Epidemiological and statistical methods

The choice of the right method is essential in epidemiology. Which sample size is necessary to verify an association between a risk factor and a disease, taking potential statistic variations into account? To which degree do other risk factors for the examined disease distort the outcome of a study? In order to get meaningful results, these questions must be evaluated for every new scenario.



Dr André Karch


Curriculum Vitae

André Karch is a postdoctoral research fellow at the Department of Epidemiology. After attending medical school in Würzburg, Trondheim and Rochester he received his MD in 2010 from Julius Maximilians University and was board certified in the same year.  He then graduated with an MSc in Epidemiology from the London School of Hygiene and Tropical Medicine (LSHTM) in 2011 and received a medical doctorate (Dr. med.) for a thesis on molecular antibiotic resistance mechanisms in Neisseria lactamica from Julius Maximilians University in 2012. From 2011 to 2013 he worked as a physician at the Department of Neurology, University Hospital Göttingen, and was a research fellow at the National Reference Center for Prion diseases in Göttingen. His research interests are the role of apathogenic microbiota for human health and the improvement of diagnostic processes in both infectious and neurodegenerative diseases.  André Karchs work has a strong focus on epidemiological and statistical methods. He currently holds a DZIF MD/PhD fellowship.



Selected publications



Bennett DA, Brayne C, Feigin VL, Barker-Collo S, Brainin M, Davis D, Gallo V, Jette N, Karch A, Kurtzke JF, Lavados PM, Logroscino G, Nagel G, Preux PM, Rothwell PM & Svenson LW. (2015). Development of the Standards of Reporting of Neurological Disorders (Strond) Checklist: A Guideline for the Reporting of Incidence and Prevalence Studies in Neuroepidemiology. Eur J Epidemiol. doi: 10.1007/s10654-015-0034-5

Karch A. (2015). Standardized Surveillance of Prion Diseases in Resource-Poor Settings Is Crucial for Individual Patient-Care as Well as for Decision-Making of Healthcare Authorities. J Neurosci Rural Pract, 6(1), 4-5. doi: 10.4103/0976-3147.143164

Karch A, Castell S, Schwab F, Geffers C, Bongartz H, Brunkhorst FM, Gastmeier P & Mikolajczyk RT. (2015). Proposing an Empirically Justified Reference Threshold for Blood Culture Sampling Rates in Intensive Care Units. J Clin Microbiol, 53(2), 648-652. doi: 10.1128/JCM.02944-14

Maier IL, Karch A, Mikolajczyk R, Bahr M & Liman J. (2015). Effect of Beta-Blocker Therapy on the Risk of Infections and Death after Acute Stroke--a Historical Cohort Study. PLoS One, 10(2), e0116836. doi: 10.1371/journal.pone.0116836

Naghavi M, Karch A, Murray CJ & Lopez A. (2015). Global, Regional, and National Age-Sex Specific All-Cause and Cause-Specific Mortality for 240 Causes of Death, 1990-2013: A Systematic Analysis for the Global Burden of Disease Study 2013. Lancet, 385(9963), 117-171. doi: 10.1016/S0140-6736(14)61682-2

Rubsamen N, Castell S, Horn J, Karch A, Ott JJ, Raupach-Rosin H, Zoch B, Krause G & Mikolajczyk RT. (2015). Ebola Risk Perception in Germany, 2014. Emerg Infect Dis, 21(6), 1012-1018. doi: 10.3201/eid2106.150013

Werfel T, Heratizadeh A, Niebuhr M, Kapp A, Roesner LM, Karch A, Erpenbeck VJ, Losche C, Jung T, Krug N, Badorrek P & Hohlfeld JM. (2015). Exacerbation of Atopic Dermatitis on Grass Pollen Exposure in an Environmental Challenge Chamber. J Allergy Clin Immunol. doi: 10.1016/j.jaci.2015.04.015



