Chemical Microbiology

Biofilm CMIK

Together we are strong – a slogan many of us, but most especially bacteria, live by. As such, they form well-organized communities called biofilms on top of moist surfaces. They love doing this in our bathroom drain as much as on the surfaces of our teeth. Some of them make us sick, others lead a peaceful co-existence with us, and a few may even be beneficial. To understand these biofilms and potentially influence them, our scientists have to know which bacteria team up under what conditions. To figure this out, our researchers are essentially watching bacteria at work.


  • Abraham,W.R.; (2016). Going beyond the Control of Quorum-Sensing to Combat Biofilm Infections. 5 1 DOI: 10.3390/antibiotics5010003. HZI repository PubMed
  • Duarte,M.; Seixas,A.; Peres de,Carvalho M.; Tasca,T.; Macedo,A.J.; (2015). Amaurocine: anti-Trichomonas vaginalis protein produced by the basidiomycete Amauroderma camerarium. 161, 6-11 PubMed
  • Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzman,C.A.; Abraham,W.R.; Höfle,M.G.; (2015). Cohort study of airway mycobiome in adult cystic fibrosis patients: Differences in community structure between fungi and bacteria reveal predominance of transient fungal elements. 53 9, 2900-290700951137 WEBURLS
  • Abraham,W.-R.; (2015). Implant related infections. Lecture Notes in Applied and Computational Mechanics: 74, 163-174
  • de Carvalho,M.P.; Weich,H.; Abraham,W.R.; (2015). Macrocyclic trichothecenes as antifungal and anticancer compounds. 23, 23-35 PubMed
  • Estrela,A.B.; Turck,P.; Stutz,E.; Abraham,W.R.; (2015). Release of Periplasmic Nucleotidase Induced by Human Antimicrobial Peptide in E. coli Causes Accumulation of the Immunomodulator Adenosine. PLoS ONE: 10 9, e0138033 DOI: 10.1371/journal.pone.0138033 HZI repository PubMed
  • de Carvalho,M.P.; Türck,P.; Abraham,W.R.; (2015). Secondary metabolites control the associated bacterial communities of saprophytic basidiomycotina fungi. 30 2, 196-19813426311 DOI: 10.1264/jsme2.ME14139 HZI repository PubMed
  • Kramer,R.; Sauer-Heilborn,A.; Welte,T.; Guzmán,Carlos A.; Höfle,Manfred G.; Abraham,Wolf-Rainer; (2014). A rapid method for breath analysis in cystic fibrosis patients. European Journal of Clinical Microbiology and Infectious Diseases: 34, 745-751 DOI: 10.1007/s10096-014-2286-5 HZI repository PubMed
  • Abraham,Wolf-Rainer; (2014). Applications and impacts of stable isotope probing for analysis of microbial interactions. Applied Microbiology and Biotechnology: 98, 4817-4828 DOI: 10.1007/s00253-014-5705-8 HZI repository PubMed
  • Berod,L.; Friedrich,C.; Nandan,A.; Freitag,J.; Hagemann,S.; Harmrolfs,K.; Sandouk,A.; Hesse,C.; Castro,C.N.; Bahre,H.; Tschirner,S.K.; Gorinski,N.; Gohmert,M.; Mayer,C.T.; Hühn,Jochen; Ponimaskin,E.; Abraham,Wolf-Rainer; Müller,Rolf; Lochner,M.; Sparwasser,Tim; (2014). De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nature medicine: 20, 1327-1333 PubMed
  • Abraham,Wolf-Rainer; (2014). Different implants have different biofilm communities-lessons for implant optimization. Biomedizinische Technik: 59, S1192-S119500135585 DOI: 10.1515/bmt-2014-5014 HZI repository PubMed
  • Blanka,A.; Schulz,S.; Eckweiler,D.; Franke,R.; Bielecka,A.; Nicolai,T.; Casilag,F.; Düvel,J.; Abraham,Wolf-Rainer; Kaever,V.; Häußler,Susanne; (2014). Identification of the alternative sigma factor SigX regulon and its implications for pseudomonas aeruginosa pathogenicity. Journal of Bacteriology: 196 2, 345-35600219193 DOI: 10.1128/JB.01034-13 HZI repository PubMed
  • Scopel,M.; Abraham,Wolf-Rainer; Antunes,A.L.; Henriques,A.T.; Macedo,A.J.; (2014). Mevalonolactone: An Inhibitor of Staphylococcus Epidermidis Adherence and Biofilm Formation. Medicinal Chemistry: 10 3, 246-251 PubMed
  • Glaubitz,S.; Abraham,Wolf-Rainer; Jost,G.; Labrenz,M.; Jurgens,K.; (2014). Pyruvate utilization by a chemolithoautotrophic epsilonproteobacterial key player of pelagic Baltic Sea redoxclines. Fems Microbiology Ecology: 87 3, 770-779 PubMed
