Microbial Natural Products


This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)


Even today efficient drugs against many diseases are missing but finding new active substances is very complex. Support comes out of the ground. Myxobacteria are soil-living microorganisms that produce many active agents. Here you learn more about the search for new compounds with biological activity.

Leader

  • Prof Dr Rolf Müller

    Rolf Müller

    Managing Director of the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Head of the Department Microbial Natural Products

    +49 681 98806-3000

    +49 681 98806-3009

    Write E-Mail

Selected Publikations

Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. (2017) Bacterial versus chemical diversity: The phylogeny paradigm in microbial natural product discovery, Nat. Commun., accepted.

Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogensAngew. Chem. Int. Ed., epub ahead of print.

Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E, Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 348 (6239): 1106-12.

Quade, N., Huo, L., Rachid, S., Heinz, D.W. and Müller, R. (2011) Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol., 8 (1): 117-124.

Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S, Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. and Müller, R. (2007) Complete genome sequence of the myxobacterium Sorangium cellulosum, Nat. Biotechnol., 25 (11): 1281-1289.

Selected Highlights

Von Tesmar, A.*, Hoffmann, M.*, Pippel, J., Abou Fayad, A., Dausend-Werner, S., Bauer, A., Blankenfeldt, W. and Müller, R. (2017) Total biosynthesis of the pyrrolo [4,2] benzo-diazepine scaffold tomaymycin on an in vitro reconstituted NRPS system, Cell. Chem. Biol., accepted. *These authors contributed equally to this work.

Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. (2017) Bacterial versus chemical diversity: The phylogeny paradigm in microbial natural product discovery, Nat. Commun., accepted. 

Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogensAngew. Chem. Int. Ed., epub ahead of print. 

Fu, C., Auerbach, D., Li, Y., Scheid, U., Luxenburger, E., Garcia, R., Irschik, H. and Müller, R. (2017) Solving the puzzle of one-carbon loss in ripostatin biosynthesis, Angew. Chem. Int. Ed., 56 (8): 2192-2197. 

Kjaerulff, L., Raju, R., Panter, F., Scheid, U., Garcia, R., Herrmann, J. and Müller, R. (2017) Pyxipyrrolones: Novel cytotoxic myxobacterial metabolites. Structure elucidation and biosynthesis proposal, Angew. Chem. Int. Ed., 53 (32), 9614-18. 

Rox, K., Rohde, M., Chhatwal, G.S. and Müller, R. (2017) Disorazoles block group A streptococcal invasion into epithelial cells via interference with host factor ezrin, Cell Chemical Biology, 24 (2): 159-170. 

Viehrig, K., Surup, F., Volz, C., Herrmann, J., Abou Fayad, A., Adam, S., Köhnke, J., Trauner, D. and Müller, R. (2017) Structure and biosynthesis of crocagins: Polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus, Angew. Chem. Int. Ed., epub ahead of print. 

Gemperlein, K., Zipf, G., Bernauer, H.S., Müller, R. and Wenzel, S.C. (2016) Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase, Metab. Eng., 33: 98-108. 

Lee, W., Schaefer, K., Qiao, Y., Srisuknimit, V., Steinmetz, H., Müller, R., Kahne, D. and Walker Suzanne. (2016) The mechanism of action of lysobactin, J. Am. Chem. Soc., 138 (1): 100-3. 

Steinmetz, H., Li, J., Fu, C., Zaburannyi, N., Kunze, B., Harmrolfs, K., Schmitt, V., Herrmann, J., Reichenbach, H., Höfle, G., Kalesse, M.* and Müller, R.* (2016) Isolation, structure elucidation and (bio)synthesis of haprolid, a cell-type-specific myxobacterial cytotoxin, Angew. Chem. Int. Ed., 55 (34): 10113-7. *These authors contributed equally to this work.

Wang, H., Li, Z., Jia, R., Hou, Y., Yin, J., Bian, X., Li, A., Müller, R., Stewart, A.F., Fu, J. and Zhang, Y. (2016) RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Nat. Prot., 11 (7): 1175-90. 

Bian, X., Plaza, A., Zhang, Y. and Müller, R. (2015) Two more pieces of the colibactin genotoxin puzzle form Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety, Chem. Sci., 6 (5): 3154-3160. 

Fu, C., Keller, L., Bauer, A., Brönstrup, M., Froidbise, A., Hammann, P., Herrmann, J., Mondesert, G., Kurz, M., Schiell, M., Schummer, D., Toti, L., Wink, J. and Müller, R. (2015) Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity, J. Am. Chem. Soc.,137 (24): 7692-705. 

Keller, L., Plaza, A., Dubiella, C., Groll, M., Kaiser, M. and Müller, R. (2015) Macyranones: Structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome, J. Am. Chem. Soc., 137 (25): 8121-30. 

Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E, Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 348 (6239): 1106-12. 

Mohr, K.I., Volz, C., Jansen, R., Wray, V., Hoffmann, J., Bernecker, S., Wink, J., Gerth, K., Stadler, M. and Müller, R. (2015) Pinensins: The first antifungal lantibiotics, Angew. Chem. Int. Ed. Engl., 54 (38): 11254-8. 

Sucipto, H., Sahner H. J., Prusov, E., Wenzel, S.C., Hartmann, R., Koehnke, J. and Müller, R., (2015) In Vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis, Chem. Sci., 6 (8): 5076-5085. 

Wenzel, S.C., Hoffmann, H., Zhang, J., Debussche, L., Haag-Richter, S., Kurz, M., Nardi, F., Lukat, P., Kochems, I., Tietgen, H., Schummer, D., Nicolas, J.-P., Calvet, L., Czepczor, V., Vrignaud, P., Mühlenweg, A., Pelzer S., Müller, R. and Brönstrup, M. (2015) Production of the bengamide class of marine natural products in myxobacteria: Biosysnthesis and structure-activity relationships, Angew. Chem. Int. Ed., 54 (51): 15560-64. 

Baumann, S., Herrmann, J., Raju, R., Steinmetz, H., Mohr, K.I., Hüttel, S., Harmrolfs, K., Stadler, M. and Müller, R. (2014) Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity, Angew. Chem. Int. Ed.,53 (52): 14605-14609. 

Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, S., Hesse, C., Castro, C., Bähre, H., Tschirner, S., Gorinski, N., Gohmert, M., Mayer, C.T., Huehn, J., Ponimaskin, E., Abraham, W.R., Müller, R., Lochner, M. and Sparwasser, T. (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells, Nat. Med., 20 (11): 1327-33. 

Gemperlein, K., Rachid, S., Garcia, R., Wenzel, S.C. and Müller, R. (2014) Polyunsaturated fatty acid biosynthesis in myxobacteria: Different PUFA synthases and their product diversity, Chem. Sci., 5 (5): 1733-1741. 

Hoffmann, T., Krug, D., Hüttel, S. and Müller, R. (2014) Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow, Anal. Chem., 86 (21): 10780-10788. 

Kolinko, I., Lohße, A., Borg, S., Raschdorf, O., Jogler, C., Tu, Q., Pósfai, M., Tompa, É., Plitzko, J.M., Brachmann, A., Wanner, G., Müller, R., Zhang, Y. and Schüler, D. (2014) Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters, Nat. Nanotechnol., 9 (3): 193-197. 

Reker, D., Perna, A., Rodrigues, T., Schneider, P., Reutlinger, M., Mönch, B., Koeberle, A., Lamers, C., Gabler, M., Steinmetz, H., Müller, R., Schubert-Zsilavecz, M., Werz, O. and Schneider, G. (2014) Revealing the macromolecular targets of complex natural products, Nat. Chem., 6 (12): 1072-1078. 

Surup, F., Viehrig, K., Mohr, K.I., Herrmann, J., Jansen, R. and Müller, R. (2014) Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant Staphylococci, Angew. Chem., 53 (49): 13588-91. 

Hoffmann, T., Müller, S., Nadmid, S., Garcia, R. and Müller, R. (2013) Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont, J. Am. Chem. Soc., 135 (45): 16904-11. 

Viehrig, K., Surup, F., Harmrolfs, K., Jansen, R., Kunze, B. and Müller, R. (2013) Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease in-hibitor crocapeptin, J. Am. Chem. Soc., 135 (45): 16885-94. 

Barbier, J., Jansen, R., Irschik, H., Benson, S., Gerth, K., Böhlensorf, B., Höfle, G., Reichenbach, H., Wegner, J., Zeilinger, C., Kirschning, A. and Müller, R. (2012) Isolation and total synthesis of icumazoles and noricumazoles - antifungal antibiotics and cation-channel blockers from Sorangium cellulosum, Angew. Chem. Int. Ed., 51 (5): 1256-1260. 

Cortina, N.S., Krug, D., Plaza, A., Revermann, O. and Müller, R. (2012) Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome, Angew. Chem. Int. Ed., 51 (3): 811-816. 

Fu, J., Bian, X., Hu, S., Wang, H., Huang, F., Seibert, P.M., Plaza, A., Xia, L., Müller, R.*, Stewart, A.F.* and Zhang, Y.*(2012) Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Nat. Biotechnol., 30 (5): 440-446. *These authors contributed equally to this work.

Huo, L., Rachid, S., Stadler, M., Wenzel, S.C. and Müller, R. (2012) Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis, Chem. Biol., 19 (10): 1278-1287. 

Jahns, C., Hoffmann, T, Müller, S., Gerth, K., Washausen, P., Höfle, G., Reichenbach, H., Kalesse, M. and Müller, R. (2012) Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum, Angew. Chem., Int. Ed., 51 (21): 5239-5243. 

Katsuyama, Y., Harmrolfs, K., Pistorius, D., Li, Y. and Müller, R. (2012) A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase, Angew. Chem., Int. Ed., 51 (37): 9437-9440. 

Li, Y., Luxenburger, E. and Müller, R. (2013) An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase, Angew. Chem., Int. Ed., 52 (4): 1304-1308. 

Quade, N., Huo, L., Rachid, S., Heinz, D.W. and Müller, R. (2011) Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol., 8 (1): 117-124. 

Dehn, R.*, Katsuyama, Y.*, Weber, A., Gerth, K., Jansen, R., Steinmetz, H., Höfle, G., Müller, R.** and Kirschning, A.** (2011) Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition / macrolactonization, Angew. Chem., Int. Ed., 50 (17): 3882-3887. 

Pistorius, D., Li, Y., Mann, S. and Müller, R. (2011) Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis, J. Am. Chem. Soc., 133 (32): 12362-12365. 

Steinmetz, H., Gerth, K., Jansen, R., Schläger, N., Dehn, R., Reinecke, S., Kirschning, A. and Müller, R. (2011) Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers, Angew. Chem. Int. Ed., 50 (2): 532-536. 

Chai, Y., Pistorius, D., Ullrich, A., Weissman, K.J., Kazmaier, U. and Müller R. (2010) Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004, Chem. Biol., 17 (3): 296-309. 

Buntin, K., Rachid, S., Scharfe, M., Blöcker, H., Weissman, K.J. and Müller, R. (2008) Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications, Angew. Chem., Int. Ed., 47 (24): 4595-4599. 

Li, Y., Weissman, K.J. and Müller, R. (2008) Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester, J. Am. Chem. Soc., 130 (24): 7554-7555 

Menche, D., Arikan, F., Perlova, O., Horstmann, N., Ahlbrecht, W., Wenzel, S.C., Jansen, R., Irschik, H. and Müller, R. (2008) Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA-polymerase inhibitor from the myxobacterium Sorangium cellulosum, J. Am. Chem. Soc., 130 (43): 14234-14243. 

Sandmann, A., Dickschat, J., Jenke-Kodama, H., Kunze, B., Dittmann, E. and Müller, R. (2007) A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis, Angew. Chem., Int. Ed., 46 (15): 2712-2716. 

Meiser, P., Bode, H.B. and Müller, R. (2006) The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation, Proc. Natl. Acad. Sci. U.S.A., 103 (50): 19128-19133. 

Wenzel, S.C., Meiser, P., Binz, T.M., Mahmud, T. and Müller, R. (2006) Nonribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversityAngew. Chem., Int. Ed., 45 (14): 2296-2301. 

Wenzel, S.C., Williamson, R.M., Grünanger, C., Xu, J., Gerth, K., Martinez, R.A., Moss, S.R., Carroll, B.J., Grond, S., Unkefer, C.J., Müller, R. and Floss H.G. (2006) On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A, J. Am. Chem. Soc., 128 (44): 14325-14336. 

Bode, H.B., Dickschat, J.S., Kroppenstedt, R.M., Schulz, S. and Müller, R. (2005) Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from α-oxidation of iso-odd fatty acids, J. Am. Chem. Soc., 127 (2): 532-533. 

Wenzel, S.C., Gross, F., Zhang, Y., Fu, J., Stewart, A.F. and Müller, R. (2005) Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering, Chem. Biol., 12 (3): 349-356. 

Bode, H.B., Wenzel, S.C., Irschik, H., Höfle, G. and Müller, R. (2004) Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosum, Angew. Chem. Int. Ed., 43 (32): 4163-4167. 

Gaitatzis, N., Kunze, B. and Müller, R. (2001) In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: biochemical characterisation of a reductive release mechanism from nonribosomal peptide synthetases, Proc. Natl. Acad. Sci. U.S.A., 98 (20): 11136-11141. 

Complete publication list

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369. Von Tesmar, A., Hoffmann, M., Pippel, J., Abou Fayad, A., Dausend-Werner, S., Bauer, A., Blankenfeldt, W. and Müller, R. (2017) Total biosynthesis of the pyrrolo [4,2] benzo-diazepine scaffold tomaymycin on an in vitro reconstituted NRPS system, Cell. Chem. Biol., accepted.

368. Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. (2017) Bacterial versus chemical diversity: The phylogeny paradigm in microbial natural product discovery, Nat. Commun., accepted.

