Microbial Communication

If when you wake up in the morning your teeth feel sticky, this indicates bacteria that live in your mouth have formed a slimy structure called a biofilm. To do this, they engage in a very special form of communication using chemical signals. Furthermore, bacteria in the ocean communicate with one another as well as with the tiny planktonic algae which provide about half of the world´s primary production to the global carbon cycle. Our scientists are deciphering these processes in order to be able to influence them, for instance to prevent caries.


  • Milici,M.; Tomasch,J.; Wos-Oxley,M.L.; Decelle,J.; Jauregui,R.; Wang,H.; Deng,Z.L.; Plumeier,I.; Giebel,H.A.; Badewien,T.H.; Wurst,M.; Pieper,D.H.; Simon,M.; Wagner-Döbler,I.; (2016). Bacterioplankton Biogeography of the Atlantic Ocean: A Case Study of the Distance-Decay Relationship. 7, 590 DOI: 10.3389/fmicb.2016.00590 HZI repository PubMed
  • Wagner-Döbler,I.; (2016). Biofilm transplantation in the deep sea. 25 9, 1905-1907 DOI: 10.1111/mec.13612 HZI repository PubMed
  • Wagner-Döbler, I.; (2016). Biofilm transplantation in the deep sea.. Mol.Ecol.: 25, 1905-1907 PubMed
  • Reck,M.; Wagner-Döbler,I.; (2016). Carolacton Treatment Causes Delocalization of the Cell Division Proteins PknB and DivIVa in Streptococcus mutans in vivo. 7, 684 DOI: 10.3389/fmicb.2016.00684 HZI repository PubMed
  • Milici,M.; Deng,Z.L.; Tomasch,J.; Decelle,J.; Wos-Oxley,M.L.; Wang,H.; Jauregui,R.; Plumeier,I.; Giebel,H.A.; Badewien,T.H.; Wurst,M.; Pieper,D.H.; Simon,M.; Wagner-Döbler,I.; (2016). Co-occurrence Analysis of Microbial Taxa in the Atlantic Ocean Reveals High Connectivity in the Free-Living Bacterioplankton. 7, 649 DOI: 10.3389/fmicb.2016.00649 HZI repository PubMed
  • Cabarcas-Montalvo,M.; Maldonado-Rojas,W.; Montes-Grajales,D.; Bertel-Sevilla,A.; Wagner-Döbler,I.; Sztajer,H.; Reck,M.; Flechas-Alarcon,M.; Ocazionez,R.; Olivero-Verbel,J.; (2016). Discovery of antiviral molecules for dengue: In silico search and biological evaluation. 110, 87-97 DOI: 10.1016/j.ejmech.2015.12.030 HZI repository PubMed
  • Patzelt,D.; Michael,V.; Pauker,O.; Ebert,M.; Tielen,P.; Jahn,D.; Tomasch,J.; Petersen,J.; Wagner-Döbler,I.; (2016). Gene Flow Across Genus Barriers - Conjugation of Dinoroseobacter shibae's 191-kb Killer Plasmid into Phaeobacter inhibens and AHL-mediated Expression of Type IV Secretion Systems. 7, 742 DOI: 10.3389/fmicb.2016.00742 HZI repository PubMed
  • Beckers,V.; Poblete-Castro,I.; Tomasch,J.; Wittmann,C.; (2016). Integrated analysis of gene expression and metabolic fluxes in PHA-producing Pseudomonas putida grown on glycerol. Microbial Cell Factories: 15 1, 73 DOI: 10.1186/s12934-016-0470-2 HZI repository PubMed
  • Milici,M.; Tomasch,J.; Wos-Oxley,M.L.; Wang,H.; Jauregui,R.; Camarinha-Silva,A.; Deng,Z.L.; Plumeier,I.; Giebel,H.A.; Wurst,M.; Pieper,D.H.; Simon,M.; Wagner-Döbler,I.; (2016). Low diversity of planktonic bacteria in the tropical ocean. 6, 1-920452322 DOI: 10.1038/srep19054 HZI repository PubMed
  • Gomez-Consarnau,L.; Gonzalez,J.M.; Riedel,T.; Jaenicke,S.; Wagner-Döbler,I.; Sanudo-Wilhelmy,S.A.; Fuhrman,J.A.; (2016). Proteorhodopsin light-enhanced growth linked to vitamin-B1 acquisition in marine Flavobacteria. 10 5, 1102-1112 PubMed
  • Gottschick,C.; Szafranski,S.P.; Kunze,B.; Sztajer,H.; Masur,C.; Abels,C.; Wagner-Döbler,I.; (2016). Screening of Compounds against Gardnerella vaginalis Biofilms. PLoS ONE: 11 4, e0154086 DOI: 10.1371/journal.pone.0154086 HZI repository PubMed
  • Donner,J.; Reck,M.; Bergmann,S.; Kirschning,A.; Müller,R.; Wagner-Döbler,I.; (2016). The biofilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target. 6, 29677 DOI: 10.1038/srep29677 HZI repository PubMed
  • Voget,S.; Bruns,H.; Wagner-Döbler,I.; Schulz,S.; Daniel,R.; (2015). Draft Genome Sequence of Roseovarius tolerans EL-164, a Producer of N-Acylated Alanine Methyl Esters and N-Acylhomoserine Lactones. 3 5 DOI: 10.1128/genomeA.01096-15 HZI repository PubMed
  • Szafranski,S.P.; Deng,Z.-L.; Tomasch,J.; Jarek,J.; Bhuju,S.; Meisinger,C.; Kühnisch,J.; Sztajer,H.; Wagner-Döbler,I.; (2015). Functional biomarkers for chronic periodontitis and insights into the roles of Prevotella nigrescens and Fusobacterium nucleatum ; a metatranscriptome analysis. Biofilms and Microbiomes: 1, 15017 DOI: 10.1038/npjbiofilms.2015.17 HZI repository PubMed
