Virus Transmission

Hepatitis C virus is transmitted by direct blood-to-blood contact: while blood transfusions were the main problem prior to 1990, transmission by blood products is no longer an issue in Germany - owing to highly sensitive tests. Nowadays, insufficient hygiene is the main hepatitis C virus infection risk. What can we do against the spread of this virus due to deficient hygiene? Prevention is the silver bullet for control of the hepatitis C virus. Another aspect in the focus of the members of the Virus Transmission research group: The envelope of the virus also plays a central role for infection of the host, the host's defence strategies and the production and release of new viruses.

Leader

Selected Publications

Pfaender S, Walter S, Grabski E, Todt D, Bruening J, Romero-Brey I, Gather T, Brown RJ, Hahn K, Puff C, Pfankuche VM, Hansmann F, Postel A, Becher P, Thiel V, Kalinke U, Wagner B, Bartenschlager R, Baumgartner W, Feige K et al. (2017) Immune protection against reinfection with nonprimate hepacivirus. Proc Natl Acad Sci U S A 114: E2430-E2439

Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E (2015) Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. Hepatology 62: 702-714

Todt D, Gisa A, Radonic A, Nitsche A, Behrendt P, Suneetha PV, Pischke S, Bremer B, Brown RJ, Manns MP, Cornberg M, Bock CT, Steinmann E, Wedemeyer H (2016) In vivo evidence for ribavirin-induced mutagenesis of the hepatitis E virus genome. Gut 65: 1733-1743

Ciesek S, Friesland M, Steinmann J, Becker B, Wedemeyer H, Manns MP, Steinmann J, Pietschmann T, Steinmann E (2010) How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201: 1859-66

Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E (2011) The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology 54: 1947-1955

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