Experimental Immunology

Every day we are attacked by a large number of different pathogens that our immune system tries to repel by using various strategies. To combat these, cells of the immune system have learnt to distinguish between harmless self structures and potentially dangerous foreign ones. Sometimes, however, immune cells are generated, which are falsely programmed and can attack structures in their own body. Learn more about the body`s protection against these cells and how we can use this mechanism in therapy.


Selected Publications

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J (2017) Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cellsOncotarget 8: 35542-35557

Pasztoi M, Bonifacius A, Pezoldt J, Kulkarni D, Niemz J, Yang J, Teich R, Hajek J, Pisano F, Rohde M, Dersch P, Huehn J (2017) Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Cell Mol Life Sci 74: 2839-2850

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J (2015) Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43: 1537-1548

Cording S, Wahl B, Kulkarni D, Chopra H, Pezoldt J, Buettner M, Dummer A, Hadis U, Heimesaat M, Bereswill S, Falk C, Bode U, Hamann A, Fleissner D, Huehn J*, Pabst O* (2014) The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol 7: 359-368

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cellsImmunity 36: 262-275

Publikationen der Arbeitsgruppe

  • Authors: Schmoeckel,K.; Mrochen,D.M.; Hühn,J.; Pötschke,C.; Bröker,B.M.; ( Year: 2018). Title: Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree. Journal: PLoS ONE Volume: 13 Issue: 2, S-Page: Article number e0192197 DOI: 10.1371/journal.pone.0192197 Fulltext PubMed
  • Authors: Ranjan,S.; Goihl,A.; Kohli,S.; Gadi,I.; Pierau,M.; Shahzad,K.; Gupta,D.; Bock,F.; Wang,H.; Shaikh,H.; Kahne,T.; Reinhold,D.; Bank,U.; Zenclussen,A.C.; Niemz,J.; Schnoder,T.M.; Brunner-Weinzierl,M.; Fischer,T.; Kalinski,T.; Schraven,B.; Luft,T.; Hühn,J.; Naumann,M.; Heidel,F.H.; Isermann,B.; ( Year: 2017). Title: Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Journal: Nature Communications Volume: 8 Issue: 1, S-Page: 311 DOI: 10.1038/s41467-017-00169-4 HZI repository PubMed
  • Authors: Nikolouli,E.; Hardtke-Wolenski,M.; Hapke,M.; Beckstette,M.; Geffers,R.; Floess,S.; Jaeckel,E.; Huehn,J.; ( Year: 2017). Title: Alloantigen-induced regulatory t cells generated in presence of vitamin c display enhanced stability of foxp3 expression and promote skin allograft acceptance. Journal: Frontiers in Immunology Volume: 8 Issue: 748 DOI: 10.3389/fimmu.2017.00748 HZI repository PubMed
  • Authors: Schuster,M.; Plaza-Sirvent,C.; Matthies,A.M.; Heise,U.; Jeron,A.; Bruder,D.; Visekruna,A.; Hühn,J.; Schmitz,I.; ( Year: 2017). Title: c-REL and IkappaBNS Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors. Journal: Journal of Immunology Volume: 199 Issue: 3, S-Page: 920- E-Page: 930 DOI: 10.4049/jimmunol.1600877 PubMed
  • Authors: Ciurkiewicz,M.; Herder,V.; Khan,M.A.; Uhde,A.K.; Teich,R.; Floess,S.; Baumgartner,W.; Hühn,J.; Beineke,A.; ( Year: 2017). Title: Cytotoxic CD8+ T cells ablation enhances the capacity of regulatory T cells to delay viral elimination in Theiler's murine encephalomyelitis. Journal: Brain Pathol. DOI: 10.1111/bpa.12518 PubMed
