Experimental Immunology

Every day we are attacked by a large number of different pathogens that our immune system tries to repel by using various strategies. To combat these, cells of the immune system have learnt to distinguish between harmless self structures and potentially dangerous foreign ones. Sometimes, however, immune cells are generated, which are falsely programmed and can attack structures in their own body. Learn more about the body`s protection against these cells and how we can use this mechanism in therapy.

Leader

Publikationen der Arbeitsgruppe

  • Authors: Pink,M.; Ratsch,B.A.; Mardahl,M.; Durek,P.; Polansky,J.K.; Karl,M.; Baumgrass,R.; Wallner,S.; Cadenas,C.; Gianmoena,K.; Floess,S.; Chen,W.; Nordstroem,K.; Tierling,S.; Olek,S.; Walter,J.; Hamann,A.; Syrbe,U.; (Year: 2016). Title: Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene.Volume: 197, S-Page: 3406-E-Page: 3414 PubMed
  • Authors: Goldstein,J.D.; Burlion,A.; Zaragoza,B.; Sendeyo,K.; Polansky,J.K.; Hühn,J.; Piaggio,E.; Salomon,B.L.; Marodon,G.; (Year: 2016). Title: Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.Journal: PLoS ONEVolume: 11Issue: 4, S-Page: e0153682 DOI: 10.1371/journal.pone.0153682 HZI repository PubMed
  • Authors: Pezoldt,J.; Huehn,J.; (Year: 2016). Title: Tissue-Specific Induction of CCR6 and Nrp1 During Early CD4+ T Cell Differentiation.Volume: 6Issue: 3, S-Page: 219-E-Page: 226 PubMed
  • Authors: Uhde,A.K.; Herder,V.; Akram,Khan M.; Ciurkiewicz,M.; Schaudien,D.; Teich,R.; Floess,S.; Baumgartner,W.; Hühn,J.; Beineke,A.; (Year: 2016). Title: Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.Journal: PLoS ONEVolume: 11Issue: 9, S-Page: e0161883 PubMed
  • Authors: Milanez-Almeida,P.; Ulas,T.; Pasztoi,M.; Glage,S.; Schughart,K.; Lutz,M.B.; Schultze,J.L.; Hühn,J.; (Year: 2015). Title: CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.Volume: 5Issue: 4, S-Page: 246-E-Page: 255 PubMed
  • Authors: Hühn,J.; Floess,S.; Ohkura,N.; Sakaguchi,S.; (Year: 2015). Title: Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans".Journal: Journal of ImmunologyVolume: 194Issue: 8, S-Page: 3533-E-Page: 353400221767 WEBURLS
  • Authors: Yang,B.H.; Flöß,Stefan; Hagemann,S.; Deyneko,Igor V.; Gröbe,Lothar; Pezoldt,J.; Sparwasser,Tim; Lochner,M.; Hühn,Jochen; (Year: 2015). Title: Development of a unique epigenetic signature during in vivo Th17 differentiation.Volume: 43Issue: 3, S-Page: 1537-E-Page: 1548 DOI: 10.1093/nar/gkv014 HZI repository PubMed
  • Authors: Hühn,J.; Beyer,M.; (Year: 2015). Title: Epigenetic and transcriptional control of Foxp3 regulatory T cells.Volume: 27Issue: 1, S-Page: 10-E-Page: 18 PubMed
  • Authors: Roesner,L.M.; Flöß,S.; Witte,T.; Olek,S.; Hühn,J.; Werfel,T.; (Year: 2015). Title: Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients.Journal: Allergy: European Journal of Allergy and Clinical ImmunologyVolume: 70Issue: 12, S-Page: 1656-E-Page: 1660 PubMed