  • Zimmer,K.R.; Macedo,A.J.; Giordani,R.B.; Conceicao,J.M.; Nicastro,G.G.; Boechat,A.L.; Baldini,R.L.; Abraham,Wolf-Rainer; Termignoni,C.; (2013). A steroidal molecule present in the egg wax of the tick Rhipicephalus (Boophilus) microplus inhibits bacterial biofilms. Environmental Microbiology: 15 7, 2008-201814622912 WEBURLS
  • Scopel,M.; Dos,Santos O.; Frasson,A.P.; Abraham,Wolf-Rainer; Tasca,T.; Henriques,A.T.; Macedo,A.J.; (2013). Anti-Trichomonas vaginalis activity of marine-associated fungi from the South Brazilian Coast. Experimental Parasitology: 133 2, 211-216 DOI: 10.1016/j.exppara.2012.11.006 PubMed
  • Abraham,Wolf-Rainer; Lünsdorf,Heinrich; Vancanney,M.; Smit,J.; (2013). Cauliform bacteria lacking phospholipids from an abyssal hydrothermal vent: Proposal of Glycocaulis abyssi gen. nov., sp. nov., belonging to the family Hyphomonadaceae. International Journal of Systematic and Evolutionary Microbiology: 63 PART6, 2207-221514665026 WEBURLS
  • Abraham,Wolf-Rainer; Rohde,Manfred; Bennasar,A.; (2013). Caulobacteraceae.: The Prokaryotes: Alphaproteobacteria and Betaproteobacteria. Rosenberg,E.; DeLong,E.F.; Lory,S.; Stackebrandt,E.; Thompson,F.; (Ed.). Berlin - Heidelberg : Springer Verlag, 179-205 DOI: 10.1111/1574-6968.12445 HZI repository PubMed
  • Scopel,M.; Abraham,Wolf-Rainer; Henriques,A.T.; Macedo,A.J.; (2013). Dipeptide cis-cyclo(Leucyl-Tyrosyl) produced by sponge associated Penicillium sp. F37 inhibits biofilm formation of the pathogenic Staphylococcus epidermidis. Bioorganic and Medicinal Chemistry Letters: 23 3, 624-626 DOI: 10.1016/j.bmcl.2012.12.020 HZI repository PubMed
  • Abraham,Wolf-Rainer; Pereira,R.; (2013). Floating dish microcosm: A versatile tool to study the development of biofilm communities.: Microcosms: Ecology, Biological Implications and Environment Impact. Harris,C.C.; (Ed.). Columbus, Ohio, USA : Nova Publishers, 143-155 ISBN: 978-1-62618-662-0
  • Estrela,Andreia B.; Rohde,Manfred; Gutierrez,Maximiliano G.; Molinari,Gabriella; Abraham,Wolf-Rainer; (2013). Human beta-defensin 2 induces extracellular accumulation of adenosine in Escherichia coli. Antimicrobial Agents and Chemotherapy: 57 9, 4387-4393 PubMed
  • Abraham,Wolf-Rainer; Rohde,Manfred; (2013). Hyphomonadaceae.: The Prokaryotes: Alphaproteobacteria and Betaproteobacteria. Rosenberg,E.F.; DeLong,S.; Lory,E.; Stackebrandt,E.; Thompson,F.; (Ed.). Berlin - Heidelberg : Springer Verlag, 283-299
  • Abraham,Wolf-Rainer; Schaumann,S.; Stiesch,M.; (2013). Infected dental implants of incisors and molars show different microbial communities. International Journal of Medical Microbiology: 302S1, 124
  • Abraham,Wolf-Rainer; Schaumann,S.; Stiesch,M.; (2013). Infections of dental implants are different for incisors and molars. Bionanomaterials: 13, 220
  • Abraham,Wolf-Rainer; (2013). Microbial ecology: Stable isotopes allow insights into microbial communities. Biospektrum: 19 5, 505-50709470867 WEBURLS
  • Bresciani,F.R.; Santi,L.; Macedo,A.J.; Abraham,Wolf-Rainer; Vainstein,M.H.; Beys-da-Silva,W.O.; (2013). Production and activity of extracellular lipase from Luteibacter sp.. Annals of Microbiology: DOI: 10.1007/s13213-013-0657-2
  • Abraham,Wolf-Rainer; Estrela,Andreia B.; Rohde,Manfred; Smit,J.; Vancanneyt,M.; (2013). Prosthecate sphingomonads: proposal of Sphingomonas canadensis sp. nov. International Journal of Systematic and Evolutionary Microbiology: 63 Pt 9, 3214-3219 PubMed
  • Pichlmaier,M.; Knigina,L.; Kuehn,C.; Khaladj,N.; Oswald,H.; Klein,G.; Haverich,A.; Abraham,Wolf-Rainer; (2013). The role of cohabitant unusual bacterial species in infection of cardiovascular implantable electronic devices (CIED). Technology and Health Care: 21 1, 87-96 PubMed
  • Trentin,D.S.; Gorziza,D.F.; Abraham,Wolf-Rainer; Antunes,A.L.S.; Lerner,C.; Mothes,B.; Termignoni,C.; Macedo,A.J.; (2012). Antibiofilm activity of Cobetia marina filtrate upon Staphylococcus epidermidis catheter-related isolates. Brazilian Journal of Microbiology: 42 3, 1329-1333
