI: 10.1159/000345112 HZI repository PubMed
  • Authors: Tosiek,M.J.; Gruber,A.D.; Bader,S.; Hoymann,H.G.; Mauel,S.; Tschwernig,T.; Buer,J.; Gereke,M.; Bruder,Dunja*; ( Year: 2011). Title: CD4 + CD25 + Foxp3 + regulatory T cells are dispensable for controlling CD8 + T cell-mediated lung inflammation. Journal: Journal of Immunology Volume: 186 Issue: 11, S-Page: 6106- E-Page: 6118
  • Authors: Hasenberg,M.; Köhler,A.; Jeron,Andreas*; Bonifatius,S.; Gunzer,M.; ( Year: 2011). Title: Direct observation of phagocytosis and NET formation by neutrophils in infected lungs using 2-photon microscopy3332. Journal: Journal of Visualized Experiments Volume: 52 Issue: art. no. e2659 DOI: 10.3791/2659
  • Authors: Alberts,R.; Chen,H.; Pommerenke,C.; Smit,A.B.; Spijker,S.; Williams,R.W.; Geffers,Robert*; Bruder,Dunja*; Schughart,Klaus*; ( Year: 2011). Title: Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease1. Journal: BMC GENOMICS Volume: 12, S-Page: 610 PubMed
  • Authors: Ukena,S.N.; Velaga,S.; Geffers,Robert*; Grosse,J.; Baron,U.; Buchholz,S.; Stadler,M.; Bruder,Dunja*; Ganser,A.; Franzke,A.; ( Year: 2011). Title: Human regulatory T cells in allogeneic stem cell transplantation. Journal: Blood Volume: 118 Issue: 13, S-Page: e82- E-Page: e92 PubMed
  • Authors: Liesz,A.; Zhou,W.; Mracskó,E.; Karcher,S.; Doerr,H.; Schwarting,S.; Sun,L.; Bruder,Dunja*; Stegemann,S.; Cerwenka,A.; Sommer,C.; Dalpke,A.; Veltkamp,R.; ( Year: 2011). Title: Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Journal: Brain Volume: 134 Issue: 3, S-Page: 704- E-Page: 720
  • Authors: Cappuccini,F.; Eldh,T.; Bruder,Dunja*; Gereke,M.; Jastrow,H.; Schulze-Osthoff,K.; Fischer,U.; Kohler,D.; Stuschke,M.; Jendrossek,V.; ( Year: 2011). Title: New insights into the molecular pathology of radiation-induced pneumopathy. Journal: Radiotherapy and Oncology Volume: 101 Issue: 1, S-Page: 86- E-Page: 92 DOI: 10.1016/j.radonc.2011.05.064 HZI repository PubMed
  • Authors: Kang,T.W.; Yevsa,T.; Woller,N.; Hoenicke,L.; Wuestefeld,T.; Dauch,D.; Hohmeyer,A.; Gereke,M.; Rudalska,R.; Potapova,A.; Iken,M.; Vucur,M.; Weiss,Siegfried*; Heikenwalder,M.; Khan,S.; Gil,J.; Bruder,Dunja*; Manns,M.; Schirmacher,P.; Tacke,F.; Ott,M.; Luedde,T.; Longerich,T.; Kubicka,S.; Zender,Lars*; ( Year: 2011). Title: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Journal: Nature Volume: 479 Issue: 7374, S-Page: 547- E-Page: 551 PubMed
  • Authors: Bar-On,L.; Birnberg,T.; Lewis,K.L.; Edelson,B.T.; Bruder,Dunja*; Hildner,K.; Buer,J.; Murphy,K.M.; Reizis,B.; Jung,S.; ( Year: 2010). Title: CX3CR1+ CD8alpha+ dendritic cells are a steady-state population related to plasmacytoid dendritic cells. Journal: Proceedings of the National Acadamy of Sciences of the United States of America Volume: 107 Issue: 33, S-Page: 14745- E-Page: 14750 DOI: 10.1073/pnas.1001562107 HZI repository PubMed
  • Authors: Bruns,S.; Kniemeyer,O.; Hasenberg,M.; Aimanianda,V.; Nietzsche,S.; Thywissen,A.; Jeron,Andreas*.; Latge,J.P.; Brakhage,A.A.; Gunzer,Matthias*; ( Year: 2010). Title: Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. Journal: PLoS Pathogens Volume: 6 Issue: 4, S-Page: e1000873 DOI: 10.1371/journal.ppat.1000873 HZI repository PubMed
  • Authors: Gereke,M.; Jung,S.; Buer,J.; Bruder,Dunja*; ( Year: 2009). Title: Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Journal: American Journal of Respiratory and Critical Care Medicine Volume: 179 Issue: 5, S-Page: 344- E-Page: 355 PubMed