367. Cheng, B., Müller, R. and Trauner, D. (2017) Total syntheses of cystobactamids and structural confirmation of cystobactamid 919-2, Angew. Chem. Int. Ed., epub ahead of print.

366. Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. (2017) Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogensAngew. Chem. Int. Ed., epub ahead of print.

365. Kjaerulff, L., Raju, R., Panter, F., Scheid, U., Garcia, R., Herrmann, J. and Müller, R. (2017) Pyxipyrrolones: Novel cytotoxic myxobacterial metabolites. Structure elucidation and biosynthesis proposal, Angew. Chem. Int. Ed., 53 (32), 9614-18.

364. Bock, T., Luxenburger, E., Hoffmann, J., Schütza, V., Feiler, C., Müller, R. and Blankenfeldt, W. (2017) AibA/AibB induces an intramolecular decarboxylation in isovalerate biosynthesis by Myxococcus xanthusAngew. Chem. Int. Ed., epub ahead of print. .

363. Viehrig, K., Surup, F., Volz, C., Herrmann, J., Abou Fayad, A., Adam, S., Köhnke, J., Trauner, D. and Müller, R. (2017) Structure and biosynthesis of crocagins: Polycyclic postranslationally modified ribosomal peptides from Chondromyces crocatus, Angew. Chem. Int. Ed., epub ahead of print.

362. Bian, X., Tang, B., Yu, Y., Tu, Q., Gross, F., Wang, H., Li. A., Fu, J., Shen, Y., Li., Y., Stewart, A. F., Zhao, G., Ding, X., Müller, R. and Zhang, Y. (2017) Heterologous production and yield improvement of epothilones in the Burkholderiales strain DSM 7029, ACS Chem. Biol., epub ahead of print.

361. Montes Vidal, D., v. Rymon-Lipinski, A.-L., Ravella, S., Groenhagen, U., Herrmann, J., Zaburannyi, N., Zarbin, P.H.G, Varadarajan, A.R., Ahrens, C.H., Weisskopf, L., Müller, R. and Schulz, S. (2017) Long-chain alkyl cyanides: Unprecedented volatile compounds released by Pseudomonas and Micromonospora bacteriaAngew. Chem. Int. Ed., 56 (15): 4342-4346.

360. Awal, R.P., Garcia, R., Gemperlein, K., Wink, J., Kunwar, B., Parajuli, N. and Müller, R. (2017) Vitiosangium cumulatum gen. nov., sp. nov. and Vitiosangium subalbum sp. nov., novel soil myxobacteria from Nepal, and emended descriptions of genus Archangium and Angiococcus, and of Cystobacteraceae family, Int. J. Syst. Evol. Microbiol., 67(5), 1422-30.

359. Kirschning, A., Wang, L.L., Candito, D., Herrmann, J., Müller, R. and Dräger, G. (2017) Harnessing a p-quinone methide intermediate in the biomimetic total synthesis of the highly acitve antibiotic 20-deoxy-elansolid B1, Chemistry, epub ahead of print.

358. Thomas, L., Rao, Z., Gerstmeier, J., Raasch, M., Weinigel, C., Rummler, S., Menche, D., Müller, R., Pergola, C., Mosig, A. and Werz, O. (2017) Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with V-ATPase, Biochem. Pharmacol., 130: 71-82.

357. Wenzel, S.C. and Müller, R. (2017) Host Organisms: Myxobacterium, In: Industrial Biotechnology, Wiley-VCH, 455-485.

356. Pergola, C., Schubert, K., Pace, S., Ziereisen, J., Nikels, F., Scherer, O., Hüttel, S., Zahler, S., Vollmar, A.M., Weinigel, C., Rummler, S., Müller, R., Raasch, M., Mosig, A., Koeberle, A. and Werz, O. (2017) Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy, Sci. Rep., epub ahead of print.

355. Wang, Y., Schnell, B., Baumann, S., Müller, R. and Begley, T.P. (2017) Biosynthesis of branched alkoxy groups: interative methyl group alkylation by a cobalamin-dependent radical SAM enzyme, J. Am. Chem. Soc, 139 (5):1742-1745.

354. Fu, C., Auerbach, D., Li, Y., Scheid, U., Luxenburger, E., Garcia, R., Irschik, H. and Müller, R. (2017) Solving the puzzle of one-carbon loss in ripostatin biosynthesis, Angew. Chem. Int. Ed., 56 (8): 2192-2197.

353. Rox, K., Rohde, M., Chhatwal, G.S. and Müller, R. (2017) Disorazoles block group A streptococcal invasion into epithelial cells via interference with host factor ezrin, Cell Chem. Biol., 24 (2): 159-170.

352. Bock, T., Volz, C., Hering, V., Scrima, A., Müller, R. and Blankenfeldt, W. (2017) The AibR-isovaleryl coenzyme A regulator and its DNA binding site – A model for the regulation of alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthusNuc. Acids Res., 45 (4), 2166-78.

351. Chen, J., Liu, M., Liu, X., Miao, J., Fu, C., Gao, H., Müller, R., Zhang, Q., Zhang, L. (2016) Interrogation of Streptomyces avermitilis for efficient production of avermectins, Synth. Syst. Biotechnol., epub ahead of print.

350. Kjaerulff, L., Benie, A.J., Hoeck, C., Gotfredsen, C.H., Sorensen, O.W. (2016) S(3) HMBC: spin-state-selective HMBC for accurate measurement of homonuclear coupling constants. Application to strychnine yielding thirteen hitherto unreported J(HH), J. Magn. Reson., 263: 101-107.

349. Preisitsch, M., Niedermeyer, T.H.J., Heiden, S.E., Neidhardt, I., Kumpfmüller, J., Wurster, M., Harmrolfs, K., Wiesner, C., Enke, H., Müller, R. and Mundt, S. (2016) Cylindrofridins A-C, linear cylindrocyclophane-related alkylresorcinols from the cyanobacterium Cylindrospermum stagnale, J. Nat. Prod., 79 (1): 106-115.

348. Bartel, K., Winzi, M., Ulrich, M., Koeberle, A., Menche, D., Werz, O., Müller, R., Guck, J., Vollmar, A. M. and Schwarzenberg, K. (2016) V-ATPase inhibition increases cancer cell stiffnes and blocks membrane related Ras signaling - a new option for HCC therapy, Oncotarget, epub ahead of print.

347. Mann, G., Huo, L., Adam, S., Nardone, B., Vendome, J., Westwood, N.J., Müller, R. and Koehnke, J. (2016) Structure and substrate recognition of the bottromycin maturation enzyme BotP, ChemBioChem, 17 (23), 2286-2292.

346. Herrmann, J., Abou Fayad, A. and Müller R. (2016) Natural products from myxobacteria: novel metabolites and bioactivities, Nat. Prod. Rep., epub ahead of print.

345. Herrmann, J., Lukežič, T., Kling, A., Baumann, S., Hüttel, S., Petković, H. and Müller R. (2016) Strategies for the discovery and development of the new antibiotics from natural products: Three case studies, In: Current topics in microbiology and immunology, Springer, 398: 339-363.

344. Schmidt, W., Jones, P.G., Herrmann, J., Müller, R. and Schulz, St. (2016) An unprecedented octahydro-3H-oxeto 2,3,4-ij isochromene ring system formed by a trichloromethyl-anion-induced reaction cascade, Synlett, epub ahead of print.

343. Wink, J., Moradi, A., Ebrahimipour, G.H., Mohr, K., Kämpfer, P., Glaeser, St., Hennessen, F., Gemperlein, K., Awal, R.P., Wolf, C. and Müller, R. (2016) Racemicystis persica sp. nov., a novel myxobacterium from Iranian soil, Int. J. Syst. Evol. Microbiol., epub ahead of print.

342. Luniak, N., Meiser, P. Burkart, S. and Müller, R. (2016) Heterologous expression of the plant cysteine protease bromelain and its inhibitor in Pichia pastoris, Biotechnology progress, epub ahead of print.

341. Wang, M., Carver, J.J., Phelan, V.V., Sanchez, L.M., Garg, N., Peng, Y., Nguyen, D.D., Watrous, J., Kapono, C.A., Luzzatto-Knaan, T., Porto, C., Bouslimani, A., Melnik, A.V., Meehan, M.J., Liu, W.T., Crüsemann, M., Boudreau, P.D., Esquenazi, E., Sandoval-Calderón, M., Kersten, R.D., Pace, L.A., Quinn, R.A., Duncan, K.R., Hsu, C.C., Floros, D.J., Gavilan, R.G., Kleigrewe, K., Northen, T., Dutton, R.J., Parrot, D., Carlson, E.E., Aigle, B., Michelsen, C.F., Jelsbak, L., Sohlenkamp, C., Pevzner, P., Edlund, A., McLean, J., Piel. J., Murphy, B.T., Gerwick, L., Liaw, C.C., Yang, Y.L., Humpf, H.U., Maansson, M., Keyzers, R.A., Sims, A.C., Johnson, A.R., Sidebottom, A.M., Sedio, B.E., Klitgaard, A., Larson, C.B., Boya, P.C.A, Torres-Mendoza D., Gonzalez, D.J., Silva, D.B., Marques, L.M., Demarque, D.P., Pociute, E., O'Neill, E.C., Briand, E., Helfrich, E.J., Granatosky, E.A., Glukhov, E., Ryffel, F., Houson, H., Mohimani, H., Kharbush, J.J., Zeng, Y., Vorholt, J.A., Kurita, K.L., Charusanti, P., McPhail, K.L., Nielsen, K.F., Vuong, L., Elfeki, M., Traxler, M.F., Engene, N., Koyama. N., Vining, O.B., Baric, R., Silva, R.R., Mascuch, S.J., Tomasi, S., Jenkins, S., Macherla, V., Hoffman, T., Agarwal, V., Williams, P.G., Dai, J., Neupane, R., Gurr, J., Rodríguez, A.M., Lamsa, A., Zhang, C., Dorrestein, K., Duggan, B.M., Almaliti, J., Allard, P.M., Phapale, P., Nothias, L.F., Alexandrov, T., Litaudon, M., Wolfender, J.L., Kyle, J.E., Metz, T.O., Peryea, T., Nguyen, D.T., VanLeer. D., Shinn, P., Jadhav, A., Müller, R., Waters, K.M., Shi, W., Liu, X., Zhang, L., Knight, R., Jensen, P.R., Palsson, B.Ø., Pogliano, K., Linington, R.G., Gutiérrez, M., Lopes, N.P., Gerwick, W.H., Moore, B.S., Dorrestein, P.C., Bandeira, N. (2016) Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking, Nat. Biotechnol., 34(8): 828-837.

340. Maurer, C.K., Fruth, M., Empting, M., Avrutina, O., Hoßmann, J., Nadmid, S. Gorges, J., Herrmann, J., Kazmaier, U., Dersch, P., Müller, R. and Hartmann, R. (2016) Discovery of the first small-molecule CrsA-RNA interaction inhibitors using biosphysical screening technologies, Future Med. Chem., 8(9): 931-947.

339. Meusel, M., Hufsky, F., Panter, F., Krug, D., Müller, R. and Böcker, S. (2016) Predicting the presence of uncommon elements in unknown biomolecules from isotope patterns, Anal. Chem., 88 (15): 7556-66.

338. Donner, J., Reck, M., Bergmann, S., Kirschning, A., Müller R. and Wagner-Döbler, I. (2016) The biolfilm inhibitor Carolacton inhibits planktonic growth of virulent pneumococci via a conserved target, Sci. Rep, 6: 29677.

337. Bock, T., Müller, R. and Blankenfeldt, W. (2016) Crystal structure of AibC, a reductase involved in alternative de novo isovaleryl coenzyme A biosynthesis in Myxococcus xanthus, Acta Crystallogr. F Struct. Biol. Commun., 72(Pt 8):652-8.

336. Bock, T., Reichelt, J., Müller, R. and Blankenfeldt, W. (2016) The structure of LiuC, a 3-hydroxy-3-methylglutaconyl CoA dehydratase involved in isovaleryl CoA biosynthesis in Myxococcus xanthus, reveals insights into specificity and catalysis, ChemBioChem, 17 (17), 1658-1664.

335. Beck, S., Henß, L., Weidner, T., Herrmann, J., Müller, R., Chao, Y.-K., Grimm, C., Weber, C., Sliva, K., and Schnierle, B. S. (2016) Identification of entry inhibitors of Ebola virus pseudotyped vectors from a myxobacterial compound library, Antiviral Res., 132: 85-91.

334. Steinmetz, H., Li, J., Fu, C., Zaburannyi, N., Kunze, B., Harmrolfs, K., Schmitt, V., Herrmann, J., Reichenbach, H., Höfle, G., Kalesse, M.* and Müller, R.* (2016) Isolation, structure elucidation and (bio)synthesis of haprolid, a cell-type-specific myxobacterial cytotoxin, Angew. Chem. Int. Ed., 55 (34): 10113-7. *These authors contributed equally to this work.

333. Fengler, V.H.I, Macheiner, T., Kessler, S.M., Czepukojc, B., Gemperlein, K., Müller, R., Kiemer, A.K., Magnes, C., Haybaeck, J., Lackner, C. and Sargsyan, K. (2016) Susceptibility of different mouse wild type strains to develop diet-included NAFLD/AFLD-associated liver desease, PLoS One, 11(5): e0155163.

332. Tautz, T., Hoffmann, J., Hoffmann, T., Steinmetz, H., Washausen, P., Kunze, B., Huch, V., Kitsche, A., Reichenbach, H., Höfle, G., Müller, R.* and Kalesse, M.* (2016) Isolation, structure elucidation, biosynthesis, and synthesis of antalid, a secondary metabolite from Polyangium species, Org. Lett., 18 (11): 2560–2563. *These authors contributed equally to this work.

331. Kessler, S.M., Laggai, S., Van Wonterg, E., Gemperlein, K., Müller, R., Haybaeck, J., Vandenbroucke, R.E., Ogris, M., Libert, C. and Kiemer, A.K. (2016) Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation, Front. Physiol., 7:147: 1-11.