  • Szafranski,S.P.; Wos-Oxley,M.L.; Vilchez-Vargas,R.; Jauregui,R.; Plumeier,I.; Klawonn,F.; Tomasch,J.; Meisinger,C.; Kühnisch,J.; Sztajer,H.; Pieper,D.H.; Wagner-Döbler,I.; (2015). High-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis. 81 3, 1047-105800992240 DOI: 10.1128/AEM.03534-14 HZI repository PubMed
  • Ziesche,L.; Bruns,H.; Dogs,M.; Wolter,L.; Mann,F.; Wagner-Döbler,I.; Brinkhoff,T.; Schulz,S.; (2015). Homoserine Lactones, Methyl Oligohydroxybutyrates, and Other Extracellular Metabolites of Macroalgae-Associated Bacteria of the Roseobacter Clade: Identification and Functions. ChemBioChem: 16 14, 2094-2107 PubMed
  • Wang,H.; Tomasch,J.; Michael,V.; Bhuju,S.; Jarek,M.; Petersen,J.; Wagner-Döbler,I.; (2015). Identification of Genetic Modules Mediating the Jekyll and Hyde Interaction of Dinoroseobacter shibae with the Dinoflagellate Prorocentrum minimum. 6, 1262 DOI: 10.3389/fmicb.2015.01262 HZI repository PubMed
  • Klingner,A.; Bartsch,A.; Dogs,M.; Wagner-Döbler,I.; Jahn,D.; Simon,M.; Brinkhoff,T.; Becker,J.; Wittmann,C.; (2015). Large-scale 13C-flux profiling reveals conservation of the Entner-Doudoroff pathway as glycolytic strategy among glucose-using marine bacteria. 81, 2408-2422 PubMed
  • Soora,M.; Tomasch,J.; Wang,H.; Michael,V.; Petersen,J.; Engelen,B.; Wagner-Döbler,I.; Cypionka,H.; (2015). Oxidative stress and starvation in Dinoroseobacter shibae: the role of extrachromosomal elements. 6, 233 DOI: 10.3389/fmicb.2015.00233 HZI repository PubMed
  • Reck,M.; Tomasch,J.; Deng,Z.; Jarek,M.; Husemann,P.; Wagner-Döbler,I.; (2015). Stool metatranscriptomics: A technical guideline for mRNA stabilisation and isolation. BMC GENOMICS: 16, 494 DOI: 10.1186/s12864-015-1694-y HZI repository PubMed
  • Stumpp,N.; Premnath,P.; Schmidt,T.; Ammermann,J.; Dräger,G.; Reck,M.; Jansen,R.; Stiesch,M.; Wagner-Döbler,I.; Kirschning,A.; (2015). Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria. Organic and Biomolecular Chemistry: 13 20, 5765-577414770520 DOI: 10.1039/c5ob00460h HZI repository PubMed
  • Reck,M.; Tomasch,J.; Wagner-Döbler,I.; (2015). The Alternative Sigma Factor SigX Controls Bacteriocin Synthesis and Competence, the Two Quorum Sensing Regulated Traits in Streptococcus mutans. 11 7, e1005353 PubMed
  • Wang,Hui; Tomasch,Jürgen; Jarek,Michael; Wagner-Döbler,Irene; (2014). A dual-species co-cultivation system to study the interactions between Roseobacters and dinoflagellates. Frontiers in Microbiology: 5, 311 DOI: 10.3389/fmicb.2014.00311 HZI repository PubMed
  • Musharraf,A.; Kruspe,D.; Tomasch,Jürgen; Besenbeck,B.; Englert,C.; Landgraf,K.; (2014). BOR-syndrome-associated Eya1 mutations lead to enhanced proteasomal degradation of Eya1 protein. PLoS ONE: 9 119326203 WEBURLS
  • Conrads,G.; de Soet,J.J.; Song,L.; Henne,K.; Sztajer,Helena; Wagner-Döbler,Irene; Zeng,A.P.; (2014). Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level.. Journal of Oral Microbiology: 6, 26189 HZI repository PubMed
  • Riedel,Thomas; Fiebig,A.; Goker,M.; Klenk,H.P.; (2014). Complete genome sequence of the bacteriochlorophyll a-containing Roseibacterium elongatum type strain (DSM 19469(T)), a representative of the Roseobacter group isolated from Australian coast sand. Standards in Genomic Sciences: 9 3, 840-854 PubMed
  • Sudhakar,P.; Reck,Michael; Wang,W.; He,F.Q.; Wagner-Döbler,Irene; Zeng,A.P.; (2014). Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. BMC GENOMICS: 15 1, 36214712164 DOI: 10.1186/1471-2164-15-362 HZI repository PubMed
  • Sudhakar,P.; Reck,Michael; Wang,W.; He,F.Q.; Wagner-Döbler,Irene; Zeng,A.P.; (2014). Correction: Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. BMC GENOMICS: 15 1, 73914712164 WEBURLS
  • Sztajer,H.; Szafranski,S.P.; Tomasch,Jürgen; Reck,Michael; Nimtz,Manfred; Rohde,Manfred; Wagner-Döbler,Irene; (2014). Cross-feeding and interkingdom communication in dual-species biofilms of Streptococcus mutans and Candida albicans. ISME Journal: 8 11, 2256-2271 DOI: 10.1038/ismej.2014.73 HZI repository PubMed
