Innate immunity and viral evasion

Bild Macrophages

If a virus attacks us, our immune system registers this attack and starts a whole chain of reactions. Messengers initiate the release of cellular proteins, through which our cells prevent the spread of viruses – known as antiviral factors. However, some viruses have developed very effective strategies against these antiviral factors, so that the self-protection mechanism of the cells is ultimately insufficient to defend against the infection. Wanted: new antiviral factors which can fight off even these viruses – of which HIV is one. 

Lodermeyer, V., Suhr K, Schrott N, Kolbe C, Stürzel CM, Krnavek D, Münch J, Dietz C, Waldmann T, Kirchhoff F, Goffinet C.. 90K, an interferon-stimulated gene product, reduces the infectivity of HIV-1. Retrovirology, 10(1):11 (2013)

Yolamanova, M., Meier, C., Shaytan, A.K.,  Vas, V., Bertoncini, C.W., Arnold, F., Zirafi, O., Usmani, S.M, Müller, J., Sauter, D., Goffinet, C., Palesch, D., Walther, P., Roan, N.R., Geiger, H., Lunov, O.,  Simmet, T., Bohne, J., Schrezenmeier, H., Schwarz, K., Ständker, L., Forssmann, W.G., Salvatella, X., Khalatur, P.V., Khokhlov, A.R.,  Knowles, T., Weil, T., Kirchhoff, F., and Münch, J. Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for virus concentration. Nature Nanotechnology, 8(2):130 (2013)

Götz, N., Sauter, D., Usmani, S.M., Fritz, J.V., Goffinet, C., Heigele, A., Geyer, M., Bibollet-Ruche, F., Learn, G.H., Fackler, O.T., Hahn, B.H., and Kirchhoff, F. Nef-mediated tetherin antagonism in a chimpanzee experimentally infected with HIV-1. Cell Host & Microbe, 12(3):373 (2012)

Sliva, K., Resch, T., Kraus, B., Goffinet, C., Keppler, O.T., and Schnierle, B.S. The cellular antiviral restriction factor tetherin does not inhibit poxviral replication. Journal of Virology, 86, 1893 (2012)

Erikson, E., Adam, T., Lehmann-Koch, J, Schmidt, S., Over, B., Goffinet, C., Harter, C., Bekeredjian-Ding, I., Sertel, S., Lasitschka, F. and Keppler, O.T. In vivo-expression profile of the antiviral restriction factor and tumor-targeting antigen CD317/BST-2/HM1.24/tetherin in humans. Proceedings of the National Academy of Sciences, 108(33): 13688 (2011)
Goffinet, C., Schmidt, S., Kern, C., Oberbremer L., Keppler O.T. Endogenous CD317/Tetherin Limits Replication of HIV-1 and MLV in Rodent Cells and is Resistant to Antagonists from Primate Viruses. Journal of Virology, 84(21):11374 (2010)

Goffinet, C., Homann, S., Ambiel, I., Tibroni, N., Rupp, D., Keppler, O.T. and Fackler, O.T. Antagonism of CD317 restriction of HIV-1 particle release and depletion of CD317 are separable activities of HIV-1 Vpu. Journal of Virology, 84(8):4089 (2010)

Goffinet, C., Allespach, I., Oberbremer, L., Golden, P. L., Foster, S. A., Johns, B.A., Weatherhead, J.G., Novick, S.J., Chiswell, K.E., Garvey, E.P., Keppler, O.T. Pharmacovirological  impact  of  an  integrase  inhibitor  on  HIV-1 cDNA  species  in vivo.
Journal of Virology, 83(15):7706 (2009)

Goffinet C., Allespach I., Homann S., Tervo H.-M., Habermann A., Rupp D., Oberbremer L., Kern C., Tibroni N., Welsch S., Krijnse-Locker J., Banting G., Kräusslich H.-G., Fackler O.T., Keppler O.T. HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor. Cell Host & Microbe, 19(5):3 (2009)
Michel, N., Goffinet, C., Ganter, K., Allespach, I., Kewalramani, V.N., Saifuddin, M., Littman, D.R., Greene, W.C., Goldsmith, M.A., Keppler, O.T. Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo. Retrovirology, 13(6):2 (2009)

Tervo, H.-M, Goffinet, C., Keppler, O.T. Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration. Retrovirology, 8(5):58 (2008)

Geuenich, S., Goffinet, C., Venzke, S., Nolkemper, S., Baumann, I., Plinkert, P., Reichling, J., Keppler, O.T. Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology 20(5):27 (2008)

Münch, J., Rücker, E., Ständker, L., Adermann, K., Goffinet, C., Schindler, M., Wildum, S., Chinnadurai, R., Rajan, D., Specht, A., Giménez-Gallego, G., Sánchez, P.C., Fowler, D.M., Koulov, A., Kelly, J.W., Mothes, W., Grivel, J.C., Margolis, L., Keppler, O.T., Forssmann, W.G., Kirchhoff, F. Semen-derived amyloid fibrils drastically enhance HIV infection. Cell 131(6):1059 (2007)

Goffinet, C., Allespach, I., Tervo, H.-M., Hermann, V., Kräusslich, H.-G., Greene, W.C. and Keppler, O.T. Primary T Cells From Human CD4/CCR5-Transgenic Rats Efficiently Support Early Steps of HIV-1 Replication, but Display Impaired Viral Gene Expression. Retrovirology 4:53 (2007)

Goffinet, C., Allespach, I. and Keppler, O.T. HIV-Susceptible Transgenic Rats Allow Rapid Preclinical Testing of Antiviral Compounds Targeting Virus Entry or Reverse Transcription. Proceedings of the National Academy of Sciences 104: 1015 (2007)

Goffinet, C. and Keppler, O.T. Efficient Nonviral Gene Delivery Into Primary Lymphocytes From Rats and Mice. FASEB Journal 20:500 and full-length online article (2006)


  • Prof Dr Christine Goffinet

    Christine Goffinet

    Head of Research Group

    +49 511 220027 198