330. Schneider, L.S., Ulrich, M. Lehr, T., Menche, D., Müller, R. and von Schwarzenberg, K. (2016) MDM2 antagonist nutlin-3a sensitizes tumors to V-ATPase inhibition, Mol. Oncol., 10 (7): 1054-62.

329. Salamanca-Pinzon, S.G., Khatri, Y., Carius, Y., Keller, L., Müller, R., Lancaster, C.R.D. and Bernhardt, R. (2016) Structure-function analysis for the hydroxylation of Δ4 C21-steroids by the myxobacterial CYP260B1, FEBS Lett., 590 (2016): 1838–1851.

328. Bock, T., Kasten, J., Müller R. and Blankenfeldt, W. (2016) Crystal structure of the HMG-CoA synthase MvaS from the Gram-negative bacterium Myxococcus xanthusChemBioChem, 17 (13): 1257-62.

327. Tu, Q., Yin, J., Fu, J., Herrmann, J., Li., Y., Yin, Y, Stewart, A.F., Müller R. and Zhang, Y. (2016) Room temperature electrocompetent bacterial cells improve DNA transformation and recombineering efficiency, Sci. Rep, 6: 24648.

326. Awal, R.P., Garcia R. and Müller, R. (2016) Racemicystis crocea gen. nov., a novel soil myxobacterium in Polyangiaceae, Int. J. Syst. Evol. Microbiol., 66 (6): 2389–2395.

325. Lohße, A., Kolinko, I., Raschdorf, O., Uebe, R., Borg, S., Brachmann, A., Plitzko, J.M., Müller, R., Zhang, Y. and Schüler, D. (2016) Overproduction of mangnetosomes by genomic amplification of biosynthetis-related gene clusters in a magnetotactic bacterium, Appl. Environ. Microbiol., 82 (10): 3032-3041.

324. Zaburannyi, N., Bunk, B., Maier, J., Overmann, J. and Müller R. (2016) Genome analysis of the fruiting body-forming myxobacterium Chondromyces crocatus reveals high potential for natural product biosynthesis, Appl. Environ. Microbiol., 82 (6): 1945-57.

323. Wang, H., Li, Z., Jia, R., Hou, Y., Yin, J., Bian, X., Li, A., Müller, R., Stewart, A.F., Fu, J. and Zhang, Y. (2016) RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression, Nat. Prot., 11 (7): 1175-90.

322. Wu, H., Wang, Y., Yuan, L., Mao, Y., Wang, W., Zhu, L., Wu, P., Fu, C., Müller, R., Weaver, D.T., Zhang, L. and Zang, B. (2016) Inactiviation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea, Syst. Synth. Biol., 1 (1): 39-46.

321. Tu, Q., Herrmann, J., Hu, S., Raju, R., Bian, X., Zhang, Y. and Müller, R. (2016) Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering, Sci. Rep., 6: 21066.

320. Essig, S., Schmalzbauer, B., Bretzke, S., Scherer, O., Koeberle, A., Werz, O., Müller, R. and Menche, D. (2016) Predictive bioinformatic assignment of methyl-bearing stereocenters, total synthesis, and an additional molecular target of ajudazol B, J. Org. Chem., 81 (4): 1333 –1357.

319. Elnakady, Y.A., Chatterjee, I., Bischoff, M., Rohde, M., Josten, M., Sahl, H.-G., Herrmann, M. and Müller, R. (2016) Investigations to the antibacterial mechanism of action of kendomycin, PLoS One, 11 (1): e0146165.

318. Preisitsch, M., Heiden, S.E., Beerbaum, M. Niedermeyer, T.H.J., Schneefeld, M., Herrmann, J., Kumpfmüller, J., Thürmer, A., Neidhardt, I., Wiesner, C., Daniel, R., Müller, R., Bange, F.-C., Schmieder, P., Schweder, T. and Mundt, S. (2016) Effects of halide ions on the carbamidocyclophane biosynthesis in Nostoc sp. CAVN2, Mar. Drugs., 14 (1): E21.

317. Jackson, D., Tu, Stephanie S., Nguyen, M., Barajas, J., Schaub, A., Krug, D., Pistorius, D., Luo, R., Müller, R. and Tsai, S.C. (2016) Structural insights into anthranilate priming during type II polyketide biosynthesis, ACS Chem. Biol., 11 (1): 95-103.

316. Perin P.M., Haid S., Brown R.J., Doerrbecker J., Schulze K., Zeilinger C., von Schaewen M., Heller B., Vercauteren K., Luxenburger E., Baktash Y.M., Vondran F.W., Speerstra S., Awadh A., Mukhtarov F., Schang L.M., Kirschning A., Müller R., Guzman C.A., Kaderali, L., Randall, G., Meuleman, P., Ploss, A. and Pietschmann, T. (2016) Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1, Hepatology, 63 (1): 49-62.

315. Gemperlein, K., Zipf, G., Bernauer, H.S., Müller, R. and Wenzel, S.C. (2016) Metabolic engineering of Pseudomonas putida for production of docosahexaenoic acid based on a myxobacterial PUFA synthase, Metab. Eng., 33: 98-108.

314. Lee, W., Schaefer, K., Qiao, Y., Srisuknimit, V., Steinmetz, H., Müller, R., Kahne, D. and Walker Suzanne. (2016) The mechanism of action of lysobactin, J. Am. Chem. Soc., 138 (1): 100-3.

313. Garcia, R., Stadler, M., Gemperlein, K. and Müller, R. (2016) Aetherobacter fasciculatus gen. nov., sp. nov. and Aetherobacter rufus gen. nov., sp. nov., two novel myxobacteria with promising biotechnological applications, Int. J. Syst. Evol. Microbiol., 66: 928-938.

312. Todorova, K., Maurer, P., Rieger, M., Becker, T., Bui, N.K., Gray, J., Vollmer, W., Hakenbeck, R. (2015) Transfer of penicillin resistance from Streptococcus oralis to Streptococcus pneumoniae identifies murE as resistance determinant, Mol. Microbiol., 97 (5): 866-880. 6

311. Hoffmann, T., Dorrestein, P.C. (2015) Homogeneous matrix deposition on dried agar for MALDI imaging mass spectrometry of microbial cultures, J. Am. Soc. Mass. Spectrom., 26(11): 1959-62.

310. Yin, J., Hoffmann, M., Bian, X., Tu, Q., Yan, F., Xia, L., Ding, X., Stewart, A.F., Müller, R., Fu, J., and Zhang, Y. (2015) Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2), Sci. Rep., 5: 15081.

309. Zhang, S., Schneider, L.S., Vick, B., Grunert, M., Jeremias, I., Menche, D., Müller, R., Vollmar, A. M. and Liebl, J. (2015) Anti-leukemic effects of the V-ATPase inhibitor Archalozid A, Oncotarget, 6 (41): 43508-28.

308. Wenzel, S.C., Hoffmann, H., Zhang, J., Debussche, L., Haag-Richter, S., Kurz, M., Nardi, F., Lukat, P., Kochems, I., Tietgen, H., Schummer, D., Nicolas, J.-P., Calvet, L., Czepczor, V., Vrignaud, P., Mühlenweg, A., Pelzer S., Müller, R. and Brönstrup, M. (2015) Production of the bengamide class of marine natural products in myxobacteria: Biosysnthesis and structure-activity relationships, Angew. Chem. Int. Ed., 54 (51): 15560-64.

307. Knapp, A., Voget, S., Gao, R., Zaburannyi, N., Krysciak, D., Breuer, M., Hauer, B. Streit, W. R., Müller, R., Daniel, R. and Jaeger, K.-E. (2015) Mutations improving production and secretion of extracellular lipase by Burkholderia glumae PG1, Appl. Microbiol. Biotechnol., epub ahead of print.

306. Kuhnert, E., Surup F., Herrmann J., Huch V., Müller, R. and Stadler M. (2015) Rickenyls A-E, new antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota), Phytochemistry, 118: 68-73.

305. Medema, M.H, Kottmann, R., Yilmaz, P., Cummings, M, Biggins, J.B., Blin, K., de Bruijn, I., Chooi, Y.H., Claesen, J., Coates, R.C., Cruz-Morales, P., Duddela, S., Düsterhus, S., Edwards, D.J., Fewer, D.P., Garg, N., Geiger, C., Gomez-Escribano, J.P., Greule, A., Hadjithomas, M., Haines, AS., Helfrich, E.J., Hillwig, M.L., Ishida, K., Jones, A.C., Jones, C.S., Jungmann, K., Kegler, C., Kim, H.U., Kötter, P., Krug, D., Masschelein, J., Melnik, A.V., Mantovani, S.M., Monroe, E.A., Moore, M., Moss, N., Nützmann, H.W., Pan, G., Pati, A., Petras. D., Reen, F.J., Rosconi, F., Rui, Z., Tian, Z., Tobias, N.J., Tsunematsu. Y., Wiemann, P., Wyckoff. E., Yan, X., Yim, G., Yu, F., Xie, Y., Aigle, B., Apel, A. K., Balibar, C.J., Balskus E.P., Barona-Gómez, F., Bechthold, A., Bode, H.B., Borriss, R., Brady, S.F., Brakhage, A.A., Caffrey, P., Cheng, Y.Q., Clardy, J., Cox, R.J., De Mot, R., Donadio, S., Donia, M.S., van der Donk, W.A., Dorrestein, P.C., Doyle, S., Driessen, A.J., Ehling-Schulz, M., Entian, K.D., Fischbach, M.A., Gerwick, L., Gerwick, W.H., Gross, H., Gust B., Hertweck, C., Höfte, M., Jensen, S.E., Ju, J., Katz, L., Kaysser, L., Klassen, JL., Keller, N.P., Kormanec, J., Kuipers, O.P., Kuzuyama, T., Kyrpides, N.C., Kwon, H.J., Lautru, S., Lavigne, R., Lee, C.Y., Linquan, B., Liu. X., Liu, W., Luzhetskyy, A., Mahmud, T., Mast, Y., Méndez, C., Metsä-Ketelä, M., Micklefield, J., Mitchell, D.A., Moore, B.S., Moreira, L.M., Müller, R., Neilan, B.A., Nett, M., Nielsen, J, O'Gara, F., Oikawa, H., Osbourn, A., Osburne, M.S., Ostash, B., Payne, S.M., Pernodet, J.L., Petricek, M., Piel, J., Ploux, O., Raaijmakers, J.M., Salas, J.A., Schmitt, E,K., Scott, B., Seipke, R.F., Shen, B., Sherman, D.H., Sivonen, K., Smanski, M.J., Sosio, M., Stegmann, E., Süssmuth, R.D., Tahlan, K., Thomas, C.M., Tang, Y., Truman, A.W., Viaud, M., Walton, J.D., Walsh, C.T., Weber, T., van Wezel, G.P., Wilkinson, B., Willey, J.M., Wohlleben, W., Wright, G.D., Ziemert, N., Zhang, C., Zotchev, S.B., Breitling, R., Takano, E. and Glöckner, F.O. (2015) Minimum information about a biosynthetic gene cluster, Nat. Chem. Biol., 11 (9): 625-31.

304. Jungmann, K., Jansen, R., Gerth, K., Huch, V., Krug, D., Fencial, W. and Müller, R. (2015) Two of a kind – The biosynthetic pathways of chlorotonil and anthracimycin, ACS Chem. Biol., 10 (11): 2480-90. 7

303. Braig, S., Schmidt, S., Stoiber, K., Händel, C., Möhn, T., Werz, O., Müller, R., Zahler, S., Koeberle, A., Käs, J.A., Vollmar, A.M. (2015) Pharmacological targeting of membrane rigidity: Implications on cancer cell migration and invasionNew. J. Phys., 17 (2015): 1-11.

302. Nadmid, S., Plaza, A., Garcia, R. and Müller, R. (2015) Cystochromones, unusual chro-mone-containing polyketides from the myxobacterium Cystobacter sp. MCy9104, J. Nat. Prod., 78 (8): 2023-8.

301. Mohr, K.I., Volz, C., Jansen, R., Wray, V., Hoffmann, J., Bernecker, S., Wink, J., Gerth, K., Stadler, M. and Müller, R. (2015) Pinensins: The first antifungal lantibiotics, Angew. Chem. Int. Ed. Engl., 54 (38): 11254-8.

300. Keller, L., Plaza, A., Dubiella, C., Groll, M., Kaiser, M. and Müller, R. (2015) Macyranones: Structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome, J. Am. Chem. Soc., 137 (25): 8121-30.

299. Koutsoudakis, G., Romero-Brey, I., Berger, C., Pérez-Vilaró, G., Perin, P.M., Vondran, F.W. R., Kalesse, M., Harmrolfs, K., Müller, R., Martinez, J. P., Pietschmann, T., Bartenschlager, R., Brönstrup, M., Meyerhans, A. and Díez, J. (2015) Soraphen A: A broad-spectrum antiviral natural product with potent anti-hepatitis C virus activity, J. Hepatol., 63 (4): 813–821.

298. Fu, C., Keller, L., Bauer, A., Brönstrup, M., Froidbise, A., Hammann, P., Herrmann, J., Mondesert, G., Kurz, M., Schiell, M., Schummer, D., Toti, L., Wink, J. and Müller, R. (2015) Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity, J. Am. Chem. Soc.,137 (24): 7692-705.

297. Karmann, L., Schultz, K., Herrmann, J., Müller, R. and Kazmaier, U. (2015) Total syntheses and biological evalution of miuraenamides, Angew. Chem. Int. Ed. Engl., 54 (15): 4502-7.

296. Singaravelu, R., Desrochers, G.F., Srinivasan, P., O’Hara, S., Lyn, R.K., Müller, R., Jones, D.M., Russell, R.S. and Pezacki, P.J. (2015) Soraphen A: A probe for investigating the role of de novo lipogenesis during viral infectionACS Infect. Dis., 1 (3): 130-134.