  • Wang,Hui; Ziesche,L.; Frank,O.; Michael,V.; Martin,M.; Petersen,J.; Schulz,S.; Wagner-Döbler,Irene; Tomasch,Jürgen; (2014). The CtrA phosphorelay integrates differentiation and communication in the marine alphaproteobacterium Dinoroseobacter shibae. BMC GENOMICS: 15, 130 DOI: 10.1186/1471-2164-15-130 HZI repository PubMed
  • Riedel,Thomas; Rohlfs,M.; Buchholz,I.; Wagner-Döbler,Irene; Reck,Michael; (2013). Complete sequence of the suicide vector pJP5603. 69 1, 104-107 DOI: 10.1016/j.plasmid.2012.07.005 HZI repository PubMed
  • Song,L.; Wang,W.; Conrads,G.; Rheinberg,A.; Sztajer,Helena; Reck,Michael; Wagner-Döbler,Irene; Zeng,A.P.; (2013). Correction: Genetic variability of mutans streptococci revealed by wide whole-genome sequencing. BMC GENOMICS: 14, 811 PubMed
  • Apel,C.; Barg,A.; Rheinberg,A.; Conrads,G.; Wagner-Döbler,Irene; (2013). Dental composite materials containing carolacton inhibit biofilm growth of Streptococcus mutans. Dental Materials: 29 11, 1188-119901095641 WEBURLS
  • Nagel,S.; Ehrentraut,S.; Tomasch,Jürgen; Quentmeier,H.; Meyer,C.; Kaufmann,M.; Drexler,H.G.; MacLeod,R.A.; (2013). Ectopic Expression of Homeobox Gene NKX2-1 in Diffuse Large B-Cell Lymphoma Is Mediated by Aberrant Chromatin Modifications. PLoS ONE: 8 4, e61447 DOI: 10.1371/journal.pone.0061447 HZI repository PubMed
  • Song,L.; Wang,W.; Conrads,G.; Rheinberg,A.; Sztajer,Helena; Reck,M.; Wagner-Döbler,Irene; Zeng,A.P.; (2013). Genetic variability of mutans streptococci revealed by wide whole-genome sequencing. BMC GENOMICS: 14, 430 DOI: 10.1186/1471-2164-14-430 HZI repository PubMed
  • Fiebig,A.; Pradella,S.; Petersen,J.; Michael,V.; Pauker,O.; Rohde,Manfred; Goker,M.; Klenk,H.P.; Wagner-Döbler,Irene; (2013). Genome of the marine alphaproteobacterium Hoeflea phototrophica type strain (DFL-43(T)). Standards in Genomic Sciences: 7 3, 440-448 DOI: 10.4056/sigs.3486982 HZI repository PubMed
  • Fiebig,A.; Pradella,S.; Petersen,J.; Päuker,O.; Michael,V.; Lünsdorf,Heinrich; Göker,M.; Klenk,H.P.; Wagner-Döbler,Irene; (2013). Genome of the R-body producing marine alphaproteobacterium Labrenzia alexandrii type strain (DFL-11T). Standards in Genomic Sciences: 7 3, 413-42619443277 DOI: 10.4056/sigs.3456959 HZI repository PubMed
  • Fiebig,A.; Riedel,T.; Gronow,S.; Petersen,J.; Klenk,H.P.; Göker,M.; (2013). Genome sequence of the reddish-pigmented Rubellimicrobium thermophilum type strain (DSM 16684T), a member of the Roseobacter clade. Standards in Genomic Sciences: 8 319443277 DOI: Article WEBURLS
  • Riedel,Thomas; Gomez-Consarnau,L.; Tomasch,Jürgen; Martin,M.; Jarek,Michael; Gonzalez,J.M.; Spring,S.; Rohlfs,M.; Brinkhoff,T.; Cypionka,H.; Goker,M.; Fiebig,A.; Klein,J.; Goesmann,A.; Fuhrman,J.A.; Wagner-Döbler,Irene; (2013). Genomics and physiology of a marine flavobacterium encoding a proteorhodopsin and a xanthorhodopsin-like protein. PLoS ONE: 8 3, e57487 DOI: 10.1371/journal.pone.0057487 HZI repository PubMed
  • Neumann,A.; Patzelt,Diana; Wagner-Döbler,Irene; Schulz,S.; (2013). Identification of New N-Acylhomoserine Lactone Signalling Compounds of Dinoroseobacter shibae DFL-12(T) by Overexpression of luxI Genes. ChemBioChem: 14 17, 2355-2361 PubMed
  • Brock,N.L.; Citron,C.A.; Zell,C.; Berger,M.; Wagner-Döbler,Irene; Petersen,J.; Brinkhoff,T.; Simon,M.; Dickschat,J.S.; (2013). Isotopically labeled sulfur compounds and synthetic selenium and tellurium analogues to study sulfur metabolism in marine bacteria. Beilstein Journal of Organic Chemistry: 9, 942-95018605397 DOI: 10.3762/bjoc.9.108 HZI repository PubMed
  • Spring,S.; Riedel,Thomas; (2013). Mixotrophic growth of bacteriochlorophyll a-containing members of the OM60/NOR5 clade of marine gammaproteobacteria is carbon-starvation independent and correlates with the type of carbon source and oxygen availability. BMC Microbiology: 13 1, 11714712180 DOI: 10.1186/1471-2180-13-117 HZI repository PubMed
  • Bruns,H.; Thiel,V.; Voget,S.; Patzelt,Diana; Daniel,R.; Wagner-Döbler,Irene; Schulz,S.; (2013). N-acylated alanine methyl esters (NAMEs) from Roseovarius tolerans, structural analogs of quorum-sensing autoinducers, N-acylhomoserine lactones. Chemistry and Biodiversity: 10 9, 1559-157316121872 WEBURLS
