Biostatistics

Gate at control

High-Throughput-technologies generate large amounts of data. The drawback: these biological and medical data must be processed to results with statistical methods and models. Concepts from robust and computational statistics as well as visualisation techniques help to better understand, estimate and cope with the uncertainty and strong variation that are often inherent in biological and medical data.

The project group „Biostatistics“ is part of the research group „Cellular Proteome Research” which is led by Lothar Jänsch.

Publications

  • Grigull,L.; Lechner,W.; Petri,S.; Kollewe,K.; Dengler,R.; Mehmecke,S.; Schumacher,U.; Lucke,T.; Schneider-Gold,C.; Kohler,C.; Guttsches,A.K.; Kortum,X.; Klawonn,F.; (2016). Diagnostic support for selected neuromuscular diseases using answer-pattern recognition and data mining techniques: a proof of concept multicenter prospective trial. 16 1, 31 PubMed
  • Thumfart,J.O.; Abidi,N.; Mindt,S.; Costina,V.; Hofheinz,R.; Klawonn,F.; Neumaier,M.; Findeisen,P.; (2016). LC/MS based monitoring of endogenous decay markers for quality assessment of serum specimens. J Proteomics Bioinform: 8 5, 091-097 DOI: 10.4172/jpb.1000356 HZI repository PubMed
  • Seeger,B.; Klawonn,F.; Nguema,Bekale B.; Steinberg,P.; (2016). Mixture Effects of Estrogenic Pesticides at the Human Estrogen Receptor alpha and beta. PLoS ONE: 11 1, e0147490 PubMed
  • Rother,A.K.; Schwerk,N.; Brinkmann,F.; Klawonn,F.; Lechner,W.; Grigull,L.; (2015). Diagnostic Support for Selected Paediatric Pulmonary Diseases Using Answer-Pattern Recognition in Questionnaires Based on Combined Data Mining Applications-A Monocentric Observational Pilot Study. PLoS ONE: 10 8, e0135180 PubMed
  • Klawonn,F.; Kruse,R.; Winkler,R.; (2015). Fuzzy clustering: More than just fuzzification. 281, 272-27901650114 DOI: 10.1016/j.fss.2015.06.024 HZI repository PubMed
  • Preusse,M.; Schughart,K.; Wilk,E.; Klawonn,F.; Pessler,F.; (2015). Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains. 8, 225 DOI: 10.1186/s13104-015-1195-8 HZI repository PubMed
  • Szafranski,S.P.; Wos-Oxley,M.L.; Vilchez-Vargas,R.; Jauregui,R.; Plumeier,I.; Klawonn,F.; Tomasch,J.; Meisinger,C.; Kühnisch,J.; Sztajer,H.; Pieper,D.H.; Wagner-Döbler,I.; (2015). High-resolution taxonomic profiling of the subgingival microbiome for biomarker discovery and periodontitis diagnosis. 81 3, 1047-105800992240 DOI: 10.1128/AEM.03534-14 HZI repository PubMed
  • J. König, L. Grigull, H.-W. Fritsch, F. Klawonn; (2015). IT-Unterstützung zur Diagnosefindung seltener Erkrankungen - Umfassende Datenanalyse bei komplexen Fällen. Der Klinikarzt: 44, 16-21
  • Wirsing,L.; Klawonn,F.; Sassen,W.A.; Lünsdorf,H.; Probst,C.; Hust,M.; Mendel,R.R.; Kruse,T.; Jänsch,L.; (2015). Linear Discriminant Analysis Identifies Mitochondrially Localized Proteins in Neurospora crassa. 14 9, 3900-3911 PubMed
  • Worthmann,H.; Tryc,A.B.; Dirks,M.; Schuppner,R.; Brand,K.; Klawonn,F.; Lichtinghagen,R.; Weissenborn,K.; (2015). Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection. 12 117422094 DOI: 10.1186/s12974-014-0231-2 HZI repository PubMed
  • Novoselova,N.; Wang,J.; Klawonn,F.; (2015). Optimized leaf ordering with class labels for hierarchical clustering. 13 4, Article number 155001202197200 WEBURLS
  • Winkler,R.; Klawonn,F.; Kruse,R.; (2015). Prototype based fuzzy clustering algorithms in high-dimendional features spaces. Studies in Fuzzines and Soft Computing: 322, 233-243
  • Rand,U.; Riedel,J.; Hillebrand,U.; Shin,D.; Willenberg,S.; Behme,S.; Klawonn,F.; Köster,M.; Hauser,H.; Wirth,D.; (2015). Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters. 10 2, 323-33118606768 WEBURLS
  • Seeger,B.; Klawonn,F.; Bekale,B.N.; Steinberg,P.; (2015). The ability of the YAS and AR CALUX assays to detect the additive effects of anti-androgenic fungicide mixtures. 241, 193-199 PubMed