  • Authors: Yang,B.H.; Hagemann,S.; Mamareli,P.; Lauer,U.; Hoffmann,U.; Beckstette,M.; Fohse,L.; Prinz,I.; Pezoldt,J.; Suerbaum,S.; Sparwasser,T.; Hamann,A.; Floess,S.; Hühn,J.; Lochner,M.; (Year: 2015). Title: Foxp3 T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.Volume: 9, S-Page: 444-E-Page: 457 DOI: 10.1038/mi.2015.74 HZI repository PubMed
  • Authors: Klysz,D.; Tai,X.; Robert,P.A.; Craveiro,M.; Cretenet,G.; Oburoglu,L.; Mongellaz,C.; Flöß,S.; Fritz,V.; Matias,M.I.; Yong,C.; Surh,N.; Marie,J.C.; Hühn,J.; Zimmermann,V.; Kinet,S.; Dardalhon,V.; Taylor,N.; (Year: 2015). Title: Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation.Volume: 8Issue: 396, S-Page: ra97 PubMed
  • Authors: Braun,A.; Dewert,N.; Brunnert,F.; Schnabel,V.; Hardenberg,J.H.; Richter,B.; Zachmann,K.; Cording,S.; Classen,A.; Brans,R.; Hamann,A.; Hühn,J.; Schon,M.P.; (Year: 2015). Title: Integrin alpha(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. PubMed
  • Authors: Pasztoi,M.; Pezoldt,J.; Hühn,J.; (Year: 2015). Title: Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells.Volume: 136, S-Page: 35-E-Page: 56 PubMed
  • Authors: Walter,F.R.; Veszelka,S.; Pasztoi,M.; Peterfi,Z.A.; Toth,A.; Rakhely,G.; Cervenak,L.; Abraham,C.S.; Deli,M.A.; (Year: 2015). Title: Tesmilifene modifies brain endothelial functions and opens the blood-brain/blood-glioma barrier.Volume: 134Issue: 6, S-Page: 1040-E-Page: 1054 PubMed
  • Authors: Tebartz,C.; Horst,Sarah A.; Sparwasser,Tim; Hühn,Jochen; Beineke,A.; Peters,G.; Medina,Eva; (Year: 2014). Title: A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection.Journal: Journal of ImmunologyVolume: 194Issue: 3, S-Page: 1100-E-Page: 1111 PubMed
  • Authors: Khailaie,Sahamoddin; Robert,Phillipe A.; Toker,Aras; Hühn,Jochen; Meyer-Hermann,Michael; (Year: 2014). Title: A signal integration model of thymic selection and natural regulatory T cell commitment.Journal: Journal of ImmunologyVolume: 193Issue: 12, S-Page: 5983-E-Page: 5996 PubMed
  • Authors: Mayer,Christian T.; Lahl,K.; Milanez-Almeida,P.; Watts,D.; Dittmer,U.; Fyhrquist,N.; Hühn,Jochen; Kopf,M.; Kretschmer,K.; Rouse,B.; Sparwasser,Tim; (Year: 2014). Title: Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice.Journal: Immunity, Inflammation and DiseaseVolume: 2Issue: 3, S-Page: 162-E-Page: 165 DOI: 10.1002/iid3.33 HZI repository PubMed
  • Authors: Berod,L.; Friedrich,C.; Nandan,A.; Freitag,J.; Hagemann,S.; Harmrolfs,K.; Sandouk,A.; Hesse,C.; Castro,C.N.; Bahre,H.; Tschirner,S.K.; Gorinski,N.; Gohmert,M.; Mayer,C.T.; Hühn,Jochen; Ponimaskin,E.; Abraham,Wolf-Rainer; Müller,Rolf; Lochner,M.; Sparwasser,Tim; (Year: 2014). Title: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.Journal: Nature medicineVolume: 20, S-Page: 1327-E-Page: 1333 PubMed
  • Authors: Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; (Year: 2014). Title: Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen.Volume: 4Issue: 3, S-Page: 147-E-Page: 155 PubMed
  • Authors: Prajeeth,C.K.; Lohr,K.; Flöß,Stefan; Zimmermann,J.; Ulrich,R.; Gudi,V.; Beineke,A.; Baumgartner,W.; Muller,M.; Hühn,Jochen; Stangel,M.; (Year: 2014). Title: Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia.Journal: Brain, Behavior, and ImmunityVolume: 37, S-Page: 248-E-Page: 259 DOI: 10.1016/j.bbi.2014.01.001 HZI repository PubMed