  • de Carvalho,M.P.; Abraham,Wolf-Rainer; (2012). Antimicrobial and biofilm inhibiting diketopiperazines. Current Medicinal Chemistry: 19 21, 3564-3577 HZI repository PubMed
  • Kramer,R.; Abraham,Wolf-Rainer; (2012). Volatile sesquiterpenes from fungi: what are they good for?. Phytochemistry Reviews: 11, 15-37 DOI: 10.1007/s11101-011.9216-2 HZI repository PubMed
  • Estrela,A.B.; Abraham,Wolf-Rainer*; (2011). Adenosine in the inflamed gut: a janus faced compound. Current Medicinal Chemistry: 18 18, 2791-2815 HZI repository PubMed
  • Peres de Carvalo,M.; Abraham,Wolf-Rainer*; (2011). Antimicrobial secondary metabolites from fungi for food safety.: Natural Antimicrobials for Biosafety and Quality. Rai,M.; Chikindas,M.; (Ed.). CABI, UK, 104-113
  • Abraham,Wolf-Rainer*; Macedo,A.J.; Lünsdorf,Heinrich*; Nikitin,D.; (2011). Genus V. Arcicella Nikitin, Strömpl, Oranskaya and Abraham. 2004, 683VP. (Arcocella Nitikin, Oranskaya, Pitryuk, Chernykh and Lysenko. 1994, 152).: Bergey's Manual of Systematic Bacteriology. Garrity,G.M.; (Ed.Vol.4: Hedlund,B.; Krieg,N.R.; Ludwig,W.; Paster,B.J.; Staley,J.T.; Ward,N.; Whitman,W.B.); (Ed.)., 377-380
  • Pawelczyk,S.; Bumann,D.; Abraham,Wolf-Rainer*; (2011). Kinetics of carbon sharing in a bacterial consortium revealed by combining stable isotope probing with fluorescence-activated cell sorting. Journal of Applied Microbiology: 110, 1065-1073 DOI: 10.1111/j.1365-2672.2011.04964.x HZI repository PubMed
  • Stiesch,M.; Abraham,Wolf-Rainer*; Hauser,Hansjörg*; Müller,Peter*; Borchers,L.; Kohorst,P.; Winkel,A.; Bach,F.W.; Hübsch,C.; Dempwolf,W.; Menzel,H.; (2011). Materialoptimierung und Funktionalisierung dentaler Implantat-Abutments.: Spitzenforschung in der Zahnheilkunde., 158-1651861-4620
  • Abraham,Wolf-Rainer*; (2011). Megacities as sources for pathogenic bacteria in rivers and their fate downstream3008. International Journal of Microbiology: Special issue on "Microbial Ecology and Global Health art. no. 798292, e798292 DOI: 10.1155/2011/798292 HZI repository PubMed
  • Heuer,W.; Stiesch,M.; Abraham,Wolf-Rainer*; (2011). Microbial diversity of supra- and subgingival biofilms on freshly colonized titanium implant abutments in the human mouth. European Journal of Clinical Microbiology and Infectious Diseases: 30, 193-200 PubMed
  • Jakobs-Schonwandt,D.; Mathies,H.; Abraham,Wolf-Rainer*; Pritzkow,W.; Stephan,I.; Noll,M.; (2010). Biodegradation of a biocide (Cu-N-cyclohexyldiazenium dioxide) component of a wood preservative by a defined soil bacterial community. Applied and Environment Microbiology: 76 24, 8076-8083 PubMed
  • Stiesch,M.; Heuer,W.; Kohorst,P.; Winkel,A.; Stumpp,S.N.; Menzel,H.; Pfaffenroth,C.; Hauser,Hansjörg*; Müller,Peter P.*; Abraham,Wolf-Rainer*; (2010). Biofilmbildung auf dentalen Implantaten.: Sonderforschungsbereich Zukunftsfähige bioresorbierbare und permanente Implantate aus metallischen und keramischen Werkstoffen. Lenarz,Thomas; (Ed.). Sonderforschungsbereich 599, 264 Seiten
  • Stiesch,M.; Heuer,W.; Kohorst,P.; Winkel,A.; Stumpp,S.N.; Menzel,H.; Pfaffenroth,C.; Behrens,P.; Chichkov,B.; Abraham,Wolf-Rainer*; (2010). Biofilmbildung auf dentalen Implantaten - Biofilm formation on dental implants. Biomedizinische Technik - Biomedical Engineering: 55 Suppl. 1 DOI: 10.1515/BMT.2010.375
  • Abraham,Wolf-Rainer*; Estrela,A.B.; Nikitin,D.I.; Smit,J.; Vancanneyt,M.; (2010). Brevundimonas halotolerans sp. nov., Brevundimonas poindexterae sp. nov. and Brevundimonas staleyi sp. nov., prosthecate bacteria from aquatic habitats. International Journal of Systematic and Evolutionary Microbiology: 60 Pt 8, 1837-1843 PubMed
  • Estrela,A.B.; Abraham,Wolf-Rainer*; (2010). Brevundimonas vancanneytii sp. nov., isolated from blood of a patient with endocarditis. International Journal of Systematic and Evolutionary Microbiology: 60 Pt 9, 2129-2134 DOI: 10.1099/ijs.0.015651-0 HZI repository PubMed