  • Authors: Prajeeth,C.K.; Kronisch,J.; Khorooshi,R.; Knier,B.; Toft-Hansen,H.; Gudi,V.; Floess,S.; Hühn,J.; Owens,T.; Korn,T.; Stangel,M.; ( Year: 2017). Title: Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. Journal: J.Neuroinflammation. Volume: 14 Issue: 1, S-Page: 204 DOI: 10.1186/s12974-017-0978-3 HZI repository PubMed
  • Authors: Beyer,M.; Hühn,J.; ( Year: 2017). Title: Epigenetic orchestration of thymic T reg cell development. Journal: Nat.Immunol. Volume: 18 Issue: 2, S-Page: 144- E-Page: 146 DOI: 10.1038/ni.3660 HZI repository PubMed
  • Authors: Szilagyi,B.A.; Triebus,J.; Kressler,C.; de,Almeida M.; Tierling,S.; Durek,P.; Mardahl,M.; Szilagyi,A.; Floess,S.; Hühn,J.; Syrbe,U.; Walter,J.; Polansky,J.K.; Hamann,A.; ( Year: 2017). Title: Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells. Journal: Mucosal.Immunol. Volume: 10 Issue: 6, S-Page: 1443- E-Page: 1454 DOI: 10.1038/mi.2017.7 HZI repository PubMed
  • Authors: Kyburz,A.; Urban,S.; Altobelli,A.; Floess,S.; Hühn,J.; Cover,T.L.; Muller,A.; ( Year: 2017). Title: Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy. Journal: Clin.Exp.Allergy DOI: 10.1111/cea.12996 HZI repository PubMed
  • Authors: Pezoldt,J.; Pisano,F.; Heine,W.; Pasztoi,M.; Rosenheinrich,M.; Nuss,A.M.; Pils,M.C.; Prinz,I.; Forster,R.; Hühn,J.; Dersch,P.; ( Year: 2017). Title: Impact of CCR7 on T-Cell Response and Susceptibility to Yersinia pseudotuberculosis Infection. Journal: J Infect.Dis. Volume: 216 Issue: 6, S-Page: 752- E-Page: 760 DOI: 10.1093/infdis/jix037 HZI repository PubMed
  • Authors: Pasztoi,M.; Pezoldt,J.; Beckstette,M.; Lipps,C.; Wirth,D.; Rohde,M.; Paloczi,K.; Buzas,E.I.; Hühn,J.; ( Year: 2017). Title: Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3+ regulatory T cells. Journal: European Journal of Immunology Volume: 47 Issue: 12, S-Page: 2142- E-Page: 2152 DOI: 10.1002/eji.201746960 HZI repository PubMed
  • Authors: Essig,K.; Hu,D.; Guimaraes,J.C.; Alterauge,D.; Edelmann,S.; Raj,T.; Kranich,J.; Behrens,G.; Heiseke,A.; Floess,S.; Klein,J.; Maiser,A.; Marschall,S.; Hrabe de Angelis,M.; Leonhardt,H.; Calkhoven,C.F.; Noessner,E.; Brocker,T.; Hühn,J.; Krug,A.B.; Zavolan,M.; Baumjohann,D.; Heissmeyer,V.; ( Year: 2017). Title: Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells. Journal: Immunity Volume: 47 Issue: 6, S-Page: 1067- E-Page: 1082 DOI: 10.1016/j.immuni.2017.11.008 PubMed
  • Authors: van,Ham M.; Teich,R.; Philipsen,L.; Niemz,J.; Amsberg,N.; Wissing,J.; Nimtz,M.; Grobe,L.; Kliche,S.; Thiel,N.; Klawonn,F.; Hubo,M.; Jonuleit,H.; Reichardt,P.; Muller,A.J.; Hühn,J.; Jänsch,L.; ( Year: 2017). Title: TCR signalling network organization at the immunological synapses of murine regulatory T cells. Journal: European Journal of Immunology Volume: 47 Issue: 12, S-Page: 2043- E-Page: 2058 DOI: 10.1002/eji.201747041 HZI repository PubMed
  • Authors: Niemz,J.; Kliche,S.; Pils,M.C.; Morrison,E.; Manns,A.; Freund,C.; Crittenden,J.R.; Graybiel,A.M.; Galla,M.; Jänsch,L.; Hühn,J.; ( Year: 2017). Title: The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells. Journal: Eur.J.Microbiol.Immunol.(Bp) Volume: 7 Issue: 2, S-Page: 112- E-Page: 126 DOI: 10.1556/1886.2017.00007 HZI repository PubMed
