Epidemiology conducts research on health and disease at the population level – infection epidemiology is concerned with contagious diseases. Their tools and methods are systematic queries, clinical examinations and laboratory diagnostic documentation for both healthy and afflicted individuals, as well as statistical analysis of the compiled data. Causes and risk factors for infections can thus be identified. Infectious diseases epidemiology contributes to the development of preventive measures, early detection and therapy for diseases. Moreover, it examines the efficacy of such measures. Thus epidemiology ties in with scientific findings in basic research as well as medicine, and examines these processes at the population level.



Dr Stefanie Castell

Deputy Head of department Epidemiology and Scientist



Karo B, Krause G, Castell S, Kollan C, Hamouda O, Haas W. Immunological recovery in tuberculosis/HIV co-infected patients on antiretroviral therapy: implication for tuberculosis preventive therapy. BMC Infectious Diseases. 2017;17(1).

Obenauer J, Rübsamen N, Castell S, Hoodgarzadeh M, Klett-Tammen CJ, Mikolajczyk RT, Karch A. Perceptions of Zika virus risk in Germany in 2016, 2017. European Journal of Public Health. 2017;accepted.

Rübsamen N, Akmatov MK, Castell S, Karch A, Mikolajczyk RT. Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design. Emerging Themes in Epidemiology. 2017;14(1).


Karo B, Krause G, Hollo V, van der Werf MJ, Castell S, Hamouda O, Haas W. Impact of HIV infection on treatment outcome of tuberculosis in Europe. AIDS. 2016;30(7):1089-98.

Klett-Tammen CJ, Krause G, von Lengerke T, Castell S. Advising vaccinations for the elderly: a cross-sectional survey on differences between general practitioners and physician assistants in Germany. BMC family practice. 2016;17(1):98.

Loddenkemper R, Brönneke M, Castell S, Diel R. [Tuberculosis and Tobacco Smoking] Tuberkulose und Rauchen. Pneumologie. 2016;70(1):17-22.

Raupach-Rosin H, Rubsamen N, Szkopek S, Schmalz O, Karch A, Mikolajczyk R, Castell S. Care for MRSA carriers in the outpatient sector: a survey among MRSA carriers and physicians in two regions in Germany. BMC Infect Dis. 2016;16:184.

Schönfeld N, Haas W, Richter E, Bauer T, Boes L, Castell S, Hauer B, Magdorf K, Matthiessen W, Mauch H, Reuss A, et al. Recommendations of the German Central Committee against Tuberculosis (DZK) and the German Respiratory Society (DGP) for the Diagnosis and Treatment of Non-tuberculous Mycobacterioses. Pneumologie. 2016;70(4):250-76.

Smieszek T*, Castell S*, Barrat A, Cattuto C, White PJ, Krause G. Contact diaries versus wearable proximity sensors in measuring contact patterns at a conference: method comparison and participants’ attitudes. BMC Infectious Diseases. 2016;16(1). [*contributed equally]

Zapf A, Castell S, Morawietz L, Karch A. Measuring inter-rater reliability for nominal data - which coefficients and confidence intervals are appropriate? BMC Med Res Methodol. 2016;16:93.


Karch A, Castell S, Schwab F, Geffers C, Bongartz H, Brunkhorst FM, Gastmeier P, Mikolajczyk RT. Proposing an empirically justified reference threshold for blood culture sampling rates in intensive care units. J Clin Microbiol. 2015;53(2):648-52.

Karch A, Schmitz RP, Rissner F, Castell S, Topel S, Jakob M, Brunkhorst FM, Mikolajczyk RT. Bloodstream infections, antibiotic resistance and the practice of blood culture sampling in Germany: study design of a Thuringia-wide prospective population-based study (AlertsNet). BMJ Open. 2015;5(12):e009095.

Raupach-Rosin H, Klett-Tammen CJ, Schmalz O, Karch A, Castell S, Mikolajczyk R. ["I cannot kiss my wife"- An Analysis of Daily Experiences of MRSA-carriers]. Gesundheitswesen. 2015;http://dx.doi.org/10.1055/s-0035-1559710 Titel anhand dieser DOI in Citavi-Projekt übernehmen 

Rübsamen N, Castell S, Horn J, Karch A, Ott JJ, Raupach-Rosin H, Zoch B, Krause G, Mikolajczyk RT. Ebola risk perception in Germany, 2014. Emerg Infect Dis. 2015;21(6):1012-8.


Castell S*, Akmatov MK*, Obi N, Flesh-Janys D, Nieters A, Kemmling Y, Pessler F, Krause G. Test-retest reliability of an infectious disease questionnaire and evaluation of self-assessed vulnerability to infections : findings of Pretest 2 of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014;57(11):1300-7. [*contributed equally]

Castell S, Krause G, Schmitt M, Pawlita M, Delere Y, Obi N, Flesch-Janys D, Kemmling Y, Kaufmann AM. Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014;57(11):1270-6.

Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Gunther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F, Krause G. Collection of vaccination data in the German National Cohort : Findings of a feasibility study in three study centers. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014;57(11):1292-9.


Castell S. Infektionsprävention bei Tuberkulose in der Praxis. Krankenhaushygiene up2date 02/2012. 2013;7:79-93.

Schönfeld N, Haas W, Richter E, Bauer TT, Bos L, Castell S, Hauer B, Magdorf K, Matthiessen W, Mauch H, Reuss A, et al. [Recommendations for diagnosis and treatment of nontuberculous mycobacterioses of the German Central Committee against tuberculosis and the German Respiratory Society]. Pneumologie. 2013;67(11):605-33.


