Microbial Natural Products

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)


Even today efficient drugs against many diseases are missing but finding new active substances is very complex. Support comes out of the ground. Myxobacteria are soil-living microorganisms that produce many active agents. Here you learn more about the search for new compounds with biological activity.

Leader

  • Prof Dr Rolf Müller

    Rolf Müller

    Managing Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Head of the Department Microbial Natural Products

    +49 681 98806-3000

    +49 681 98806-3009

    Write E-Mail

Selected Publikations

Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. (2018) Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteriaNat. Commun., 9 (1): 803.

Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens, Angew. Chem. Int. Ed., 56 (41): 12760-64.

Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E, Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 348 (6239): 1106-12.

Quade, N., Huo, L., Rachid, S., Heinz, D.W. and Müller, R. (2011) Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol., 8 (1): 117-124.

Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S, Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. and Müller, R. (2007) Complete genome sequence of the myxobacterium Sorangium cellulosum, Nat. Biotechnol., 25 (11): 1281-1289.

Selected Highlights

Download Highlight-list here

Complete publication list

Download full publication list

Further Information

A current overview of the team and further information about the research group can be found on the HIPS page.

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Video

  • KrankheitsErregend - Antibiotika

    Zufall und Unordnung im Labor führten dazu, dass der schottische Wissenschaftler Sir Alexander Fleming 1928 eine Wunderwaffe gegen bakterielle Infektionskrankheiten entdeckte. Das von einem Schimmelpilz hergestellte Penicillin hindert Bakterien am Wachsen und wurde erfolgreich als erstes Antibiotikum eingesetzt. Danach fanden Forscher weitere, von Mikroorganismen produzierte Stoffe, die für Bakterien giftig sind. Sie zählen zu den effektivsten Mitteln gegen bakterielle Infektionen. Durch häufigen Antibiotika-Einsatz sind heutzutage viele Mikroorganismen resistent gegen die Medikamente. Im Rahmen der zweiten Veranstaltung der Vortragsreihe „KrankheitsErregend – Meilensteine der Medizin“ ging es sowohl um die Geschichte des Wundermittels als auch um die heutige Forschung und die Probleme in der klinischen Praxis.

  • Paper of the month Juni 2015

    The prize "Paper of the Month" for June 2015 was awarded to Angela Kling from the department Mikrobielle Naturstoffe at HIPS in Saarbrücken. The prize was handed to Peer Lukat, the other first author of the paper, because Andrea Kling was not present at the day. Her publication "Targeting DnaN for tuberculosis therapy using novel griselimycins" was released in the journal Science. Find out more about their research in this videopodcast.

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

  • How do researchers at the HZI and HIPS develop antibiotic candidates from natural products?

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