  • Authors: De Buhr,M.F.; Hedrich,H.J.; Westendorf,Astrid M.*; Obermeier,F.; Hofmann,C.; Zschemisch,N.H.; Buer,J.; Bumann,D.; Goyert,S.M.; Bleich,A.; ( Year: 2009). Title: Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Journal: Inflammatory Bowel Diseases Volume: 15 Issue: 12, S-Page: 1824- E-Page: 1836 DOI: 10.1002/ibd.21030 HZI repository PubMed
  • Authors: Westendorf,A.M.; Fleissner,D.; Gröbe,Lothar*; Jung,S.; Gruber,A.D.; Hansen,W.; Buer,J.; ( Year: 2009). Title: CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. Journal: GUT Volume: 58 Issue: 2, S-Page: 211- E-Page: 219 PubMed
  • Authors: Jeron,A.; Pfoertner,S.; Bruder,Dunja*; Geffers,Robert*; Hammerer,P.; Hofmann,R.; Buer,J.; Schrader,A.J.; ( Year: 2009). Title: Frequency and Gene Expression Profile of Regulatory T Cells in Renal Cell Carcinoma. Journal: Tumor Biology Volume: 30 Issue: 3, S-Page: 160- E-Page: 170 PubMed
  • Authors: Probst-Kepper,M.; Geffers,R.; Kroger,A.; Viegas,N.; Erck,C.; Hecht,H.-J.; Lünsdorf,H.; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,A.; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,R.; Hauser,H.; Buer,J.; Weiss,S.; ( Year: 2009). Title: GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal: Journal of Cellular and Molecular Medicine Volume: 13 Issue: 9, S-Page: 3343- E-Page: 3357 PubMed
  • Authors: Stegemann,S.; Dahlberg,S.; Kroger,A.; Gereke,M.; Bruder,Dunja*; Henriques-Normark,B.; Gunzer,Matthias*; ( Year: 2009). Title: Increased susceptibility for superinfection with Streptococcus pneumoniae during influenza virus infection is not caused by TLR7-mediated lymphopenia. Journal: PLoS ONE Volume: 4 Issue: 3, S-Page: e4840 DOI: 10.1371/journal.pone.0004840 HZI repository PubMed
  • Authors: Lienenklaus,S.; Cornitescu,M.; Zietara,N.; Lyszkiewicz,M.; Gekara,N.; Jablonska,J.; Edenhofer,F.; Rajewsky,K.; Bruder,Dunja*; Hafner,M.; Staeheli,P.; Weiss,Siegfried*; ( Year: 2009). Title: Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo. Journal: Journal of Immunology Volume: 183 Issue: 5, S-Page: 3229- E-Page: 3236 PubMed
  • Authors: Barth,K.; Weinhold,K.; Guenther,A.; Linge,A.; Gereke,Marcus*; Kasper,M.; ( Year: 2008). Title: Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells. Journal: International Journal of Biochemistry and Cell Biology Volume: 40 Issue: 10, S-Page: 2230- E-Page: 2239 DOI: 10.1016/j.biocel.2008.03.001 PubMed
  • Authors: Hansen,W.; Westendorf,A.M.; Reinwald,S.; Bruder,Dunja*; Deppenmeier,S.; Gröbe,Lothar*; Probst-Kepper,Michael*; Gruber,A.D.; Geffers,Robert*; Buer,Jan*; ( Year: 2007). Title: Chronic antigen stimulation in vivo induces a distinct population of antigen-specific Foxp3 - CD25 - regulatory T cells 1. Journal: Journal of Immunology Volume: 179, S-Page: 8059- E-Page: 8068
  • Authors: Gereke,M.; Gröbe,L.; Prettin,S.; Kasper,M.; Deppenmeier,S.; Gruber,A.D.; Enelow,R.I.; Buer,J.; Bruder,D.; ( Year: 2007). Title: Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation. Journal: Respiratory research Volume: 8, S-Page: 47 DOI: 10.1186/1465-9921-8-47 HZI repository PubMed
  • Authors: Ukena,S.N.; Singh,A.; Dringenberg,U.; Engelhardt,R.; Seidler,U.; Hansen,W.; Bleich,A.; Bruder,Dunja*; Franzke,A.; Rogler,G.; Suerbaum,S.; Buer,Jan*; Gunzer,F.; Westendorf,Astrid .M.*; ( Year: 2007). Title: Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. Journal: PLoS ONE Volume: 2 Issue: 12, S-Page: e1308 DOI: 10.1371/journal.pone.0001308 HZI repository PubMed