  • Authors: Milanez-Almeida,P.; Meyer-Hermann,Michael; Toker,Aras; Khailaie,Sahamoddin; Hühn,Jochen; (Year: 2014). Title: Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen.Journal: European Journal of ImmunologyVolume: 45, S-Page: 153-E-Page: 166 PubMed
  • Authors: Prajeeth,C.K.; Beineke,A.; Iskandar,C.; Gudi,V.; Herder,V.; Gerhauser,I.; Haist,V.; Teich,R.; Hühn,J.; Baumgartner,W.; Stangel,M.; (Year: 2014). Title: Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.Volume: 11Issue: 1, S-Page: 180 PubMed
  • Authors: Franckaert,D.; Dooley,J.; Roos,E.; Flöß,Stefan; Hühn,Jochen; Luche,H.; Fehling,H.J.; Liston,A.; Linterman,M.A.; Schlenner,S.M.; (Year: 2014). Title: Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells.Journal: Immunology and Cell BiologyVolume: 93Issue: 4, S-Page: 417-E-Page: 423 DOI: 10.1038/icb.2014.108 HZI repository PubMed
  • Authors: Cording,S.; Wahl,B.; Kulkarni,D.; Chopra,H.; Pezoldt,Jörn; Buettner,M.; Dummer,A.; Hadis,U.; Heimesaat,M.; Bereswill,S.; Falk,C.; Bode,U.; Hamann,A.; Fleissner,D.; Hühn,Jochen; Pabst,O.; (Year: 2014). Title: The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes.Journal: Mucosal ImmunologyVolume: 7Issue: 2, S-Page: 359-E-Page: 368 DOI: 10.1038/mi.2013.54 PubMed
  • Authors: Schreiber,L.; Pietzsch,Beate; Flöß,Stefan; Farah,Carla; Jänsch,Lothar; Schmitz,Ingo; Hühn,Jochen; (Year: 2014). Title: The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling.Journal: PLoS ONEVolume: 9Issue: 2, S-Page: e8831819326203 WEBURLS
  • Authors: Delacher,M.; Schreiber,L.; Richards,D.M.; Farah,C.; Feuerer,M.; Hühn,J.; (Year: 2014). Title: Transcriptional control of regulatory T cells.Volume: 381, S-Page: 83-E-Page: 124 PubMed
  • Authors: Khailaie,Sahamoddin; Bahrami,F.; Janahmadi,M.; Milanez-Almeida,P.; Hühn,Jochen; Meyer-Hermann,Michael; (Year: 2013). Title: A mathematical model of immune activation with a unified self-nonself concept.Journal: Frontiers in ImmunologyVolume: 4, S-Page: 474 DOI: 10.3389/fimmu.2013.00474 HZI repository PubMed
  • Authors: Toker,Aras; Engelbert,D.; Garg,Garima; Polansky,Julia K.; Floess,Stefan; Miyao,T.; Baron,U.; Düber,Sandra; Geffers,Robert; Giehr,P.; Schallenberg,S.; Kretschmer,K.; Olek,S.; Walter,J.; Weiss,Siegfried; Hori,S.; Hamann,A.; Hühn,Jochen; (Year: 2013). Title: Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus.Journal: Journal of ImmunologyVolume: 190Issue: 7, S-Page: 3180-E-Page: 318800221767 WEBURLS
  • Authors: Cording,S.; Fleißner,Diana; Heimesaat,M.M.; Bereswill,S.; Loddenkemper,C.; Uematsu,S.; Akira,S.; Hamann,A.; Hühn,Jochen; (Year: 2013). Title: Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches.Journal: European Journal of Microbiology and ImmunologyVolume: 3Issue: 1, S-Page: 1-E-Page: 10 PubMed