  • Authors: Garg,G.; Nikolouli,E.; Hardtke-Wolenski,M.; Toker,A.; Ohkura,N.; Beckstette,M.; Miyao,T.; Geffers,R.; Floess,S.; Gerdes,N.; Lutgens,E.; Osterloh,A.; Hori,S.; Sakaguchi,S.; Jaeckel,E.; Hühn,J.; ( Year: 2017). Title: Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells. Journal: Oncotarget. Volume: 8 Issue: 22, S-Page: 35542- E-Page: 35557 DOI: 10.18632/oncotarget.16221 HZI repository PubMed
  • Authors: Pasztoi,M.; Bonifacius,A.; Pezoldt,J.; Kulkarni,D.; Niemz,J.; Yang,J.; Teich,R.; Hajek,J.; Pisano,F.; Rohde,M.; Dersch,P.; Hühn,J.; ( Year: 2017). Title: Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Journal: Cell Mol.Life Sci. Volume: 74 Issue: 15, S-Page: 2839- E-Page: 2850 DOI: 10.1007/s00018-017-2516-y HZI repository PubMed
  • Authors: Yang,B.H.; Hagemann,S.; Mamareli,P.; Lauer,U.; Hoffmann,U.; Beckstette,M.; Fohse,L.; Prinz,I.; Pezoldt,J.; Suerbaum,S.; Sparwasser,T.; Hamann,A.; Floess,S.; Hühn,J.; Lochner,M.; ( Year: 2016). Title: Foxp3+ T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Journal: Mucosal.Immunol. Volume: 9, S-Page: 444- E-Page: 457 DOI: 10.1038/mi.2015.74 HZI repository PubMed
  • Authors: Pink,M.; Ratsch,B.A.; Mardahl,M.; Durek,P.; Polansky,J.K.; Karl,M.; Baumgrass,R.; Wallner,S.; Cadenas,C.; Gianmoena,K.; Floess,S.; Chen,W.; Nordstroem,K.; Tierling,S.; Olek,S.; Walter,J.; Hamann,A.; Syrbe,U.; ( Year: 2016). Title: Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene. Journal: J Immunol. Volume: 197, S-Page: 3406- E-Page: 3414 DOI: 10.4049/jimmunol.1502434 PubMed
  • Authors: Goldstein,J.D.; Burlion,A.; Zaragoza,B.; Sendeyo,K.; Polansky,J.K.; Hühn,J.; Piaggio,E.; Salomon,B.L.; Marodon,G.; ( Year: 2016). Title: Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression. Journal: PLoS ONE Volume: 11 Issue: 4, S-Page: e0153682 DOI: 10.1371/journal.pone.0153682 HZI repository PubMed
  • Authors: Noyan,F.; Zimmermann,K.; Hardtke-Wolenski,M.; Knoefel,A.; Schulde,E.; Geffers,R.; Hust,M.; Hühn,J.; Galla,M.; Morgan,M.; Jokuszies,A.; Manns,M.P.; Jaeckel,E.; ( Year: 2016). Title: Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. Journal: Am J Transplant. Volume: 17 Issue: 4, S-Page: 917- E-Page: 930 DOI: 10.1111/ajt.14175 HZI repository PubMed
  • Authors: Pezoldt,J.; Huehn,J.; ( Year: 2016). Title: Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation. Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 6 Issue: 3, S-Page: 219- E-Page: 226 DOI: 10.1556/1886.2016.00018 PubMed
  • Authors: Uhde,A.K.; Herder,V.; Akram,Khan M.; Ciurkiewicz,M.; Schaudien,D.; Teich,R.; Floess,S.; Baumgartner,W.; Hühn,J.; Beineke,A.; ( Year: 2016). Title: Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice. Journal: PLoS ONE Volume: 11 Issue: 9, S-Page: e0161883 DOI: 10.1371/journal.pone.0161883 PubMed
  • Authors: Milanez-Almeida,P.; Ulas,T.; Pasztoi,M.; Glage,S.; Schughart,K.; Lutz,M.B.; Schultze,J.L.; Hühn,J.; ( Year: 2015). Title: CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 5 Issue: 4, S-Page: 246- E-Page: 255 PubMed
  • Authors: Hühn,J.; Floess,S.; Ohkura,N.; Sakaguchi,S.; ( Year: 2015). Title: Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans". Journal: Journal of Immunology Volume: 194 Issue: 8, S-Page: 3533- E-Page: 3534 WEBURLS
