Virus Transmission

Hepatitis C virus is transmitted by direct blood-to-blood contact: while blood transfusions were the main problem prior to 1990, transmission by blood products is no longer an issue in Germany - owing to highly sensitive tests. Nowadays, insufficient hygiene is the main hepatitis C virus infection risk. What can we do against the spread of this virus due to deficient hygiene? Prevention is the silver bullet for control of the hepatitis C virus. Another aspect in the focus of the members of the Virus Transmission research group: The envelope of the virus also plays a central role for infection of the host, the host's defence strategies and the production and release of new viruses.


Relevant Publications

Ciesek, S., M. Friesland, J. Steinmann, B. Becker, H. Wedemeyer, M.P. Manns, J. Steinmann, T. Pietschmann, E. Steinmann. (2010). How stable is the hepatitis C virus (HCV)? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 201(12), 1859-1866. 

Doerrbecker, J., M. Friesland, S. Ciesek, T.J. Erichsen, P. Mateu-Gelabert, J. Steinmann, J. Steinmann, T. Pietschann, E. Steinmann. (2011). Inactivation and survival of hepatitis C virus on inaminate surfaces. J Infect Dis 204(12), 1830-1838

Juliane Doerrbecker, Patrick Behrendt, Pedro-Mateu-Gelabert, Sandra Ciesek, Nina Riebesehl, Corinne Wilhelm, Joerg Steinmann, Thomas Pietschmann, Eike Steinmann (2012). Transmission of hepatitis C virus among people who inject drugs: viral stability and association with drug preparation equipment. J Infect Dis Jan;207(2):281-7

Juliane Doerrbecker, Philip Meuleman, Jonghoon Kang, Nina Riebesehl, Corinne Wilhelm, Martina Friesland, Stephanie Pfaender, Joerg Steinmann, Thomas Pietschmann, Eike Steinmann (2013). Thermostability of seven hepatitis C virus genotypes in vitro and in vivo. JVH Jul;20(7):478-85

Stephanie Pfaender, Julia Heyden, Martina Friesland, Sandra Ciesek, Asim Ejaz, Joerg Steinmann, Jochen Steinmann, Andrea Malarski, Heribert Stoiber, Giorgos Tsiavaliaris, Werner Bader, Georg, Jahreis, Thomas Pietschmann, Eike Steinmann (2013). Inactivation of hepatitis C virus infectivity by human breast milk. J Infect Dis ahead of print

Steinmann J, Becker B, Bischoff B, Magulski T, Steinmann J, Steinmann E. Virucidal activity of Formulation I of the World Health Organization's alcohol-based handrubs: impact of changes in key ingredient levels and test parameters Antimicrob Resist Infect Control. 2013 Dec 12;2(1):34. doi: 10.1186/2047-2994-2-34.

Steinmann, E., C. Brohm, S. Kallis, R. Bartenschlager, and T. Pietschmann. 2008. Efficient trans-encapsidation of hepatitis C virus RNAs into infectious virus-like particles. J Virol 82:7034-7046. 

Bankwitz, D., E. Steinmann, J. Bitzegeio, S. Ciesek, M. Friesland, E. Herrmann, M. B. Zeisel, T. F. Baumert, Z. Y. Keck, S. K. Foung, E. I. Pecheur, and T. Pietschmann. 2010. Hepatitis C virus hypervariable region 1 modulates receptor interactions, conceals the CD81 binding site, and protects conserved neutralizing epitopes. J Virol 84:5751-5763. 

Frentzen, A. K. Hueging, J. Bitzegeio, M. Friesland, S. Haid, J. Gentzsch, M. Hoffmann, D. Lindemann, G. Zimmer, F. Zielecki, F. Weber, E. Steinmann, and T. Pietschmann. 2011. Completion of Hepatitis C Virus Replication Cycle in Heterokaryons Excludes Dominant Restrictions in Human Non-liver and Mouse Liver Cell Lines. PLoS pathogens 7: PLoS Pathog 7(4): e1002029.

Eike Steinmann, Juliane Doerrbecker, Martina Friesland, Nina Riebesehl, Corinne Ginkel, Julia Hillung, Juliane Gentzsch, Chris Lauber, Richard Brown, Anne Frentzen, Thomas Pietschmann (2013). Characterization of intra- and intergenotypic chimeras reveals a role of the glycoproteins in virius envelopment. J Virol ahead of print

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