  • Authors: Kühlhorn,F.; Rath,M.; Schmoeckel,K.; Cziupka,K.; Nguyen,H.H.; Hildebrandt,P.; Hünig,T.; Sparwasser,Tim; Hühn,Jochen; Pötschke,C.; Bröker,B.M.; (Year: 2013). Title: Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis.Journal: PLoS ONEVolume: 8Issue: 5, S-Page: e6510919326203 DOI: 10.1371/journal.pone.0065109 HZI repository PubMed
  • Authors: Huang,Yi-Ju; Haist,V.; Baumgartner,W.; Fohse,L.; Prinz,I.; Suerbaum,S.; Floess,Stefan; Hühn,Jochen; (Year: 2013). Title: Induced and thymus-derived Foxp3 regulatory T cells share a common niche.Journal: European Journal of ImmunologyVolume: 44Issue: 2, S-Page: 460-E-Page: 468 DOI: 10.1002/eji.201343463 PubMed
  • Authors: Kreutzfeldt,M.; Bergthaler,A.; Fernandez,M.; Brück,W.; Steinbach,K.; Vorm,M.; Coras,R.; Blümcke,I.; Bonilla,W.V.; Fleige,A.; Forman,R.; Müller,W.; Becher,B.; Misgeld,T.; Kerschensteiner,M.; Pinschewer,D.D.; Merkler,D.; (Year: 2013). Title: Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss.Journal: Journal of Experimental MedicineVolume: 210Issue: 10, S-Page: 2087-E-Page: 210300221007 DOI: 10.1084/jem.20122143 HZI repository PubMed
  • Authors: Sledzinska,A.; Hemmers,S.; Mair,F.; Gorka,O.; Ruland,J.; Fairbairn,L.; Nissler,A.; Müller,W.; Waisman,A.; Becher,B.; Buch,T.; (Year: 2013). Title: TGF-beta Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function.Journal: PLoS BiologyVolume: 11Issue: 10, S-Page: e100167415449173 DOI: 10.1371/journal.pbio.1001674 HZI repository PubMed
  • Authors: Schweer,Janina; Kulkarni,Devesha; Kochut,Annika; Pezoldt,Jörn; Pisano,Fabio; Pils,Marina C.; Genth,H.; Hühn,Jochen; Dersch,Petra; (Year: 2013). Title: The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases.Journal: PLoS PathogensVolume: 9Issue: 11, S-Page: e1003746 DOI: 10.1371/journal.ppat.1003746 HZI repository PubMed
  • Authors: Patzelt,Diana; Wang,Hui; Buchholz,I.; Rohde,Manfred; Gröbe,Lothar; Pradella,S.; Neumann,A.; Schulz,S.; Heyber,S.; Munch,K.; Munch,R.; Jahn,D.; Wagner-Döbler,Irene; Tomasch,Jürgen; (Year: 2013). Title: You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae.Journal: ISME JournalVolume: 7Issue: 12, S-Page: 2274-E-Page: 2286 DOI: 10.1038/ismej.2013.107 PubMed
  • Authors: Hinz,D.; Bauer,M.; Roder,S.; Olek,S.; Hühn,Jochen; Sack,U.; Borte,M.; Simon,J.C.; Lehmann,I.; Herberth,G.; (Year: 2012). Title: Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year.Journal: Allerg: European Journal of Allergy and Clinical ImmunologyVolume: 67Issue: 3, S-Page: 380-E-Page: 389 PubMed
  • Authors: Brand,S.; Kesper,D.A.; Teich,R.; Kilic-Niebergall,E.; Pinkenburg,O.; Bothur,E.; Lohoff,M.; Garn,H.; Pfefferle,P.I.; Renz,H.; (Year: 2012). Title: DNA methylation of T H1/T H2 cytokine genes affects sensitization and progress of experimental asthma.Journal: Journal of Allergy and Clinical ImmunologyVolume: 129Issue: 6, S-Page: 1602-E-Page: 1610
  • Authors: König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; (Year: 2012). Title: First insight into the kinome of human regulatory T cells.Journal: PLoS ONEVolume: 7Issue: 7, S-Page: e40896 DOI: 10.1371/journal.pone.0040896 HZI repository PubMed
