Chemical Biology

In their ongoing quest for new therapies against pathogens, scientists are focusing primarily on chemical and biological agents. These can function as antibiotics or stimulate the immune system. Discovering new drugs, characterising their functionality and optimising their properties are the three main goals of the department “Chemical Biology” at the HZI.  

Leader

Team

Prof Dr Peter Paul Müller

Scientist

Peter Paul Müller

+49 531 6181-5070

+49 531 6181-5002

Write E-Mail

 

 

Curriculum Vitae

Publications of Prof. Dr. Peter Müller

MedlineGoogleScopus

Vascular iron implant degradation kinetics, corrosion product localization and transcriptional response in a novel murine model. Peter P. Mueller, Sylvia Arnold, Muhammad Badar, Dirk Bormann, Heinz Haferkamp, Andreas Drynda , Andrea Meyer-Lindenberg, Hansjörg Hauser, Matthias Peuster. Journal of Biomedical Materials Research: Part A. 2012 Accepted.

 

Reich U, Fadeeva E, Warnecke A, Paasche G, Müller P, Chichkov B, Stöver T, Lenarz T, Reuter G. (2012) Directing neuronal cell growth on implant material surfaces by microstructuring.  Journal of Biomedical Materials Research: Part B - Applied Biomaterials. Pubmed

 

Böldicke, T., S. Somplatzki, G. Sergeev, P.P. Mueller. (2011) Functional inhibition of transitory proteins by intrabody-mediated retention in the endoplasmatic reticulum. Methods doi:10.1016/j.ymeth.2011.10.008 

 

Buschart A, Gremmer K, El-Mowafy M, van den Heuvel J, Mueller PP, Bilitewski U. (2012) A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity. J Biotechnol. 157, 268-277 Link

 

Ehlert N., A. Hoffmann, G. Gross, P.P. Mueller, M. Stieve, T. Lenarz, P. Behrens (2011) Amino modified silica surfaces efficiently immobilize Bone Morphogenetic Protein 2 (BMP2) for medical purposes. Acta Biomaterialia 7, 1772-1779 Link
   
Ehlert N., M. Badar, M. Stieve, T. Lenarz, P.P. Müller, P. Behrens (2011). Mesoporous Silica Coatings for Controlled Release of Ciprofloxacin from Implants. J. Mater. Chem. 21, 752-760 Link

 

Badar M., K. Hemmen, M. Nimtz, H. Hauser, M. Stieve, M. Stiesch, T. Lenarz, U. Möllmann, S. Vogt, M. Schnabelrauch, P.P. Mueller. (2010). Evaluation of madurahydroxylactone as a slow release antibacterial implant coating. TOBEJ, 4: 263-270. Link

 

Ehlert N., P.P. Mueller, M. Stieve, P. Behrens (2010). Immobilization of alkaline phosphatase on modified silica coatings. Microporous & Mesoporous Materials 131: 51-57. Link

 

Mojallal H, M. Stieve, I. Krueger, P. Behrens, P. P. Mueller, T. Lenarz (2009). A Biomechanical Ear Model to Evaluate Middle Ear Reconstruction.  International Journal of Audiology. Int J Audiol. 48(12):876-84. PubMed

 

Mueller PP, Drynda A, Goltz D, Hoehn R, Hauser H, Peuster M. (2009) Common gene expression signatures in the postnatal arterial duct and in stented arteries. Cardiol Young 19:352-359 PubMed

 

Stieve M, Hedrich HJ, Battmer RD, Behrens P, Müller P, Lenarz T. (2009) Experimental middle ear surgery in rabbits: a new approach for reconstructing the ossicular chain. Laboratory Animals 43(2):198-204 PubMed

 

Vogt JC, Brandes G, Ehlert N, Behrens P, Nolte I, Mueller PP, Lenarz T, Stieve M. (2009) Free Bioverit(R) II Implants Coated with a Nanoporous Silica Layer in a Mouse Ear Model - A Histological Study.  J Biomater Appl. 24(2):175-191. PubMed

 

Stieve M, Hedrich H, Mojallal H, Behrens P, Müller P, Lenarz T. (2008) Normative data of Multifrequency Tympanometry in rabbits. Laboratory Animals 42, 320-325 PubMed 

 