  • Wu,Ching-Fang; Andzinski,Lisa; Kasnitz,Nadine; Kröger,Andrea; Klawonn,Frank; Lienenklaus,Stefan; Weiss,Siegfried; Jablonska,Jadwiga; (2015). The lack of type I interferon induces neutrophil-mediated pre-metastatic niche formation in the mouse lung. International Journal of Cancer: 137, 837-847 PubMed
  • Casilag,F.; Lorenz,A.; Kruger,J.; Klawonn,F.; Weiss,S.; Häußler,S.; (2015). The LasB elastase of Pseudomonas aeruginosa acts in concert with alkaline protease AprA to prevent flagellin-mediated immune recognition. Infection and Immunity: 84, 162-171 PubMed
  • Ince,K.; Klawonn,Frank; (2014). Decision and regression trees in the context of attributes with different granularity levels. Studies in Fuzziness and Soft Computing: 285, 331-342
  • Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; (2014). Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen. 4 3, 147-155 PubMed
  • Ince,K.; Klawonn,Frank; (2014). Handling different levels of granularity within naive Bayes classifiers. Lecture Notes in Computer Science: 8206 LNCS, 521-528
  • Tschumitschew,K.; Klawonn,Frank; (2014). High against low quantile comparison for biomarker and classifier evalution. Lecture Notes in Computer Science: 8206 LNCS, 561-568
  • Shevchuk,Olga; Abidi,Nada; Klawonn,Frank; Wissing,Josef; Nimtz,Manfred; Kugler,C.; Steinert,M.; Goldmann,T.; Jänsch,Lothar; (2014). HOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies. Journal of Proteome Research: 13 11, 5230-523915353893 WEBURLS
  • Montvida,O.; Klawonn,Frank; (2014). Relative cost curves: An alternative to AUC and an extension to 3-class problems. Kybernetika: 50 5, 647-66000235954 WEBURLS
  • Wuestefeld,T.; Pesic,M.; Rudalska,R.; Dauch,D.; Longerich,T.; Kang,T.W.; Yevsa,T.; Heinzmann,F.; Hoenicke,L.; Hohmeyer,A.; Potapova,A.; Rittelmeier,I.; Jarek,Michael; Geffers,Robert; Scharfe,Maren; Klawonn,Frank; Schirmacher,P.; Malek,N.P.; Ott,M.; Nordheim,A.; Vogel,A.; Manns,M.P.; Zender,L.; (2013). A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell: 153 2, 389-40100928674 WEBURLS
  • Klawonn,Frank; Jayaram,B.; Crull,Katja; Kukita,A.; Pessler,Frank; (2013). Analysis of contingency tables based on generalized median polish with power transformations and non-additive models. Health Information Science & Systems: 1, 11
  • Jayaram,B.; Klawonn,Frank; (2013). Can fuzzy clustering avoid local minima and undesired partitions?. Studies in Computational Intelligence: 445, 31-44
  • Klawonn,Frank; (2013). Case-centred multidimensional scaling for classification visualisation in medical diagnosis. LNCS: 7798, 137-148 DOI: 10.1007/978-3-642-37899-7_12 HZI repository
  • Tschumitschew,K.; Klawonn,Frank; (2013). Change Detection Based on the Distribution of p-Values.: Towards Advanced Data Analysis by Combining Soft Computing and Statistics. Borgelt,C.; Gil,M.A.; Sousa,J.M.C.; Verleysen,M.; (Ed.). Berlin : Springer, 191-203 ISBN: 978-3-642-30277-0 DOI: 10.1007/978-3-642-30278-7_16
  • Jayaram,B.; Klawonn,Frank; (2013). Generalised median Polish based on additive generators. Advances in Intelligent Systems and Computing: 190 AISC, 439-448
  • Preusse,Matthias; Tantawy,M.A.; Klawonn,Frank; Schughart,Klaus; Pessler,Frank; (2013). Infection- and procedure-dependent effects on pulmonary gene expression in the early phase of influenza A virus infection in mice. BMC Microbiology: 13 1, art.no. 29314712180 WEBURLS
  • Scheiter,Maxi; Bulitta,Björn; van,Ham Marco; Klawonn,Frank; Konig,S.; Jänsch,Lothar; (2013). Protein Kinase Inhibitors CK59 and CID755673 Alter Primary Human NK Cell Effector Functions. Frontiers in Immunology: 4, 66 DOI: 10.3389/fimmu.2013.00066 HZI repository PubMed
  • Scheiter,Maxi; Lau,Ulrike; van,Ham Marco; Bulitta,Björn; Gröbe,Lothar; Garritsen,H.; Klawonn,Frank; Konig,S.; Jänsch,Lothar; (2013). Proteome analysis of distinct developmental stages of human natural killer (NK) cells. Molecular and Cellular Proteomics: 12 5, 1099-1114 DOI: 10.1074/mcp.M112.024596 HZI repository PubMed