  • Authors: Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; (Year: 2012). Title: Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies.Journal: Journal of Visualized Experiments: JoVEIssue: 701940087X DOI: 4322. WEBURLS
  • Authors: O'Connor,R.A.; Floess,S.; Hühn,Jochen; Jones,S.A.; Anderton,S.M.; (Year: 2012). Title: Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production.Journal: European Journal of ImmunologyVolume: 42Issue: 5, S-Page: 1174-E-Page: 1179 PubMed
  • Authors: Koenecke,C.; Lee,C.W.; Thamm,K.; Fohse,L.; Schafferus,M.; Mittrucker,H.W.; Floess,S.; Hühn,Jochen; Ganser,A.; Forster,R.; Prinz,I.; (Year: 2012). Title: IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease.Journal: Journal of ImmunologyVolume: 189Issue: 6, S-Page: 2890-E-Page: 2896 PubMed
  • Authors: Schuster,M.; Glauben,R.; Plaza-Sirvent,C.; Schreiber,L.; Annemann,M.; Floess,S.; Kuhl,A.A.; Clayton,L.K.; Sparwasser,Tim; Schulze-Osthoff,K.; Pfeffer,K.; Hühn,Jochen; Siegmund,B.; Schmitz,Ingo; (Year: 2012). Title: IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor.Journal: ImmunityVolume: 37Issue: 6, S-Page: 998-E-Page: 1008 DOI: 10.1016/j.immuni.2012.08.023 HZI repository PubMed
  • Authors: Herder,V.; Gerhauser,I.; Klein,S.K.; Almeida,P.; Kummerfeld,M.; Ulrich,R.; Seehusen,F.; Rohn,K.; Schaudien,D.; Baumgartner,W.; Hühn,Jochen; Beineke,A.; (Year: 2012). Title: Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis.Journal: Journal of NeuroimmunologyVolume: 249Issue: 1-2, S-Page: 27-E-Page: 39 PubMed
  • Authors: Bettini,M.L.; Pan,F.; Bettini,M.; Finkelstein,D.; Rehg,J.E.; Floess,S.; Bell,B.D.; Ziegler,S.F.; Hühn,Jochen; Pardoll,D.M.; Vignali,D.A.; (Year: 2012). Title: Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency.Journal: ImmunityVolume: 36Issue: 5, S-Page: 717-E-Page: 730 PubMed
  • Authors: Weiss,J.M.; Bilate,A.M.; Gobert,M.; Ding,Y.; de Lafaille,M.A.C.; Parkhurst,C.N.; Xiong,H.; Dolpady,J.; Frey,A.B.; Ruocco,M.G.; Yang,Y.; Flöss,Stefan; Hühn,Jochen; Oh,S.; Li,M.O.; Niec,R.E.; Rudensky,A.Y.; Dustin,M.L.; Littman,D.R.; Lafaille,J.J.; (Year: 2012). Title: Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells.Journal: Journal of Experimental MedicineVolume: 209Issue: 10, S-Page: 1723-E-Page: 174200221007 DOI: 10.1084/jem.20120914 HZI repository PubMed
  • Authors: Miyao,T.; Floess,S.; Setoguchi,R.; Luche,H.; Fehling,H.J.; Waldmann,H.; Hühn,Jochen; Hori,S.; (Year: 2012). Title: Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.Journal: ImmunityVolume: 36Issue: 2, S-Page: 262-E-Page: 275 PubMed
  • Authors: Ohkura,N.; Hamaguchi,M.; Morikawa,H.; Sugimura,K.; Tanaka,A.; Ito,Y.; Osaki,M.; Tanaka,Y.; Yamashita,R.; Nakano,N.; Hühn,Jochen; Fehling,H.J.; Sparwasser,Tim*; Nakai,K.; Sakaguchi,S.; (Year: 2012). Title: T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development.Journal: ImmunityVolume: 37Issue: 5, S-Page: 785-E-Page: 799 DOI: 10.1016/j.immuni.2012.09.010 HZI repository PubMed
  • Authors: Berod,L.; Puttur,F.; Hühn,Jochen; Sparwasser,Tim*; (Year: 2012). Title: Tregs in infection and vaccinology: heroes or traitors?.Journal: Microbial BiotechnologyVolume: 5Issue: 2, S-Page: 260-E-Page: 269 PubMed