  • Stiesch,M.; Menzel,H.; Abraham,Wolf-Rainer*; Müller,Peter P.*; Dempwolf,W.; Pfaffenroth,C.; Borchers,L.; Kohorst,P.; Winkel,A.; (2010). Chemische Funktionalisierung und Materialoptimierung dentaler Imlantat-Abutments zur Reduktion der oralen Biofilmbildung.: Sonderforschungsbereich 599 - Zukunftsfähige bioresorbierbare und permanente Implantate aus metallischen und keramischen Werkstoffen. Lenarz,T.; Bach,F.-W.; Nolte,I.; (Ed.)., 99-116 HZI repository
  • Estrela,A.B.; Abraham,Wolf-Rainer*; (2010). Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections. Pharmaceuticals: 3 5, 1374 DOI: 10.3390/ph3051374 HZI repository PubMed
  • Menyailo,O.V.; Abraham,Wolf-Rainer*; Conrad,R.; (2010). Tree species affect atmospheric CH4 oxidation without community composition of soil methanotrophs. Soil Biology and Biochemistry: 42 1, 101-107 DOI: 10.1016/j.soilbio.2009.10.005 Full text
  • Estrela,Andreia B.*; Seixas,A.; Teixeira,Vde O.; Pinto,A.F.; Termignoni,C.; (2010). Vitellin- and hemoglobin-digesting enzymes in Rhipicephalus (Boophilus) microplus larvae and females. Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology: 157 4, 326-335 PubMed
  • Glaubitz,S.; Lueders,T.; Abraham,Wolf-Rainer*; Jost,G.; Jürgens,K.; Labrenz,M.; (2009). 13 C-isotope analyses reveal that chemolithoautotrophic Gamma - and Epsilon-proteobacteria feed a microbial food web in a pelagic redoxcline ot the central Baltic Sea. Environmental Microbiology: 11 2, 326-337 DOI: 10.1111/j.1462-2920.2008.01770x PubMed
  • Osanjo,G.O.; Muthike,E.W.; Tsuma,L.; Okoth,M.W.; Bulimo,W.D.; Lünsdorf,Heinrich*; Abraham,Wolf-Rainer*; Dion,M.; Timmis,Kenneth N.*; Golyshin,Peter N.*; Mulaa,F.J.; (2009). A salt lake extremophile, Paracoccus bogoriensis sp. nov., efficiently produces xanthophyll carotenoids. African Journal of Microbiology Research: 3 8, 426-433
  • Macedo,A.J.; Abraham,W.-R.; (2009). Ambivalent role of microbial communities in polluted rivers.: River Pollution Research Progress. Mattia N.Gallo; Marco H.Ferrari; (Ed.). Nova Science Publishers, 335-349 ISBN: 978-1-60456-643-7
  • Abraham,Wolf-Rainer*; (2009). Biosynthetic oils, fats, isoprene, isoprenoids, sterols, waxes: Analytical methods, diversity, characteristics.: Handbook of hydrocarbon microbiology: Microbial interactions with hydrocarbons, oils, fats and related hydrophobic substrates and products. Timmis,K.N.; (Ed.). Springer, 79-95
  • Macedo,A.J.; Abraham,Wolf-Rainer*; (2009). Can infectious biofilms be controlled by blocking bacterial communication?. Medicinal Chemistry: 5, 517-528
  • Macedo,A.J.; Abraham,Wolf-Rainer*; (2009). Gemeinsam sind sie stark: Mikrobielle Gemeinschaften in Biofilmen nutzen hydrophobe Schadstoffe. Bioforum: 32 5, 45-47
  • Estrela,A.B.; Heck,M.G.; Abraham,Wolf-Rainer*; (2009). Novel approaches to control biofilm infections. Current Medicinal Chemistry: 16 12, 1512-1530 PubMed
  • Abang,M.M.; Abraham,Wolf-Rainer*; Asiedu,R.; Hoffmann,P.; Wolf,G.; Winter,S.; (2009). Secondary metabolite profile and phytotoxic activity of genetically distinct forms of Colletotrichum gloeosporioides from yam (Dioscorea spp.). Mycological Research: 113 Pt 1, 130-140 DOI: 10.1016/j.mycres.2008.09.004 PubMed
  • Shrestha,M.; Abraham,Wolf-Rainer*; Shrestha,P.M.; Noll,M.; Konrad,R.; (2008). Activity and composition of methanotrophic bacterial communities in planted rice soil studied by flux measurements, analyses of mpo A gene and stable isotope probing of phospholipid fatty acids. Environmental Microbiology: 10, 400-412 DOI: 10.1111/j.1462-2920.2007.01462.x HZI repository PubMed
  • Qiu,Q.; Noll,M.; Abraham,Wolf-Rainer*; Lu,Y.; Conrad,R.; (2008). Applying stable isotope probing of phospholipid fatty acids and rRNA in a Chinese rice field to study activity and composition of the methanotrophic bacterial communities in situ. The ISME Journal: 2 6, 602-614 PubMed