Karch A, Krumkamp R & Kreuels B. (2014). Randomized, Placebo-Controlled Trial or Post Hoc Subgroup Analysis: The Importance of Standardized and Comprehensive Reporting. J Infect Dis. doi: 10.1093/infdis/jiu028

Karch A, Raddatz LM, Ponto C, Hermann P, Summers D & Zerr I. (2014). Diagnostic Profiles of Patients with Late-Onset Creutzfeldt-Jakob Disease Differ from Those of Younger Creutzfeldt-Jakob Patients: A Historical Cohort Study Using Data from the German National Reference Center. J Neurol, 261(5), 877-883. doi: 10.1007/s00415-014-7283-1

Karch A & Thomas SL. (2014). Autoimmune Thyroiditis as a Risk Factor for Stroke: A Historical Cohort Study. Neurology, 82(18), 1643-1652. doi: 10.1212/WNL.0000000000000377

Kassebaum NJ, […] Karch A, […] Murray CJ & Lozano R. (2014). Global, Regional, and National Levels and Causes of Maternal Mortality During 1990-2013: A Systematic Analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 980-1004. doi: 10.1016/S0140-6736(14)60696-6

Minikel EV, Zerr I, Collins SJ, Ponto C, Boyd A, Klug G, Karch A, Kenny J, Collinge J, Takada LT, Forner S, Fong JC, Mead S & Geschwind MD. (2014). Ascertainment Bias Causes False Signal of Anticipation in Genetic Prion Disease. Am J Hum Genet, 95(4), 371-382. doi: 10.1016/j.ajhg.2014.09.003

Murray CJ, […] Karch A, […] Lopez AD & Vos T. (2014). Global, Regional, and National Incidence and Mortality for Hiv, Tuberculosis, and Malaria During 1990-2013: A Systematic Analysis for the Global Burden of Disease Study 2013. Lancet, 384(9947), 1005-1070. doi: 10.1016/S0140-6736(14)60844-8

Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Gunther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F & Krause G. (2014). Collection of Vaccination Data in the German National Cohort : Findings of a Feasibility Study in Three Study Centers. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 57(11), 1292-1299. doi: 10.1007/s00103-014-2050-0



Karch A, Manthey H, Ponto C, Hermann P, Heinemann U, Schmidt C & Zerr I(2013). Investigating the Association of Apoe Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia. PLoS One, 8(12), e84405. doi: 10.1371/journal.pone.0084405

Karch A & Zerr I. (2013). A Comparison of Tau and 14-3-3 Protein in the Diagnosis of Creutzfeldt-Jakob Disease. Neurology, 80(22), 2081. doi: 10.1212/01.wnl.0000431029.13491.59c

Schmidt C, Karch A, Artjomova S, Hoeschel M & Zerr I. (2013). Pre-Progression Rates in Alzheimer's Disease Revisited. J Alzheimers Dis, 35(3), 451-454. doi: 10.3233/JAD-130074

Wasser K, Karch A, Groschel S, Witzenhausen J, Groschel K, Bahr M & Liman J(2013). Plaque Morphology Detected with Duplex Ultrasound before Carotid Angioplasty and Stenting (Cas) Is Not a Predictor of Carotid Artery in-Stent Restenosis, a Case Control Study. BMC Neurol, 13, 163. doi: 10.1186/1471-2377-13-163



Schmidt C, Karch A, Korth C & Zerr I. (2012). On the Issue of Transmissibility of Alzheimer Disease: A Critical Review. Prion, 6(5), 447-452. doi: 10.4161/pri.22502

Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, Sanchez-Valle R, Mitrova E, Sklaviadis T, Kulczycki J, Slivarichova D, Saiz A, Calero M, Knight R, Aguzzi A, Laplanche JL, Peoc'h K, Schelzke G, Karch A, van Duijn CM & Zerr I. (2012). Cerebrospinal Fluid Biomarker Supported Diagnosis of Creutzfeldt-Jakob Disease and Rapid Dementias: A Longitudinal Multicentre Study over 10 Years. Brain, 135(Pt 10), 3051-3061. doi: 10.1093/brain/aws238


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