Cellular Proteome Research

Pathogenic bacteria, viruses and fungi utilize and alter physiological cellular processes of the infected host. Our studies focus on the identification of unknown processes in complex and molecular networks, which are involved in infectious diseases.


CPRO Projects in molecular immunology:

  • Control of immunological synapse formation in regulatory T lymphocytes with focus on microtubule mediated signal component transport (B16, CRC854, Magdeburg, Germany).
  • Characterization of human mucosal associated invariant T cells (MAITs) (coop. Prof. Sandberg, Karolinska, Sweden).
  • Characterization of S100A4 as a key regulator for granule positioning (coop. E. Mace / J. Orange, US).
  • Characterization of human NK subsets in treated & untreated HCV patients (coop. Prof. Wedemeyer, Hannover Medical School, Germany).
  • De-ubiquitin protease mediated immune control in SIRS and Sepsis (coop. Prof. Schlüter, University Magdeburg and Dr. Lodes ICU Magdeburg, Germany).
  • Fungal mitochondrial proteome analyses (coop. TU, Mendel).


CPRO projects with focus on pathogen induced immune Regulation:

  • Characterizing the role of CD56 negative NK cells in HIV/HCV infections (coop. Prof. Sandberg, Prof. Björkström, Karolinska, Sweden).
  • EBV-specific alterations of the ubiquitin system in the process of B cell transformation (coop. Prof. Delecluse, DKFZ, Heidelberg, Germany).
  • Analyses of host signaling induced by PLY from Streptococcus pneumoniae (coop. Chakraborty, University Gießen, Germany).
  • Importance of Tubulin-tyrosine-ligase (TTL) controlled microtubule dynamics in viral infection (coop. Prof. Sodeik, Medical School Hannover, Germany).
  • Identification of protein interactions in CMV infection (coop. Prof. S. Jonjic, Croatia)