Microbial Strain Collection

Myxobakterien

Bacterial secondary metabolites offer great potential for the discovery and development of leads in anti-infective research. One of the most promising ways for generating novel antibiotic scaffolds is the biodiversity guided expansion of existing microbial strain collections at the HZI. Although intensively studied, the actinomycetes, and the much less analyzed myxobacteria, are far from being exhausted as resources of novel chemistry. In fact, recent research has shown their enormous potential for future discoveries.

Publications

2015

[Translate to übersetzung:] Sood S, Awal RP, Wink J, Mohr KI, Rohde M, Stadler M, Kämpfer P, Glaeser S, Schumann P, Garcia R, Müller R (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample. Int J Syst Evol Microbiol 65:745-753 (doi:10.1099/ijs.0.061176-0)

2014

[Translate to übersetzung:] Müller R, Wink J (2014) Future potential for anti-infectives from bacteria - How to exploit biodiversity and genomic potential, International Journal of Medical Microbiology, 304, 3-13.

Wink J, Schumann P, Spoer C, Eisenbarth K, Glaeser SP, Martin K, Kämpfer P (2014) Emended description of Actinoplanes friuliensis and description of Actinoplanes nipponensis sp. nov., antibiotic-producing species of the genus Actinoplanes, International Journal of Systematic and Evolutionary Microbiology, 64, 599 – 606.

Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K I, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014) Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity, Angewandte Chemie - International Edition,  53, 14605-14609.

Reker D, Perna A, Rodrigues T, Schneider P, Reutlinger M, Mönch B, Koeberle A, Lamers C, Gabler M, Steinmetz H, Müller R, Schubert-Zsilavecz M, Werz O and Schneider G,  Revealing the macromolecular targets of complex natural products,  Nature Chemistry 6 (12), 1072-1078.  

Sood S., Steinmetz H, Beims H, Mohr KI, Stadler M, Djukic M, von der Ohe W, Steinert M, Daniel R, Muller R, Paenilarvins: Iturin Family Lipopeptides from the Honey Bee Pathogen Paenibacillus larvae, ChemBioChem, 15(13): 1947–1955.

Sood S, Awal RP, Wink J, Mohr KI, Rohde M, Stadler M, Kämpfer P, Glaeser S, Schumann P, Garcia R, Müller R (2014) Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating   myxobacterium isolated from a soil sample, Int J Syst Evol Microbiol , Mar 3,

2013

[Translate to übersetzung:] Martinez, J.P., Hinkelmann, B., Fleta-Soriano, E., Steinmetz, H., Jansen, R., Diez, J., Frank, R., Sasse, F., Meyerhans, A. (2013) Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay, Microbial Cell Factories 12 (1), art. no. 85.  

Martinez, J.P., Perez-Vilaro, G., Muthukumar, Y., Scheller, N., Hirsch, T., Diestel, R., Steinmetz, H., Jansen, R., Frank, R., Sasse, F., Meyerhans, A., Diez, J. (2013) Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology, RNA Biology 10 (11), 1661-1669.

2012

[Translate to übersetzung:] Dufour, C., J. Wink, M. Kurz, H. Kogler, H. Olivan, S. Sablé, W. Heyse, M. Gerlitz, L. Toti, A. Nußer, A. Rey, C. Couturier, A. Bauer and M. Brönstrup. (2012) Isolation and structural elucidation of armeniaspirols A-C: Potent antibiotics against gram-positive pathogens, Chemistry - A European Journal, 18: 16123-16128.

Okanya, P.W., Mohr, K.I., Gerth, K., Steinmetz, H., Huch, V., Jansen, R. and Müller, R. (2012) Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum, J. Nat. Prod., 75: 768-770.

Bielecki, P., Lukat, P., Hüsecken, K., Dötsch, A., Steinmetz, H., Hartmann, R.W., Müller, R. and Häussler, S. (2012) Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosa, ChemBioChem, 13 (16): 2339-2345.

Steinmetz, H., Mohr, K., Zander, W., Jansen, R. and Müller, R. (2012) Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticus, J. Nat. Prod., 75 (10): 1803-1805.

Steinmetz, H., Zander, W., Shushni, M.A., Jansen, G., Dehn, R., Dräger, G., Kirschning, A. and Müller, R. (2012) Precursor-directed syntheses and biological evaluation of new elansolid derivatives, ChemBioChem, 13 (12): 1813-1817.

Zander, W., Irschik, H., Augustiniak, H., Herrmann, M., Jansen, R., Steinmetz, H., Gerth, K., Kessler, W., Kalesse, M., Höfle, G. and Müller, R. (2012) Sulfangolids, macrolide sulfate esters from Sorangium cellulosum, Chem. -- Eur. J., 18 (20): 6264-6271.