Organ-Specific Immune Regulation

Infections and inflammatory diseases can appear in all organs and tissues. The development of these diseases is influenced by the underlying pathogen, the immune system as well as local organ-specific factors. These three factors regulate one another in a complex interaction. The goal of our scientists is to understand the crosstalk between the immune-system and the respective organ-specific factors and its impact on the development of infections. This research should result in new therapeutic options for the treatment of infections.



selected publications (# = als Dienstadresse HZI gelistet)

Nishanth,G.; Wolleschak,D.; Fahldieck,C.; Fischer,T.; Mullally,A.; Perner,F.; Schnöder, T.M.; Just,S.; Heidel,F.H.; Schlüter,D.; (2017). Gain of function in Jak2V617F positive T-cells. Leukemia: DOI: 10.1038/leu.2017.6. #

Schmid,U.; Stenzel,W.; Koschel,J.; Raptaki,M.; Wang,X.; Naumann,M.; Matuschewski,K.; Schlüter,D.; Nishanth,G.; (2017). CYLD Dampens CD8+ T cell Responses and is a Critical Factor for Experimental Cerebral Malaria and Blood-Brain Barrier Damage. Frontiers in Immunology: 8:27. DOI: 10.3389/fimmu.2017.00027. #

Just,S.; Nishanth,G.; Buchbinder,J.H.; Wang,X.; Naumann,M.; Lavrik,I.; Schlüter,D.; (2016). A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection. Scientific Reports 6:39796: DOI: 10.1038/srep39796.  #

Hrdinka,M.; Sudan,K.; Just,S.; Schlüter,D.; Reinhold,D.; Jordan,B.A.; Ginschel,P.; Schraven,B.; Kreutz,M.R.; (2016). Normal development and function of T cells in proline rich 7 (Prr7) deficient mice. PLoS One 11(9):e0162863: DOI: 10.1371/journal.pone.0162863.  #

Kummer A, Nishanth G, Koschel J, Klawonn F, Schlüter D, Jänsch L. (2016). Listeriosis down-regulates hepatic cytochrome P450 enzymes in sub-lethal murine infection. Proteomics Clinical Applications 10(9-10):1025-1035: DOI: 10.1002/prca.201600030.  #

Möhle,L.; Israel,N.; Paarman,K.; Krohn,M.; Pietkiewicz,S.; Müller,M.; Lavrik,I.; Buguliskis,J.; Schott,B.; Schlüter,D.; Gundelfinger,E.; Montag,D.; Seifert,U.; Pahnke,J.; Dunay,I.R.; (2016). Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathologica Communications 4(1):25: DOI: 10.1186/s40478-016-0293-8.

Wex,K.; Schmid,U.; Just,S.; Wang,X.; Wurm,R.; Naumann,M.; Schlüter,D.; Nishanth,G.; (2016). Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages. Frontiers in Immunology 6:650: DOI: 10.3389/fimmu.2015.00650.  #

Tammer,I.; Geginat,G.; Lange,S.; Kropf,S.; Lodes,U.; Schlüter,D.; Lippert,H.; Meyer,F.; (2016). Antibiotic Consumption and the Development of Antibiotic Resistance in Surgical Units. Zentralblatt für Chirurgie 141(1):53-61: DOI: 10.1055/s-0033-1351087.

Stokkou,S.; Geginat,G.; Schlüter,D.; Tammer,I.; (2015). Direct disk diffusion test using European Clinical Antimicrobial Susceptibility Testing breakpoints provides reliable results compared with the standard method. European Journal of Microbioloy and Immunology (Bp) (1):103-11: DOI: 10.1556/EUJMI-D-15-00005.  #

Dong,W.; Wang,H.; Shahzad,K.; Bock,F.; Al-Dabet,M.; Ranjan,S.; Wolter,J.; Kohli,S.; Hoffmann,J.; Dhople,V.M.; Zhu,C.; Lindquist,J.A.; Esmon,C.T.; Gröne,E.; Gröne,H.J.; Madhusudhan,T.; Mertens,P.R.; Schlüter,D.*; Isermann,B.*; (2015). Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protei 1 Ubiquitination. Journal of the American Society of Nephrology. DOI: 10.1681/ASN.2014080846.
*contributed equally

Wurm,R.; Just,S.; Wang,X.; Wex,K.; Schmid,U.; Blanchard,N.; Waisman,A.; Schild,H.J.; Naumann,M.; Schlüter,D.; Nishanth,G.; (2015). Protective dendritic cell responses against listeriosis induced by the short form of the deubiquitinating enzyme CYLD are inhibited by full-length CYLD.
European Journal of Immunology:  DOI: 10.1002/eji.201445116. PubMed #