  • Menyailo,O.V.; Hungate,B.A.; Abraham,Wolf-Rainer*; Conrad,R.; (2008). Changing land use reduces soil CH4 uptake by altering biomass and activity but not composition of high-affinity methanotrophs. Global Change Biology: 14 10, 2405-2419
  • Pawelczyk,S.; Abraham,Wolf-Rainer*; Harms,H.; Müller,S.; (2008). Community-based degradation of 4-chorosalicylate tracked on the single cell level. Journal of Microbiological Methods: 75 1, 117-126 DOI: 10.1016/j.mimet.2008.05.018 HZI repository PubMed
  • Pichlmaier,M.; Marwitz,V.; Kuhn,C.; Niehaus,M.; Klein,G.; Bara,C.; Haverich,A.; Abraham,Wolf-Rainer*; (2008). High prevalence of asymptomatic bacterial colonization of rhythm management devices. Europace: 10 9, 1067-1072 PubMed
  • Abraham,W.R.; Hoffmann,H.M.R.; Kieslich,K.; Reng,G.; Stumpf,B.; (2008). Microbial Transformations of Some Monoterpenoids and Sesquiterpenoids.: Enzymes in Organic Synthesis. John Wiley and Sons Ltd., 146-170 ISBN: 9780470720929 (ISBN); 0272797855 (ISBN); 9780272797853 (ISBN) DOI: Book WEBURLS
  • Peres de Carvalho,M.; Abraham,Wolf-Rainer*; Macedo,A.J.; (2008). Microorganismos em favor da saude humana. Revista Liberto: 2008 11, 77-811518-8043
  • Abraham,Wolf-Rainer*; Macedo,A.J.; Lünsdorf,Heinrich*; Fischer,R.; Pawelczyk,S.; Smit,J.; Vancanneyt,M.; (2008). Phylogeny by a polyphasic approach of the order Caulobacterales , proposal of Caulobacter mirabilis sp. nov., Phenylobacterium haematophilum sp. nov. and Phenylobacterium conjunctum sp. nov., and emendation of the genus Phenylobacterium. International Journal of Systematic and Evolutionary Microbiology: 58 8, 1939-1949 DOI: 10.1099/ijs.0.65567-0 HZI repository PubMed
  • Abraham,Wolf-Rainer*; Macedo,A.J.; Gomes,L.H.; Tavares,F.C.A.; (2007). Occurrence and restistance of pathogenic bacteria along the Tiete River in Brazil. Clean - Soil, Air, Water: 35 4, 339-347 HZI repository
  • Stiesch-Scholz,M.; Menzel,H.; Hauser,Hansjörg*; Abraham,Wolf-Rainer*; Bach,F.-W.; (2007). Orale Biofilmbildung auf chemisch funktionalisierten dentalen Implantatoberflächen. Biomaterialien: 8 3, 251
  • Lu,Y.; Abraham,W.-R.; Conrad,R.; (2007). Spatial variation of active microbiota in the rice rhizosphere revealed by in situ stable isotope probing of phospholipid fatty acids. Environmental Microbiology: 9 2, 474-481 DOI: 10.1111/j.1462-2920.2006.01164.x HZI repository PubMed
  • Wittich,R.-M.; Busse,H.-J.; Kämpfer,P.; Tiirola,M.; Wieser,M.; Macedo,Alexandre J.*; Abraham,Wolf-Rainer*; (2007). Sphingobium aromaticiconvertans sp. nov., a xenobiotic compounds degrading bacterium from polluted river sediment. International Journal of Systematic and Evolutionary Microbiology: 57 2, 306-310 DOI: 10.1099/ijs.0.64433-0 HZI repository PubMed
  • Wittich,Rolf-Michael*; Busse,H.-J.; Kämpfer,P.; Macedo,A.J.; Tiirola,M.; Wieser,M.; Abraham,Wolf-Rainer*; (2007). Sphingomonas fennica sp. nov. and Sphingomonas haloaromaticamans sp. nov., outliers of the genus Sphingomonas. International Journal of Systematic and Evolutionary Microbiology: 57 8, 1740-1746 DOI: 10.1099/ijs.0.648350 HZI repository PubMed
  • Macedo,A.J.; Timmis,Kenneth N.*; Abraham,Wolf-Rainer*; (2007). Widespread capacity to metabolize polychlorinated biphenyls by diverse microbial communities in soils with no significant exposure to PCB contamination. Environmental Microbiology: 9 8, 1890-1897
  • Macedo,A.J.; Neu,T.R.; Kuhlicke,U.; Abraham,Wolf-Rainer*; (2006). Adaptation of microbial communities in soil contaminated with polychlorinated biphenyls, leading to the transformation of more highly chlorinated congeners in biofilm communities. Biofilms: 3 1, 37-46 DOI: 10.1017/S1479050507002116 HZI repository
  • Vasilyeva,L.V.; Omelchenko,M.V.; Berestovskaya,Y.Y.; Lysenko,A.M.; Abraham,Wolf-Rainer*; Dedysh,S.N.; Zavarzin,G.A.; (2006). Asticcacaulis benevestitus sp. nov., a psychrotolerant, dimorphic, prosthecate bacterium from tundra wetland soil. International Journal of Systematic and Evolutionary Microbiology: 56, 2083-2088 DOI: 10.1099/ijs.0.64122-0 HZI repository PubMed