  • Spring,S.; Riedel,Thomas; Spröer,C.; Yan,S.; Harder,J.; Fuchs,B.M.; (2013). Taxonomy and evolution of bacteriochlorophyll a-containing members of the OM60/NOR5 clade of marine gammaproteobacteria: Description of Luminiphilus syltensis gen. nov., sp. nov., reclassification of Haliea rubra as Pseudohaliea rubra gen. nov., comb. nov. BMC Microbiology: 13 1, 11814712180 DOI: 10.1186/1471-2180-13-118 HZI repository PubMed
  • Patzelt,Diana; Wang,Hui; Buchholz,I.; Rohde,Manfred; Gröbe,Lothar; Pradella,S.; Neumann,A.; Schulz,S.; Heyber,S.; Munch,K.; Munch,R.; Jahn,D.; Wagner-Döbler,Irene; Tomasch,Jürgen; (2013). You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae. ISME Journal: 7 12, 2274-2286 DOI: 10.1038/ismej.2013.107 PubMed
  • Song,L.; Sudhakar,P.; Wang,W.; Conrads,G.; Brock,A.; Sun,J.; Wagner-Döbler,Irene; Zeng,A.P.; (2012). A genome-wide study of two-component signal transduction systems in eight newly sequenced mutans streptococci strains. BMC GENOMICS: 13 1, 12814712164 WEBURLS
  • Brinkhoff,T.; Fischer,D.; Vollmers,J.; Vogel,S.; Beardsley,C.; Thole,S.; Mussmann,M.; Kunze,B.; Wagner-Döbler,Irene*; Daniel,R.; Simon,M.; (2012). Biogeography and phylogenetic diversity of a cluster of exclusively marine myxobacteria. ISME Journal: 6 6, 1260-1272
  • Riedel,T.; Held,B.; Nolan,M.; Lucas,S.; Lapidus,A.; Tice,H.; Del Rio,T.G.; Cheng,J.-F.; Han,C.; Tapia,R.; Goodwin,L.A.; Pitluck,S.; Liolios,K.; Mavromatis,K.; Pagani,I.; Ivanova,N.; Mikhailova,N.; Pati,A.; Chen,A.; Palaniappan,K.; Rohde,Manfred*; Tindall,B.J.; Detter,J.C.; Göker,M.; Bristow,J.; Eisen,J.A.; Markowitz,V.; Hugenholtz,P.; Kyrpides,N.C.; Klenk,H.-P.; Woyke,T.; (2012). Genome sequence of the Antarctic rhodopsins-containing flavobacterium Gillisia limnaea type strain (R-8282T). Standards in Genomic Sciences: 7 1, 107-119 DOI: 10.4056/sigs.3216895 HZI repository PubMed
  • Riedel,T.; Held,B.; Nolan,M.; Lucas,S.; Lapidus,A.; Tice,H.; Del Rio,T.G.; Cheng,J.-F.; Han,C.; Tapia,R.; Goodwin,L.A.; Pitluck,S.; Liolios,K.; Mavromatis,K.; Pagani,I.; Ivanova,N.; Mikhailova,N.; Pati,A.; Chen,A.; Palaniappan,K.; Rohde,Manfred*; Tindall,B.J.; Detter,J.C.; Göker,M.; Woyke,T.; Bristow,J.; Eisen,J.A.; Markowitz,V.; Hugenholtz,P.; Klenk,H.-P.; Kyrpides,N.C.; (2012). Genome sequence of the orange-pigmented seawater bacterium Owenweeksia hongkongensis type strain (USt20020801). Standards in Genomic Sciences: 7 1, 120-130 DOI: 10.4056/sigs.3296896 HZI repository PubMed
  • Xue, X., Li, J., Wang, W., Sztajer, H. and I. Wagner Döbler ; (2012). The global impact of the delta subunit RpoE of the RNA polymerase on the proteome of Streptococcus mutans.. Microbiology: Jan; 158, 191-206
  • Nagel,S.; Ehrentraut,S.; Tomasch,J.; Lienenklaus,S.; Schneider,B.; Geffers,Robert; Meyer,C.; Kaufmann,M.; Drexler,H.G.; MacLeod,R.A.; (2012). Transcriptional Activation of Prostate Specific Homeobox Gene NKX3-1 in Subsets of T-Cell Lymphoblastic Leukemia (T-ALL). PLoS ONE: 7 7, e40747 DOI: 10.1371/journal.pone.0040747 HZI repository PubMed
  • Stelzer,M.; Sun,Jibin*; Kamphans,T.; Fekete,S.P.; Zeng,A.P.; (2011). An extended bioreaction database that significantly improves reconstruction and analysis of genome-scale metabolic networks. Integrative Biology: 3 11, 1071-1086 DOI: 10.1039/c1ib00008j HZI repository PubMed
  • Jaramillo-Colorado,B.; Olivero-Verbel,J.; Stashenko,E.E.; Wagner-Döbler,Irene*; Kunze,B.; (2011). Anti-quorum sensing activity of essential oils from Colombian plants. Natural Product Research: 26 12, 1075-1086 DOI: 10.1080/14786419.2011.557376 PubMed
  • Brinkhoff, T., Fischer, D., Vollmers, J., Voget, S., Beardsley, C., Thole, S., Mussmann, M., Kunze, B., Wagner-Döbler, I., Daniel, R., Simon, M.; (2011). Biogeography and phylogenetic diversity of a cluster of exclusively marine myxobacteria. ISME:
  • Xue,X.; Sztajer,H.; Buddruhs,N.; Petersen,J.; Rohde,Manfred*; Talay,S.R.; Wagner-Döbler,Irene*; (2011). Lack of the Delta Subunit of RNA Polymerase Increases Virulence Related Traits of Streptococcus mutans. PLoS ONE: 6 5, e20075 PubMed