295. Raju, R., Mohr, K.I., Bernecker, S., Herrmann, J. and Müller, R. (2015) Cystodienoic acid: A new diterpene isolated from the myxobacterium, Cystobacter sp., J. Antibiot., 68 (7): 473-5.

294. Franke, J., Bock, M., Dehn, R., Fohrer J., Mhaske, S. B., Migliorini, A., Kanakis A.A., Jansen, R., Herrnmann J., Müller, R. and Kirschning A. (2015) Total and semi-syntheses of antimicrobial thuggacin derivatives, Chem.--Eur. J.., 21 (11): 4272-84.

293. Sucipto, H., Sahner H. J., Prusov, E., Wenzel, S.C., Hartmann, R., Koehnke, J. and Müller, R., (2015) In Vitro reconstitution of α-pyrone ring formation in myxopyronin biosynthesis, Chem. Sci., 6 (8): 5076-5085.

292. Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H.U., Bruccoleri, R., Lee, S.Y., Fischbach, M.H. and Müller, R., Wohlleben, W., Breitling, R., Takano, E. and Medema, M.H (2015) AntiSMASH 3.0 – A comprehensive resource for the genome mining of biosynthetic gene clusters, Nucleic Acids Res., 43 (W1): W 237-43.

291. Bian, X., Plaza, A., Zhang, Y. and Müller, R. (2015) Two more pieces of the colibactin genotoxin puzzle form Escherichia coli show incorporation of an unusual 1-aminocyclo-propanecarboxylic acid moiety, Chem. Sci., 6 (5): 3154-3160.

290. Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E, Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M., Lair, C., Matter, H., Nuermberger, 8

E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. (2015) Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 348 (6239): 1106-12.

289. Moreno, M., Elgaher W.A.M., Herrmann, J., Schläger, N., Hamed, M.M., Baumann, S., Müller, R., Hartmann, R.W. and Kirschning, A. (2015) Synthesis and biological evaluation of cystobactamid 507: a bacterial topoisomerase inhibitor from Cystobacter sp., Synlett, 26 (09): 1175-1178.

288. Bian, X., Plaza, A., Yan, F., Zhang, Y. and Müller, R. (2015) Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivoBiotechnol. Bioeng., 112 (7):1343-53.

287. Lesnik, U., Lukezic, T., Podgorsek, A., Horvat, J., Polak, T., Sala, M., Jenko, B., Harmrolfs, K., Ocampo-Sosa, A., Martinez Martinez, L., Herron, P.R., Fujs, S., Kosec, G., Hunter, I.S., Müller, R. and Petkovic, H. (2015) Construction of a new class of tetracycline lead structures with potent antibacterial activity through biosynthetic engineering, Angew. Chem. Int. Ed., 54 (13): 3937-40.

286. Sahner, J.H., Sucipto, H., Wenzel, S.C., Groh, M., Hartmann, R.W. and Müller, R. (2015) Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvusChemBioChem, 16 (6): 946-53.

285. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A. and Müller, R. (2015) Albaflavenol B, a new sesquiterpene isolated from the terrestrial actinomycete, Streptomyces sp., J. Antibiot., 68 (4): 286-288.

284. Yin, J., Zhu, H., Xia, L., Ding, X., Hoffmann, T., Hoffmann, M., Bian, X., Müller, R., Fu, J., Stewart, A.F. and Zhang, Y. (2015) A new recombineering system for Photorhabdus and XenorhabdusNucleic Acids Res., 46 (6): 1-9.

283. Tang, Y., Frewert, S., Harmrolfs, K., Herrmann, J., Karmann, L., Xia, L., Zhang, Y. and Müller, R. (2015) Heterologous expression of an orphan NRPS gene cluster from Paenibacillus larvae in Escherichia coli revealed production of sevadicin, J. Biotechnol., 194 (2015): 112-4.

282. Preisitsch, M., Harmrolfs, K., Pham, H.T., Heiden, S.E., Füssel, A., Wiesner, C., Pretsch, A., Swiatecka-Hagenbruch, M., Niedermeyer, T.H., Müller, R. and Mundt, S. (2015) Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2, J. Antibiot. (Tokyo), 68 (3): 165-177.

281. Sood, S., Awal, R.P., Wink, J., Mohr, K.I., Rohde, M., Stadler, M., Kämpfer, P., Glaeser, S.P., Schumann, P., Garcia, R. and Müller, R. (2015) Aggregicoccus edonensis gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample, Int. J. Syst. Evol. Microbiol., 65 (Pt 3): 745-53.

280. Wolf, A., Schoof, S., Baumann, S., Arndt, H.D. and Kirschner, K.N. (2014) Structure-activity relationships of thiostrepton derivatives: implications for rational drug design. J. Comut. Aided Mol. Des., 28 (12): 1205-1215.

279. Baumann, S., Herrmann, J., Raju, R., Steinmetz, H., Mohr, K.I., Hüttel, S., Harmrolfs, K., Stadler, M. and Müller, R. (2014) Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity, Angew. Chem. Int. Ed.,53 (52): 14605-14609.

278. Fruth, M., Plaza, A., Hinsberger, S., Sahner, J.H., Haupenthal, J., Bischoff, M., Jansen, R., Müller, R. and Hartmann, R.W. (2014) Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach, ACS Chem. Biol., 9 (11): 2656-2663. 9

277. Menhofer, M.H., Kubisch, R., Schreiner, L., Zorn, M., Förster, F., Müller, R., Rädler, J.O., Wagner, E., Vollmar, A.M. and Zahler, S. (2014) The actin targeting compound chondramide inhibits breast cancer metastasis via reduction of cellular contractility, PLoS One, 9 (11): e112542.

276. Hamm, R., Zeino, M., Frewert, S. and Efferth, T. (2014) Up-regulation of cholesterol associated genes as novel resistance mechanism in glioblastoma cells in response to archazolid B, Toxicol. Appl. Pharmacol., 281 (2014): 78-86.

275. Plaza, A. and Müller, R. (2014) Myxobacteria: Chemical diversity and screening strategies In: A. Osbourn, R. J. Goss and G. T. Carter (Eds) Natural Products: Discourse, Diversity, and Design, John Wiley & Sons, Inc., Hoboken, NJ, USA, epub ahead of print.

274. Jansen, R., Sood, S., Mohr, K.I., Kunze, B., Irschik, H., Stadler, M. and Müller, R. (2014) Nannozinones and sorazinones, unprecedented pyrazinones from myxobacteriaJ. Nat. Prod., 77 (11): 2545-52.

273. Simon, Y., Kessler, S.M., Gemperlein, K., Bohle, R.M., Müller, R., Baybaeck, J. and Kiemer, A.K. (2014) Elevated free cholesterol as a hallmark of non-alcoholic steatohepatitis in p62/insulin-like growth factor 2 mRNA binding protein 2-2 transgenic animals, World J. Gastroenterol., 20 (47): 17839-50.

272. Hoffmann, T., Krug, D., Hüttel, S. and Müller, R. (2014) Improving natural products identification through targeted LC-MS/MS in an untargeted secondary metabolomics workflow, Anal. Chem., 86 (21): 10780-10788.

271. Reker, D., Perna, A., Rodrigues, T., Schneider, P., Reutlinger, M., Mönch, B., Koeberle, A., Lamers, C., Gabler, M., Steinmetz, H., Müller, R., Schubert-Zsilavecz, M., Werz, O. and Schneider, G. (2014) Revealing the macromolecular targets of complex natural products, Nat. Chem., 6 (12): 1072-1078.

270. Menhofer, M.H., Bartel, D., Liebl, J., Kubisch, R., Busse, J., Wagner, E., Müller, R., Vollmar, A.M. and Zahler, S. (2014) In vitro and in vivo characterization of the actin polymerizing compound chondramide as an angiogenic inhibitor, Cardiovasc. Res., 104 (2): 303-314.

269. Surup, F., Viehrig, K., Mohr, K.I., Herrmann, J., Jansen, R. and Müller, R. (2014) Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant Staphylococci, Angew. Chem., 53 (49): 13588-91.

268. Berod, L., Friedrich, C., Nandan, A., Freitag, J., Hagemann, S., Harmrolfs, K., Sandouk, S., Hesse, C., Castro, C., Bähre, H., Tschirner, S., Gorinski, N., Gohmert, M., Mayer, C.T., Huehn, J., Ponimaskin, E., Abraham, W.R., Müller, R., Lochner, M. and Sparwasser, T. (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells, Nat. Med., 20 (11): 1327-33.

267. Garcia, R., Gemperlein, K. and Müller, R. (2014) Minicystis rosea gen. nov., sp. nov., a polyunsaturated fatty acid-rich and steroid-producing soil myxobacterium, Int. J. Syst. Evol. Microbiol., 64 (Pt 11): 3733-42.

266. Katsuyama, Y., Li, X.W., Müller, R. and Nay, B. (2014) Chemically unprecedented biocatalytic (AuaG) retro-[2,3]-wittig rearrangement: A new insight into aurachin B biosynthesis, ChemBioChem, 15 (16): 2349-2352.

265. Scherer, O., Steinmetz, H., Kaether, C., Weinigel, C., Barz, D., Kleinert, H., Menche, D., Müller, R., Pergola, C. and Werz, O. (2014) Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum, Biochem. Pharmacol., 91 (4): 490-500.

264. Held, J., Gebru, T., Kalesse, M., Jansen, R., Gerth, K., Müller, R. and Mordmüller, B. (2014) Antimalarial activity of the myxobacterial macrolide chlorotonil A, Antimicrob. Agents Chemother., 58 (11): 6378-6384.

263. Sood, S., Steinmetz, H., Beims, H., Mohr, K.I., Stadler, M., Djukic, M., von der Ohe, W., Steinert, M., Daniel, R. and Müller, R. (2014) Paenilarvins: Iturin family lipopeptides from the honey bee pathogen Paenibacillus larvaeChemBioChem, 15 (13): 1947-1955.

262. Oßwald, C., Zaburannyi, N., Burgard, C., Hoffmann, T., Wenzel, S.C. and Müller, R. (2014) A highly unusual polyketide synthase directs dawenol polyene biosynthesis in Stigmatella aurantiacaJ. Biotechnol., 191: 54-63.

261. Förster, F., Braig, S., Moser, C., Kubisch, R., Busse, J., Wagner, E., Schmöckel, E., Mayr, D., Schmitt, S., Hüttel, S., Zischka, H., Müller, R. and Vollmar, A. (2014) Targeting the actin cytoskeleton: selective anti-tumor action via trapping PKCε, Cell Death Dis., 5: e1398.

260. Nadmid, S., Plaza, A., Lauro, G., Garcia, R., Bifulco, G. and Müller, R. (2014) Hyalachelins A-C, unusual siderophores isolated from the terrestrial myxobacterium Hyalangium minutumOrg. Lett., 16 (16): 4130-4133.

259. Bian, X., Huang, F., Wang, H., Klefisch, T., Müller, R. and Zhang, Y. (2014) Heterologous production of glidobactins/luminmycins in Escherichia coli nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029, ChemBioChem, 15 (15): 2221-2224.

258. Beck, P., Heinemeyer, W., Späth, A.L., Elnakady, Y.A., Müller, R. and Groll, M. (2014) Interactions of the natural product kendomycin and the 20S proteasome, J. Mol. Biol., 426 (18): 3108-3117.

257. Brötz, E., Herrmann, J., Wiese, J., Zinecker, H., Maier, A., Kelter, G., Imhoff, J.F., Müller, R., and Paululat, T. (2014) Synthesis and cytotoxic activity of a small naphthoquinone library - first synthesis of juglonbutin, European J. Org. Chem., 2014 (24): 5318-5330.

256. Müller, S., Rachid, S., Hoffmann, T., Surup, F., Volz, C., Zaburannyi, N. and Müller, R. (2014) Biosynthesis of crocacin involves an unprecedented hydrolytic release domain showing similarity to condensation domains, Chem. Biol., 21 (7): 855-865.

255. Okanya, P.W., Mohr, K.I., Gerth, K., Kessler, W., Jansen, R., Stadler, M. and Müller, R. (2014) Hyafurones, hyapyrrolines, and hyapyrones: polyketides from Hyalangium minutumJ. Nat. Prod., 77 (6): 1420-1429.

254. Etzbach, L., Plaza, A., Garcia, R., Baumann, S. and Müller, R. (2014) Cystomanamides: structure and biosynthetic pathway of a family of glycosylated lipopeptides from myxobacteriaOrg. Lett., 16 (9): 2414-2417.

253. Raju, R., Garcia, R. and Müller, R. (2014) Angiolactone, a new butyrolactone isolated from the terrestrial myxobacterium, Angiococcus sp., J. Antibiot. (Tokyo), 67 (10): 725-726.

252. Laggai, S., Kessler, S.M., Boettcher, S., Lebrun, V., Gemperlein, K., Lederer, E., Leclercq, I.A., Müller, R., Hartmann, R.W., Haybaeck, J. and Kiemer, A. (2014) The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis, J. Lipid Res., 55 (6): 1087-1097. 11

251. Krug, D. and Müller, R. (2014) Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products, Nat. Prod. Rep., 31 (6): 768-783.

250. Kessler, S.M., Simon, Y., Gemperlein, K., Gianmoena, K., Cadenas, C., Zimmer, V., Pokorny, J., Barghash, A., Helms, V., van Rooijen, N., Bohle, R.M., Lammert, F., Hengstler, J.G., Müller, R., Haybaeck, J. and Kiemer, A.K. (2014) Fatty acid elongation in non-alcoholic steatohepatitis and hepatocellular carcinoma, Int. J. Mol. Sci., 15 (4): 5762-5773.