Blanchard,N.; Dunay,I.R.*; Schlüter,D.*; (2015). Persistence of Toxoplasma gondii in the central nervous system: a fine tuned balance between the parasite, the brain and the immune system. Parasite Immunology: 37, 150-8. DOI: 10.1111/pim.12173. PubMed #
*contributed equally

Detje,C.; Lienenklaus,S.; Chhatbar,C.; Spanier,J.; Prajeeth,C.; Soldner,C.; Tovey,M.; Schlüter,D.; Weiss,S.; Stangel,M.; Kalinke,U.; (2015). Upon intranasal VSV infection astrocytes in the olfactory bulb are important IFN-β producers that protect from lethal encephalitis. Journal of Virology: 89, 2731-8. DOI: 10.1128/JVI.02044-14. PubMed #

Parlog,A.; Schlüter,D.; Dunay,I.R.; (2015).Toxoplasma gondii induced neuronal alterations. Parasite Immunology: 37, 159-70. DOI: 10.1111/pim.12157. PubMed #

Stoycheva,D.; Deiser,K.; Stärck,L.; Nishanth,G.; Schlüter,D.; Uckert,W.; Schüler,T.; (2014). Interferon-gamma regulates CD8+ memory  T cell differentiation and survival in response to weak but not strong TCR signals. Journal of Immunology: 194, 553-9. DOI:10.4049/jimmunol.1402058 PubMed #

Xuan,N.T.*; Wang,X.*; Nishanth,G.; Waisman,A.; Borucki,K.; Isermann,B.; Naumann,M.; Deckert,M.; Schlüter,D.; (2014). A20 expression in dendritic cells protects mice from LPS-induced mortality. European Journal of Immunology:  DOI: 10.1002/eji.201444795. PubMed #
* contributed equally

Pleyer,U.; Schlüter,D.; Mänz,M.; (2014). Ocular Toxoplasmosis: Recent Aspects of Pathophysiology and Clinical Implications. Ophthalmic Research: 52, 116-123. DOI: 10.1159/000363141. PubMed

Schlüter,D.; Däubener,W.; Schares,G.; Groß,U.; Pleyer,U.; Lüder,C.; (2014). Animals are key to human toxoplasmosis. International Journal of Medical Microbiology: 304, 917-29. DOI: 10.1016/j.ijmm.2014.09.002. PubMed #

Pick,J.; Arra,A.; Lingel,H.; Hegel,J.K.; Huber,M.; Nishanth,G.; Jorch,G.; Fischer,K.D.; Schlüter,D.; Tedford,K.; Brunner-Weinzierl,M.C.; (2014). CTLA-4 (CD152) enhances the Tc17 differentiation program. European Journal of  Immunology: 44, 2139-52.  DOI: 10.1002/eji.201343497. PubMed #

Schalk,E.; Geginat,G.; Schulz,C.; Schlüter,D.; Fischer,T.; (2014). The incidence of norovirus infections in cancer patients shows less seasonal variability compared to patients with other diseases. Annals of Hematology: 93, 889-90. DOI: 10.1007/s00277-013-1885-z. PubMed

Maenz,M.; Schlüter,D.; Liesenfeld,O.; Schares,G.; Gross,U.; Pleyer,U.; (2014). Ocular Toxoplasmosis Past, present and new aspects of an old disease. Progress in  Retinal and Eye Research: 39:77-106. DOI: 10.1016/j.preteyeres.2013.12.005 PubMed

Tammer,I.; Geginat,G.; Lange,S.; Kropf,S.; Lodes,U.; Schlüter,D.; Lippert,H.; Meyer,F.; (2014). Antibiotic Consumption and the Development of Antibiotic Resistance in Surgical Units. Zentralblatt für Chirurgie: DOI: 10.1055/s-0033-1351087 PubMed

Selgrad,M.; Tammer,I.; Langner,C.; Bornschein,J.; Meißle,J.; Kandulski, A.; Varbanova,M.; Wex,T.; Schlüter,D.; Malfertheiner,P.; (2014). Different antibiotic susceptibility between antrum and corpus of the stomach, a possible reason for treatment failure of Helicobacter pylori infection. World Journal of Gastroenterology: 20, 16245-51. DOI: 10.3748/wjg.v20.i43.16245 PubMed

Jensen,S.;  Steffensen,M.A.;  Jensen,B.A.; Schlüter,D.; Christensen,J.P.; Thomsen,A.R.; (2013). An adenovirus-based vaccine against Listeria monocytogenes: Extending the concept of invariant chain linkage. Journal of Immunology: 191, 4152-64 DOI: 10.4049/jimmunol.1301290 PubMed

Wang,X.; Deckert,M.; Xuan,N.T.; Nishanth,G.; Just,S.; Waisman,A.; Naumann,M.; Schlüter,D.; (2013). Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathologica: 126, 5:711-724  DOI: 10.1007/s00401-013-1183-9 PubMed

