Structural Infection Biology
To understand and eventually manipulate pathways that control the interaction of pathogens (e.g. bacteria, virus, parasite) with their hosts (e.g. human, plants) requires an interdisciplinary research approach, which often combines different fields of research such as cell biology and microbiology. In our laboratory, however, we take a closer look at the processes occurring during an infection at the cellular and atomic level by harnessing a variety of modern biophysical methods that allow addressing the spatio-temporal dynamics of an infectious disease at a high resolution. The department is located at the Center for Structural Systems Biology (CSSB) at the heart of the Germany’s largest accelerator center DESY (Deutsches Elektronen-Synchrotron) in Hamburg.
Moura-Alves P et al, Aryl hydrogen receptor senses bacterial pigmented virulence factors and orchestrates antibacterial defenses, Nature, 512: 387-392 (2014)
Shigella flexneri type 3 secretion system caught in the act
Dohlich K, Brotcke Zumsteg A, Goosmann C, Kolbe M, A Substrate-Fusion Protein is Trapped inside the Type III Secretion System Channel in Shigella flexneri, PLoS Pathogens, e003881 (2014)
3-dimensional model of the type 3 secretion needle in Salmonella typhimurium
Loquet A Sgourakis NG, Gupta R, Giller K, Riedel D, Goosmann C, Griesinger C, Kolbe* M, Baker D, Becker S, Lange* A, Atomic model of the type III secretion system needle, Nature, 486: 276-279 (2012)
Structure and mechanism of type 3 secretion system needle assembly
Poyraz O, Schmidt H, Seidel K, Delissen F, Ader C, Tenenboim H, Goosmann C, Laube B, Thünemann AF, Zychlinsky A, Baldus M, Lange A, Griesinger C, Kolbe M, Protein refolding is required for assembly of the type three secretion needle. Nat. Struct. Mol. Biol., 17: 788-792 (2010)
Structural based prediction of a conserved effector-chaperone motif for type 3 secretion
Lunelli, M, Lokareddy, RK, Zychlinsky, A, Kolbe, M, IpaB-IpgC interaction defines binding motif for type III secretion translocator. Proc. Natl. Acad. Sci., 106: 9661-9666 (2009)
Prof Dr Michael Kolbe
Head of the department Structural Infection Biology
+49 30 28460332
Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!