Molecular Infection Biology

Gastrointestinal infections are counted among the most common types of infectious diseases worldwide. In particular in developing countries, diarrhoeal diseases are still a leading course of death. Indeveloped countries, diarrhoeal diseases are under better control, but they still represent a very common affliction, especially among children and the elderly. Among the most important bacterial pathogens of food-animal origin are Salmonella, Shiga toxin-producing Escherichia coli, and enteropathogenic Yersinia species. Their primary route of transmission from animals to humans is through contaminated food. Once inside our bodies, they trigger an impressive range of different intestinal disorders from diarrhoea to acute infections of the small and large intestines – at times with severe consequences! Our primary focus is on Yersinia. We study the ways in which these bacteria adhere to the intestinal epithelium, penetrate it, and ultimately spread within the host.

Publications

  • Zeitouni,N.E.; Dersch,P.; Naim,H.Y.; Von Köckritz-Blickwede,M.; (2016). Hypoxia decreases invasin-mediated yersinia enterocolitica internalization into Caco-2 Cells. PLoS ONE: 11 119326203 DOI: 10.1371/journal.pone.0146103 HZI repository PubMed
  • Labouta,H.I.; Menina,S.; Kochut,A.; Gordon,S.; Geyer,R.; Dersch,P.; Lehr,C.M.; (2015). Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery. 220, 414-424 DOI: 10.1016/j.jconrel.2015.10.052 HZI repository PubMed
  • Rosenheinrich,M.; Heine,W.; Schmuhl,C.M.; Pisano,F.; Dersch,P.; (2015). Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes. PLoS ONE: 10 8, e0136290 DOI: 10.1371/journal.pone.0136290 HZI repository PubMed
  • Avican,K.; Fahlgren,A.; Huss,M.; Heroven,Ann Kathrin; Beckstette,M.; Dersch,Petra; Fallman,M.; (2015). Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis. PLoS Pathogens: 11 1, e1004600 DOI: 10.1371/journal.ppat.1004600 HZI repository PubMed
  • Nitzsche,R.; Rosenheinrich,M.; Kreikemeyer,B.; Oehmcke-Hecht,S.; (2015). Streptococcus pyogenes triggers activation of the human contact system by streptokinase. Infection and Immunity: 83 8, 3035-304200199567 WEBURLS
  • Giogha,C.; Wong Fok,Lung T.; Mühlen,S.; Pearson,J.S.; Hartland,E.L.; (2015). Substrate recognition by the zinc metalloprotease effector NleC from enteropathogenic Escherichia coli. 17 12, 1766-177814625814 WEBURLS
  • Nuss,A.M.; Heroven,A.K.; Waldmann,B.; Reinkensmeier,J.; Jarek,M.; Beckstette,M.; Dersch,P.; (2015). Transcriptomic Profiling of Yersinia pseudotuberculosis Reveals Reprogramming of the Crp Regulon by Temperature and Uncovers Crp as a Master Regulator of Small RNAs. 11 315537390 DOI: 10.1371/journal.pgen.1005087 HZI repository PubMed
  • Nuss,Aaron M.; Schuster,Franziska; Heroven,Ann Kathrin; Heine,Wiebke; Pisano,Fabio; Dersch,Petra; (2014). A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC. RNA Biology: 11 5 PubMed
  • Heroven,Ann Kathrin; Dersch,Petra; (2014). Bacterial protein and RNA thermometers: Molecular thermometers for the control of the virulence of Yersinia. Biospektrum: 20 4, 376-37918686249 WEBURLS
  • Heroven,Ann Kathrin; Dersch,Petra; (2014). Coregulation of host-adapted metabolism and virulence by pathogenic. Frontiers in Cellular and Infection Microbiology: 4, 146 DOI: 10.3389/fcimb.2014.00146 HZI repository PubMed
