Experimental Immunology

Every day we are attacked by a large number of different pathogens that our immune system tries to repel by using various strategies. To combat these, cells of the immune system have learnt to distinguish between harmless self structures and potentially dangerous foreign ones. Sometimes, however, immune cells are generated, which are falsely programmed and can attack structures in their own body. Learn more about the body`s protection against these cells and how we can use this mechanism in therapy.

Publikationen von Prof. Jochen Hühn

  • Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; (2009). Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD. European Journal of Immunology: 39 11, 3091-3096 PubMed
  • Hühn,Jochen*; Polansky,J.K.; Hamann,A.; (2009). Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?. Nature Reviews Immunology: 9 2, 83-89 DOI: 10.1038/nri2474 PubMed
  • Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; (2009). Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells. Europen Journal of Immunology: 39 11, 3066-3077 PubMed
  • Hoffmann,P.; Boeld,T.J.; Eder,R.; Hühn,Jochen*; Floess,S.; Wieczorek,G.; Olek,S.; Dietmaier,W.; Andreesen,R.; Edinger,M.; (2009). Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. European Journal of Immunology: 39 4, 1088-1097 PubMed
  • Molenaar R, Greuter M, van der Marel AP, Roozendaal R, Martin SF, Edele F, Huehn J, Förster R, O'Toole T, Jansen W, Eestermans IL, Kraal G, Mebius RE; (2009). Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol.: 183 10, 6395-6402 PubMed
  • Schaub,B.; Liu,J.; Hoppler,S.; Schleich,I.; Hühn,Jochen*; Olek,S.; Wieczorek,G.; Illi,S.; von,Mutius E.; (2009). Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. Journal of Allergy and Clinical Immunology: 123 4, 774-782 DOI: 10.1016/j.jaci.2009.01.056 HZI repository PubMed
  • Lahl K, Mayer CT, Bopp T, Huehn J, Loddenkemper C, Eberl G, Wirnsberger G, Dornmair K, Geffers R, Schmitt E, Buer J, Sparwasser T; (2009). Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J Immunol.: 183 9, 5662-5672 PubMed
  • Wieczorek,G.; Asemissen,A.; Model,F.; Turbachova,I.; Floess,S.; Liebenberg,V.; Baron,U.; Stauch,D.; Kotsch,K.; Pratschke,J.; Hamann,A.; Loddenkemper,C.; Stein,H.; Volk,H.D.; Hoffmuller,U.; Grutzkau,A.; Mustea,A.; Hühn,Jochen*; Scheibenbogen,C.; Olek,S.; (2009). Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Research: 69 2, 599-608 PubMed
  • Loddenkemper,C.; Hoffmann,C.; Stanke,J.; Nagorsen,D.; Baron,U.; Olek,S.; Hühn,Jochen*; Ritz,J.P.; Stein,H.; Kaufmann,A.M.; Schneider,A.; Cichon,G.; (2009). Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer. Cancer Science: 100 6, 1112-1117 PubMed
  • Ghani S, Feuerer M, Doebis C, Lauer U, Loddenkemper C, Huehn J, Hamann A, Syrbe U; (2009). T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment. Immunology: 128, 870-880 PubMed
  • Doebis,C.; Siegmund,K.; Loddenkemper,C.; Lowe,J.B.; Issekutz,A.C.; Hamann,A.; Hühn,Jochen*; Syrbe,U.; (2008). Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. American Journal of Pathology: 173 4, 1067-1076 PubMed
  • Apostolou,I.; Verginis,P.; Kretschmer,K.; Polansky,J.; Hühn,Jochen*; von,Boehmer H.; (2008). Peripherally induced Treg: mode, stability, and role in specific tolerance. Journal of Clinical Immunology: 28 6, 619-624 PubMed
  • Menning,A.; Hopken,U.E.; Siegmund,K.; Lipp,M.; Hamann,A.; Hühn,Jochen*; (2007). Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets. European Journal of Immunology: 37 6, 1575-1583 PubMed
  • Baron,U.; Floess,S.; Wieczorek,G.; Baumann,K.; Grutzkau,A.; Dong,J.; Thiel,A.; Boeld,T.J.; Hoffmann,P.; Edinger,M.; Turbachova,I.; Hamann,A.; Olek,S.; Hühn,Jochen*; (2007). DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. European Journal of Immunology: 37 9, 2378-2389 DOI: 10.3390/md8122976 HZI repository PubMed
  • Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K., Chang, H.-D., Bopp, T., Schmitt, E., Klein-Hessling, S., Serfling, E., Hamann, A., Huehn, J.; (2007). Epigenetic control of the foxp3 locus in regulatory T cells. PloS Biol.: 5 PubMed
  • Siewert,C.; Menning,A.; Dudda,J.; Siegmund,K.; Lauer,U.; Floess,S.; Campbell,D.J.; Hamann,A.; Hühn,Jochen*; (2007). Induction of organ-selective CD4+ regulatory T cell homing. European Journal of Immunology: 37 4, 978-989 PubMed
  • Lahl,K.; Loddenkemper,C.; Drouin,C.; Freyer,J.; Arnason,J.; Eberl,G.; Hamann,A.; Wagner,H.; Hühn,Jochen*; Sparwasser,T.; (2007). Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. Journal of Experimental Medicine: 204 1, 57-63 PubMed
  • Polansky,J.K.; Hühn,Jochen*; (2007). [To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells]. Zeitschrift für Rheumatologie: 66 5, 417-420 PubMed
  • Hansen, W., Loser, K., Westendorf, A.M., Bruder, D., Pfoertner, S., Siewert, C., Huehn, J., Beissert, S., Buer J.; (2006). G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.. J Immunol.: 177 1, 209-215 PubMed
  • Huehn, J., Hamann, A.; (2006). Homing to suppress: address codes for Treg migration.. Trends Immunol.: 26 12, 632-636 PubMed
  • Feuerer, M., Eulenburg, K., Loddenkemper, C., Hamann, A., Huehn, J.; (2006). Self-limitation of Th1-mediated inflammation by IFN-gamma.. J Immunol.: 176 5, 2857-2863 PubMed
  • Dudda JC, Lembo A, Bachtanian E, Huehn J, Siewert C, Hamann A, Kremmer E, Förster R, Martin SF; (2005). Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol.: 35 4, 1056-1065 PubMed
  • Siegmund, K., Feuerer, M., Siewert, C., Ghani, S., Haubold, U., Dankof, A., Krenn, V., Schön, M.P., Scheffold, A., Lowe, J.B., Hamann, A., Syrbe, U., Huehn, J.; (2005). Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo.. Blood: 106 9, 3097-3104 PubMed
  • Huehn, J., Siegmund, K., Hamann, A.; (2005). Migration rules: functional properties of naive and effector/memory-like regulatory T cell subsets.. Curr Top Microbiol Immunol.: 293, 89-114 PubMed
  • Scheffold A, Hühn J, Höfer T; (2005). Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango. Eur J Immunol.: 35 5, 1336-1341 PubMed
  • Frey O, Petrow PK, Gajda M, Siegmund K, Huehn J, Scheffold A, Hamann A, Radbruch A, Bräuer R; (2005). The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther.: 7 2, R291-301 PubMed
  • Huehn,J.; Siegmund,K.; Lehmann,J.C.U.; Siewert,C.; Haubold,U.; Feuerer,M.; Debes,G.F.; Lauber,J.; Frey,O.; Przybylski,G.K.; Niesner,U.; de la Rosa,M.; Schmidt,C.A.; Bräuer,R.; Buer,J.; Scheffold,A.; Hamann,A.; (2004). Developmental stage, phenotype and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. Journal of Experimental Medicine: 199, 303-313
  • Hamann A, Syrbe U, Kretschmer U, Jennrich S, Hühn J; (2004). Selectin ligands on T cells. Ernst Schering Res Found Workshop.: 44, 1-14 PubMed
  • Lehmann, J., Huehn, J., de la Rosa, M., Maszyna, F., Kretschmer, U., Krenn, V., Brunner, M., Scheffold, A., Hamann, A.; (2002). Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.. Proc Natl Acad Sci USA.: 99 20, 13031-13036 PubMed
  • Hühn J, Ehrlich S, Fleischer B, von Bonin A; (2000). Molecular analysis of CD26-mediated signal transduction in T cells. Immunol Lett.: 72 2, 127-132 PubMed
  • Hühn J, Olek S, Fleischer B, von Bonin A; (1999). The adenosine deaminase-binding region is distinct from major anti-CD26 mAb epitopes on the human dipeptidyl peptidase IV(CD26) molecule. Cell Immunol.: 192 1, 33-40 PubMed
  • von Bonin A, Hühn J, Fleischer B; (1998). Dipeptidyl-peptidase IV/CD26 on T cells: analysis of an alternative T-cell activation pathway. Immunol Rev.: 161, 43-53 PubMed
  • Fleischer B, Steeg C, Hühn J, von Bonin A; (1997). Molecular associations required for signalling via dipeptidyl peptidase IV (CD26). Adv Exp Med Biol.: 421, 117-125 PubMed


  • Prof Jochen Hühn

    Jochen Hühn

    Head of Department

    +49 531 6181-3310

    +49 531 6181-3399



Bachelor & Master
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