Organ-Specific Immune Regulation

Infections and inflammatory diseases can appear in all organs and tissues. The development of these diseases is influenced by the underlying pathogen, the immune system as well as local organ-specific factors. These three factors regulate one another in a complex interaction. The goal of our scientists is to understand the crosstalk between the immune-system and the respective organ-specific factors and its impact on the development of infections. This research should result in new therapeutic options for the treatment of infections.

Leader

Selected Publications

Nishanth G, Wolleschak D, Fahldieck C, Fischer T, Mullally A, Perner F, Schnöder TM, Just S, Heidel FH, Schlüter D. Gain of function in Jak2(V617F)-positive T-cells. Leukemia. 2017 Apr;31(4):1000-1003. DOI:10.1038/leu.2017.6 . Epub 2017 Jan 11. PubMed PMID: 28074070 .

Wang X, Deckert M, Xuan NT, Nishanth G, Just S, Waisman A, Naumann M, Schlüter D. Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-?B- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol. 2013 Sep 29. [Epub ahead of print] PubMed PMID: 24077734 .

Nishanth G, Deckert M, Wex K, Massoumi R, Schweitzer K, Naumann M, Schlüter D. CYLD enhances severe listeriosis by impairing IL-6/STAT3-dependent fibrin production. PLoS Pathog. 2013;9(6):e1003455. DOI:10.1371/journal.ppat.1003455 . Epub 2013 Jun 27. PubMed PMID: 23825949 ; PubMed Central PMCID: PMC3695090.

Haroon F, Drögemüller K, Händel U, Brunn A, Reinhold D, Nishanth G, Mueller W, Trautwein C, Ernst M, Deckert M, Schlüter D. Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation. J  Immunol. 2011 Jun 1;186(11):6521-31. DOI:10.4049/jimmunol.1001135 . Epub 2011 Apr 22. PubMed PMID: 21515788.

Meissner M, Schlüter D, Soldati D. Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science. 2002 Oct 25;298(5594):837-40. PubMed PMID: 12399593 .

Vollständige Publikationsliste

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