  • Authors: Yang,B.H.; Flöß,Stefan; Hagemann,S.; Deyneko,Igor V.; Gröbe,Lothar; Pezoldt,J.; Sparwasser,Tim; Lochner,M.; Hühn,Jochen; ( Year: 2015). Title: Development of a unique epigenetic signature during in vivo Th17 differentiation. Journal: Nucleic Acids Res Volume: 43 Issue: 3, S-Page: 1537- E-Page: 1548 DOI: 10.1093/nar/gkv014 HZI repository PubMed
  • Authors: Hühn,J.; Beyer,M.; ( Year: 2015). Title: Epigenetic and transcriptional control of Foxp3 regulatory T cells. Journal: Semin.Immunol. Volume: 27 Issue: 1, S-Page: 10- E-Page: 18 DOI: 10.1016/j.smim.2015.02.002 PubMed
  • Authors: Roesner,L.M.; Flöß,S.; Witte,T.; Olek,S.; Hühn,J.; Werfel,T.; ( Year: 2015). Title: Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients. Journal: Allergy: European Journal of Allergy and Clinical Immunology Volume: 70 Issue: 12, S-Page: 1656- E-Page: 1660 PubMed
  • Authors: Klysz,D.; Tai,X.; Robert,P.A.; Craveiro,M.; Cretenet,G.; Oburoglu,L.; Mongellaz,C.; Flöß,S.; Fritz,V.; Matias,M.I.; Yong,C.; Surh,N.; Marie,J.C.; Hühn,J.; Zimmermann,V.; Kinet,S.; Dardalhon,V.; Taylor,N.; ( Year: 2015). Title: Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation. Journal: Sci Signal Volume: 8 Issue: 396, S-Page: ra97 PubMed
  • Authors: Braun,A.; Dewert,N.; Brunnert,F.; Schnabel,V.; Hardenberg,J.H.; Richter,B.; Zachmann,K.; Cording,S.; Classen,A.; Brans,R.; Hamann,A.; Hühn,J.; Schon,M.P.; ( Year: 2015). Title: Integrin alpha(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. Journal: J Invest Dermatol. PubMed
  • Authors: Pasztoi,M.; Pezoldt,J.; Hühn,J.; ( Year: 2015). Title: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells. Journal: Prog.Mol.Biol.Transl.Sci Volume: 136, S-Page: 35- E-Page: 56 DOI: 10.1016/bs.pmbts.2015.07.012 PubMed
  • Authors: Walter,F.R.; Veszelka,S.; Pasztoi,M.; Peterfi,Z.A.; Toth,A.; Rakhely,G.; Cervenak,L.; Abraham,C.S.; Deli,M.A.; ( Year: 2015). Title: Tesmilifene modifies brain endothelial functions and opens the blood-brain/blood-glioma barrier. Journal: J Neurochem. Volume: 134 Issue: 6, S-Page: 1040- E-Page: 1054 PubMed
  • Authors: Tebartz,C.; Horst,Sarah A.; Sparwasser,Tim; Hühn,Jochen; Beineke,A.; Peters,G.; Medina,Eva; ( Year: 2014). Title: A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection. Journal: Journal of Immunology Volume: 194 Issue: 3, S-Page: 1100- E-Page: 1111 PubMed
  • Authors: Khailaie,S.; Robert,P.A.; Toker,A.; Hühn,J.; Meyer-Hermann,M.; ( Year: 2014). Title: A signal integration model of thymic selection and natural regulatory T cell commitment. Journal: Journal of Immunology Volume: 193 Issue: 12, S-Page: 5983- E-Page: 5996 PubMed
  • Authors: Mayer,Christian T.; Lahl,K.; Milanez-Almeida,P.; Watts,D.; Dittmer,U.; Fyhrquist,N.; Hühn,Jochen; Kopf,M.; Kretschmer,K.; Rouse,B.; Sparwasser,Tim; ( Year: 2014). Title: Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Journal: Immunity, Inflammation and Disease Volume: 2 Issue: 3, S-Page: 162- E-Page: 165 DOI: 10.1002/iid3.33 HZI repository PubMed
  • Authors: Berod,L.; Friedrich,C.; Nandan,A.; Freitag,J.; Hagemann,S.; Harmrolfs,K.; Sandouk,A.; Hesse,C.; Castro,C.N.; Bahre,H.; Tschirner,S.K.; Gorinski,N.; Gohmert,M.; Mayer,C.T.; Hühn,Jochen; Ponimaskin,E.; Abraham,Wolf-Rainer; Müller,Rolf; Lochner,M.; Sparwasser,Tim; ( Year: 2014). Title: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Journal: Nature medicine Volume: 20, S-Page: 1327- E-Page: 1333 PubMed