  • Bodenhofer,U.; Krone,M.; Klawonn,Frank; (2013). Testing noisy numerical data for monotonic association. Information Sciences: 245, 21-37 DOI: 10.1016/j.ins.2012.11.026 HZI repository PubMed
  • Beffa,Cristina D.; Slansky,E.; Pommerenke,C.; Klawonn,Frank; Li,J.; Dai,L.; Schumacher,H.R.,Jr.; Pessler,Frank; (2013). The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. PLoS ONE: 8 8, e72494 PubMed
  • Della Beffa,Cristina; Slansky,E.; Pommerenke,C.; Klawonn,Frank; Li,J.; Dai,L.; Schumacher,H.R.,Jr.; Pessler,Frank; (2013). The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. PLoS ONE: 8 8, e72494 DOI: 10.1371/journal.pone.0072494 HZI repository PubMed
  • Abidi,N.; Klawonn,Frank; Thumfart,J.O.; (2013). Time point estimation of a single sample from high throughput experiments based on time-resolved data and robust correlation measures. LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)): 8207, 32-43
  • Pommerenke,C.; Friedrich,B.; Johl,T.; Jänsch,Lothar; Häußler,Susanne; Klawonn,F.; (2012). A modified apriori algorithm for analysing high-dimensional gene data. LNCS: 6936, 236-243
  • Winkler,R.; Kruse,R.; Klawonn,Frank; (2012). A New Distance Function for Fuzzy c-Means Clustering in High-Dimensional Spaces with Applications in S.O.D.A..: Data Analysis Methods and its Applications. Pociecha,J.; Decker,R.; (Ed.). Warszawa : Wydawnictwo C.H. Beck ISBN: 978-83-7252-578-9
  • Jayaram,B.; Klawonn,Frank; (2012). Can unbounded distance measures mitigate the curse of dimensionality?. International Journal of Data Mining, Modelling and Management: 4 4, 361-383 DOI: 10.1504/IJDMMM.2012.049883
  • Klawonn,F.; Abidi,N.; Berger,E.; Jänsch,Lothar*; (2012). Curve fitting for short time series data from high throughput experiments with correction for biological variation. Lecture Notes in Computer Science: LNCS 7619, 150-160
  • Johl,T.; Nimtz,Manfred; Jänsch,Lothar; Klawonn,Frank; (2012). Detecting glycosylations in complex samples. IFIP Advances in Information and Communication Technology: 381 AICT (Part 1) 234, 243
  • Nedelko,Tatiana; Kollmus,Heike; Klawonn,Frank; Spijker,S.; Lu,L.; Hessman,M.; Alberts,R.; Williams,R.W.; Schughart,Klaus; (2012). Distinct gene loci control the host response to influenza H1N1 virus infection in a time-dependent manner. BMC GENOMICS: 13, 411 DOI: 10.1186/1471-2164-13-411 HZI repository PubMed
  • Tschumitschew,K.; Klawonn,F.; (2012). Incremental statistical measures.: Learning in Non-Stationary Environments: Methods and Applications. Springer New York, 21-55 ISBN: 9781441980205 (ISBN); 1441980199 (ISBN); 9781441980199 (ISBN) WEBURLS
  • Klawonn,Frank; Crull,Katja; Kukita,A.; Pessler,Frank; (2012). Median polish with power transformations as an alternative for the analysis of contingency tables with patient data. LNCS (Lecture Notes in Computer Sience (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)): 7231, 25-35
  • Grigull,L.; Betzel,C.; Schumacher,U.; Rother,A.-K.; Mücke,U.; Klawonn,F.; Lechner,W.M.; (2012). Should paediatricians use a computer to receive diagnostic support? [Sollten Kinderärzte zur Unterstützung bei der Diagnostik einen Computer nutzen?]. Pediatrische Praxis: 79 4, 545-555
  • Gernert,C.; Klawonn,Frank; Jänsch,Lothar; (2012). SignalNet: Visualization of signal network responses by quantitative proteome data. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics: 6936 LNCS, 361-368
  • Klawonn,Frank; (2012). Significance tests to identify regulated proteins based on a large number of small samples. Kybernetika: 48 3, 478-493
  • Gernert,C.; Berger,E.; Klawonn,F.; Jänsch,Lothar; (2012). Tackling misleading peptide regulation fold changes in quantitative proteomics. Advances in Intelligent and Soft Computing: 154, 269-276
  • Klawonn,Frank*; Höppner,F.; May,S.; (2011). An alternative to ROC and AUC analysis of classifiers. LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)): 7014, 210-221
  • Georgieva,O.; Tschumitschew,K.; Klawonn,Frank*; (2011). Cluster validity measures based on the minimum description length principle. Lecture Notes in Computer Science: 6881 LNAI (part 1), 82-89