Reich U, Mueller PP, Fadeeva E, Chichkov BN, Stoever T, Fabian T, Lenarz T, Reuter G. (2008) Differential fine-tuning of cochlear implant material-cell interactions by femtosecond laser microstructuring. J Biomed Mater Res B Appl Biomater. 2008;87B(1):146-153. PubMed
 

 

Froese N, Schwarzer M, Niedick I, Frischmann U, Köster M, Kröger A, Mueller PP, Nourbakhsh M, Pasche B, Reimann J, Staeheli P, and Hauser H. (2006): Innate Immune Responses in NF-kappaB-repressing factor (NRF)-Deficient Mice. Mol. Cell. Biol. 26(1):293-302. PubMed

 

Mueller PP, May T, Perz A, Hauser H, Peuster M. (2006): Control of smooth muscle cell proliferation by ferrous iron. Biomaterials 27, 2193–2200. PubMed

 

Witte F, Reifenrath J, Müller PP, Crostack H-A, Nellesen J, Bach FW, Bormann D, Rudert M. (2006) Cartilage repair on magnesium scaffolds used as a subchondral bone replacement. Mat.-wiss. u. Werkstofftech. 2006, 37, 504-508. Link

 

Boldicke T, Weber H, Mueller PP, Barleon B, Bernal M. 2005 Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR). J Immunol Methods. 300:146-59. Link 

 
May T, Wirth D, Hauser H, Mueller PP. 2005 Transcriptionally regulated immortalization overcomes side effects of temperature-sensitive SV40 large T antigen. Biochem Biophys Res Commun. 327:734-41. PubMed

 

Reich U, Reuter G, Müller P, Stöver T, Lubatschowski H, Lenarz T. 2005 Untersuchung des Zellwachstums auf mikrostrukturierten Elektrodenmaterialien. Biomaterialien 6, 194 Link 

 

May, T., Müller, P.P., Weich, H., Froese, N., Deutsch, U., Wirth, D., Kröger, A. and Hauser, H. (2005): Establishment of murine cell lines by constitutive and conditional immortalization. J. Biotech. 120, 99-110. PubMed

 

Samuelsson CV, Lienenklaus S, Muller PP, Zawatzky R, Hauser H, Weiss S. 2005 Transformation of mouse fibroblasts alters the induction pattern of type I IFNs after virus infection. Biochemical and Biophysical Research Community. 335:584-589 PubMed

 

Niedick I, Froese N, Oumard A, Mueller PP, Nourbakhsh M, Hauser H, Koster M. Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF. J Cell Sci. 2004 ;117:3447-58. PubMed 

 

May, T. Lindenmaier, W. Wirth, D. Mueller, P.P. 2004 Application of a Reversible Immortalization System for the Generation of Proliferation-Controlled Cell Lines. Cytotechnology. 46:69-78 PubMed

 

Kroger A, Koster M, Schroeder K, Hauser H, Mueller PP. 2002 Activities of IRF-1. J Interferon Cytokine Res. 22:5-14. PubMed

 

Schroeder K, Koschmieder S, Ottmann OG, Hoelzer D, Hauser H, Mueller PP. (2002) Coordination of cell growth in cocultures by a genetic proliferation control system. Biotechnol Bioeng. 78, 346-52.

 

Müller, P.; Oumard, A.; Wirth, D.; Kröger, A.; Hauser, H. Polyvalent vectors for coexpression of multiple genes. In Plasmids for Therapy and Vaccination (ed. Schleef, M.) Wiley-VCH, Weinheim, 119-136 (2001)

 

Schroeder, K.; Koschmieder, S.; Ottmann, O.G.; Hoelzer, D.; Hauser, H.; Müller, P.P. Establishment of a genetic system to coordinate feeder cell growth in cocultures with primary cells.  In Animal Cell Technology: From Target to Market (eds. Lindner-Olsson, E. et al.) Kluwer Academic Publishers, The Netherlands, 2001 :565-567

 

Geserick C, Bonarius H, Kongerslev L, Hauser H, Mueller PP (2000). Enhanced productivity during controlled proliferation of BHK cells in continuously perfused bioreactors. Biotech. and Bioeng. 69, 266-274. PubMed

 

Carvalhal, A.V.; J.L. Moreira; P. Mueller; H. Hauser; M.J.T. Carrondo (2000) Manipulation of culture conditions for BHK cell growth inhibition by IRF-1 activation. Cytotechnology 32, 135-145.