  • Authors: Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Brettar,I.; Höfle,Manfred G.*; (Year: 2011). Title: Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526.Journal: Microbial EcologyVolume: 63Issue: 2, S-Page: 383-E-Page: 397 DOI: 10.1007/s00248-011-9918-4 PubMed
  • Authors: Mayer,C.T.; Floess,S.; Baru,A.M.; Lahl,K.; Hühn,Jochen*; Sparwasser,T.; (Year: 2011). Title: CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity.Journal: European Journal of ImmunologyVolume: 41Issue: 3, S-Page: 716-E-Page: 725 DOI: 10.1002/eji.201040913 HZI repository PubMed
  • Authors: Steinfelder,S.; Floess,S.; Engelbert,D.; Haeringer,B.; Baron,U.; Rivino,L.; Steckel,B.; Gruetzkau,A.; Olek,S.; Geginat,J.; Hühn,Jochen*; Hamann,A.; (Year: 2011). Title: Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells.Journal: BloodVolume: 117Issue: 10, S-Page: 2839-E-Page: 2846 DOI: 10.1182/blood-2010-06-293027 HZI repository PubMed
  • Authors: Brand,S.; Teich,René*; Dicke,T.; Harb,H.; Yildirim,A.O.; Tost,J.; Schneider-Stock,R.; Waterland,R.A.; Bauer,U.M.; von,Mutius E.; Garn,H.; Pfefferle,P.I.; Renz,H.; (Year: 2011). Title: Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes.Journal: Journal of Allergy and Clinical ImmunologyVolume: 128Issue: 3, S-Page: 618-E-Page: 625.e7 PubMed
  • Authors: Blankenhaus,B.; Klemm,U.; Eschbach,M.L.; Sparwasser,T.; Hühn,Jochen*; Kuhl,A.A.; Loddenkemper,C.; Jacobs,T.; Breloer,M.; (Year: 2011). Title: Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice.Journal: Journal of ImmunologyVolume: 186Issue: 7, S-Page: 4295-E-Page: 4305 PubMed
  • Authors: Toker,A.; Hühn,Jochen*; (Year: 2011). Title: To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms.Journal: Science SignalingVolume: 4Issue: 158, S-Page: e4 DOI: 10.1126/scisignal.2001783 HZI repository PubMed
  • Authors: Hubert,S.; Rissiek,B.; Klages,K.; Hühn,Jochen*; Sparwasser,T.; Haag,F.; Koch-Nolte,F.; Boyer,O.; Seman,M.; Adriouch,S.; (Year: 2010). Title: Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.Journal: Journal of Experimental MedicineVolume: 207Issue: 12, S-Page: 2561-E-Page: 2568 DOI: 10.1084/jem.20091154 HZI repository PubMed
  • Authors: Humrich,J.Y.; Morbach,H.; Undeutsch,R.; Enghard,P.; Rosenberger,S.; Weigert,O.; Kloke,L.; Heimann,J.; Gaber,T.; Brandenburg,S.; Scheffold,A.; Hühn,Jochen*; Radbruch,A.; Burmester,G.R.; Riemekasten,G.; (Year: 2010). Title: Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.Journal: Proceedings of the National Academy of Sciences of the United States of AmericaVolume: 107Issue: 1, S-Page: 204-E-Page: 209 PubMed
  • Authors: Polansky,J.K.; Schreiber,L.; Thelemann,C.; Ludwig,L.; Kruger,M.; Baumgrass,R.; Cording,S.; Floess,S.; Hamann,A.; Hühn,Jochen*; (Year: 2010). Title: Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells.Journal: Journal of Molecular MedicineVolume: 88Issue: 10, S-Page: 1029-E-Page: 1040 PubMed