  • Schaake,Julia; Drees,A.; Grüning,P.; Uliczka,F.; Pisano,Fabio; Thiermann,T.; von Altrock,A.; Seehusen,F.; Valentin-Weigand,P.; Dersch,Petra; (2014). Essential role of invasin for colonization and persistence of Yersinia enterocolitica in its natural reservoir host, the pig. Infection and Immunity: 82 3, 960-96900199567 WEBURLS
  • Pisano,Fabio; Heine,Wiebke; Rosenheinrich,Maik; Schweer,Janina; Nuss,Aaron M.; Dersch,Petra; (2014). Influence of PhoP and Intra-Species Variations on Virulence of Yersinia pseudotuberculosis during the Natural Oral Infection Route. PLoS ONE: 9 7, e103541 DOI: 10.1371/journal.pone.0103541 HZI repository PubMed
  • Rasch,U.; Ünal,C.M.; Steinert,Michael; (2014). Peptidylprolyl cis-trans isomerases of Legionella pneumophila: Virulence, moonlighting and novel therapeutic targets. Biochemical Society Transactions: 42, 1728-173303005127 WEBURLS
  • Bücker,R.; Heroven,Ann Kathrin; Becker,J.; Dersch,Petra; Wittmann,C.; (2014). The Pyruvate - Tricarboxylic Acid Cycle Node: a Focal Point of Virulence Control in the Enteric Pathogen Yersinia pseudotuberculosis. Journal of Biological Chemistry: 289, 30114-30132 DOI: 10.1074/jbc.M114.581348 HZI repository PubMed
  • Valentin-Weigand,P.; Heesemann,J.; Dersch,Petra; (2014). Unique virulence properties of Yersinia enterocolitica O:3 - An emerging zoonotic pathogen using pigs as preferred reservoir host. International Journal of Medical Microbiology: 304, 824-834 PubMed
  • Kochut,Annika; Dersch,Petra; (2013). Bacterial invasion factors: Tools for crossing biological barriers and drug delivery?. European Journal of Pharmaceutics and Biopharmaceutics: 84 2, 242-25009396411 DOI: 10.1016/j.ejpb.2012.11.013 HZI repository PubMed
  • Schaake,Julia; Kronshage,Malte; Uliczka,F.; Rohde,Manfred; Knuuti,T.; Strauch,E.; Fruth,A.; Wos-Oxley,M.; Dersch,Petra; (2013). Human and animal isolates of Yersinia enterocolitica show significant serotype-specific colonization and host-specific immune defense properties. Infection and Immunity: 81 11, 4013-4025 DOI: 10.1128/IAI.00572-13 HZI repository PubMed
  • Schweer,Janina; Kulkarni,Devesha; Kochut,Annika; Pezoldt,Jörn; Pisano,Fabio; Pils,Marina C.; Genth,H.; Hühn,Jochen; Dersch,Petra; (2013). The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases. PLoS Pathogens: 9 11, e1003746 DOI: 10.1371/journal.ppat.1003746 HZI repository PubMed
  • Steinmann,Rebekka; Dersch,Petra; (2013). Thermosensing to adjust bacterial virulence in a fluctuating environment. Future Microbiology: 8 1, 85-105 DOI: 10.2217/fmb.12.129 HZI repository PubMed
  • Böhme,Katja*; Steinmann,R.; Kortmann,J.; Seekircher,S.; Heroven,A.K.; Berger,E.; Pisano,F.; Thiermann,T.; Wolf-Watz,H.; Narberhaus,F.; Dersch,Petra*; (2012). Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence.. PLoS Pathogens: 8 2, e1002518 DOI: 10.1371/journal.ppat.1002518 HZI repository PubMed
  • Heroven,A.K.; Sest,M.; Pisano,F.; Scheb-Wetzel,M.; Steinmann,R.; Bohme,K.; Klein,J.; Munch,R.; Schomburg,D.; Dersch,Petra*; (2012). Crp Induces Switching of the CsrB and CsrC RNAs in Yersinia pseudotuberculosis and Links Nutritional Status to Virulence. Frontiers in Cellular and Infection Microbiology: 2, 158 DOI: 10.3389/fcimb.2012.00158 HZI repository PubMed