 

Mueller, P.P., Schlenke, P., Nimtz, M., Conradt, H.S. and Hauser, H. (1999). Recombinant glycoprotein product quality in proliferation controlled BHK-21 cells. Biotech. and Bioeng. 65, 529-536. PubMed

 

Fussenegger, M., Bailey, J. E., Hauser, H. and Müller, P. P (1999). Genetic optimization of recombinant glycoprotein production by mammalian cells. Trends in Biotechnology, 17:35-42.

 

Mueller PP, Grueter P, Hinnebusch AG, Trachsel H (1998). A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recycling. J Biol Chem 273, 32870-7.

 

Koloteva N, Muller PP, McCarthy JE. (1997) The position dependence of translational regulation via RNA-RNA and RNA-protein interactions in the 5'-untranslated region of eukaryotic mRNA is a function of the thermodynamic competence of 40 S ribosomes in translational initiation. J Biol Chem. 272, 16531-16539. 

 

Vasilescu, S., Ptuskina, M., Lintz, B. Muller, P.P. and McCarthy, J.E. (1996) Mutants of eukaryotic initiation factor eIF-4E with altered mRNA cap binding specificity reprogram mRNA selection by ribosomes in Saccharomyces cerevisiae. J. Biol. Chem 271, 7030-7037.

 

Altmann M, Muller PP, Wittmer B, Ruchti F, Lanker S and Trachsel H. (1993). A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity. EMBO J. 12, 3997-4003.

 

Lanker, S., Müller, P. P., Altmann, M., Goyer, C., Sonenberg, S. and Trachsel, H. (1992). Interactions of the eIF-4F subunits in the yeast Saccharomyces cerevisiae. J. Biol. Chem. 267, 21167-21171.

 

Lanker, S., Bushman J. L., Hinnebusch, A.G., Trachsel, H. and Mueller, P. P. (1992). Autoregulation of the yeast lysyl-tRNA synthetase gene GCD5/KRS1 by translational and transcriptional control mechanisms. Cell 70, 647-658. PubMed 

 

Müller, P.P. and Trachsel, H. (1990). Translation and regulation of translation in the yeast Sacchromyces cerevisiae. Eur. J. Biochem. 191, 257-261.

 

Altmann, M., Müller, P.P., Pelletier, J. Sonnenberg, N. and Trachsel, H. (1989). A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J. Biol. Chem. 264, 12145-12147.

 

Müller, P.P., Trachsel, H. and Linder, P. (1989). Genetic localization of the Saccharomyces cerevisiae genes TIF1 and TIF2. Curr. Genet. 16, 127-128.

 

Williams, N.P., Mueller, P.P. and Hinnebusch, A.G. (1988). The positive regulatory function of the 5' proximal open reading frames in GCN4 mRNA can be mimicked by heterologous, short coding sequences. Mol. Cell. Biol. 8, 3827-3836.

 

Mueller, P.P., Jackson, B.M., Miller, P.F. and Hinnebusch, A.G. (1988). The first and the fourth upstream open reading frames in the GCN4 mRNA have similar initiation efficiencies but respond differently in translational control to changes in length and sequence. Mol. Cell. Biol. 8, 5439-5447. Link

 

Hinnebusch, A.G., Jackson, B.M. and Mueller, P.P. (1988). Evidence for regulation of reinitiation in translational control of GCN4 mRNA. Proc. Natl. Acad. Sci. USA 85, 7279-7283. 

 

Mueller, P.P., Harashima, S. and Hinnebusch, A.G. (1987). A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript. Proc. Natl. Acad. Sci. USA 84, 2863-2867.

 

Mueller, P.P. and Hinnebusch, A.G. (1986). Multiple upstream AUG codons mediate translational control of GCN4. Cell 45, 201-207. PubMed

 

Costanzo, M.C., Mueller, P.P., Strick, C.A. and Fox, T.D. (1986). Primary structure of wild-type and mutant alleles of the pet494 gene of Saccharomyces cerevisiae. Mol. Gen. Genet. 202, 294-301.