Nishanth,G.;  Deckert,M.; Wex,K.; Massoumi,R.; Schweitzer,K.; Naumann,M.; Schlüter,D.; (2013). CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. PLoS Pathogens: 9, 6: e1003455. DOI:10.1371/journal.ppat.1003455 PubMed #

Selgrad,M.; Meißle,J.; Bornschein,J.; Kandulski,A.; Langner,C.; Varbanova,M.; Wex,T.; Tammer,I.;  Schlüter,D.; Malfertheiner,P.; (2013). Antibiotic susceptibility of Helicobacter pylori in central Germany and its relationship to the number of eradication therapies. European Journal of Gastroenterology & Hepatology: 25:1257-60. DOI: 10.1097/MEG.0b013e3283643491 PubMed

Wang,X.; Haroon,F.; Karray,S.; Deckert,M.; Schlüter,D.; (2013). Astrocytic Fas ligand-expression is required to induce T-cell apoptosis and recovery from experimental autoimmune encephalomyelitis. European Journal of Immunology: 43:115-124. DOI: 10.1002/eji.201242679 PubMed

Haroon,F.; Händel,U.; Angenstein,F.; Goldschmidt,J.; Kreutzmann,P.; Lison,H.;  Fischer,K.D.; Scheich,H.; Wetzel,W.; Schlüter,D.;*, E. Budinger*; (2012). Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS One: 7, 4: e35516. DOI:10.1371/journal.pone.0035516 (* equal contribution) PubMed

Händel,U.; Brunn,A.; Drögemüller,K.; Müller,W.; Deckert,M.; Schlüter,D.; (2012). Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis. The American Journal of Pathology:, 181:163-173 PubMed

Hövelmeyer,N.; Reissig,S.; Xuan,N.T.; Adams-Quack,P.; Lukas,D.; Nikolaev,A.; Schlüter,D.;*  Waisman,A.*; (2011). A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. European Journal of Immunology: 41:595-601. (* equal contribution) PubMed

Haroon,F.; Drögemüller,K.; Händel,U.; Brunn,A.; Reinhold,D.; Nishanth,G.; Mueller,W.; Trautwein,C.;  Ernst,M.; Deckert,M.; Schlüter,D.; (2011). Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. The Journal of Immunology: 186: 6521-31 PubMed

Nishanth,G.;  Sakowicz-Burkiewicz,M.; Kliche,S.; Naumann,M.; Deckert,M.; Schlüter,D.; (2010). Protective Toxoplasma gondii-specific T cell responses require T cell-specific expression of protein kinase C-theta. Infection and Immunity: 78:3454-3464 PubMed

Mayer-Barber,K.D.; Barber,D.L.; Shenderov,K.; White,S.; Feng,C.G.; Cheever,A.; Kugler,D.; Hieny,S.;  Caspar,P.; Iwakura,Y.; Núñez,G.; Schlüter,D.; Flavell,R.A.; Sutterwala,F.S.; Sher,A.; (2010). Caspase-1 independent IL-1beta production is critical for host resistance to Mycobacterium tuberculosis and does not require TLR signaling in vivo. The Journal of Immunology: 184, 7:3326-3330. DOI: 10.4049/jimmunol.0904189 PubMed

Drögemüller,K.; Helmuth,U.; Brunn,A.; Sakowicz-Burkiewicz,M.; Gutmann,D.H.; Mueller,W.; Deckert,M.; Schlüter,D.; (2008). Astrocyte gp130-expression is critical for the survival of mice with Toxoplasma  encephalitis. The Journal of Immunology: 181:2683-2693 PubMed

Sanchez-Ruiz,M.; Wilden,L.; Müller,W.; Stenzel,W.; Schlüter,D.;* Deckert,M.*; (2008). Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease. The Journal of Immunology: 180:8421-33. (*equal contribution) PubMed

Sakowicz-Burkiewicz,M.; Nishanth,G.; Helmuth,U.; Drögemüller,K.; Busch,D.H.; Utermöhlen,O.;  Naumann,M.; Deckert,M.; Schlüter,D.; (2008). Proteinkinase C-theta critically regulates the activation and proliferation of pathogen-specific T cells in murine listeriosis. The Journal of Immunology: 180:5601-5612 PubMed

Stenzel,W.; Soltek,S.; Sanchez-Ruiz,M.; Courts,C.; Akira,S.; Miletic,H.; Schlüter,D.; Deckert,M.; (2008). Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess. The American Journal of Pathology: 172:132-145 PubMed

Mueller,A.K.; Deckert,M.; Heiss,K.; Goetz,K.; Matuschewski,K.; Schlüter,D.; (2007). Genetically  attenuated Plasmodium berghei liver stages persist and elicit sterile protection primarily via CD8 T cells. The American Journal of Pathology: 171:107-115 PubMed

