Cellular Proteome Research

Pathogenic bacteria and viruses utilize and manipulate cellular processes of our immune system. The identification of protein functions in the human immune system that decisively control the progression of infections constitutes the central aim of the research group Cellular Proteomics at the HZI.

Leader

Our Research

Actin (red) and microtubule (green) staining of T and B lymphocyte constituting an immunological synapse.

Proteins are the functional building blocks in infection and the prime target in drug research. Our immune cells establish highly distinct protein networks to mediate their individual immune responses. The activation of such immune responses depends from cell contacts at immunological synapses and is essentially under the control of post-translational mechanisms (phosphorylation, ubiquitnation, molecular transport, ROS).

Quantitative phosphopeptide sequencing. MS/MS spectrum (part) with induced tyrosine phosphorylation

Our research combines modern technologies of mass spectrometry and proteomics with methods of molecular immunology and cell biology to identify novel mechanisms of immune regulation in infection.

Central aspects of our research are:

  • Characterizing T and NK cell signaling pathways that control their activities
  • Molecular phenotyping of tissues and immune cell subsets
  • in acute and chronic infections (donor- / patient-specific).
  • Immune controlling mechanisms at immunological synapses.

Service

Analytical pipelines (Proteome Analytics, Bioinformatics and Biostatistics) are evaluated as part of our research and are provided as service towards internal and external partners. As part of the institutional platforms, we are particularly interested to support translational and clinical relevant projects.

News

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

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