 

Mueller, P.P. and Fox, T.D. (1984). Molecular cloning and genetic mapping of the PET494 gene of Saccharomyces cerevisiae. Mol. Gen. Genet. 195, 275-280.

 

Mueller, P.P. Reif, M.K., Shen Zonghou, Sengstang, C. Mason, T.L. and Fox, T.D. (1984). A nuclear yeast mutation, pet494-1, post-transcriptionally blocks accumulation of the mitochondrial gene product cytochrome oxidase subunit III, but can be suppressed by a mitochondrial gene rearrangement. J. Mol. Biol. 175, 431-452.

Patents:

 

Mueller PP, Geserick C, Schroeder K, Hauser H (1999). Promoter-transactivator system for inducible high-level mammalian gene expression with the option of cell growth control. Patent EP10467210 A1. International Patent No. PCT/EP 00/03638.

 

Mueller PP, Hauser H, Steinhilber W, Schäfer K (2001). Novel Recombinant Gene Expression Method. US2006099673 (A1) Link

Book contributions:

Kroger A, Koster M, Schroeder K, Mueller PP, Wirth, D, Unsinger J, Hauser H,. (2003) Genetic approaches to recombinant protein production in mammalian cells. Vinci VA, Parekh SR (eds). Handbook of industrial cell culture: Mammalian, microbial and plant cells. Humana Press Inc. Totowa, NJ, 21- 49. 

 

Kroger A, Koster M, Schroeder K, Hauser H, Mueller PP. (2002) Review: Activities of IRF-1. J Interferon Cytokine Res. 22, 5-14.

 

Katharina Schroeder, Steffen Koschmieder, Oliver G. Ottmann, Dieter Hoelzer, Hansjörg Hauser and Peter P. Mueller (2001). Establishment of a genetic system to coordinate feeder cell growth in cocultures with primary cells. In: Lindner-Olsson, E., Chatziassavidou, N. and Lüllau, E. (eds). Animal cell technology: from target to market. Kluwer Academic Publishers, 565-567.

 

Peter P. Müller, André Oumard, Dagmar Wirth, Andrea Kröger and Hansjörg Hauser (2001) Polyvalent vectors for coexpression of multiple genes. Schleef M. (Ed.): Plasmids for Therapy and vaccination. Wiley-VCH, Weinheim, Germany. 

 

Geserick C, Schroeder K, Bonarius H, Kongerslev L, Schlenke P, Hauser H, Mueller PP (1999). Recombinant pharmaceutical protein overexpression in an IRF-1 proliferation controlled production system. In: Bernard, A., Griffiths, B., Noe W. and Wurm F. (eds.). Animal cell technology: Products from cells, cells as products. Kluwer Academic Publishers, 3-7.

 

Mueller, P.P., Carvalhal, A.V., Moreira J.L., Geserick, C., Schroeder, K., Carrondo M.J.T. and Hauser, H. (1999). Development of an IRF-1-based proliferation control system. In: Al Rubeai, M. (ed). Cell Engineering 1. Kluwer Academic Publishers, pp. 220-238.

 

Müller PP, Kirchhoff S, Hauser H. (1998) Sustained expression in proliferation controlled BHK-21 cells. In: Merten O-W, Perrin P, Griffiths B. (eds). New developments and new applications in animal cell technology. Kluwer Academic Publishers, 209-213.

 

Carvalhal, A.V.; J.L. Moreira; P. Mueller; H. Hauser; M.J.T. Carrondo (1997) "Cell Growth Inhibition by the IRF-1 System". In: O.-W. Merten, P. Perrin and J.B. Griffiths (eds.), "New Developments and New Applications in Animal Cell Technology". Kluwer Academic Publ. pp. 215-217.

 

Lanker, S., Bushman J. L., Hinnebusch, A.G., Trachsel, H. and Mueller, P. P. (1993). Uncharged tRNA and derepression of general amino acid control: Autoregulation of yeast lysyl-tRNA synthetase. Springer Verlag Berlin, NATO ASI Series, Vol. H71, 143-155.

 

Müller, P.P., Blum, S., Altmann, M., Lanker, S. and Trachsel, H. (1990). Initiation factors involved in mRNA binding to ribosomes in Sacchromyces cerevisiae. Springer Verlag Berlin, NATO ASI Series, Vol. H49, 487-495.

