Microbial Natural Products
This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)
Even today efficient drugs against many diseases are missing but finding new active substances is very complex. Support comes out of the ground. Myxobacteria are soil-living microorganisms that produce many active agents. Here you learn more about the search for new compounds with biological activity.
Leader
Selected Publikations
Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. (2018) Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria, Nat. Commun., 9 (1): 803.
Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens, Angew. Chem. Int. Ed., 56 (41): 12760-64.
Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E, Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 348 (6239): 1106-12.
Quade, N., Huo, L., Rachid, S., Heinz, D.W. and Müller, R. (2011) Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol., 8 (1): 117-124.
Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S, Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. and Müller, R. (2007) Complete genome sequence of the myxobacterium Sorangium cellulosum, Nat. Biotechnol., 25 (11): 1281-1289.
Selected Highlights
Complete publication list
Further Information
A current overview of the team and further information about the research group can be found on the HIPS page.
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