249. Jansen, R., Mohr, K., Bernecker, S., Stadler, M. and Müller, R. (2014) Indothiazinone, an indolyl-thiazolyl-ketone from a novel myxobacterium belonging to the SorangiineaeJ. Nat. Prod., 77 (4): 1054-1060.

248. Schempp, C.M., von Schwarzenberg, K., Schreiner, L., Kubisch, R., Müller, R., Wagner, E. and Vollmar, A.M. (2014) V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells, Mol. Cancer Ther., 13 (4): 926-937.

247. Raju, R., Gromyko, O., Andriy, B., Fedorekno, V., Luzhetskyy, A. and Müller, R. (2014) Oleamycins A and B: new antibacterial cyclic hexadepsipeptides isolated from a terrestrial Streptomyces sp., J. Antibiot., 67 (4): 339-343.

246. Kubisch, R., von Gamm, M., Braig, S., Ullrich, A., Burkhart, J.L., Colling, L., Herrmann, J., Scherer, O., Müller, R., Werz, O., Kazmaier, U. and Vollmer, A. (2014) Simplified pretubulysin derivatives and their biological effects on cancer cells, J. Nat. Prod., 77 (3): 536-542.

245. Jansen, R., Sood, S., Huch, V., Kunze, B., Stadler, M. and Müller, R. (2014) Pyrronazols, metabolites from the myxobacteria Nannocystis pusilla and N. exedens, are unusual chlorinated pyrone-oxazole-pyrroles, J. Nat. Prod., 77 (2): 320-326.

244. Kolinko, I., Lohße, A., Borg, S., Raschdorf, O., Jogler, C., Tu, Q., Pósfai, M., Tompa, É., Plitzko, J.M., Brachmann, A., Wanner, G., Müller, R., Zhang, Y. and Schüler, D. (2014) Biosynthesis of magnetic nanostructures in a foreign organism by transfer of bacterial magnetosome gene clusters, Nat. Nanotechnol., 9 (3): 193-197.

243. Gemperlein, K., Rachid, S., Garcia, R., Wenzel, S.C. and Müller, R. (2014) Polyunsaturated fatty acid biosynthesis in myxobacteria: Different PUFA synthases and their product diversityChem. Sci., 5 (5): 1733-1741.

242. Wang, H., Bian, X., Xia, L., Ding, X., Müller, R., Zhang, Y., Fu, J. and Stewart, F.A. (2014) Improved seamless mutagenesis by recombineering using ccdB for counterselection, Nucleic Acids Res., 42 (5): e37.

241. Kreutzer, M.F., Kage, H., Herrmann, J., Pauly, J., Hermenau, R., Müller, R., Hoffmeister, D. and Nett, M. (2014) Precursor-directed biosynthesis of micacocidin derivatives with activity against Mycoplasma pneumoniaeOrg. Biomol. Chem., 12 (1): 113-118.

240. von Schwarzenberg, K., Lajtos, T., Simon, L., Müller, R., Vereb, G. and Vollmar, A.M. (2014) V-ATPase inhibition overcomes trastuzumab resistance in breast cancerMol. Oncol., 8 (1): 9-19.

239. Müller, R. and Wink, J. (2014) Future potential for anti-infectives from bacteria – how to exploit biodiversity and genomic potential, Int. J. Med. Microbiol., 304 (1): 3-13.

238. Garcia, R. and Müller, R. (2014) The Family Myxococcaceae In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds) The Prokaryotes 4th Edition, Springer, Berlin/Heidelberg, 191-212. 12

237. Garcia, R. and Müller, R. (2014) The Family Nannocystaceae In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds) The Prokaryotes 4th Edition, Springer, Berlin/Heidelberg, 213-229.

236. Garcia, R. and Müller, R. (2014) The Family Haliangiaceae In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds) The Prokaryotes 4th Edition, Springer, Berlin/Heidelberg, 173-181.

235. Garcia, R. and Müller, R. (2014) The Family Polyangiaceae In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds) The Prokaryotes 4th Edition, Springer, Berlin/Heidelberg, 247-279.

234. Garcia, R. and Müller, R. (2014) The Family Phaselicystidaceae In: Rosenberg, E., DeLong, E.F., Lory, S., Stackebrandt, E., Thompson, F. (Eds) The Prokaryotes 4th Edition, Springer, Berlin/Heidelberg, 239-245.

233. Oßwald, C., Zipf, G., Schmidt, G., Maier, J., Bernauer, H.S., Müller, R. and Wenzel, S. (2014) Modular construction of a functional artificial epothilone polyketide pathway, ACS Synth. Biol., 3 (10): 759-772.

232. Plaza, A., Viehrig, K., Garcia, R. and Müller, R. (2013) Jahnellamides, α-keto-β-methionine-containing peptides from the terrestrial myxobacterium Jahnella sp.: structure and biosynthesis, Org. Lett., 15 (22): 5882-5885.

231. Young, J., Stevens, D.C., Carmichael, R., Tan, J., Rachid, S., Boddy, C.N., Müller, R. and Taylor, R.E. (2013) Elucidation of gephyronic acid biosynthetic pathway revealed unexpected SAM-dependent methylations, J. Nat. Prod., 76 (12): 2269-2276.

230. Hoffmann, T., Müller, S., Nadmid, S., Garcia, R. and Müller, R. (2013) Microsclerodermins from terrestrial myxobacteria: An intriguing biosynthesis likely connected to a sponge symbiont, J. Am. Chem. Soc., 135 (45): 16904-11.

229. Viehrig, K., Surup, F., Harmrolfs, K., Jansen, R., Kunze, B. and Müller, R. (2013) Concerted action of P450 plus helper protein to form the amino-hydroxy-piperidone moiety of the potent protease in-hibitor crocapeptin, J. Am. Chem. Soc., 135 (45): 16885-94.

228. Storz, M.P., Brengel, C., Weidel, E., Hoffmann, M., Hollemeyer, K., Steinbach, A., Müller, R., Empting, M. and Hartmann, R.W. (2013) Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures, ACS Chem. Biol., 8 (12): 2794-2801.

227. Groß, P.C., Burkart, S.C. and Müller, R. (2013) Analytics of the therapeutic peptide aviptadil by sheathless CE-MS and comparison with nanoRP-HPLC-MS, J. Pharmaceut. Biomed. Anal., 88C, 477-482.

226. Sahner, J.H., Brengel, C., Storz, M.P., Groh, M., Plaza, A., Müller, R. and Hartmann, R.W. (2013) Combining in silico and biophysical methods for the development of Pseudomonas aeruginosa quorum sensing inhibitors ─ an alternative approach for structure-based drug design, J. Med. Chem., 56 (21): 8656-8664.

225. Sucipto, H., Wenzel, S.C. and Müller, R. (2013) Exploring chemical diversity of α-pyrone antibiotics: molecular basis of myxopyronin biosynthesis, ChemBioChem, 14 (13): 1581-1589.

224. Herrmann, J., Hüttel, S. and Müller, R. (2013) Discovery and biological activity of new chondramides from Chondromyces sp., ChemBioChem, 14 (13): 1573-1580. 13

223. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A. and Müller, R. (2013) Oleaceran: A novel spiro[isobenzofuran-1,2'-naptho[1,8-bcfuran] isolated from a terrestrial Streptomyces sp., Org. Lett., 15 (14): 3487-3489.

222. Weidel, E., DeJong, J.C., Brengel, C., Storz, M.P., Braunshausen, A., Negri, M., Plaza, A., Steinbach, A., Müller, R. and Hartmann, R.W. (2013) Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR and molecular docking, J. Med. Chem., 56 (15): 6146-6155.

221. Li, X.W., Herrmann, J., Zang, Y., Grellier, P., Prado, S., Müller, R.* and Nay, B.* (2013) Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues, Beilstein J. Org. Chem., 9: 1551-1558.

220. Zeino, M., Zhao, Q., Eichhorn, T., Herrmann, J., Müller, R. and Efferth, T. (2013) Molecular docking studies of myxobacterial disorazoles and tubulysins to tubulin, J. Biosci. Med., 3 (1): 37-44.

219. Ongley, S.E., Bian, X., Zhang, Y., Gerwick, W., Müller, R. and Neilan, B.A. (2013) High-titer heterologous production of lyngbyatoxin in E. coli, a protein kinase C activator from an uncultured marine cyanobacterium, ACS Chem. Biol., 8 (9): 1888-1893.

218. Ongley, S.E., Bian, X., Neilan, B.A. and Müller, R. (2013) Recent advances in the hetero-logous expression of microbial natural product biosynthetic pathways, Nat. Prod. Rep., 30 (8): 1121-1138.

217. Bian, X., Fu, J., Plaza, A., Herrmann, J., Pistorius, D., Stewart, A.F., Zhang, Y. and Müller, R. (2013) In vivo evidence for a prodrug activation mechanism during colibactin maturation, ChemBioChem, 14 (10): 1194-1197.

216. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A., Müller, R. (2013) Lorneic acids C and D, new trialkyl-substituted aromatic acids isolated from a terrestrial Streptomyces sp., J. Antibiot., 66 (6): 347-349.

215. Schmalzbauer, B., Herrmann, J., Müller, R. and Menche, D. (2013) Total synthesis and antibacterial activity of dysidavarone A, Org. Lett., 15 (4): 964-967.

214. Irschik, H., Washausen, P., Sasse, F., Fohrer, J., Huch, V., Müller, R. and Prusov, E.V. (2013) Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from Myxobacteria, Angew. Chem., Int. Ed., 52 (20): 5402-5405.

213. Li, Y., Luxenburger, E. and Müller, R. (2013) An alternative isovaleryl CoA biosynthetic pathway involving a previously unknown 3-methylglutaconyl CoA decarboxylase, Angew. Chem., Int. Ed., 52 (4): 1304-1308.

212. Wenzel, S.C. and Müller, R. (2013) Antibiotika In: Sahm, H., Antranikian, G., Stahmann, K.P., Takors, R. (Eds) Industrielle Mikrobiologie, Springer Spektrum, Berlin/Heidelberg, 149-178.

211. Kaufmann, K., Simmons, L., Herrmann, J., Schwär, G., Luniak, N. and Müller, R. (2013) Activity-guided screening of bioactive natural compounds implementing a new glucocorticoid-receptor-translocation assay and detection of new anti-inflammatory steroids from bacteriaBiotechnol. Lett., 35 (1): 11-20.

210. Arnison, P.G., Bibb, M.J., Bierbaum, G., Bowers, A.A., Bugni, T.S., Bulaj, G., Camarero, J.A., Campopiano, D.J., Challis, G.L., Clardy, J., Cotter, P.D., Craik, D.J., Dawson, M., Dittmann, E., Donadio, S., Dorrestein, P.C., Entian, K.D., Fischbach, M.A., Garavelli, J.S., Göransson, U., Gruber, C.W., Haft, D.H., Hemscheidt, T.K., Hertweck, C., Hill, C., Horswill, A.R., Jaspars, M., Kelly, W.L., Klinman, J.P., Kuipers, O.P., Link, A.J., Liu, W., Marahiel, M.A., Mitchell, D.A., Moll, G.N., Moore, B.S., Müller, R., Nair, S.K., Nes, I.F., Norris, G.E., Olivera, B.M., Onaka, H., Patchett, M.L., Piel, J., Reaney, M.J.T., Rebuffat, S., Ross, R.P., Sahl, H.G., Schmidt, E.W., Selsted, M.E., Severinov, K., Shen, B., Sivonen, K., Smith, L., Stein, T., Süssmuth, R.E., Tagg, J.R., Tang, G.L., Truman, A.W., Vederas, J.C., Walsh, C.T., Walton, J.D., Wenzel, S.C., Willey, J.M. and van der Donk, W. (2013) Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature, Nat. Prod. Rep., 30 (1): 108-160.

209. Raju, R., Gromyko, O., Fedorenko, V., Herrmann, J., Luzhetskyy, A. and Müller, R. (2013) Rubimycinone A, a new anthraquinone from a terrestrial Streptomyces sp., Tetrahedron Lett., 54 (8): 900-902.

208. Essig, S., Bretzke, S., Müller, R. and Menche, D. (2012) Full stereochemical determination of ajudazols A and B by bioinformatics gene cluster analysis and total synthesis of ajudazol B by an asymmetric ortholithiation strategy, J. Am. Chem. Soc., 134 (47): 19362-19365.

207. Barbie, P., Huo, L., Müller, R. and Kazmaier, U. (2012) Stereoselective synthesis of deuterium-labeled (2S)-cyclohexenyl alanines, biosynthetic intermediates of cinnabaramide, Org. Lett., e14 (23): 6064-6067. 

206. Okanya, P.W., Mohr, K.I., Gerth, K., Steinmetz, H., Huch, V., Jansen, R. and Müller, R. (2012) Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutumJ. Nat. Prod., 75: 768-770.

205. Wiedmann, R.M., von Schwarzenberg, K., Palamidessi, A., Schreiner, L., Kubisch, R., Liebl, J., Schempp, C., Trauner, D., Vereb, G., Zahler, S., Wagner, E., Müller, R., Scita, G. and Vollmar, A.M. (2012) The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1, Cancer Res., 72 (22): 5976-5987.

204. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A., Plaza, A. and Müller, R. (2012) Juniperolide A: A new polyketide isolated from a terrestrial actinomycete, Streptomyces sp., Org. Lett., e14 (23): 5860-5863.

203. Bielecki, P., Lukat, P., Hüsecken, K., Dötsch, A., Steinmetz, H., Hartmann, R.W., Müller, R. and Häussler, S. (2012) Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosaChemBioChem, 13 (16): 2339-2345.

202. Volz, C., Kegler, C. and Müller, R. (2012) Enhancer binding proteins act as hetero-oligomers and link secondary metabolite production to myxococcal development, motility, and predation, Chem. Biol., 19 (11): 1447-1459.