  • Authors: Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; ( Year: 2014). Title: Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen. Journal: Eur.J Microbiol.Immunol.(Bp) Volume: 4 Issue: 3, S-Page: 147- E-Page: 155 PubMed
  • Authors: Prajeeth,C.K.; Lohr,K.; Flöß,Stefan; Zimmermann,J.; Ulrich,R.; Gudi,V.; Beineke,A.; Baumgartner,W.; Muller,M.; Hühn,Jochen; Stangel,M.; ( Year: 2014). Title: Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia. Journal: Brain, Behavior, and Immunity Volume: 37, S-Page: 248- E-Page: 259 DOI: 10.1016/j.bbi.2014.01.001 HZI repository PubMed
  • Authors: Milanez-Almeida,P.; Meyer-Hermann,M.; Toker,A.; Khailaie,S.; Hühn,J.; ( Year: 2014). Title: Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen. Journal: European Journal of Immunology Volume: 45, S-Page: 153- E-Page: 166 PubMed
  • Authors: Prajeeth,C.K.; Beineke,A.; Iskandar,C.; Gudi,V.; Herder,V.; Gerhauser,I.; Haist,V.; Teich,R.; Hühn,J.; Baumgartner,W.; Stangel,M.; ( Year: 2014). Title: Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. Journal: J Neuroinflammation. Volume: 11 Issue: 1, S-Page: 180 PubMed
  • Authors: Franckaert,D.; Dooley,J.; Roos,E.; Flöß,Stefan; Hühn,Jochen; Luche,H.; Fehling,H.J.; Liston,A.; Linterman,M.A.; Schlenner,S.M.; ( Year: 2014). Title: Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells. Journal: Immunology and Cell Biology Volume: 93 Issue: 4, S-Page: 417- E-Page: 423 DOI: 10.1038/icb.2014.108 HZI repository PubMed
  • Authors: Cording,S.; Wahl,B.; Kulkarni,D.; Chopra,H.; Pezoldt,Jörn; Buettner,M.; Dummer,A.; Hadis,U.; Heimesaat,M.; Bereswill,S.; Falk,C.; Bode,U.; Hamann,A.; Fleissner,D.; Hühn,Jochen; Pabst,O.; ( Year: 2014). Title: The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Journal: Mucosal Immunology Volume: 7 Issue: 2, S-Page: 359- E-Page: 368 DOI: 10.1038/mi.2013.54 PubMed
  • Authors: Schreiber,L.; Pietzsch,Beate; Flöß,Stefan; Farah,Carla; Jänsch,Lothar; Schmitz,Ingo; Hühn,Jochen; ( Year: 2014). Title: The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling. Journal: PLoS ONE Volume: 9 Issue: 2, S-Page: e88318 WEBURLS
  • Authors: Delacher,M.; Schreiber,L.; Richards,D.M.; Farah,C.; Feuerer,M.; Hühn,J.; ( Year: 2014). Title: Transcriptional control of regulatory T cells. Journal: Curr Top.Microbiol.Immunol. Volume: 381, S-Page: 83- E-Page: 124 PubMed
  • Authors: Khailaie,Sahamoddin; Bahrami,F.; Janahmadi,M.; Milanez-Almeida,P.; Hühn,Jochen; Meyer-Hermann,Michael; ( Year: 2013). Title: A mathematical model of immune activation with a unified self-nonself concept. Journal: Frontiers in Immunology Volume: 4, S-Page: 474 DOI: 10.3389/fimmu.2013.00474 HZI repository PubMed
  • Authors: Toker,A.; Engelbert,D.; Garg,G.; Polansky,J.K.; Floess,S.; Miyao,T.; Baron,U.; Düber,S.; Geffers,R.; Giehr,P.; Schallenberg,S.; Kretschmer,K.; Olek,S.; Walter,J.; Weiss,S.; Hori,S.; Hamann,A.; Hühn,J.; ( Year: 2013). Title: Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. Journal: Journal of Immunology Volume: 190 Issue: 7, S-Page: 3180- E-Page: 3188 WEBURLS
  • Authors: Cording,S.; Fleißner,Diana; Heimesaat,M.M.; Bereswill,S.; Loddenkemper,C.; Uematsu,S.; Akira,S.; Hamann,A.; Hühn,Jochen; ( Year: 2013). Title: Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches. Journal: European Journal of Microbiology and Immunology Volume: 3 Issue: 1, S-Page: 1- E-Page: 10 PubMed