  • Pisano,F.; Kochut,A.; Uliczka,F.; Geyer,R.; Stolz,T.; Thiermann,T.; Rohde,Manfred*; Dersch,Petra*; (2012). In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence. Infection and Immunity: 80 3, 1050-1064 PubMed
  • Dersch,Petra*; (2012). Protein Folding, Transport and Degradation.: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology. Schomburg,D.; (Ed.). John Wiley & Sons, 244-258
  • Heroven,A.K.; Bohme,K.; Dersch,Petra*; (2012). Regulation of virulence gene expression by regulatory RNA elements in Yersinia pseudotuberculosis. Advances in Experimental Medicine and Biology: 954, 315-323 PubMed
  • Quade,N.; Mendonca,C.; Herbst,K.; Heroven,A.K.; Ritter,Christiane; Heinz,Dirk W.; Dersch,Petra; (2012). Structural Basis for Intrinsic Thermosensing by the Master Virulence Regulator RovA of Yersinia. Journal of Biological Chemistry: 287 43, 35796-35803 DOI: 10.1074/jbc.M112.379156 HZI repository PubMed
  • Heroven,A.K.; Bohme,K.; Dersch,Petra*; (2012). The Csr/Rsm system of Yersinia and related pathogens: A post-transcriptional strategy for managing virulence. RNA Biology: 9 4, 379-391 HZI repository PubMed
  • Uliczka,F.; Dersch,Petra*; (2012). Unique virulence properties of Yersinia enterocolitica O:3. Advances in Experimental Medicine and Biology: 954, 281-287 DOI: 10.1007/978-1-4614-3561-7_35 HZI repository PubMed
  • Uliczka,F.; Pisano,F.; Kochut,A.; Opitz,W.; Herbst,K.; Stolz,T.; Dersch,Petra*; (2011). Monitoring of Gene Expression in Bacteria during Infections Using an Adaptable Set of Bioluminescent, Fluorescent and Colorigenic Fusion Vectors. PLoS ONE: 6 6, e20425 DOI: 10.1371/journal.pone.0020425 HZI repository PubMed
  • Quade,N.; Dieckmann,M.; Haffke,M.; Heroven,A.K.; Dersch,Petra*; Heinz,Dirk W.*; (2011). Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis. Acta Crystallographica Section D: Biological Crystallography: 67 Pt 2, 81-90 DOI: 10.1107/S0907444910049681 HZI repository PubMed
  • Uliczka,F.; Pisano,F.; Schaake,J.; Stolz,T.; Rohde,Manfred*; Fruth,A.; Strauch,E.; Skurnik,M.; Batzilla,J.; Rakin,A.; Heesemann,J.; Dersch,Petra; (2011). Unique cell adhesion and invasion properties of Yersinia enterocolitica O:3, the most frequent cause of human Yersiniosis. PLoS Pathogens: 7 7, e1002117 DOI: 10.1371/journal.ppat.1002117 HZI repository PubMed
  • Homann,A.; Qamar,R.-U.; Serim,S.; Dersch,Petra*; Seibel,J.; (2010). Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. Beilstein Journal of Organic Chemistry: 6 art. no. 24 DOI: 10.3762/bjoc.6.24 HZI repository PubMed
  • Göpel,Y.; Luttmann,D.; Heroven,A.K.; Reichenbach,B.; Dersch,Petra*; Gorke,B.; (2010). Common and divergent features in transcriptional control of the homologous small RNAs GlmY and GlmZ in Enterobacteriaceae. Nucleic Acids Research: 39 4, 1294-1309 DOI: 10.1093/nar/gkq986 PubMed
  • Göpel,Y.; Lüttmann,D.; Heroven,A.K.; Reichenbach,B.; Dersch,Petra*; Görke,B.; (2010). Control of small RNA GlmY and GlmZ expression by the two-component system GlrR/GirK. Nucleic Acid Research: DOI: 10.10.93
  • Fleissner,A.; Dersch,Petra*; (2010). Expression and export: recombinant protein production systems for Aspergillus. Applied Microbiology and Biotechnology: 87 4, 1255-1270 PubMed
  • Driouch,H.; Roth,A.; Dersch,Petra*; Wittmann,C.; (2010). Filamentous fungi in good shape: Microparticles for tailor-made fungal morphology and enhanced enzyme production. Bioengineered Bugs: 2 2 DOI: 10.4161/bbug.2.2.13757 HZI repository PubMed