201. Steinmetz, H., Mohr, K., Zander, W., Jansen, R. and Müller, R. (2012) Indiacens A and B: prenyl indoles from the myxobacterium Sandaracinus amylolyticusJ. Nat. Prod., 75 (10): 1803-1805.

200. Huo, L., Rachid, S., Stadler, M., Wenzel, S.C. and Müller, R. (2012) Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis, Chem. Biol., 19 (10): 1278-1287.

199. Katsuyama, Y., Harmrolfs, K., Pistorius, D., Li, Y. and Müller, R. (2012) A semipinacol rearrangement directed by an enzymatic system featuring dual-function FAD-dependent monooxygenase, Angew. Chem., Int. Ed., 51 (37): 9437-9440. 15

198. Rath, S., Liebl, J., Fürst, R., Ullrich, A., Burkhart, J.L., Kazmaier, U., Herrmann, J., Müller, R., Günther, M., Schreiner, L., Wagner, E., Vollmar, A.M. and Zahler, S. (2012) Anti-angiogenic effects of the tubulysin precursor pretubulysin and of simplified pretubulysin derivatives, Br. J. Pharmacol., 167 (5): 1048-1061.

197. Wischang, D., Radlow, M., Schulz, H., Vilter, H., Viehweger, L., Altmeyer, M.O., Kegler, C., Herrmann, J., Müller, R., Gaillard, F., Delage, L., Leblanc, C. and Hartung, J. (2012) Molecular cloning, structure, and reactivity of the second bromoperoxidase from Ascophyllum nodosumBioorg. Chem., 44: 25-34.

196. Bian, X., Plaza, A., Zhang, Y. and Müller, R. (2012) Luminmycins A-C, cryptic natural products from Photorhabdus luminescens identified by heterologous expression in Escherichia coliJ. Nat. Prod., 75 (9): 1652-1655.

195. Klein, T., Henn, C., de Jong, J.C., Zimmer, C., Kirsch, B., Maurer, C.K., Pistorius, D., Müller, R., Steinbach, A. and Hartmann, R.W. (2012) Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization, ACS Chem. Biol., 7 (9): 1496-1501.

194. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A. and Müller, R. (2012) Leopolic acid A, isolated from a terrestrial actinomycete, Streptomyces sp., Tetrahedron Lett., 53(46):6300-6301.

193. Herrmann, J., Elnakady, Y.A., Wiedmann, R.M., Ullrich, A., Rohde, M., Kazmaier, U., Vollmar, A.M. and Müller, R. (2012) Pretubulysin: From hypothetical biosynthetic intermediate to potential lead in tumor therapy, PLoS ONE, 7 (5): e37416.

192. Plaza, A., Garcia, R., Bifulco, G., Martinez, J.P., Huttel, S., Sasse, F., Meyerhans, A., Stadler, M. and Müller, R. (2012) Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter"Org. Lett., 14 (11): 2854-2857.

191. Bian, X., Huang, F., Stewart, F.A., Xia, L., Zhang, Y. and Müller, R. (2012) Direct cloning, genetic engineering, and heterologous expression of the syringolin biosynthetic gene cluster in E. coli through Red/ET recombineering, ChemBioChem, 13 (13): 1946-1952.

190. Ruge, C.A., Schaefer, U.F., Herrmann, J., Kirch, J., Cañadas, O., Echaide, M., Pérez-Gil, J., Casals, C., Müller, R. and Lehr, C.M. (2012) The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles, PLoS ONE, 7 (7): e40775.

189. Hüttel, S. and Müller, R. (2012) Methods to optimize myxobacterial fermentations using off-gas analysis, Microb. Cell Fact., 11 (1): 59.

188. Steinmetz, H., Zander, W., Shushni, M.A., Jansen, G., Dehn, R., Dräger, G., Kirschning, A. and Müller, R. (2012) Precursor-directed syntheses and biological evaluation of new elansolid derivatives, ChemBioChem, 13 (12): 1813-1817.

187. Raju, R., Gromyko, O., Fedorenko, V., Luzhetskyy, A. and Müller, R. (2012) Pimprinols A-C, from the terrestrial actinomycete, Streptomyces sp.Tetrahedron Lett., 53 (24): 3009-3011.

186. Jahns, C., Hoffmann, T, Müller, S., Gerth, K., Washausen, P., Höfle, G., Reichenbach, H., Kalesse, M. and Müller, R. (2012) Pellasoren: structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosumAngew. Chem., Int. Ed., 51 (21): 5239-5243.

185. Fu, J., Bian, X., Hu, S., Wang, H., Huang, F., Seibert, P.M., Plaza, A., Xia, L., Müller, R.*, Stewart, A.F.* and Zhang, Y.*(2012) Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting, Nat. Biotechnol., 30 (5): 440-446. *These authors contributed equally to this work.

184. Cortina, N.S., Krug, D., Plaza, A., Revermann, O. and Müller, R. (2012) Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome, Angew. Chem. Int. Ed., 51 (3): 811-816.

183. Barbier, J., Jansen, R., Irschik, H., Benson, S., Gerth, K., Böhlensorf, B., Höfle, G., Reichenbach, H., Wegner, J., Zeilinger, C., Kirschning, A. and Müller, R. (2012) Isolation and total synthesis of icumazoles and noricumazoles - antifungal antibiotics and cation-channel blockers from Sorangium cellulosumAngew. Chem. Int. Ed., 51 (5): 1256-1260.

182. Zander, W., Irschik, H., Augustiniak, H., Herrmann, M., Jansen, R., Steinmetz, H., Gerth, K., Kessler, W., Kalesse, M., Höfle, G. and Müller, R. (2012) Sulfangolids, macrolide sulfate esters from Sorangium cellulosumChem. -- Eur. J., 18 (20): 6264-6271.

181. Mohr, K.I., Garcia, R.O., Gerth, K., Irschik, H. and Müller, R. (2012) Sandaracinus amylolyticus gen. nov., sp. nov., a starch degrading soil myxobacterium and the description of Sandaracinaceae fam. nov., Int. J. Syst. Evol. Microbiol.,62 (Pt 5): 1191-1998.

180. Pistorius, D., and Müller, R. (2012) Discovery of the rhizopodin biosynthetic gene cluster in Stigmatella aurantiaca Sg a15 by genome mining, ChemBioChem, 13 (3): 416-426.

179. Xiao, Y., Gerth, K., Müller, R. and Wall, D. (2012) Myxobacterium-produced antibiotic TA (myxovirescin) inhibits type II signal peptidase, Antimicrob. Agents Chemother., 56 (4): 2014-2021.

178. Chai, Y., Shan, S., Weissman, K.J., Hu, S., Zhang, Y. and Müller, R. (2012) Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using red/ET recombineering and inactivation mutagenesis, Chem. Biol., 19 (3): 361-371.

177. Quade, N., Huo, L., Rachid, S., Heinz, D.W. and Müller, R. (2011) Unusual carbon fixation gives rise to diverse polyketide extender units, Nat. Chem. Biol., 8 (1): 117-124.

176. Zander, W., Mohr, K.I., Gerth, K., Jansen, R. and Müller, R. (2011) p-hydroxyacetophenone amides from Cystobacter ferrugineus, strain Cb G35, J. Nat. Prod., 74 (6): 1358-1363.

175. Gawas, D., Garcia, R., Huch, V. and Müller, R. (2011) A highly conjugated dihydroxylated C-28 steroid from a myxobacterium, J. Nat. Prod., 74 (5): 1281-1283.

174. Burkhart, J.L., Müller, R. and Kazmaier, U. (2011) Syntheses and evaluation of simplified pretubulysin analogues, Eur. J. Org. Chem., 2011 (16): 3050-3059.

173. Khatri, Y., Hannemann, F., Perlova, O., Müller, R. and Bernhardt, R. (2011) Investigation of cytochromes P450 in myxobacteria: excavation of cytochromes P450 from the genome of Sorangium cellulosum So ce56, FEBS Lett., 585 (11): 1506-1513.

172. Proschak, A., Schultz, K., Herrmann, J., Dowling, A.J., Brachmann, A.O., ffrench-Constant, R., Müller, R. and Bode,H.B. (2011) Cytotoxic fatty acid amides from XenorhabdusChemBioChem, 12 (13): 2011-2015.

171. Pistorius, D., Li, Y., Mann, S. and Müller, R. (2011) Unprecedented anthranilate priming involving two enzymes of the acyl adenylating superfamily in aurachin biosynthesis, J. Am. Chem. Soc., 133 (32): 12362-12365. 17

170. Pistorius, D., Li, Y., Sandmann, A., Weissman, K.J. and Müller, R. (2011) Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15, Mol. Biosyst., 7 (12): 3308-3315.

169. Stec, E., Pistorius, D., Müller, R. and Li, S.M. (2011) AuaA, a membrane-bound farnesyltransferase from Stigmatella aurantiaca, catalyzes the prenylation of 2-methyl-4-hydroxyquinoline in the biosynthesis of aurachins, ChemBioChem, 12 (11): 1724-1730.

168. Simmons, L., Kaufmann, K.; Garcia, R.; Schwaer, G.; Huch, V. and Müller, R. (2011) Bendigoles D-F, bioactive sterols from the marine sponge-derived Actinomadura sp. SBMs009, Bioorg. Med. Chem., 19 (22): 6570-6575.

167. Cortina, N.S., Revermann, O., Krug, D. and Müller, R. (2011) Identification and characterization of the althiomycin biosynthetic gene cluster in Myxococcus xanthus DK897, ChemBioChem., 12 (9): 1411-1416.

166. Pereira, A. R., Etzbach, L., Engene, N., Müller, R. and Gerwick, W. H. (2011) Molluscicidal Metabolites from an Assemblage of Palmyra Atoll Cyanobacteria, J. Nat. Prod., 74 (5): 1175-1181.

165. Kopp, M., Irschik, H., Gemperlein, K., Buntin, K., Meiser, P., Weissman, K. J., Bode, H.B. and Müller, R. (2011) Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum So ce690, Mol. Biosyst., 7 (5): 1549-1563.

164. Jansen, R., Gerth, K., Steinmetz, H.,Reinecke, S., Kessler, W., Kirschning, A. and Müller, R. (2011) Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sanctiChem. -- Eur. J., 17 (28): 7739-7744.

163. Garcia, R., Pistorius, D., Stadler, M. and Müller, R. (2011) Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids, J. Bacteriol., 193 (8): 1930-1942.

162. Okanya, P., Mohr, K., Gerth, K., Jansen, R. and Müller, R. (2011) Marinoquinolines A – F, pyrroloquinolines from the bacterium Ohtaekwangia kribbensis (bacteroidetes), J. Nat. Prod., 74 (4): 603-608.

161. Zander, W., Gerth, K., Mohr, K.I., Kessler, W., Jansen, R. and Müller, R. (2011) Roimatacene, an antibiotic against gram-negative bacteria isolated from Cystobacter ferrugineus Cb G35 (myxobacteria), Chem. Eur. J., 17 (28): 7875-7881.

160. Rachid, S., Huo, L., Herrmann, J., Stadler, M., Köpcke, B., Bitzer, J. and Müller, R. (2011) Mining the cinnabaramide biosynhetic pathway to generate novel proteasome inhibitors, ChemBioChem, 12 (6): 922-931.

159. Garcia, R., Pistorius, D., Stadler, M. and Müller, R. (2011) Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids, J. Bacteriol., 193 (8): 1930-1942.

158. Huntley, S., Hamann, N., Wegener-Feldbrügge, S., Treuner-Lange, A., Kube, M., Reinhardt, R., Klages, S., Müller, R., Ronning, C.M., Nierman, W.C. and Søgaard-Andersen, L. (2011) Comparative genomic analysis of fruiting body formation in myxococcales, Mol. Biol. Evol., 28 (2): 1083-1097.

157. Pistorius, D., Ullrich, A., Lucas, S., Hartmann, R. W., Kazmaier, U. and Müller, R. (2011) Biosynthesis of 2-alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity, ChemBioChem, 12 (6): 850-853. 18

156. Dehn, R.*, Katsuyama, Y.*, Weber, A., Gerth, K., Jansen, R., Steinmetz, H., Höfle, G., Müller, R.** and Kirschning, A.** (2011) Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition / macrolactonization, Angew. Chem., Int. Ed., 50 (17): 3882-3887. *These authors contributed equally to this work. **These authors contributed equally to this work.

155. Steinmetz, H., Gerth, K., Jansen, R., Schläger, N., Dehn, R., Reinecke, S., Kirschning, A. and Müller, R. (2011) Elansolid A, a unique macrolide antibiotic from Chitinophaga sancti isolated as two stable atropisomers, Angew. Chem. Int. Ed., 50 (2): 532-536.

154. Khatri, Y., Hannemann, F., Ewen, K.M., Pistorius, D., Perlova, O., Kagawa, N., Brachmann, A.O., Müller, R. and Bernhard, R. (2010) The CYPome of Sorangium cellulosum So ce56 and identification of CYP109D1 as a new fatty acid hydroxylase, Chem. Biol., 17 (12): 1295-1305.

153. Nawrath, T., Gerth, K., Müller, R. and Schulz, S. (2010) Volatile methyl esters of medium chain length from the bacterium Chitinophaga Fx7914, Chem. Biodivers., 7 (9): 2228-2253.

152. Brodmann, T., Janssen, D., Sasse, F., Irschik, H., Jansen, R., Müller, R. and Kalesse, M. (2010) Isolation and Synthesis of Chivotriene, a Chivosazole Shunt Product from Sorangium cellulosum, Eur. J. Org. Chem., 2010 (27): 5155-5159.

151. Binz, T.M., Maffioli, S.I., Sosio, M., Donadio, S. and Müller, R. (2010) Insights into an unusual nonribosomal peptide synthetase biosynthesis: the identification and characterization of the GE81112 biosynthetic gene cluster, J. Biol. Chem., 285 (43): 32710-32719.

150. Weissman, K.J. and Müller, R. (2010) Myxobacterial secondary metabolites: bioactivities and modes-of-action, Nat. Prod. Rep., 27 (9): 1276-1295.