  • Authors: Kühlhorn,F.; Rath,M.; Schmoeckel,K.; Cziupka,K.; Nguyen,H.H.; Hildebrandt,P.; Hünig,T.; Sparwasser,Tim; Hühn,Jochen; Pötschke,C.; Bröker,B.M.; ( Year: 2013). Title: Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis. Journal: PLoS ONE Volume: 8 Issue: 5, S-Page: e65109 DOI: 10.1371/journal.pone.0065109 HZI repository PubMed
  • Authors: Huang,Yi-Ju; Haist,V.; Baumgartner,W.; Fohse,L.; Prinz,I.; Suerbaum,S.; Floess,Stefan; Hühn,Jochen; ( Year: 2013). Title: Induced and thymus-derived Foxp3 regulatory T cells share a common niche. Journal: European Journal of Immunology Volume: 44 Issue: 2, S-Page: 460- E-Page: 468 DOI: 10.1002/eji.201343463 PubMed
  • Authors: Kreutzfeldt,M.; Bergthaler,A.; Fernandez,M.; Brück,W.; Steinbach,K.; Vorm,M.; Coras,R.; Blümcke,I.; Bonilla,W.V.; Fleige,A.; Forman,R.; Müller,W.; Becher,B.; Misgeld,T.; Kerschensteiner,M.; Pinschewer,D.D.; Merkler,D.; ( Year: 2013). Title: Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss. Journal: Journal of Experimental Medicine Volume: 210 Issue: 10, S-Page: 2087- E-Page: 2103 DOI: 10.1084/jem.20122143 HZI repository PubMed
  • Authors: Sledzinska,A.; Hemmers,S.; Mair,F.; Gorka,O.; Ruland,J.; Fairbairn,L.; Nissler,A.; Müller,W.; Waisman,A.; Becher,B.; Buch,T.; ( Year: 2013). Title: TGF-beta Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function. Journal: PLoS Biology Volume: 11 Issue: 10, S-Page: e1001674 DOI: 10.1371/journal.pbio.1001674 HZI repository PubMed
  • Authors: Schweer,J.; Kulkarni,D.; Kochut,A.; Pezoldt,J.; Pisano,F.; Pils,M.C.; Genth,H.; Hühn,J.; Dersch,P.; ( Year: 2013). Title: The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases. Journal: PLoS Pathogens Volume: 9 Issue: 11, S-Page: e1003746 DOI: 10.1371/journal.ppat.1003746 HZI repository PubMed
  • Authors: Patzelt,Diana; Wang,Hui; Buchholz,I.; Rohde,Manfred; Gröbe,Lothar; Pradella,S.; Neumann,A.; Schulz,S.; Heyber,S.; Munch,K.; Munch,R.; Jahn,D.; Wagner-Döbler,Irene; Tomasch,Jürgen; ( Year: 2013). Title: You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae. Journal: ISME Journal Volume: 7 Issue: 12, S-Page: 2274- E-Page: 2286 DOI: 10.1038/ismej.2013.107 PubMed
  • Authors: Hinz,D.; Bauer,M.; Roder,S.; Olek,S.; Hühn,Jochen; Sack,U.; Borte,M.; Simon,J.C.; Lehmann,I.; Herberth,G.; ( Year: 2012). Title: Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Journal: Allerg: European Journal of Allergy and Clinical Immunology Volume: 67 Issue: 3, S-Page: 380- E-Page: 389 PubMed
  • Authors: Brand,S.; Kesper,D.A.; Teich,R.; Kilic-Niebergall,E.; Pinkenburg,O.; Bothur,E.; Lohoff,M.; Garn,H.; Pfefferle,P.I.; Renz,H.; ( Year: 2012). Title: DNA methylation of T H1/T H2 cytokine genes affects sensitization and progress of experimental asthma. Journal: Journal of Allergy and Clinical Immunology Volume: 129 Issue: 6, S-Page: 1602- E-Page: 1610
  • Authors: König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; ( Year: 2012). Title: First insight into the kinome of human regulatory T cells. Journal: PLoS ONE Volume: 7 Issue: 7, S-Page: e40896 DOI: 10.1371/journal.pone.0040896 HZI repository PubMed