 

Hinnebusch, A.G., Mueller, P.P. and Harashima, S. (1988). Translational control of transcriptional activation in the regulation of amino acid biosynthesis in yeast. In Genetics of Translation , Eds. Tuite, M.F. Picard, M., Bolotin-Fukuhara, M. Springer Verlag, Berlin, NATO ASI series 14, 499-512.

 

Hinnebusch, A.G. and Mueller, P.P. (1987). Translational control of a transcriptional activator in the regulation of amino acid biosynthesis in yeast. In: Translational regulation of gene expression, Edt. Ilan, J., pp. 397-412. Plenum Publishing, New York.

 

 

Selected Theses

Etablierung und Evaluierung von molekularbiologischen Testsystemen zur in-vitro und invivo Charakterisierung von neuartigen Implantatmaterialien.  Daniela Lindemeier Diplomarbeit, FH Emden, 2008 <media 8479 - link-extern "TEXT, Diplomarbeit Daniela Lindemeier, Diplomarbeit Daniela Lindemeier.pdf, 1.7 MB">Link</media>

Differentiation of bone marrow stem cells into functional pancreatic insulin-producing cells. Thatava, Tayaramma. Helmholtz-Zentrum für Infektionsforschung (HZI) Braunschweig, 2007 Link

Auswirkung von Abrasivmitteln zum Wasserabrasivstrahlschneiden auf lebende Zellen. Schulze, Maren; Steiner, Andreas. Medizinische Hochschule Hannover, 2006 Link

 

Meetings 

P. Mueller, J. Schöne, N. Ehlert, P. Behrens, S. Leschner, S. Weiss, M. Stieve Imaging of Bacterial Infections Associated with Nanoporous Coated Implants in a Murine Model. Jahrestagung DGBM 2008 Link

R. Kucharski, D. Bormann, F.-W. Bach, M. Jendras, H. Hauser, P.P. Müller, S. Besdo, J. Reifenrath, A. Meyer-Lindenberg Herstellung von offenporigen Magnesium-Keramik-Implantaten Jahrestagung DGM 2008 Link

N. Ehlert, P. Behrens, A. Hoffmann, G. Gross, P.P. Müller, T. Lenarz, M. Stieve. Immobilization of the Signalling Protein BMP-2: A Comparison of Mesoporous and Amorphous Silica. 6th International Mesostructured Materials Symposium Mesostructured Materials: Design and Opportunities. Namur, Belgium, 2008. 

P. Behrens, N. Ehlert, D. Lindemeier, P.P. Müller, G. Brandes, J. Vogt, C. Turck, E. Hlozanek, T. Lenarz, M. Stieve Thorough Testing of Mesoporous Silica as a Biomaterial: Cell Culture, Animal Testing and Gene Expression. 6th International Mesostructured Materials Symposium Mesostructured Materials: Design and Opportunities. Namur, Belgium, 2008

D. Lindemeier, A. Steiner, M. Stahl, C. Biskup, S. Schmolke, F. Pude, D. Bormann, F. Witte, G. Gross, H. Hauser, A. Hoffmann, P. P. Mueller. Cell Culture Models for the Evaluation of Magnesium Alloys as Degradable Implant Materials.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 189 <media 11500 - link-extern "TEXT, Lindenmeier Zellkulturmodelle 2007, Lindenmeier Zellkulturmodelle 2007.pdf, 650 KB">Link</media>

J.C. Vogt, M. Stieve, N. Ehlert, D. Lindemeier, G. Brandes, H. Mojallal, T. Lenarz, P. Behrens, P.P. Mueller. Murine Models for the Evaluation of Novel Ossicular Replacement Materials.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 221 <media 11507 - link-extern "TEXT, Vogt Murine, Vogt Murine.pdf, 679 KB">Link</media>

M. Stieve, H.J. Hedrich, H. Mojallal, G. Brandes, R.D. Battmer P. Behrens, P.P.
Müller,Th. Lenarz. A functional evaluation of ossicular replacement prothesis with different pore size: Effects of conductive hearing loss on auditory brainstem response.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 158 <media 11505 - link-extern "TEXT, Stieve A functional, Stieve A functional.pdf, 501 KB">Link
</media>