149. Garcia, R., Gerth, K., Stadler, M., Dogma Jr., I.J. and Müller, R. (2010) Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables', Mol. Phylogenet. Evol., 57 (2): 878-887. 

148. Irschik, H., Kopp, M., Weissman, K.J., Buntin, K., Piel, J. and Müller, R. (2010) Analysis of the sorangicin gene cluster reinforces the utility of a combined phylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by trans-AT PKS, ChemBioChem, 11 (13): 1840-1849.

147. Daum, M., Schnell, H.J., Herrmann, S., Günther, A., Murillo, R., Müller, R., Bisel, P., Müller, M. and Bechthold, A. (2010) Functions of genes and enzymes involved in phenalinolactone biosynthesis, ChemBioChem, 11 (10): 1383-1391.

146. Nawrath, T., Gerth, K., Müller, R. and Schulz, S. (2010) The biosynthesis of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium Chitinophaga Fx7914, ChemBioChem, 11 (13): 1914-1919.

145. Erol, Ö., Schäberle, T.F., Schmitz, A., Rachid, S., Gurgui, C., El Omari, M., Lohr, F., Kehraus, S., Piel, J., Müller, R. and König, G.M. (2010) Biosynthesis of the myxobacterial antibiotic corallopyronin A, ChemBioChem, 11 (9): 1253-1265.

144. Buntin, K., Weissman, K.J. and Müller, R. (2010) An unusual thioesterase promotes isochromanone ring formation in ajudazol biosynthesis, ChemBioChem, 11 (8): 1137-1146.

143. Wenzel, S.C. and Müller, R. (2010) Myxobacteria – Unique Microbial Secondary Metabolic Factories. In: Mander, L.N., Liu, H.W. (Eds) Comprehensive Natural Products II: Chemistry 19

and Biology, Volume 2: Structural Diversity II – Secondary Metabolites: Sources, Structures and Chemical Biology, Elsevier Science & Technology, Oxford, 189-222.

142. Li, Y., Weissman, K.J. and Müller, R. (2010) Insights into multienzyme docking in hybrid PKS-NRPS megasynthetases revealed by heterologous expression and genetic engineering, ChemBioChem, 11 (8): 1069-1075.

141. Buntin, K., Irschik, H., Weissman, K.J., Luxenburger, E., Blöcker, H. and Müller, R. (2010) Biosynthesis of thuggacins in myxobacteria: comparative cluster analysis reveals basis for natural product structural diversityChem. Biol., 17 (4): 342-356.

140. Rachid, S., Revermann, O., Dauth, C., Kazmaier, U. and Müller, R. (2010) Characterization of a novel type of oxidative decarboxylase involved in the biosynthesis of the styryl moiety of chondrochloren from an acylated tyrosine, J. Biol. Chem., 285 (17): 12482-12489.

139. Chai, Y., Pistorius, D., Ullrich, A., Weissman, K.J., Kazmaier, U. and Müller R. (2010) Discovery of 23 natural tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004, Chem. Biol., 17 (3): 296-309.

138. Jansen, R., Irschik, H., Huch, V., Schummer, D., Steinmetz, H., Bock, M., Schmidt, T. Kirschning, A. and Müller, R. (2010) Carolacton - a macrolide ketocarbonic acid reducing biofilm formation by the caries- and endocarditis-associated bacterium Streptococcus mutansEur. J. Org. Chem., 2010 (7): 1284-1289.

137. Bindl, M., Ludovic, J., Herrmann, J., Müller, R. and Fürstner, A. (2009) Preparation, modification, and evaluation of cruentaren A and analogues, Chemistry, 15 (45): 12310-12319.

136. Ullrich, A., Herrmann, J., Müller, R. and Kazmaier, U. (2009) Synthesis and biological evaluation of pretubulysin and derivatives, Eur. J. Org. Chem., 2009 (36): 6367-6378.

135. Ewen, K.M., Hannemann, F., Khatri, Y., Perlova, O., Kappl, R., Krug, D., Hüttermann, J., Müller, R. and Bernhardt, R. (2009) Genome mining in Sorangium cellulosum SO CE56 – identification and characterization of the homologous electron transfer proteins of a myxobacterial cytochrome P450, J. Biol. Chem., 284 (42): 28590-28598.

134. Wenzel, S.C. and Müller, R. (2009) The impact of genomics on the exploitation of the myxobacterial secondary metabolome, Nat. Prod. Rep., 26 (11): 1385-1407.

133. Nagano, T., Pospíšil, J., Chollet, G., Schulthoff, S., Hickmann, V., Moulin, E., Herrmann, J., Müller, R. and Fürstner, A. (2009) Total synthesis and biological evaluation of the cytotoxic resin glycosides ipomoeassin A–F and analogues, Chemistry, 15 (38): 9697-9706.

132. Li, Y. and Müller, R. (2009) Non-modular polyketide synthases in myxobacteriaPhytochemistry, 70 (15-16):1850-1857.

131. Bertsch, A., Leinenbach, A., Pervukhin, A., Lubeck, M., Hartmer, R., Baessmann, C., Elnakady, Y.A., Müller, R., Böcker, S., Huber, C.G. and Kohlbacher O. (2009) De novo peptide sequencing by tandem MS using complementary CID and electron transfer dissociation, Electrophoresis, 30 (21): 3736-3747.

130. Leinenbach, A., Hartmer, R., Lubeck, M., Kneissl, B., Elnakady, Y.A., Baessmann, C., Müller, R. and Huber, C.G. (2009) Proteome analysis of Sorangium cellulosum employing 2D-HPLC-MS/MS and improved database searching strategies for CID and ETD fragment spectra, J. Proteome Res., 8 (9): 4350-4361. 20 

129. Ullrich, A., Chai, Y., Pistorius, D., Elnakady, Y.A., Herrmann, J.E., Weissman, K.J., Kazmaier, U. and Müller, R. (2009) Pretubulysin, a potent and chemically accessible tubulysin precursor from Angiococcus disciformis, Angew. Chem. Int. Ed., 48 (24): 4422-4425.

128. Garcia, R.O., Krug, D. and Müller, R. (2009) Discovering natural products from myxobacteria with emphasis on rare producer strains in combination with improved analytical methods, Methods Enzymol., 458 (Chapter 3): 59-91.

127. Krug, D. and Müller, R. (2009) Discovery of additional members of the tyrosine aminomutase enzyme family and the mutational analysis of CmdF, ChemBioChem, 10 (4): 741-750.

126. Wenzel, S.C. and Müller, R. (2009) Myxobacteria – ‘microbial factories’ for the production of bioactive secondary metabolites, Mol. Biosyst., 5 (6): 567-574.

125. Buedenbender, S., Rachid, S., Müller, R. and Schulz, G.E. (2009) Structure and action of the myxobacterial chondrochloren halogenase CndH: A new variant of FAD-dependent halogenases, J. Mol. Biol., 385 (2): 520-530.

124. Rachid, S., Scharfe, M., Blöcker, H., Weissman, K.J. and Müller, R. (2009) Unusual chemistry in the biosynthesis of the antibiotic chondrochlorens, Chem. Biol., 16 (1): 70-81.

123. Müller, R. (2009) Biosynthesis and heterologous production of epothilones. In: Mulzer, J. (Ed) The Epothilones, an Outstanding Family of Anti-Tumor Agents, Springer, New York, 29-53.

122. Perlova, O., Gerth, K., Kuhlmann, S., Zhang, Y. and Müller, R. (2009) Novel expression hosts for complex secondary metabolite megasynthetases: Production of myxochromide in the thermopilic isolate Corallococcus macrosporus GT-2, Microb. Cell Fact., 8 (1): epub.

121. Rachid, S., Gerth, K. and Müller, R. (2009) NtcA-A negative regulator of secondary metabolite biosynthesis in Sorangium cellulosumJ. Biotech., 140 (1-2): 135-142.

120. Bolten, C.J., Heinzle, E., Müller, R. and Wittmann, C. (2009) Investigation of the central carbon metabolism of Sorangium cellulosum: Metabolic network reconstruction and quantification of pathway fluxes, J. Microbiol. Biotechnol., 19 (1): 23-36.

119. Garcia, R.O., Reichenbach, H., Ring, M.W. and Müller, R. (2009) Phaselicystis flava gen., nov., sp. nov., an arachidonic acid-containing soil myxobacterium, and the description of Phaselicystidaceae fam. nov., Int. J. Syst. Evol. Microbiol., 59 (Pt6): 1524-1530.

118. Wenzel, S.C. and Müller, R. (2009) The biosynthetic potential of myxobacteria and their impact on drug discovery, Curr. Opin. Drug Discovery Dev., 12 (2): 220-230.

117. Weissman, K.J. and Müller, R. (2009) A brief tour of myxobacterial secondary metabolism, Bioorg. Med. Chem., 17 (6): 2121-2136.

116. Bode, H.B., Ring, M.W., Schwär, G., Altmeyer, M.O., Kegler, C., Jose, I.R., Singer, M. and Müller, R. (2009) Identification of additional players in the alternative biosynthesis pathway to isovaleryl-CoA in the myxobacterium Myxococcus xanthusChemBioChem, 10 (1): 128-140.

115. Zöllner, A., Dragan C.A., Pistorius, D., Müller, R., Bode, H.B., Peters, F.T., Maurer, H.H. and Bureik, M. (2009) Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid, Biol. Chem., 390 (4): 313-317. 21

114. Jansen, R., Steinmetz, H., Sasse, F., Schubert, W.D., Hagelüken, G., Albrecht, S.C., Müller, R. (2008) Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria), Tetrahedron Lett., 49 (40): 5796-5799.

113. Pérez, J., Castañeda-García, A., Jenke-Kodama, H., Müller, R. and Muñoz-Dorado, J. (2008) Eukaryotic-like protein kinases in the prokaryotes and the myxobacterial kinome, PNAS, 105 (41): 15950-15955.

112. Krug, D., Zurek, G., Schneider, B., Garcia, R. and Müller. R. (2008) Efficient mining of myxobacterial metabolite profiles enabled by liquid chromatography-electrospray ionization-time-of-flight mass spectrometry and compound-based principal component analysis, Anal. Chim. Acta, 624 (1): 97-106.

111. Fu, J., Wenzel, S.C., Perlova, O., Wang, J., Gross, F., Tang, Z., Yin, Y., Stewart, A.F., Müller, R. and Zhang, Y. (2008) Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition, Nucleic Acids Res., 36 (17): e133ff.

110. Weissman, K.J. and Müller, R. (2008) Crystal structure of a molecular assembly line, Angew. Chem., Int. Ed., 47 (44): 8344-8346.

109. Menche, D., Arikan, F., Perlova, O., Horstmann, N., Ahlbrecht, W., Wenzel, S.C., Jansen, R., Irschik, H. and Müller, R. (2008) Stereochemical determination and complex biosynthetic assembly of etnangien, a highly potent RNA-polymerase inhibitor from the myxobacterium Sorangium cellulosumJ. Am. Chem. Soc., 130 (43): 14234-14243.

108. Wenzel, S.C., Bode, H.B., Kochems, I. and Müller, R. (2008) A type I/type III polyketide synthase hybrid biosynthetic pathway for the structurally unique ansa compound kendomycin, ChemBioChem, 9 (16): 2711-2721.

107. Li, Y., Weissman, K.J. and Müller, R. (2008) Myxochelin biosynthesis: direct evidence for two- and four-electron reduction of a carrier protein-bound thioester, J. Am. Chem. Soc., 130 (24): 7554-7555.

106. Meiser, P., Weissman, K.J., Bode, H.B., Krug, D., Dickschat, J.S., Sandmann, A. and Müller, R. (2008) DKxanthene biosynthesis - Understanding the basis for diversity-oriented synthesis in myxobacterial secondary metabolism, Chem. Biol., 15 (8): 771-781.

105. Jenke-Kodama, H., Müller, R. and Dittmann, E. (2008) Evolutionary Mechanisms underlying secondary metabolite diversity. In: Petersen, F., Amstutz, R. (Eds) Progress in Drug Research, 65: 119, 121-140.

104. Knauber, T., Doss, S.D., Gerth, K., Perlova, O., Müller, R. and Treuner-Lange, A. (2008) Mutation in the rel gene of Sorangium cellulosum affects morphological and physiological differentiation, Mol. Microbiol., 69 (1): 254-266.

103. Sandmann, A., Frank, B. and Müller, R. (2008) A transposon-based strategy to scale up myxothiazol production in myxobacterial cell factories, J. Biotechnol., 135 (3): 255-261.

102. Krug, D., Zurek, G., Revermann, O., Vos, M., Velicer, G.J. and Müller, R. (2008) Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversityAppl. Environ. Microbiol., 74 (10): 3058-3068.

101. Weissman, K.J. and Müller, R. (2008) Protein-protein interactions in multienzyme megasynthetases, ChemBioChem, 9 (6): 826-48. 22

100. Meiser, P. and Müller R. (2008) Two functionally redundant Sfp-type 4’-phosphopantetheinyl transferases differentially activate biosynthetic pathways in Myxococcus xanthusChemBioChem, 9 (10): 1549-1553.

99. Buntin, K., Rachid, S., Scharfe, M., Blöcker, H., Weissman, K.J. and Müller, R. (2008) Production of the antifungal isochromanone ajudazols A and B in Chondromyces crocatus Cm c5: biosynthetic machinery and cytochrome P450 modifications, Angew. Chem., Int. Ed., 47 (24): 4595-4599.

98. Nawrath, T., Dickschat, J.S., Müller, R., Jiang, J., Cane, D.E. and Schulz, S. (2008) Identification of (8S,9S,10S)-8,10-dimethyl-1-octalin, a key intermediate in the biosynthesis of geosmin in bacteriaJ. Am. Chem. Soc, 130 (2): 430-431.