  • Authors: Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; ( Year: 2012). Title: Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies. Journal: Journal of Visualized Experiments: JoVE Issue: 70 DOI: 4322. WEBURLS
  • Authors: O'Connor,R.A.; Floess,S.; Hühn,Jochen; Jones,S.A.; Anderton,S.M.; ( Year: 2012). Title: Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production. Journal: European Journal of Immunology Volume: 42 Issue: 5, S-Page: 1174- E-Page: 1179 PubMed
  • Authors: Koenecke,C.; Lee,C.W.; Thamm,K.; Fohse,L.; Schafferus,M.; Mittrucker,H.W.; Floess,S.; Hühn,Jochen; Ganser,A.; Forster,R.; Prinz,I.; ( Year: 2012). Title: IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease. Journal: Journal of Immunology Volume: 189 Issue: 6, S-Page: 2890- E-Page: 2896 PubMed
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  • Authors: Mayer,C.T.; Floess,S.; Baru,A.M.; Lahl,K.; Hühn,Jochen*; Sparwasser,T.; ( Year: 2011). Title: CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity. Journal: European Journal of Immunology Volume: 41 Issue: 3, S-Page: 716- E-Page: 725 DOI: 10.1002/eji.201040913 HZI repository PubMed
  • Authors: Steinfelder,S.; Floess,S.; Engelbert,D.; Haeringer,B.; Baron,U.; Rivino,L.; Steckel,B.; Gruetzkau,A.; Olek,S.; Geginat,J.; Hühn,Jochen*; Hamann,A.; ( Year: 2011). Title: Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Journal: Blood Volume: 117 Issue: 10, S-Page: 2839- E-Page: 2846 DOI: 10.1182/blood-2010-06-293027 HZI repository PubMed
  • Authors: Brand,S.; Teich,René*; Dicke,T.; Harb,H.; Yildirim,A.O.; Tost,J.; Schneider-Stock,R.; Waterland,R.A.; Bauer,U.M.; von,Mutius E.; Garn,H.; Pfefferle,P.I.; Renz,H.; ( Year: 2011). Title: Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. Journal: Journal of Allergy and Clinical Immunology Volume: 128 Issue: 3, S-Page: 618- E-Page: 625.e7 PubMed
  • Authors: Blankenhaus,B.; Klemm,U.; Eschbach,M.L.; Sparwasser,T.; Hühn,Jochen*; Kuhl,A.A.; Loddenkemper,C.; Jacobs,T.; Breloer,M.; ( Year: 2011). Title: Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal: Journal of Immunology Volume: 186 Issue: 7, S-Page: 4295- E-Page: 4305 PubMed
  • Authors: Toker,A.; Hühn,Jochen*; ( Year: 2011). Title: To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. Journal: Science Signaling Volume: 4 Issue: 158, S-Page: e4 DOI: 10.1126/scisignal.2001783 HZI repository PubMed
  • Authors: Hubert,S.; Rissiek,B.; Klages,K.; Hühn,Jochen*; Sparwasser,T.; Haag,F.; Koch-Nolte,F.; Boyer,O.; Seman,M.; Adriouch,S.; ( Year: 2010). Title: Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. Journal: Journal of Experimental Medicine Volume: 207 Issue: 12, S-Page: 2561- E-Page: 2568 DOI: 10.1084/jem.20091154 HZI repository PubMed
  • Authors: Humrich,J.Y.; Morbach,H.; Undeutsch,R.; Enghard,P.; Rosenberger,S.; Weigert,O.; Kloke,L.; Heimann,J.; Gaber,T.; Brandenburg,S.; Scheffold,A.; Hühn,Jochen*; Radbruch,A.; Burmester,G.R.; Riemekasten,G.; ( Year: 2010). Title: Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 Issue: 1, S-Page: 204- E-Page: 209 PubMed
  • Authors: Polansky,J.K.; Schreiber,L.; Thelemann,C.; Ludwig,L.; Kruger,M.; Baumgrass,R.; Cording,S.; Floess,S.; Hamann,A.; Hühn,Jochen*; ( Year: 2010). Title: Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. Journal: Journal of Molecular Medicine Volume: 88 Issue: 10, S-Page: 1029- E-Page: 1040 PubMed