  • Authors: Westendorf,A.M.; Fleissner,D.; Deppenmeier,S.; Gruber,A.D.; Bruder,D.; Hansen,H.; Liblau,R.; Buer,J.; ( Year: 2006). Title: Autoimmune-mediated intestinal inflammation - impact and regulation of antigen specific CD8+ T cells. Journal: Gastroenterology Volume: 131 Issue: 2, S-Page: 510- E-Page: 524
  • Authors: Bruder,Dunja*; Srikiatkhachorn,A.; Enelow,R.I.; ( Year: 2006). Title: Cellular immunity and lung injury in respiratory virus infection. Journal: Viral Immunology Volume: 26, S-Page: 318- E-Page: 327
  • Authors: Hansen,W.; Loser,K.; Westendorf,Astrid M.*; Bruder,Dunja*; Pförtner,S.; Siewert,C.; Huehn,J.; Beissert,S.; Buer,Jan*; ( Year: 2006). Title: GPR83-overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo. Journal: Journal of Immunology Volume: 177, S-Page: 209- E-Page: 215
  • Authors: Westendorf,A.M.; Bruder,D.; Hansen,W.; Buer,J.; ( Year: 2006). Title: Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model. Journal: Annals of the New York Academy of Sciences Volume: 1072, S-Page: 401- E-Page: 406
  • Authors: Ramana,C.V.; Chintapalli,J.; Xu,L.; Alia,C.; Bruder,Dunja*; Enelow,R.I.; ( Year: 2006). Title: Lung epithelial Stat1 and NF- B signalling in response to CD8+ T cell antigen recognition. Journal: Journal of Interferon and Cytokine Research Volume: 26, S-Page: 318- E-Page: 327
  • Authors: Bruder,Dunja*; Nussbaum,A.K.; Gakamsky,D.M.; Schirle,M.; Stevanovic,S.; Singh-Jasuja,H.; Darji,A.; Chakraborty,T.; Schild,H.; Pecht,I.; Weiss,Siegfried*; ( Year: 2006). Title: Multiple synergizing factors contribute to the strength of the CD8+ T cell response against listeriolysin O. Journal: International immunology Volume: 18, S-Page: 89- E-Page: 100 DOI: 10.1093/intimm/dxh352 HZI repository PubMed
  • Authors: Pfoertner,Susanne*; Jeron,A.; Probst-Kepper,M.; Guzmán,Carlos A.*; Hansen,W.; Westendorf,A.M.; Toepfer,T.; Schrader,A.J.; Franzke,A.; Buer,Jan*; Geffers,Robert*; ( Year: 2006). Title: Signatures of human regulatory T cells: an encounter with old friends and new players. Journal: Genome Biology Volume: 7, S-Page: R54 DOI: 10.1186/gb-2006-7-7-r54 HZI repository PubMed


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  • Impfung gegen Diabetes

    Diabetes melletius ist inwzischen eine Volkskrankheit an der jährlich mehr junge Menschen erkranken. Lebenslang müssen die Betroffenen strenge Diät halten und Insulin spritzen, da ihre Bauchspeicheldrüse das Hormon nicht produziert und dadurch der Zucker im Blut nicht von den Zellen aufgenommen werden kann. Diabetes ist eine Krankheit, bei der das Immunsystem selbst für die Krankheit verantwortlich ist. Forscher am HZI versuchen die Krankheit zu verstehen und haben in Mäusen einen Weg gefunden das Immunsystem auszutricksen: Sie programmieren es um. Der erste Schritt zu einer völlig neuen Therapie.
    Länge: 06:08

Audio Podcast

  • Raucherhusten-COPDWenn der Husten ständig quält und die Luft dauerhaft knapp wird, zerstört die Autoimmunkrankheit Raucherhusten - Fachname COPD - die Lunge. Dunja Bruder und Marcus Gereke sind den Ursachen dieser Volkskrankheit auf der Spur und nehmen Sie mit auf Forschungsreise ins Labor...
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