Deckert,M.; Virna,S.; Sakowicz-Burkiewicz,M.; Lütjen,S.; Soltek,S.; Bluethmann,H.; Schlüter,D.; (2007). The interleukin-1 receptor type 1 is essential for control of cerebral, but not systemic listeriosis. The American Journal of Pathology: 170:990-1002 PubMed

Lütjen,S.; Soltek,S.; Virna,S.; Deckert,M.; Schlüter,D.; (2006). Organ and disease-stage-specific regulation of Toxoplasma gondii-specific CD8 T cell responses by CD4 T cells. Infection and Immunity: 74:5790-5801 PubMed

Virna,S.; Deckert,M.; Lütjen,S.; Soltek,S.; Foulds,K.E.; Shen,H.; Körner,H.; Sedgwick,J.D.; Schlüter,D.; (2006). Tumor necrosis factor is important for pathogen control and limits brain damage in murine cerebral listeriosis. The Journal of Immunology: 177:3972-3982 PubMed

Stenzel,W.; Soltek,S.; Miletic,H.; Hermann,M.M.; Körner,H.;  Sedgwick,J.D.; Schlüter,D.; Deckert,M.; (2005). An essential role for tumor necrosis factor in the formation of experimental murine Staphylococcus aureus-induced brain abscess and clearance. Journal of Neuropathology & Experimental Neurology: 64:27-36 PubMed

Roers,A.; Siewe,L.;  Strittmatter,E.;  Deckert,M.; Schlüter,D.; Stenzel,W.; Gruber,A.; Krieg,T.;  Rajewsky,K.; Müller,W.; (2004). T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation. The Journal of Experimental Medicine: 15:1289-97 PubMed

Ding,M.; Kwok,L.Y.; Schlüter,D.; Clayton,C.; Soldati,D.; (2004). The antioxidant systems in Toxoplasma gondii and the role of cytosolic catalase in defence against oxidative injury. Molecular Microbiology: 51:47-61 PubMed

Schlüter,D.; Lütjen,S.; Kwok,L.Y.; Soltek,S.; Sedgwick,J.; Koerner,H.; Deckert,M.; (2003). Both TNF and lymphotoxin-a are crucial for control of Toxoplasma gondii in the central nervous system. The Journal of Immunology: 170:6172-6182 PubMed

Kwok,L.Y.; Lütjen,S.; Soltek,S.; Deckert,M.; Soldati,D.; Schlüter,D.; (2003). The induction and kinetics of antigen-specific CD8 T cells are defined by the stage-specificity and compartmentalization of the antigen in murine toxoplasmosis. The Journal of Immunology: 170:1949-1957 PubMed

Meissner,M.; Schlüter,D.; Soldati,D.; (2002). Toxoplasma gondii myosin A: a virulence factor powering gliding motility and host cells invasion. Science: 298:837-840 PubMed

Kwok,L.Y.; Miletic,H.; Lütjen,S.; Busch,D.; Soltek,S.; Deckert,M.; Schlüter,D.; (2002). Protective immunosurveillance of the central nervous system by Listeria-specific CD4 and CD8 T cells in systemic listeriosis in the absence of intracerebral Listeria. The Journal of Immunology: 169:2010-2019 PubMed

Schlüter,D.; Meyer,T.; Kwok,L.Y.; Montesinos-Rongen,M.; Lütjen,S.; Strack,A.; Schmitz,L.; Deckert,M.; (2002). Phenotype and regulation of persistent intracerebral T cells in murine Toxoplasma encephalitis. The Journal of Immunology: 169:315-322 PubMed

Schlüter,D.; Deckert-Schlüter,M.; Lorenz,E.; Meyer,T.; Röllinghoff,M.; Bogdan,C.; (1999). Inhibition of inducible nitric oxide synthase exacerbates chronic cerebral toxoplasmosis in Toxoplasma gondii-susceptible C57BL/6 mice, but does not reactivate the latent disease in Toxoplasma gondii-resistant BALB/c mice. The Journal of Immunology: 162:3512-3518 PubMed

Schlüter,D.; Domann,E.; Buck,C.; Hain,T.; Hof,H.; Chakraborty,T.; Deckert-Schlüter,M.; (1998). Phosphatidylcholine-specific phospholipase C from Listeria monocytogenes is an important virulence factor in murine cerebral listeriosis. Infection and Immunity: 66:5930-5938 PubMed

Deckert-Schlüter,M.; Blüthmann,H.; Rang,A.; Hof,H.; Schlüter,D.; (1998). Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75) in murine toxoplasmosis. The Journal of Immunology: 160:3427-3436 PubMed

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