  • Abraham,Wolf-Rainer*; (2006). Bioactive sesquiterpenes produced from fungi: Possibilities and limitations.: Mycotechnology. Rai,M.; (Ed.). New Delhi : I.K. International, 264-287
  • Abraham,Wolf-Rainer*; Brüggemann,N.; Buschbaum,C.; Gutt,J.; Harms,H.; Hartmann,A.; Henle,K.; Klenke,R.; Kuhn,A.; Liebig,J.; Lüders,T.; Munch,J.C.; Papen,H.; Ring,I.; Schloter,M.; Schurr,U.; Wissel,C.; (2006). Biodiversität - im Forschungsbereich Erde und Umwelt der Helmholtz-Gemeinschaft. Gaia: 2
  • Abraham,Wolf-Rainer*; (2006). Controlling biofilms of gram-positive pathogenic bacteria. Current Medicinal Chemistry: 13 13, 1509-1524
  • Macedo,A.J.; Kuhlicke,U.; Neu,T.; Timmis,Kenneth N.*; Abraham,Wolf-Rainer*; (2006). Functional biodiversity of complex biofilms grown on polychlorinated biphenyl oil. Biofilms: 2, 245-273
  • Golyshina,Olga V.*; Golyshin,Peter N.*; Timmis,Kenneth Nigel*; Ferrer,Manuel*; (2006). The 'pH optimum anomaly' of intracellular enzymes of Ferroplasma acidiphilum. Environmental Microbiology: 8 3, 416-425 DOI: 10.1111/j.1462-2920.2005.00907.x HZI repository PubMed
  • Vancanneyt,M.; Segers,P.; Abraham,W.-R.; De Vos,P.; (2005). "Genus III. Brevundimonas Segers, Vancanneyt, Pot, Torck, Hoste, Dewettinck, Falsen, Kersters, de Vos 1994, 507VP emend. Abraham, Strömpl, Meyer, Lindholst, Moore, Christ, Vancanneyt, Tindall, Bennasar, Smit, Tesar 1999, 1070VP".: Bergey's Manual of Systematic Bacteriology. Garrity,George M.; (Ed.). New York : Springer, 308-315 ISBN: 0-0387-24145-0
  • Fritz,I.; Strömpl,C.; Nikitin,D.I.; Lysenko,A.M.; Abraham,W.-R.; (2005). Brevundimonas mediterranea sp. nov., a non-stalked species from the Mediterranean Sea. International Journal of Systematic and Evolutionary Microbiology: 55, 479-486
  • Abraham,W.-R.; (2005). Controlling Gram-negative pathogenic bacteria by interfering with their biofilm formation. Drug Design Reviews - Online: 2, 13-33
  • Abraham,W.-R.; Wenderoth,D.F.; Gläßer,W.; (2005). Diversity of biphenyl degraders in a chlorobenzene polluted aquifer. Chemosphere: 58, 529-533
  • Gomes,N.C.M.; Kosheleva,I.A.; Abraham,W.R.; Smalla,K.; (2005). Effects of the inoculant strain Pseudomonas putida KT2442 (pNF142) and of naphthalene contamination on the soil bacterial community. Fems Microbiology Ecology: 54, 21-33
  • Abraham,W.-R.; Wenderoth,D.F.; (2005). Fate of facultative pathogenic microorganisms during and after the flood of the Elbe and Mulde rivers in August 2002. Acta Hydrochimica Et Hydrobiologica: 33, 449-454
  • Golyshina,O.V.; Timmis,K.N.; (2005). Ferroplasma and relatives, recently-discovered cell wall-lacking archaea making a living in extremely acid, heavy metal-rich environments. Environmental Microbiology: 7, 1277-1288
  • Ferrer,M.; Martinez-Abarca,F.; Golyshin,P.N.; (2005). Genome and "metagenome" mining for novel cataysts. Current Opinion in Biotechnology: 16, 588-593
  • Pelz,O.; Abraham,W.-R.; Saurer,M.; Siegwolf,R.; Zeyer,J.; (2005). Microbial assimilation of plant-derived carbon in soil traced by isotope analysis. Biology and Fertility of Soils: 41 3, 153-162
  • Dinesh,D.; Sriramulu,D.D.; Lünsdorf,H.; Lam,J.S.; Römling,U.; (2005). Microcolony formations: a novel biofilm model of Pseudomonas aeruginosa for the cystic fibrosis lung. Journal of Medical Microbiology: 54, 667-676
  • Gerth,K.; Müller,R.; (2005). Moderately thermophilic Myxobacteria: novel potential for the production of natural products isolation and characterization. Environmental Microbiology: 7 6, 874-880
  • Ferrer,M.; Golyshina,O.V.; Chernikova,T.N.; Khachane,A.N.; Martins dos Santos,V.A.P.; Strompl,C.; Yakimov,M.M.; Elborough,K.; Jarvis,G.; Neef,A.; Timmis,K.N.; Golyshin,P.N.; (2005). Novel hydrolase diversity retrieved from a metagenome library of bovine rumen microflora. Environmental Microbiology: 7, 1996-2010
