Microbial Immune Regulation

The microbiota encompasses a diverse population of microorganisms that colonize many body sites such as skin and intestine of multicellular hosts. The composition of the microbiota in humans is highly variable and is influenced by nutrition, immune competence, illness and use of medication (especially antibiotics). We are interested to enhance our understanding on how these microbial communities affect human infectious diseases and how they can be manipulated to treat diseases.


Selected Publications

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG. “Human hemato-lymphoid system mice: current use and future potential for medicine.” Annu Rev Immunol. 2013;31:635-74.

Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA. “NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.” Nature. 2012 Apr 25;484(7395):510-3.

Henao-Mejia J*, Elinav E*, Strowig T*, Flavell RA. “Inflammasomes: far beyond inflammation.” Nat Immunol. 2012 Mar 19;13(4):321-4. (*equally contributed).

Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ, Camporez JP, Shulman GI, Gordon JI, Hoffman HM, Flavell RA. “Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity.” Nature. 2012 Feb 1;482(7384):179-85.

Strowig T*, Henao-Mejia J*, Elinav E*, and Flavell RA. “Inflammasomes in Health and Disease”, Nature, 2012 Jan 18; 481(7381):278-86. (*equally contributed).

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon E, Manz MG, and Flavell RA. “Transgenic expression of human SIRPa in Rag2-/-gc-/- mice improves engraftment of human hematopoietic cells in humanized mice”, PNAS. 2011 Aug 9;108(32):13218-23.

Strowig T*, Elinav E*, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, and Flavell RA. “NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis”, Cell. 2011 May 27;145(5):745-57. (*equally contributed)

Reviewed in F1000, Highlighted in Nature and Nature Microbiology.

Hu B, Elinav E, Huber S, Booth CJ, Strowig T, Jin C, Eisenbarth SC, Flavell RA. “Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4”, PNAS. 2010 Dec 14;107(50):21635-40.

Strowig T*, Chijioke O*, Carrega P, Arrey F, Meixlsperger S, Rämer PC, Ferlazzo G and Münz C. “Human NK cells of mice with reconstituted human immune system components require pre-activation to acquire functional competence”, Blood. 2010 Nov 18;116(20):4158-67. (*equally contributed)

Strowig T*, Gurer C*, Ploss A, Rice C, Young JW, Chadburn A. Cohen JI. and Münz C. “Priming of protective T cell responses in mice with human immune system components following Epstein-Barr virus infection“. J Exp Med. 2009 Jun 8;206(6):1423-34. (*equally contributed)

Strowig T, Brilot F, Arrey F, Bougras G, Thomas D, Muller W, and Münz C. “Tonsillar NK cells restrict B cell transformation by the Epstein Barr virus via IFN-g", PLoS Pathogen. 2008 Feb 8;4(2):e27.

Audio Podcast

  • 46_Mit Mäusekötteln gegen Morbus Crohn – neue Wege gegen chronisch-entzündliche DarmerkrankungenEntzündliche Darmerkrankungen bedeuten großes Leid für die Patienten, sind kaum behandelbar und bisher wissen weder Ärzte noch Forscher, wie es dazu kommt, dass allein in Deutschland etwa 300.000 Menschen an Krankheiten wie Morbus Crohn und Colitis Ulcerosa leiden. Wissenschaftler am HZI suchen in den Bakteriengemeinschaften, die im Darm leben nach Antworten. Begleiten Sie Till Strowig ins Labor und hören Sie zu, wie er ein Probenröhrchen voll Mäuseköttel für die Forschung homogenisiert…
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