  • Authors: Menning,A.; Loddenkemper,C.; Westendorf,A.M.; Szilagyi,B.; Buer,J.; Siewert,C.; Hamann,A.; Hühn,Jochen*; (Year: 2010). Title: Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation.Journal: European Journal of ImmunologyVolume: 40Issue: 9, S-Page: 2539-E-Page: 2548 PubMed
  • Authors: Klages,K.; Mayer,C.T.; Lahl,K.; Loddenkemper,C.; Teng,M.W.; Ngiow,S.F.; Smyth,M.J.; Hamann,A.; Hühn,Jochen*; Sparwasser,T.; (Year: 2010). Title: Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma.Journal: Cancer ResearchVolume: 70Issue: 20, S-Page: 7788-E-Page: 7799 PubMed
  • Authors: Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; (Year: 2009). Title: Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD.Journal: European Journal of ImmunologyVolume: 39Issue: 11, S-Page: 3091-E-Page: 3096 PubMed
  • Authors: Hühn,Jochen*; Polansky,J.K.; Hamann,A.; (Year: 2009). Title: Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?.Journal: Nature Reviews ImmunologyVolume: 9Issue: 2, S-Page: 83-E-Page: 89 DOI: 10.1038/nri2474 PubMed
  • Authors: Polansky,J.K.; Floess,S.; Freyer,J.; Hamann,A.; Hühn,J.; (Year: 2009). Title: Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells.Book Title: The Epigenetics of Autoimmune DiseasesPublisher: John Wiley and Sons, S-Page: 21-E-Page: 38 ISBN: 9780470758618 (ISBN) DOI: Book WEBURLS
  • Authors: Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; (Year: 2009). Title: Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells.Journal: Europen Journal of ImmunologyVolume: 39Issue: 11, S-Page: 3066-E-Page: 3077 PubMed
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  • Authors: Doebis,C.; Siegmund,K.; Loddenkemper,C.; Lowe,J.B.; Issekutz,A.C.; Hamann,A.; Hühn,Jochen*; Syrbe,U.; (Year: 2008). Title: Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction.Journal: American Journal of PathologyVolume: 173Issue: 4, S-Page: 1067-E-Page: 1076 PubMed
  • Authors: Apostolou,I.; Verginis,P.; Kretschmer,K.; Polansky,J.; Hühn,Jochen*; von,Boehmer H.; (Year: 2008). Title: Peripherally induced Treg: mode, stability, and role in specific tolerance.Journal: Journal of Clinical ImmunologyVolume: 28Issue: 6, S-Page: 619-E-Page: 624 PubMed
  • Authors: Menning,A.; Hopken,U.E.; Siegmund,K.; Lipp,M.; Hamann,A.; Hühn,Jochen*; (Year: 2007). Title: Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets.Journal: European Journal of ImmunologyVolume: 37Issue: 6, S-Page: 1575-E-Page: 1583 PubMed
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  • Authors: Siewert,C.; Menning,A.; Dudda,J.; Siegmund,K.; Lauer,U.; Floess,S.; Campbell,D.J.; Hamann,A.; Hühn,Jochen*; (Year: 2007). Title: Induction of organ-selective CD4+ regulatory T cell homing.Journal: European Journal of ImmunologyVolume: 37Issue: 4, S-Page: 978-E-Page: 989 PubMed
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  • Authors: Polansky,J.K.; Hühn,Jochen*; (Year: 2007). Title: [To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells].Journal: Zeitschrift für RheumatologieVolume: 66Issue: 5, S-Page: 417-E-Page: 420 PubMed

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