  • Lemme,A.; Grobe,L.; Reck,M.; Tomasch,J.; Wagner-Döbler,Irene*; (2011). Subpopulation-Specific Transcriptome Analysis of Competence-Stimulating-Peptide-Induced Streptococcus mutans. Journal of Bacteriology: 193 8, 1863-1877 DOI: 10.1128/JB.01363-10 HZI repository PubMed
  • Reck,M.; Rutz,K.; Kunze,B.; Tomasch,J.; Surapaneni,S.K.; Schulz,S.; Wagner-Döbler,Irene*; (2011). The biofilm inhibitor carolacton disturbs membrane integrity and cell division of Streptococcus mutans through the serine/threonine protein kinase PknB. Journal of Bacteriology: 193 20, 5692-5706 PubMed
  • Xue,X.; Li,J.; Wang,W.; Sztajer,H.; Wagner-Döbler,Irene*; (2011). The global impact of the delta subunit RpoE of the RNA polymerase on the proteome of Streptococcus mutans. Microbiology: 158 1, 191-206 DOI: 10.1099/mic.0.047936-0 HZI repository PubMed
  • Bodor,A.M.; Jänsch,Lothar*; Wissing,J.; Wagner-Döbler,Irene*; (2011). The luxS mutation causes loosely-bound biofilms in Shewanella oneidensis. BMC Research Notes: 4, 180 PubMed
  • Tomasch,J.; Gohl,R.; Bunk,B.; Suarez-Diez,M.; Wagner-Döbler,Irene*; (2011). Transcriptional response of the photoheterotrophic marine bacterium Dinoroseobacter shibae to changing light regimes. ISME Journal: 5 12, 1957-1968 DOI: 10.1038/ismej.2011.68
  • Schulz,S.; Dickschat,J.S.; Kunze,B.; Wagner-Döbler,Irene*; Diestel,R.; Sasse,Florenz*; (2010). Biological activity of volatiles from marine and terrestrial bacteria. Marine Drugs: 8, 2976-2987
  • Lemme,A.; Sztajer,Helena*; Wagner-Döbler,Irene*; (2010). Characterization of mleR, a positive regulator of malolactic fermentation and part of the acid tolerance response in Streptococcus mutans. BMC Microbiology: 10, 58 DOI: 10.1186/1471-2180-10-58 HZI repository PubMed
  • Riedel,T.; Tomasch,J.; Buchholz,I.; Jacobs,J.; Kollenberg,M.; Gerdts,G.; Wichels,A.; Brinkhoff,T.; Cypionka,H.; Wagner-Döbler,Irene*; (2010). Constitutive expression of the proteorhodopsin gene by a flavobacterium strain representative of the proteorhodopsin-producing microbial community in the North Sea. Applied in Environmental Microbiology: 76 10, 3187-3197 PubMed
  • Kunze,B.; Reck,M.; Dotsch,A.; Lemme,A.; Schummer,D.; Irschik,Herbert*; Steinmetz,H.; Wagner-Döbler,Irene*; (2010). Damage of Streptococcus mutans biofilms by carolacton, a secondary metabolite from the myxobacterium Sorangium cellulosum. BMC Microbiology: 10, 199 PubMed
  • Thiel,V.; Brinkhoff,T.; Dickschat,J.S.; Wickel,S.; Grunenberg,J.; Wagner-Döbler,Irene*; Simon,M.; Schulz,S.; (2010). Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade. Organic and Biomolecular Chemistry: 8 1, 234-246 PubMed
  • Vilchez,R.; Lemme,A.; Ballhausen,B.; Thiel,V.; Schulz,S.; Jansen,Rolf*; Sztajer,Helena*; Wagner-Döbler,Irene*; (2010). Streptococcus mutans Inhibits Candida albicans hyphal formation by the fatty acid signaling molecule trans-2-decenoic acid (SDSF). ChemBioChem: 11 11, 1552-1562 PubMed
  • Nawrath,T.; Dickschat,J.S.; Kunze,Brigitte*; Schulz,S.; (2010). The biosynthesis of branched dialkylpyrazines in myxobacteria. Chemistry and Biodiversity: 7 9, 2129-2144 DOI: 10.1002/cbdv.201000158 PubMed
  • Wagner-Döbler, I., Ballhausen, B., Baumgart, M., Brinkhoff, T., Buchholz, I., Bunk, B., Cypionka, H., Daniel, R., Drepper, T., Gerdts, G., Hahnke, S., Han, C., Jahn, D., Kalhoefer, D., Kiss, H., Klenk, H-P., Kyrpides, N., Liebl, W., Liesegang, H., Meincke, L., Pati, A., Petersen, J., Piekarski, T., Pommerenke, C., Pradella, S., Pukall, R., Rabus, R., Stackebrandt, E., Thole, S., Thompson, L., Tielen, P., Tomasch, J., von Jan, M., Wanphrut, N., Wichels, A., Zech, H., Simon, M. ; (2010). The complete genome sequence of the algal symbiont Dinoroseobacter shibae - a hitchhiker´s guide to life in the sea.. ISME: 4 (1), 61-77
  • Wagner-Döbler,Irene*; Ballhausen,B.; Berger,M.; Brinkhoff,T.; Buchholz,I.; Bunk,B.; Cypionka,H.; Daniel,R.; Drepper,T.; Gerdts,G.; Hahnke,S.; Han,C.; Jahn,D.; Kalhoefer,D.; Kiss,H.; Klenk,H.P.; Kyrpides,N.; Liebl,W.; Liesegang,H.; Meincke,L.; Pati,A.; Petersen,J.; Piekarski,T.; Pommerenke,C.; Pradella,S.; Pukall,R.; Rabus,R.; Stackebrandt,E.; Thole,S.; Thompson,L.; Tielen,P.; Tomasch,J.; von,Jan M.; Wanphrut,N.; Wichels,A.; Zech,H.; Simon,M.; (2010). The complete genome sequence of the algal symbiont Dinoroseobacter shibae: a hitchhiker's guide to life in the sea. ISME Journal: 4 1, 61-77 PubMed