  • Authors: Menning,A.; Loddenkemper,C.; Westendorf,A.M.; Szilagyi,B.; Buer,J.; Siewert,C.; Hamann,A.; Hühn,Jochen*; ( Year: 2010). Title: Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. Journal: European Journal of Immunology Volume: 40 Issue: 9, S-Page: 2539- E-Page: 2548 PubMed
  • Authors: Klages,K.; Mayer,C.T.; Lahl,K.; Loddenkemper,C.; Teng,M.W.; Ngiow,S.F.; Smyth,M.J.; Hamann,A.; Hühn,Jochen*; Sparwasser,T.; ( Year: 2010). Title: Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Journal: Cancer Research Volume: 70 Issue: 20, S-Page: 7788- E-Page: 7799 PubMed
  • Authors: Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; ( Year: 2009). Title: Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD. Journal: European Journal of Immunology Volume: 39 Issue: 11, S-Page: 3091- E-Page: 3096 PubMed
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  • Authors: Polansky,J.K.; Floess,S.; Freyer,J.; Hamann,A.; Hühn,J.; ( Year: 2009). Title: Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells. Book Title: The Epigenetics of Autoimmune Diseases Publisher: John Wiley and Sons, S-Page: 21- E-Page: 38 ISBN: 9780470758618 (ISBN) DOI: Book WEBURLS
  • Authors: Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; ( Year: 2009). Title: Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells. Journal: Europen Journal of Immunology Volume: 39 Issue: 11, S-Page: 3066- E-Page: 3077 PubMed
  • Authors: Hoffmann,P.; Boeld,T.J.; Eder,R.; Hühn,Jochen*; Floess,S.; Wieczorek,G.; Olek,S.; Dietmaier,W.; Andreesen,R.; Edinger,M.; ( Year: 2009). Title: Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Journal: European Journal of Immunology Volume: 39 Issue: 4, S-Page: 1088- E-Page: 1097 DOI: 10.1002/eji.200838904 PubMed
  • Authors: Schaub,B.; Liu,J.; Hoppler,S.; Schleich,I.; Hühn,Jochen*; Olek,S.; Wieczorek,G.; Illi,S.; von,Mutius E.; ( Year: 2009). Title: Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. Journal: Journal of Allergy and Clinical Immunology Volume: 123 Issue: 4, S-Page: 774- E-Page: 782 DOI: 10.1016/j.jaci.2009.01.056 HZI repository PubMed
  • Authors: Lahl,K.; Mayer,C.T.; Bopp,T.; Hühn,Jochen*; Loddenkemper,C.; Eberl,G.; Wirnsberger,G.; Dornmair,K.; Geffers,Robert*; Schmitt,E.; Buer,J.; Sparwasser,T.; ( Year: 2009). Title: Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. Journal: Journal of Immunology Volume: 183 Issue: 9, S-Page: 5662- E-Page: 5672 PubMed
  • Authors: Wieczorek,G.; Asemissen,A.; Model,F.; Turbachova,I.; Floess,S.; Liebenberg,V.; Baron,U.; Stauch,D.; Kotsch,K.; Pratschke,J.; Hamann,A.; Loddenkemper,C.; Stein,H.; Volk,H.D.; Hoffmuller,U.; Grutzkau,A.; Mustea,A.; Hühn,Jochen*; Scheibenbogen,C.; Olek,S.; ( Year: 2009). Title: Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Journal: Cancer Research Volume: 69 Issue: 2, S-Page: 599- E-Page: 608 PubMed
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  • Authors: Doebis,C.; Siegmund,K.; Loddenkemper,C.; Lowe,J.B.; Issekutz,A.C.; Hamann,A.; Hühn,Jochen*; Syrbe,U.; ( Year: 2008). Title: Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Journal: American Journal of Pathology Volume: 173 Issue: 4, S-Page: 1067- E-Page: 1076 PubMed
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