H. Mojallal, M. Stieve, N. Ehlert, P.P. Mueller, P. Behrens, Th. Lenarz. Funktionelle Evaluierung von Mittelohrprothesen in Kaninchen.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 159 <media 11504 - link-extern "TEXT, Mojallal Funktionelle, Mojallal Funktionelle.pdf, 608 KB">Link</media>

N. Ehlert, P. Behrens, A. Hoffmann, G. Gross, P.P. Müller, H. Mojallal, J. Vogt, M. Stieve. Immobilisierung von BMP-2 auf amorphem und nanoporösem Siliciumdioxid.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 2192 <media 11508 - link-extern "TEXT, Ehlert Immobilisierung BMP, Ehlert Immobilisierung BMP.pdf, 523 KB">Link</media>

M. Stieve, H.J. Hedrich, H. Mojallal, G. Brandes, R.D. Battmer P. Behrens, P.P Müller, Th. Lenarz. Biomaterialien zum Gehörknöchelchenersatz: Ein neuer chirurgischer Zugangswegzur Implantation von Gehörknöchelchenprothesen im Kaninchenmittelohr. Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 193 <media 11506 - link-extern "TEXT, Stieve Biomaterialien, Stieve Biomaterialien.pdf, 496 KB">Link</media>

Behrens, P., Müller, PP., Lenarz, T., Besdo S., Mojallal, H., Brandes, G., Hoffman, A., Gross, G., Ehlert, N., Turck, C., Vogt, J., Hlozanek, L., Doniga-Crivat, L., Stieve, M. Solutions for material problems associated with middle ear prostheses.  Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 261 <media 11501 - link-extern "TEXT, Behrens Lösungen, Behrens Lösungen.pdf, 566 KB">Link</media>

W. Heuer, A. Winkel, A. Lutzke, C. Pfaffenroth, H. Menzel, H. Hauser, PP. Müller, WR. Abraham, M. Stiesch-Scholtz,  Biokompatibilitätsuntersuchungen innovativer Implantatbeschichtungenmittels humaner Gingivafibroblasten. Jahrestagung DGBM 2007 Biomaterialien, 2007, 8: 214 <media 11503 - link-extern "TEXT, Heuer Biokompatibilitätsuntersuchungen, Heuer Biokompatibilitätsuntersuchungen.pdf, 466 KB">Link</media>

Ehlert, N., Müller, PP., Behrens, P., Immobilization of alkkaline phosphatase on modified glass surfaces.<media 11509 - - "TEXT, Ehlert Immobilisierung AP, Ehlert Immobilisierung AP.pdf, 492 KB"> </media>Jahrestagung DGBM 2007, Biomaterialien, 2007, 8: 204 <media 11509 - link-extern "TEXT, Ehlert Immobilisierung AP, Ehlert Immobilisierung AP.pdf, 492 KB">Link</media>

News

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Video

  • Epothilon: Ein HZI-Molekül wird zum Krebsmedikament

    Wissenschaftler an der ehemaligen Gesellschaft für Biotechnologische Forschung (GBF), dem heutigen HZI, haben in den 1980er Jahren Epothilon B entdeckt. Dieser Naturstoff stört die Teilung von Krebszellen: Tumore werden durch ihn im Wachstum gebremst, schrumpfen und verschwinden. Das Pharmaunternehmen Bristol-Myers Squibb (BMS) hat jetzt auf der Basis von Epothilon B ein Krebsmedikament auf den US-amerikanischen Markt gebracht. Seine Entwicklung ist so spannend wie ein Krimi...
    Länge: 11:34

Audio Podcast

  • Kleine Moleküle ganz groß – Mit Naturstoffen gegen Hepatitis CMit weltweit 130 Millionen Infizierten ist Hepatitis C eine der häufigsten Infektionskrankheiten. Die Therapien, die es derzeit gibt, sind langwierig, haben starke Nebenwirkungen und helfen nicht jedem Patienten. Florenz Sasse vom Braunschweiger Helmholtz-Zentrum für Infektionsforschung und Thomas Pietschmann vom TWINCORE in Hannover suchen gemeinsam nach neuen Wirkstoffen gegen das Hepatitis C-Virus. Hören Sie hier von ihren ersten Treffern und folgen Sie Florenz Sasse zu einer Bibliothek der anderen Art…
PrintSend per emailShare