  • Xue,X.; Tomasch,J.; Sztajer,H.; Wagner-Döbler,Irene*; (2010). The delta subunit of RNA polymerase, RpoE, is a global modulator of Streptococcus mutans environmental adaptation. Journal of Bacteriology: 192 19, 5081-5092 DOI: 10.1128/JB.00653-10 HZI repository PubMed
  • Piekarski,T.; Buchholz,I.; Drepper,T.; Schobert,M.; Wagner-Döbler,Irene*; Tielen,P.; Jahn,D.; (2009). Genetic tools for the investigation of Roseobacter clade bacteria. BMC Microbiology: 9, 265 DOI: 10.1186/1471-2180-9-265 HZI repository PubMed
  • Gawlitzek,M.; Estacio,M.; Fürch,Tobias*; Kiss,R.; (2009). Identification of cell culture conditions to control N-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells. Biotechnology and Bioengineering: 103 6, 1164-1175 PubMed
  • Thiel,V.; Vilchez,R.; Sztajer,Helena*; Wagner-Döbler,Irene*; Schulz,S.; (2009). Identification, quantification, and determination of the absolute configuration of the bacterial quorum-sensing signal autoinducer-2 by gas chromatography-mass spectrometry. ChemBioChem: 10 3, 479-485 PubMed
  • Gluszcz,P.; Ledakowicz,S.; Wagner-Döbler,Irene*; Janiszewska,I.; Boruta,D.; (2009). Integrated industrial plant for biological treatment of mercury - Contaminated wastewater. Przemysl Chemiczny: 88 12, 1352-1358
  • Furch,T.; Preusse,M.; Tomasch,J.; Zech,H.; Wagner-Döbler,Irene*; Rabus,R.; Wittmann,C.; (2009). Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade. BMC Microbiology: 9, 209 PubMed
  • Thiel,V.; Kunze,Brigitte*; Verma,P.; Wagner-Döbler,Irene*; Schulz,S.; (2009). New structural variants of homoserine lactones in bacteria. ChemBioChem: 10 11, 1861-1868 PubMed
  • Li,Jinshan*; Menche,D.; (2009). Selective deprotection of silyl ethers with sodium periodate. Synthesis: 11 art. no. Zo1709SS, 1904-1908
  • Sztajer,Helena*; Lemme,A.; Vilchez,R.; Schulz,S.; Geffers,Robert*; Yip,C.Y.Y.; Levesque,C.M.; Cvitkovitch,D.G.; Wagner-Döbler,Irene*; (2008). Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation. Journal of Bacteriology: 190 1, 401-415 DOI: 10.1128/JB.01086-07 HZI repository PubMed
  • Gluszcz,P.; Zakrzewska,K.; Wagner-Döbler,Irene*; Ledakowicz,S.; (2008). Bioreduction of ionic mercury from wastewater in a fixed-bed bioreactor with activated carbon. Chemical Papers: 62 3, 232-238
  • Höfle,Gerhard*; Kunze,Brigitte*; (2008). Biosynthesis of Aurachins A-L in Stigmatella aurantiaca : A Feeding Study. Journal of Natural Products: 71 11, 1843-1849 PubMed
  • Eggert,U.; Diestel,R.; Sasse,Florenz*; Jansen,Rolf*; Kunze,Brigitte*; Kalesse,Markus*; (2008). Chondramide C: Synthesis, configurational assignment, and structure-activity relationship studies. Angewandte Chemie - International Edition: 47 43, 6478-6482
  • Surup,F.; Shojaei,H.; von,Zezschwitz P.; Kunze,Brigitte*; Grond,S.; (2008). Iromycins from Streptomyces sp. and from synthesis: new inhibitors of the mitochondrial electron transport chain. Bioorganic & Medicinal Chemistry: 16 4, 1738-1746 DOI: 10.1016/j.bmc.2007.11.023 HZI repository PubMed
  • Kunze,Brigitte*; Böhlendorf,B.; Reichenbach,Hans*; Höfle,Gerhard*; (2008). Pedein A and B: Production, isolation, structure elucidation and biological properties of new antifungal cyclopeptides from Chondromyces pediculatus (myxobacteria). Journal of Antibiotics: 61 1, 18-26
  • Bodor,A.; Elxnat,B.; Thiel,V.; Schulz,S.; Wagner-Döbler,Irene*; (2008). Potential for luxS related signalling in marine bacteria and production of autoinducer-2 in the genus Shewanella. BMC Microbiology: 8, 13 DOI: 10.1186/1471-2180-8-13 HZI repository PubMed
  • Sztajer, H., Lemme, A., I. Wagner-Döbler; (2008). Quorum Sensing und Karies. BIOSpektrum: 6, 2-5
  • Pommerenke,C.; Gabriel,I.; Bunk,B.; Munch,R.; Haddad,I.; Tielen,P.; Wagner-Döbler,Irene*; Jahn,D.; (2008). ROSY--a flexible and universal database and bioinformatics tool platform for Roseobacter related species. In Silico Biology: 8 2, 177-186 PubMed
  • Höfle,Gerhard*; Bohlendorf,B.; Fecker,T.; Sasse,Florian*; Kunze,Brigitte*; (2008). Semisynthesis and Antiplasmodial Activity of the Quinoline Alkaloid Aurachin E. Journal of Natural Products: 71 11, 1967-1969 PubMed
