Microbial Diagnostics

Microbial pathogens find their way into our bodies in different of ways. Two important routes of transmission include food and drinking water. If a food-borne pathogen triggers an epidemic, the starting point of the chain of infection must quickly be identified to effectively curtail the epidemic. Now, HZI scientists have found a way to trace the routes of infection of bacterial pathogens that are present in our food and drinking water. Using high-resolution methods, the researchers are able to readily identify individual pathogenic bacterial strains. 


Prof Dr Manfred Höfle

We have developed a high-resolution technology that, arguably, is far too complex for routine experiments, but which will help guide us to the source of an epidemic should things get serious.

Manfred Höfle

Manfred Höfle

Manfred G. Höfle studied biology in Freiburg, earning his Ph.D. at Freiburg University’s Limnological Institute, where his research emphasis was on “ecophysiological model studies on the influence of temperature and nutrient conditions on aqueous heterotrophic bacterial pure culture material conversion“ in Max Tilzer’s lab.

After finishing his post-doc at the Woods Hole Oceanographic Institution Department of Marine Chemistry in Massachussetts, USA, Höfle worked as a scientific associate in Jürgen Overbeck’s team at the Max Planck Institutes for Limnology in Plön.

In 1991, Höfle transferred to the GBF – today’s HZI – to direct research projects in environmental microbiology. He habilitated in microbiology at the TU Braunschweig in 1998 and is a professor at this University since 2013. Currently he heads the Research Group “Microbial Diagnostics” in HZI’s Department of Vaccinology and Applied Microbiology.

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Audio Podcast

  • Legionärskrankheit – Wissenschaftler auf Spurensuche in der Wasserleitung Legionellen warten überall auf uns wo warmes Wasser gespeichert wird – in Wasserleitungen, Klimaanlagen, Schwimmbädern. Einige wenige dieser Bakterien können schon ausreichen, um bei uns eine schwere Lungenentzündung zu verursachen. Häufen sich Fälle – etwa in einem Einkaufszentrum oder einem Schwimmbad – gehen Wissenschaftler auf Legionellensuche. Manfred Höfle hat eine Technologie entwickelt, mit der er genau die Legionellen findet, die die Menschen krank machen. Begleiten Sie ihn bei seiner Detektivarbeit...
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