Castell S, Bauer T, Diel R, Hedrich A, Magdorf K, Rusch-Gerdes S, Schaberg T, Loddenkemper R, World Health O. [International Standards of Tuberculosis Care (ISTC)--comments from the German point of view]. Pneumologie. 2012;66(4):240-9.

Castell S, Diel R, Bauer T. Tuberculosis tests. Internist Prax. 2012;52(2):377-9.

Castell S, Diel R, Bauer T. Tuberculosis tests. Tagl Prax. 2012;53(2):377-9.

Diel R, Rutz S, Castell S, Schaberg T. Tuberculosis: cost of illness in Germany. Eur Respir J. 2012;40(1):143-51.

Schaberg T, Bauer T, Castell S, Dalhoff K, Detjen A, Diel R, Greinert U, Hauer B, Lange C, Magdorf K, Loddenkemper R. [Recommendations for therapy, chemoprevention and chemoprophylaxis of tuberculosis in adults and children. German Central Committee against Tuberculosis (DZK), German Respiratory Society (DGP)]. Pneumologie. 2012;66(3):133-71.

Ziegler R, Just HM, Castell S, Diel R, Gastmeier P, Haas W, Hauer B, Loytved G, Mielke M, Moser I, Nienhaus A, et al. [Tuberculosis infection control--recommendations of the DZK]. Pneumologie. 2012;66(5):269-82.

Castell S. Infektionsprävention bei Tuberkulose in der Praxis. Krankenhaushygiene up2date. 2012;07(02):79-93.


Castell S, Diel R, Loddenkemper R, Glaser-Paschke G, Stang A. [Are alcohol and drug addiction risk factors for default from tuberculosis treatment? - preliminary work for a case-control study including tuberculosis patients from Berlin and Hamburg, 2001-2009]. Gesundheitswesen. 2011;73(12):909-11.

Castell S, Hauer B, Brodhun B, Haas W. [Epidemiology of tuberculosis: The current situation in Germany and worldwide] Epidemiologie der Tuberkulose. Aktutelle Situation in Deutschland und weltweit. Pneumologe. 2011;8(1):9-16.

Castell S, Loddenkemper R. Resistente Tuberkulose - Gefahren und Lösungsansätze. Medical Special. 2011;1:19-21.

Diel R, Loytved G, Nienhaus A, Castell S, Detjen A, Geerdes-Fenge H, Haas W, Hauer B, Konigstein B, Maffei D, Magdorf K, et al. [New recommendations for contact tracing in tuberculosis]. Gesundheitswesen. 2011;73(6):369-88.

Diel R, Loytved G, Nienhaus A, Castell S, Detjen A, Geerdes-Fenge H, Haas W, Hauer B, Konigstein B, Maffei D, Magdorf K, et al. [New recommendations for contact tracing in tuberculosis. German Central Committee against Tuberculosis]. Pneumologie. 2011;65(6):359-78.

Hauer B, Castell S, Loddenkemper R. [Drug-resistant tuberculosis: Growing problems and solutions] Resistente Tuberkulose. Zunehmende Probleme und Lösungsansätze. Pneumologe. 2011;8(1):25-31.


Castell S, Hauer B, Manissero D, Ulrichs T, Zaleskis R, Loddenkemper R. [Berlin Declaration on Tuberculosis: High Level Follow-Up of High Priority Countries for TB Control in the WHO-EURO Region 'Double Trouble or Double Success? Bringing Together Diseases and Programs' - a symposium report]. Pneumologie. 2010;64(7):422-9.

Loddenkemper R, Castell S, Hauer B. Multidrug-resistant tuberculosis: problems and responses. World Medical Journal. 2010;56:60-7.


Trendelenburg G, Prass K, Priller J, Kapinya K, Polley A, Muselmann C, Ruscher K, Kannbley U, Schmitt AO, Castell S, Wiegand F, et al. Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia. J Neurosci. 2002;22(14):5879-88.

2000 and earlier

Weih M, Vetter B, Castell S, Ziemer S, Kulozik AE, Einhaupl KM. Hereditary thrombophilia in cerebral venous thrombosis. Cerebrovasc Dis. 2000;10(2):161-2.

Wiegand F, Liao W, Busch C, Castell S, Knapp F, Lindauer U, Megow D, Meisel A, Redetzky A, Ruscher K, Trendelenburg G, et al. Respiratory chain inhibition induces tolerance to focal cerebral ischemia. J Cereb Blood Flow Metab. 1999;19(11):1229-37.


Castell S. Helicobacter pylori. In: RKI, editor. Bericht zum Krebgeschehen in Deutschland 2016. Berlin2016. p. 199f.

Loddenkemper R, Siemon G, Castell S, Pädiatrie: Magdorf K. Lungentuberkulose und andere Mykobakteriosen. In: Domschke W, Berger M, Hohenberger W, Meinertz T, Possinger K, editors. Therapie-Handbuch. 5th ed. Munich: ELSEVIER Urban & Fischer; 2013. p. 1-3.

Hauer B, Loddenkemper R, Castell S. Prävention der berufsbedingten Tuberkulose. In: Nienhaus A, Brandenburg S, Teschler H, editors. Tuberkulose als Berufskrankheit. Ein Leitfaden zur Begutachtung und Vorsorge. 3rd ed. Munich: ecomed MEDIZIN; 2012.



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