  • Sztajer,H.; Lemme,A.; Wagner-Döbler,I.; (2008). Streptococcus mutans: Quorum sensing and caries. Biospektrum: 14 6, 578-58309470867 DOI: Article WEBURLS
  • Vintonyak,V.V.; Cala,M.; Lay,F.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; (2008). Synthesis and biological evaluation of cruentaren A analogues. Chemistry - A European Journal: 14 12, 3709-3720 PubMed
  • Vintonyak,V.V.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; (2008). Total synthesis and biological activity of neopeltolide and analogues. Chemistry: 14 35, 11132-11140 PubMed
  • Sandmann,A.; Dickschat,J.; Jenke-Kodama,H.; Kunze,Brigitte*; Dittmann,E.; Müller,Rolf; (2007). A type II polyketide synthase from the Gram negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis. Angewandte Chemie - International Edition: 46, 2712-2716
  • Chiu,H.-H.; Shieh,W.Y.; Lin,S.Y.; Tseng,C.-M.; Chiang,P.-W.; Wagner-Döbler,Irene*; (2007). Alteromonas tagae sp. nov. and Alteromonas simiduii sp. nov., mercury-resistant bacteria isolated from a Taiwanese estuary. International Journal of Systematic and Evolutionary Microbiology: 57, 1209-1216 DOI: 10.1099/ijs.0.64762-0 Full text HZI repository
  • Vilchez,R.; Lemme,A.; Thiel,V.; Schulz,S.; Sztajer,Helena*; Wagner-Döbler,Irene*; (2007). Analysing traces of autoinducer-2 requires standardization of the Vibrio harveyi bioassay. Analytical and Bioanalytical Chemistry: 387 2, 489-496 DOI: 10.1007/s00216-006-0824-4 HZI repository PubMed
  • Kunze,Brigitte*; Sasse,Florian*; Wieczorek,H.; Huss,M.; (2007). Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases. Febs Letters: 581 18, 3523-3527 DOI: 10.1016/j.febslet.2007.06.069
  • Biebl,Hanno*; Pukall,R.; Lünsdorf,Heinrich*; Schulz,S.; Allgaier,M.; Tindall,B.J.; Wagner-Döbler,Irene*; (2007). Description of Labrenzia alexandrii gen. nov., sp. nov., a novel alphaproteobacterium containing bacteriochlorophyll a, and a proposal reclassification of Stappia aggregata as Labrenzia aggregata comb. nov., and of Stappia alba as Labrenzia alba comb. nov. International Journal of Systematic and Evolutionary Microbiology: 57 5, 1095-1107 DOI: 10.1099/ijs.0.64821-0 HZI repository PubMed
  • Leonhäuser,J.; Wang,W.; Deckwer,Wolf-Dieter*; Wagner-Döbler,Irene*; (2007). Functioning of the mercury resistance operon at extremely high Hg(II) loads in a chemostat: A proteome analysis. Journal of Biotechnology: 132 4, 469-480 DOI: 10.1016/j.jbiotec.2007.08.018 HZI repository PubMed
  • Sobik,P.; Grunenberg,J.; Böröczky,K.; Laatsch,H.; Wagner-Döbler,Irene*; Schulz,S.; (2007). Identification, synthesis, and conformation of tri- and tetrathiacycloalkanes from marine bacteria. Journal of Organic Chemistry: 72 10, 3776-3782 DOI: 10.1021/jo070048w HZI repository PubMed
  • Gluszcz,P.; Wagner-Döbler,Irene*; Zakrzewska,K.; Ledakowicz,S.; (2007). Integrated process of ionic mercury bioreduction and adsorption from wastewater. Inzynieria Chemiczna i Procesowa: 28 4, 909-920
  • Steinmetz,Heinrich*; Irschik,Herbert*; Kunze,Brigitte*; Reichenbach,Hans*; Höfle,Gerhard*; Jansen,Rolf*; (2007). Thuggacins, macrolide antibiotics active against Mycobacterium tuberculosis : isolation from myxobacteria, structure elucidation, conformation analysis and biosynthesis. Chemisty - A European Journal: 13 20, 5822-5832 DOI: 10.1002/chem.200700269
  • Müller,I.; Weinig,S.; Steinmetz,Heinrich*; Kunze,Brigitte*; Veluthoor,S.; Mahmud,T.; Müller,R.; (2006). A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteria. ChemBioChem: 7 8, 1197-1205 DOI: 10.1002/cbic.200600057 HZI repository PubMed
  • Böröczky,K.; Laatsch,H.; Wagner-Döbler,Irene*; Schulz,S.; (2006). Cluster analysis as selection and dereplication tool for the identification of new natural compounds from large sample sets. Chemistry & Biodiversity: 3 6, 622-634
  • Kunze,Brigitte*; Steinmetz,Heinrich*; Höfle,G.; Huss,M.; Wieczorek,H.; Reichenbach,H.; (2006). Cruentaren, a new antifungal salicylate-type macrolide from Byssovorax cruenta (Myxobacteria) with inhibitory effect on mitochondrial ATPase activity. Fermentation and biological properties. Journal of Antibiotics: 59, 664-668