  • Della Beffa,Cristina*; Klawonn,Frank*; Menetski,J.P.; Schumacher,H.R.; Pessler,Frank*; (2011). Evaluation of glyceraldehyde-3-phosphate, prolylpeptidyl isomerase A, and a set of stably expressed genes as reference mRNAs in urate crystal inflammation. BMC Research Notes: 4, 4431756-0500 DOI: 10.1186/1756-0500-4-443 HZI repository
  • Winkler,R.; Klawonn,Frank*; Kruse,R.; (2011). Fuzzy clustering with polynomial fuzzifier function in connection with m-estimators. Applied and Computational Mathematics: 10 1, 146-163
  • Krone,M.; Klawonn,Frank*; Lührs,Thorsten*; (2011). Identification of nuclear magnetic resonance signals via Gaussian mixture decomposition. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics): 7014 LNCS, 234-245
  • Novoselova,N.; Klawonn,Frank*; Johl,T.; Reinl,T.; Jänsch,Lothar*; (2011). Identification of peptides with deviating regulation factors using a robust clustering scheme. Advances in Intelligent and Soft Computing: 93, 263-270
  • Krone,M.; Klawonn,Frank*; (2011). Rank correlation coefficient correction by removing worst cases.: Information Processing and Management of Uncertainty in Knowledge-Based Systems: Theory and Methods. Hüllermeier,E.; Kruse,R.; Hoffmann,F.; (Ed.). Berlin : Springer, 356-364
  • Dötsch,A.; Klawonn,F.; Jarek,M.; Scharfe,M.; Blöcker,Helmut*; Häußler,Susanne*; (2010). Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. BMC GENOMICS: 11, 234 DOI: 10.1186/1471-2164-11-234 HZI repository PubMed
  • Alberts,R.; Srivastava,B.; Wu,H.; Viegas,N.; Geffers,Robert*; Klawonn,F.; Novoselova,N.; Zaverucha,do,V; Panthier,J.J.; Schughart,Klaus*; (2010). Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection. Microbes and Infection: 12 4, 309-318 DOI: 10.1016/j.micinf.2010.01.008 HZI repository PubMed
  • Pommerenke,C.; Musken,M.; Becker,T.; Dotsch,A.; Klawonn,Frank*; Häußler,Susanne*; (2010). Global genotype-phenotype correlations in Pseudomonas aeruginosa. PLoS Pathogens: 6 8, 89-90 DOI: 10.1371/journal.ppat.1001074 HZI repository PubMed
  • Tschumitschew,K.; Klawonn,Frank*; (2010). Incremental quantile estimation. Evolving Systems: 1 4, 253-264
  • Klawonn,F.; Wüstefeld,T.; Zender,Lars*; (2010). Statistical modelling for data from experiments with short haripin RNAs. LNCS (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)): 6065, 79-90 HZI repository PubMed
  • Tschumitschew,K.; Klawonn,Frank*; (2010). The need for benchmarks with data from stochastic processes and meta-models in evolving systems.: Proceedings of the International Symposium on Evolving Intelligent Systems. Angelov,P.; Filev,D.; Kasabov,N.; (Ed.). Leicester : SSAISB, 30-33
  • Tschumitschew,K.; Klawonn,Frank*; (2009). AVEDA: Statistical tests for finding interesting visulatisations. 5711 LNAI (Part 1): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics, 235-242
  • Höppner,F.; Klawonn,Frank*; (2009). Compensation of translational displacement in time series clustering using cross correlation. Lecture Notes in Computer Science: (57772 LCNS), 71-82
  • Hundertmark,C.; Fischer,R.; Reinl,T.; May,S.; Klawonn,F.; Jänsch,Lothar*; (2009). MS-specific noise model reveals the potential of iTRAQ in quantitative proteomics. Bioinformatics: 25 8, 1004-1011 DOI: 10.1093/bioinformatics/btn551 HZI repository PubMed
  • Hundertmark,Claudia*; Klawonn,Frank*; (2008). Clustering likelihood curves: Finding deviations from single clusters.: Hybrid Artificial Intelligence Systems. Carchado,E.; Abraham,A.; Pedrycz,W.; (Ed.). Berlin Heidelberg : Springer Verlag, 385-391 ISBN: 978-3-540-97655-7 DOI: 10.1007/978-3-540-87656-4
  • Reinl,Tobias*; Wissing,Josef*; Fischer,R.; Hundertmark,C.; Klawonn,F.; Daub,H.; Wehland,Jürgen*; Jänsch,Lothar*; (2006). Quantitative analysis of receptor tyrosine kinase signaling exploited by Listeria monocytogenes. Molecular & Cellular Proteomics: 5 10, S168-S168 654 Suppl.