  • Kopp,M.; Irschik,H.; Pradella,S.; Müller,R.; (2005). Production of the tubulin destabilizer disorazol in Sorangium cellulosum: Biosynthetic machinery and regulatory genes. ChemBioChem: 6, 1277-1286
  • Abraham,W.-R.; Petzoldt,H.; Strauch,G.; (2005). Risiken durch Mikroorganismen in unseren Gewässern/Flüssen.: Schadstoffbelastung nach dem Elbe-Hochwasser 2002. Böhme,M.; Krüger,F.; Ockenfeld,K.; Geller,W.; (Ed.)., 60-66
  • Tillmann,S.; Strömpl,C.; Timmis,K.N.; Abraham,W.-R.; (2005). Stable isotope probing reveals the dominant role of Burkholderia sp. in aerobic degradation of PCBs. Fems Microbiology Ecology: 52 2, 207-217
  • Campbell,E.A.; Pavlova,O.; Zenkin,N.; Leon,F.; Irschik,H.; Jansen,R.; Severinov,K.; Darst,S.A.; (2005). Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase. Embo Journal: 24, 674-682
  • Van der Wielen,P.W.J.J.; Bolhuis,H.; Bolin,S.; Daffonchio,D.; Corselli,C.; Giuliano,L.; de Lange,G.J.; Huebner,A.; Varnavas,S.P.; Thompson,J.; Tambourini,C.; Marty,D.; McGenity,T.J.; Timmis,K.N.; (2005). The enigma of prokaryotic life in deep hypersaline anoxic basins. Science: 307, 121-123
  • Macedo,A.J.; Kuhlicke,U.; Neu,T.; Timmis,K.N.; Abraham,W.-R.; (2005). Three stages of a biofilm community developing at the liquid-liquid interface between polychlorinated biphenyls and water. Applied and Environmental Microbiology: 71, 7301-7309 DOI: 10.1128/AEM.71.11.7301-7309.2005 HZI repository PubMed
  • Khachane,A.N.; Timmis,K.N.; Martins dos Santos,V.A.P.; (2005). Uracil content of 16S rRNA of thermophilic and psychrophilic prokaryotes correlates inversely with their optimal growth temperatures. Nucleic Acids Research: 33, 4016-4022
  • Fritz,I.; Strömpl,C.; Abraham,W.-R.; (2004). Phylogenetic relationships of the genera Stella, Labrys and Angulomicrobium within the "Alphaproteobacteria" and description of Angulomicrobium amanitiforme sp. nov.. International Journal of Systematic and Evolutionary Microbiology: 54, 651-657
  • Nikitin,D.; Strömpl,C.; Oranskaya,M.S.; Abraham,W.-R.; (2004). Phylogeny of the ring-forming bacterium Arcicella aquatica gen. et sp. nov. (ex Nikitin et al. 1994) from a freshwater neuston. International Journal of Systematic and Evolutionary Microbiology: 54, 681-684
  • Yakimov,M.M.; Giuliano,L.; Denaro,R.; Cristafi,E.; Chernikova,T.; Abraham,W.-R.; Luensdorf,H.; Timmis,K.N.; Golyshin,P.N.; (2004). Thalassolituus oleivorans, gen. nov. sp. nov., and new marine bacterium confined to the utilization of hydrocarbons.. International Journal of Systematic and Evolutionary Microbilogy: 54, 141-148
  • Abraham,W.-R.; Strömpl,C.; Vancanneyt,M.; Bennasar,A.; Swings,J.; Smit,J.; Moore,E.R.B.; (2004). Woodsholea maritima gen. nov., sp. nov., a marine bacterium with a low diversity of polar lipids. International Journal of Systematic and Evolutionary Microbiology: 54, 1227-1234
  • Mauclaire,L.; Thullner,M.; Pelz,O.; Abraham,W.-R.; Zeyer,J.; (2003). Assimilation of toluene carbon along a bacteria-protist food chain determined by 13C-enrichment of biomarker fatty acids. Journal of Microbiological Methods: 55, 635-649
  • Witte,U.; Wenzhöfer,F.; Sommer,S.; Boetius,A.; Heinz,P.; Aberle,N.; Sand,M.; Cremer,A.; Abraham,W.-R.; Jörgensen,B.B.; Pfannkuche,O.; (2003). In situ experimental evidence of the fate of a phytodetritus pulse at the abyssal sea floor. Nature: 424, 763-766
  • Abraham,Wolf-Rainer*; Petzoldt,Heike; Strauch,Gerhard; (2003). Infektionsrisiken durch Mikroorganismen im Flutwasser.: Schadstoffbelastung nach dem Elbe-Hochwasser 2002. Böhme,Michael; Krüger,Frank; Ockenfeldt,Klaus; Geller,Walter; (Ed.). Magdeburg : UFZ Umweltforschungszentrum Leipzig-Halle, 60-66
  • Abraham,W.-R.; Hesse,C.; (2003). Isotope fractionations in the biosynthesis of cell compounds by different fungi: A bais for environmental carbon flux studies. Fems Microbiology Ecology: 46, 121-128
