Structural biology of biosythetic enzymes

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

Natural agents have always been the best source of antibiotics. This is exemplified by success stories such as penicillin, streptomycin, erythromycin and rifamycin. But the potential of natural agents is not being tapped to the fullest extent yet. Often, this is related to the chemical synthesis being difficult and the yields of the purification of the agents from natural sources being low. Consequently, a large number of promising natural substances have been discovered, but were not developed further for clinical application, either because their chemical structure could not be changed sufficiently or because it was impossible to produce sufficient amounts of them.

 

Team

  • Dr Jesko Köhnke

    Jesko_Köhnke.jpg

    Head of Junior Research Group Structural biology of biosynthetic enzymes

    +49 681 98806-3500

    Contact

  • Dr Hilda Sucipto

    Hilda Sucipto

    Postdoc

    +49 681 98806 3132

    Contact

  • Sebastian Adam

    Sebastian_Adam.jpg

    PhD Student

    +49 681 98806-3511

    Contact

  • Asfandyar Sikandar

    Asfandyar_Sikandar.jpg

    PhD Student

    +49 681 98806-3512

    Contact

Leader

  • Dr Jesko Köhnke

    Jesko_Köhnke.jpg

    Head of Junior Research Group Structural biology of biosynthetic enzymes

    +49 681 98806-3500

    Contact