  • Heroven,A.K.; Dersch,Petra*; (2010). Global virulence gene regulation networks in enteropathogenic Yersiniae.: Research Advances in Molecular Microbiology. Mohan,R.M.; (Ed.). Kerala, Indien : Global Research Network, 1-17
  • Driouch,H.; Roth,A.; Dersch,Petra*; Wittmann,C.; (2010). Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger. Applied Microbiology and Biotechnology: 87 6, 2011-2024 PubMed
  • Roth,A.H.; Dersch,Petra*; (2009). A novel expression system for intracellular production and purification of recombinant affinity-tagged proteins in Aspergillus niger. Applied Microbiology and Biotechnology: 86 2, 659-670 DOI: 10.1007/s00253-009-2252-9 HZI repository PubMed
  • Uliczka,F.; Kornprobst,T.; Eitel,J.; Schneider,D.; Dersch,Petra*; (2009). Cell invasion of Yersinia pseudotuberculosis by invasin and YadA requires protein kinase C, phospholipase C-gamma1 and Akt kinase. Cellular Microbiology: 11 12, 1782-1801 DOI: 10.1111/j.1462-5822.2009.01371.x HZI repository PubMed
  • Herbst,K.; Bujara,M.; Heroven,A.K.; Opitz,W.; Weichert,M.; Zimmermann,A.; Dersch,Petra*; (2009). Intrinsic thermal sensing controls proteolysis of Yersinia virulence regulator RovA. PLoS Pathogens: 5 5, e1000435 DOI: 10.1371/journal.ppat.1000435 HZI repository PubMed
  • Vlahou,G.; Schmidt,O.; Wagner,B.; Uenlue,H.; Dersch,Petra*; Rivero,F.; Weissenmayer,B.A.; (2009). Yersinia outer protein YopE affects the actin cytoskeleton in Dictyostelium discoideum through targeting of multiple Rho family GTPases. BMC Microbiology: 9, art. no. 138
  • Heroven,A.K.; Bohme,K.; Rohde,Manfred*; Dersch,Petra*; (2008). A Csr-type regulatory system, including small non-coding RNAs, regulates the global virulence regulator RovA of Yersinia pseudotuberculosis through RovM. Molecular Microbiology: 68 5, 1179-1195 DOI: 10.1111/j.1365-2958.2008.06218.x HZI repository PubMed
  • Zuccaro,A.; Gotze,S.; Kneip,S.; Dersch,Petra*; Seibel,J.; (2008). Tailor-made fructooligosaccharides by a combination of substrate and genetic engineering. ChemBioChem: 9 1, 143-149 PubMed
  • Melzer,G.; Dalpiaz,A.; Grote,A.; Kucklick,M.; Gocke,Y.; Jonas,R.; Dersch,Petra*; Franco-Lara,E.; Nortemann,B.; Hempel,D.C.; (2007). Metabolic flux analysis using stoichiometric models for Aspergillus niger: comparison under glucoamylase-producing and non-producing conditions. Journal of Biotechnology: 132 4, 405-417 PubMed
  • Heroven,A.K.; Bohme,K.; Tran-Winkler,H.; Dersch,Petra*; (2007). Regulatory elements implicated in the environmental control of invasin expression in enteropathogenic Yersinia. Advances in Experimental Medicine and Biology: 603, 156-166 PubMed

Leader

  • Prof Dr Petra Dersch

    Petra Dersch

    Head of the Department Molecular Infection Biology

    +49 531 6181-5700

    +49 531 6181-5709

    Contact

    CV and Publications

News

Audio Podcast

  • Bakterien mit Thermometer - Vom Kühlschrank in den Körper
    Yersinien machen uns Bauchschmerzen. Wenn wir die Bakterien mit verseuchtem Fleisch zu uns nehmen, infizieren sie unsere Darmzellen und vermehren sich. Aber wie wissen die Yersinien, dass sie nicht mehr in der vergammelten Wurst sind sondern in unserem Körper? Die Antwort ist simpel: Die Bakterien haben ein Thermometer. Hören Sie zu, wie das funktioniert...