  • Abraham,W.-R.; Lünsdorf,H.; Strömpl,C.; Nogales,B.; Moore,E.R.B.; Timmis,K.N.; (2003). Microbial communities in composite biofilms participating in the degradation of PCB. Water, Air and Soil Pollution: Focus: 3, 57-64
  • Strömpl,C.; Hold,G.N.; Lündsorf,H.; Graham,J.; Gallacher,S.; Abraham,W.-R.; Moore,E.R.B.; Timmis,K.N.; (2003). Oceanicaulis alexandrii gen. nov., sp. nov., a novel stalked bacterium isolated from a culture of the dinoflagellate Alexandrium tamarense (Lebour) Balech. International Journal of Systematic and Evolutionary Microbiology: 53, 1901-1906
  • Yakimov,M.M.; Giuliano,L.; Gentile,G.; Cristafi,E.; Chernikova,T.N.; Abraham,W.-R.; Lünsdorf,H.; Timmis,K.N.; Golyshin,P.N.; (2003). Oleispira antarctica gen. nov., sp. nov., a new hydrocarbonoclastic marine bacterium, isolated from an antarctic coastal seawater. International Journal of Systematic and Evolutionary Microbiology: 53, 779-785
  • Abraham,W.-R.; Spassov,G.; (2002). Biotransformations of alkaloids: a challenge. Heterocycles: 56 1-2, 711-741 ISI
  • Muriithi,M.W.; Abraham,W.R.; Addae-Kyereme,J.; Scowen,I.; Croft,S.L.; Gitu,P.M.; Kendrick,H.; Njagi,E.N.; Wright,C.W.; (2002). Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine. Journal of Natural Products: 65 7, 956-9590163-3864 PubMed
  • Abraham,W.-R.; (2002). Microbial degradation of polychlorinated biphenyls (PCBs) in the environment.: Biotransformations: Bioremediation Technology for Health an Environmental Protection. Singh,Ved Pal; Stapleton,Raymond D.; (Ed.). Elsevier : Amsterdam, 29-67
  • Golyshin,P.N.; Chernikova,T.N.; Abraham,W.R.; Lünsdorf,H.; Timmis,K.N.; Yakimov,M.M.; (2002). Oleiphilaceae fam. nov., to include Oleiphilus messinensis gen. nov., sp nov., a novel marine bacterium that obligately utilizes hydrocarbons. International Journal of Systematic and Evolutionary Microbiology: 52, 901-911 ISI
  • Abraham,W.-R.; Strömpl,C.; Bennasar,A.; Vancanneyt,M.; Snauwaert,C.Swings J.; Smit,J.; Moore E.R.B.; (2002). Phylogeny of Maricaulis Abraham et al. 1999 and proposal of Maricaulis indicus sp. nov., M. virginensis sp. nov., M. parjimensis sp. nov., M. washingtonensis sp. nov., and M. salignoratus sp. nov.. International Journal of Systematic and Evolutionary Microbiology: 52, 2191-2201
  • Abraham,W.-R.; Nogales,B.; Golyshin,P.N.; Pieper,D.H.; Timmis,K.N.; (2002). Polychlorinated biphenyl-degrading microbial communities in soils and sediments. Current Opinion in Microbiology: 5 3, 246-2531369-5274 PubMed

Selected Publications

  • Bilitewski,U.; Brenner-Weiss,G.; Hansen,P.D.; Hock,B.; Meulenberg,E.; Muller,G.; Obst,U.; Sauerwein,H.; Scheller,F.W.; Schmid,R.; Schnabl,G.; Spener,F.; (2000). Bioresponse-linked instrumental analysis. Trends in Analytical Chemistry: 19 7, 428-433 DOI: 10.1016/S0165-993600004-2 Full text ISI
  • Akkoyun,A.; Bilitewski,U.; (2000). Detection of sulphamethazine with an optical biosensor and anti-idiotypic antibodies. Sensors and Actuators B: Chemical: 70 1-3, 12-18 ISI
  • Shumyantseva,V.V.; Bulko,T.V.; Bachmann,T.T.; Bilitewski,U.; Schmid,R.D.; Archakov,A.I.; (2000). Electrochemical reduction of flavocytochromes 2B4 and 1A2 and their catalytic activity. Archives of Biochemistry and Biophysics: 377 1, 43-480003-9861 PubMed


  • Dr Wolf-Rainer Abraham

    Wolf-Rainer Abraham

    Head of the Research Group Chemical Microbiology

    +49 531 6181-4300/-4226

    +49 531 6181-4699


Audio Podcast

  • Vom Feind zum Freund - lasst sich das Gute im Biofilm fördern?
    Bakterien in Biofilmen infizieren Katheter, verstopfen Stents, ruinieren die Zähne, besiedeln Gewebe. Kurz: Sie verursachen viele Infektionen und wir kennen kein Mittel, sie dauerhaft zu zerstören. Aber müssen wir das überhaupt - wäre es nicht möglich, aus gefährlichen Biofilmen, ungefährliche zu machen? Denn in der Natur oder im Darm sind wir sogar auf sie angewiesen. Folgen Sie Wolf-Rainer Abraham in die Welt der Kleinsten und hören Sie wie er Biofilme an Zahnimplantaten manipuliert oder in Gallengangstents für uns nutzt…