  • Wagner-Döbler,Irene*; Biebl,Hanno*; (2006). Environmental Biology of the Marine Roseobacter Lineage. Annual Review of Microbiology: 60, 255-280 DOI: 10.1146/annurev.micro.60.080805.142115 HZI repository PubMed
  • Biebl,Hanno*; Wagner-Döbler,Irene*; (2006). Growth and bacteriochlorophyll a formation in taxonomically diverse aerobic anoxygenic phototrophic bacteria in chemostat culture: Influence of light regimen and starvation. Process Biochemistry: 41 10, 2153-2159 DOI: 10.1016/j.procbio.2006.06.029 HZI repository
  • Biebl,H.; Tindall,B.; Pukall,R.; Lünsdorf,H.; Allgaier,M.; Wagner-Döbler,I.; (2006). Hoeflea phototrophica , nov. sp., a new marine aerobic Alphaproteobacterium that forms bacteriochlorophyll a. International Journal of Systematic and Evolutionary Microbiology: 56, 821-826 DOI: 10.1099/ijs.0.63958-0 HZI repository PubMed
  • Jundt,Larissa*; Steinmetz,Heinrich*; Luger,P.; Weber,M.; Kunze,Brigitte*; Reichenbach,H.; Höfle,G.; (2006). Isolation and structure elucidation of cruentaren A and B - novel members of the benzolactone class of ATPase inhibitors from the myxobacterium Byssovorax cruenta. European Journal of Organic Chemistry:, 5036-5044
  • Rachid,S.; Krug,D.; Kunze,Brigitte*; Kochems,I.; Scharfe,Maren*; Zabriskie,T.M.; Blöcker,Helmut*; Müller,R.; (2006). Molecular and biochemical studies of chondramide formation-highly cytotoxic natural products from Chondromyces crocatus Cm c5. Chemistry and Biology: 13 6, 667-681
  • Leonhäuser,J.; Röhricht,M.; Wagner-Döbler,Irene*; Deckwer,Wolf-Dieter*; (2006). Reaction engineering aspects of microbial mercury removal. Engineering in Life Sciences: 6, 139-148
  • Pauling,B.V.; Wagner-Döbler,Irene*; (2006). Stream microcosm for investigating GEM impact on the Autochthonous Bacterial Community in River Water and Sediment. Process Biochemistry: 41 10, 2129-2137 DOI: 10.1016/j.procbio.2006.06.023 HZI repository
  • Biebl,H.; Allgaier,M.; Tindall,B.; Koblizek,M.; Lünsdorf,H.; Pukall,R.; Wagner-Döbler,I.; (2005). Dinoroseobacter shibae , gen. nov., sp. nov., a new aerobic phototrophic bacterium isolated from dinoflagellates. International Journal of Systematic and Evolutionary Microbiology: 55, 1089-1096 DOI: 10.1099/ijs.0.63511-0 Full text HZI repository
  • Wagner-Döbler,I.; Thiel,V.; Eberl,L.; Allgaier,M.; Bodor,A.; Meyer,S.; Ebner,S.; Hennig,A.; Pukall,R.; Schulz,S.; (2005). Discovery of complex mixtures of novel longchain quorum sensing signals in free-living and host-associated marine Alphaproteobacteria. ChemBioChem: 6 12, 2195-2206
  • Barkay,T.; Wagner-Döbler,I.; (2005). Microbial transformations of mercury: potentials, challenges, and achievements in controlling mercury toxicity in the environment. Advances in Applied Microbiology: 57, 1-52 DOI: 10.1016/S0065-216457001-1 Full text
  • Dickschat,J.S.; Reichenbach,H.; Wagner-Döbler,I.; Schulz,S.; (2005). Novel pyrazines from the Myxobacterium / Chondromyces crocatus / and Marine Bacteria. European Journal of Organic Chemistry: 2005 19, 4141-4153 DOI: 10.1002/ejoc.200500280 Full text HZI repository
  • Biebl,H.; Allgaier,M.; Lünsdorf,H.; Pukall,R.; Tindall,B.J.; Wagner-Döbler,I.; (2005). Roseovarius mucosus , sp. nov., a novel member of the Rosebacter clade with trace amounts of bacteriochlorophyll a.. International Journal of Systematic and Evolutionary Microbiology: 55, 2377-2383 DOI: 10.1099/ijs.0.63832-0 Full text HZI repository
  • Dickschat,J.; Wagner-Döbler,I.; Schulz,S.; (2005). The chafer pheromone buibuilactone and ant pyrazines are also produced by marine bacteria. Journal of Chemical Ecology: 31, 925-947 DOI: 10.1007/s10886-005-3553-9 PubMed

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  • Prof Dr Irene Wagner-Döbler

    Irene Wagner-Döbler

    Head of the Research Group Microbial Communication

    +49 531 6181-3080

    +49 531 6181-3096


    CV and Publications


Audio Podcast

  • Störfunk im Mund - Ein neuer Weg gegen Plaque
    Pelz auf den Zähnen ist nicht nur unangenehm, sondern vor allem der Auslöser für Karies. Das einzige Mittel gegen den Bakterienangriff: Zahne putzen. Weshalb nach jeder neuen Nacht wieder Millionen Bakterien unsere Zähne besiedeln und was wir in Zukunft dagegen tun können, erklärt Ihnen Irene Wagner-Döbler. Und legen Sie die Zahnbürste schon einmal bereit...