97. Bock, M., Buntin, K., Müller, R. and Kirschning, A. (2008) Sterochemical determination of thuggacin A-C, highly active antibiotics from the myxobacterium Sorangium cellulosumAngew. Chem. Int. Ed., 47 (12): 2308-2311.

96. Petković, H., Sandmann, A., Challis, I.R., Hecht, H.J., Silakowski, B., Low, L., Beeston, N., Kuščer, E., Garcia-Bernando, J., Leadlay, P.F., Kendrew, S.G., Wilkinson, B. and Müller, R. (2008) Substrate specificity of the acyl transferase domains of EpoC from the epothilone polyketide synthase, Org. Biomol. Chem., 6 (3): 500-506.

95. Binz, T.M., Wenzel, S.C., Schnell, H.J., Bechthold, A. and Müller R. (2008) Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster using Red/ET recombineering, ChemBioChem, 9 (3): 447-454.

94. Wenzel, S.C. and Müller, R. (2007) Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry, Nat. Prod. Rep., 24 (6): 1211-1224.

93. Krug, D., Zurek, G., Schneider, B., Bässmann, C. and Müller, R. (2007) Analysis of secondary metabolites from myxobacteria using ESI-TOF-MS and PCA. LCGC Europe, The Applications Book, March 2007: 41-42.

92. Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S, Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. and Müller, R. (2007) Complete genome sequence of the myxobacterium Sorangium cellulosumNat. Biotechnol., 25 (11): 1281-1289.

91. Bode, H.B., Meiser, P., Klefisch, T., Cortina, N.S., Krug, D., Göhring, A., Schwär, G., Mahmud, T., Elnakady, Y.A. and Müller, R. (2007) Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B, ChemBioChem, 8 (17): 2139-2144.

90. Bode, H.B. and Müller, R. (2007) Secondary metabolism in myxobacteria. In: Whitworth, D. (Ed) Myxobacteria: Multicellularity and differentiation. ASM press, Chicago, 259-282.

89. Gerth, K., Perlova, O. and Müller, R. (2007) Sorangium cellulosum. In: Whitworth, D. (Ed) Myxobacteria: Multicellularity and differentiation, ASM press, Chicago, 329-348.

88. Frank, B., Wenzel, S.C., Bode, H.B., Scharfe, M., Blöcker, H. and Müller, R. (2007) From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes, J. Mol. Biol., 374 (1): 24-38. 23

87. Dickschat, J.S., Nawrath, T., Thiel, V., Kunze, B., Müller, R. and Schulz, S. (2007) Biosynthesis of the off-flavor 2-methylisoborneol by the myxobacterium Nannocystis exedensAngew. Chem., Int. Ed., 46 (43): 8287-8290.

86. Rachid, S., Krug, D., Weissman, K. and Müller, R. (2007) Biosynthesis of (R)-beta-tyrosine and its incorporation into the highly cytotoxic chondramides produced by Chondromyces crocatusJ. Biol. Chem., 282 (30): 21810-21817.

85. Simunovic, V. and Müller, R. (2007) Mutational analysis of the myxovirescin biosynthetic gene cluster reveals novel insights into the functional elaboration of polyketide backbones, ChemBioChem, 8 (11): 1273-1280.

84. Backes, C., Keller, A., Kuentzer, J., Kneissl, B., Comtesse, N., Elnakady, Y.A., Müller, R., Meese, E. and Lenhof, H.P. (2007) GeneTrail - advanced gene set enrichment analysis, Nucleic Acids Res., 35: W186-W192.

83. Martens, T., Gram, L., Grossart, H.P., Kessler, D., Müller, R., Simon, M., Wenzel, S.C. and Brinkhoff, T. (2007) Bacteria of the Roseobacter clade show potential for secondary metabolite production, Microb. Ecol., 54 (1): 31-42.

82. Elnakady, Y.A., Rohde, M., Sasse, F., Backes, C., Keller, A., Lenhof, H.P., Weissman, K.J. and Müller, R. (2007) Evidence for the mode of action of the highly cytotoxic Streptomyces polyketide kendomycin, ChemBioChem, 8 (11): 1261-1272.

81. Rupprath, C., Kopp, M., Hirtz, D., Irschik, H., Müller, R. and Elling, L. (2007) An enzyme module system for in situ regeneration of deoxythymidine 5’-diphosphate (dTDP)-activated deoxy sugars, Adv. Synth. Catal., 349: 1489-1496.

80. Kopp, M., Rupprath, C., Irschik, H., Bechthold, A., Elling, L. and Müller, R. (2007) SorF, a glycosyltransferase with promiscuous donor substrate specificity in vitroChemBioChem, 8 (7): 813-819.

79. Janssen, D., Albert, D., Jansen, R., Müller, R. and Kalesse, M. (2007) Chivosazole A - elucidation of the full absolute and relative configuration, Angew. Chem., Int. Ed., 46 (26): 4898-4901.

78. Rachid, S., Gerth, K., Kochems, I. and Müller, R. (2007) Deciphering regulatory mechanisms for secondary metabolite production in the myxobacterium Sorangium cellulosum So ce56, Mol. Microbiol., 63 (6):1783-1796.

77. Simunovic, V. and Müller, R. (2007) 3-hydroxy-3-methylglutaryl-CoA-like synthases direct the formation of methyl and ethyl side groups in the biosynthesis of the antibiotic myxovirescin A, ChemBioChem, 8 (5): 497-500.

76. Bode, H.B. and Müller, R. (2007) Reversible sugar transfer by glycosyltransferases as a tool for natural product (bio)synthesis, Angew. Chem., Int. Ed., 46 (13): 2147-2150.

75. Frank, B., Knauber, J., Steinmetz, H., Scharfe, M., Blöcker, H., Beyer, S. and Müller, R. (2007) Spiroketal polyketide formation in Sorangium: identification and analysis of the biosynthetic gene cluster for the highly cytotoxic spirangienes, Chem. Biol., 14 (2): 221-233.

74. Sandmann, A., Dickschat, J., Jenke-Kodama, H., Kunze, B., Dittmann, E. and Müller, R. (2007) A type II polyketide synthase from the gram-negative bacterium Stigmatella aurantiaca is involved in aurachin alkaloid biosynthesis, Angew. Chem., Int. Ed., 46 (15): 2712-2716. 24

73. Meiser, P., Bode, H.B. and Müller, R. (2006) The unique DKxanthene secondary metabolite family from the myxobacterium Myxococcus xanthus is required for developmental sporulation, Proc. Natl. Acad. Sci. U.S.A., 103 (50): 19128-19133.

72. Gross, F., Ring, M.W., Perlova, O., Fu, J., Schneider, S., Gerth, K., Kuhlmann, S., Stewart, A.F., Zhang, Y. and Müller R. (2006) Metabolic engineering of Pseudomonas putida for methylmalonyl-CoA biosynthesis to enable complex heterologous secondary metabolite formation, Chem Biol, 13: 1253-1264.

71. Wenzel, S.C., Williamson, R.M., Grünanger, C., Xu, J., Gerth, K., Martinez, R.A., Moss, S.R., Carroll, B.J., Grond, S., Unkefer, C.J., Müller, R. and Floss H.G. (2006) On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A, J. Am. Chem. Soc., 128 (44): 14325-14336.

70. Perlova, O., Fu, J., Kuhlmann, S., Krug, D., Stewart, A.F., Zhang, Y. and Müller, R. (2006) Reconstitution of the myxothiazol biosynthetic gene cluster by Red/ET recombination and heterologous expression in Myxococcus xanthus, Appl. Environ. Microbiol., 72 (12): 7485-7494.

69. Müller, I. and Müller, R. (2006) Biochemical characterization of MelJ and MelK - Myxobacterial enzymes that transform an amide into a methyl ester, FEBS J., 273 (16): 3768-78.

68. Stephan, S., Heinzle, E., Wenzel, S.C., Krug, D., Müller, R., and Wittmann, C. (2006) Metabolic physiology of Pseudomonas putida for heterologous production of myxochromide, Process Biochem., 41: 2146-2152.

67. Bode, H.B., Ring, M.W., Schwär, G., Kroppenstedt, R.M., Kaiser, D. and Müller, R. (2006) 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in the biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation, J. Bacteriol., 188 (18): 6524-6528.

66. Schley, C., Altmeyer, M.O., Swart, R., Müller, R. and Huber C.G. (2006) Proteome analysis of Myxococcus xanthus by off-line two-dimensional chromatographic separation using monolithic poly-(styrene-divinylbenzene) columns combined with ion-trap tandem mass spectrometry, J. Proteome Res., 5 (10): 2760-2768.

65. Bode, H.B. and Müller, R. (2006) Analysis of myxobacterial secondary metabolism goes molecular, J. Ind. Microbiol. Biotechnol., 33 (7): 577-88.

64. Simunovic, V., Zapp, J., Rachid, S., Krug, D., Meiser, P. and Müller, R. (2006) Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl CoA synthases and trans-acting acyltransferases, ChemBioChem, 7 (8): 1206-1220.

63. Müller, I., Weinig, S., Steinmetz, H., Kunze, B., Veluthoor, S., Mahmud, T. and Müller, R. (2006) A unique mechanism for methyl ester formation via an amide intermediate found in myxobacteriaChemBioChem, 7 (8):1197-1205.

62. Rachid, S., Krug, D., Kochems, I., Kunze, B., Scharfe, M., Blöcker, H., Zabriskie, M. and Müller, R. (2006) Molecular and biochemical studies of chondramide formation - highly cytotoxic natural products from Chondromyces crocatus Cm c5, Chem. Biol., 13 (6): 667-681.

61. Berner, M., Krug, D., Bihlmaier, C., Vente, A., Müller, R. and Bechthold, A. (2006) Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensisJ. Bacteriol., 188 (7): 2666-2673. 25

60. Wenzel, S.C., Meiser, P., Binz, T.M., Mahmud, T. and Müller, R. (2006) Nonribosomal peptide biosynthesis: point mutations and module skipping lead to chemical diversityAngew. Chem., Int. Ed., 45 (14): 2296-2301.

59. Gross, F., Luniak, N., Perlova, O., Gaitatzis, N., Jenke-Kodama, H., Gerth, K., Gottschalk, D., Dittmann, E. and Müller, R. (2006) Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads, Arch. Microbiol., 185 (1): 28-38.

58. Rachid, S., Sasse, F., Beyer, S. and Müller, R. (2006) Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1, J. Biotechnol., 121 (4): 429-441.

57. Kegler, C., Gerth, K. and Müller, R. (2006) Establishment of a real-time PCR protocol for expression studies of secondary metabolite biosynthetic gene clusters in the G/C-rich myxobacterium Sorangium cellulosum So ce56, J. Biotechnol., 121 (2): 201-212.

56. Perlova, O., Gerth, K., Kaiser, O., Hans, A. and Müller, R. (2006) Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56, J. Biotechnol., 121 (2): 174-191.

55. Müller, R. and Gerth, K. (2006) Development of simple media which allow investigations into the global regulation of chivosazol biosynthesis with Sorangium cellulosum So ce56, J. Biotechnol., 121 (2): 192-200.

54. Dickschat, J.S., Bode, H.B., Kroppenstedt, R.M., Müller, R. and Schulz, S. (2005) Biosynthesis of iso-fatty acids in myxobacteriaOrg. Biomol. Chem.3 (15): 2824-2831.

53. Wenzel, S.C. and Müller, R. (2005) Recent developments towards the heterologous ex-pression of complex bacterial natural product biosynthetic pathways, Curr. Opin. Biotechnol., 16 (6): 594-606.

52. Jenke-Kodama, H., Sandmann, A., Müller, R. and Dittmann, E. (2005) Evolutionary implications of bacterial polyketide synthases, Mol. Biol. Evol., 22 (10): 2027-2039.

51. Dickschat, J.S., Bode, H.B., Wenzel, S.C., Müller, R. and Schulz, S. (2005) Biosynthesis and identification of volatiles released by the myxobacterium Stigmatella aurantiacaChemBioChem, 6 (11): 2023-2033.

50. Wenzel, S.C. and Müller, R. (2005) Formation of novel secondary metabolites by bacterial multimodular assembly lines: deviations from text book biosynthetic logic, Curr. Opin. Chem. Biol., 9 (5): 447-458.

49. Bode, H.B. and Müller, R. (2005) The impact of bacterial genomics on natural product research, Angew. Chem., Int. Ed., 44 (42): 6828-6846.

48. Dickschat, J.S., Bode, H.B., Mahmud, T., Müller, R. and Schulz, S. (2005) A novel type of geosmin biosynthesis in myxobacteriaJ. Org. Chem., 70 (13): 5174-5182.

47. Bredenbruch, F., Nimtz, M., Wray, V., Morr, M., Müller, R. and Häussler, S. (2005) Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines, J. Bacteriol., 187 (11): 3630-3635.

46. Kunze, B., Reichenbach, H., Müller, R. and Höfle, G. (2005) Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (Myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity, J. Antibiot., 58 (4): 244-251.

45. Kopp, M., Irschik, H., Pradella, S. and Müller, R. (2005) Production of the tubulin destabilizer disorazol in Sorangium cellulosum: biosynthetic machinery and regulatory genes, ChemBioChem, 6 (7): 1277-1286.

44. Wenzel, S.C., Gross, F., Zhang, Y., Fu, J., Stewart, A.F. and Müller, R. (2005) Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering, Chem. Biol., 12 (3): 349-356.

43. Bode, H.B., Dickschat, J.S., Kroppenstedt, R.M., Schulz, S. and Müller, R. (2005) Biosynthesis of iso-fatty acids in myxobacteria: iso-even fatty acids are derived from α-oxidation of iso-odd fatty acids, J. Am. Chem. Soc., 127 (2): 532-533.

42. Gross, F., Gottschalk, D. and Müller, R. (2005) Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase, Appl. Microbiol. Biotechnol., 68 (1): 66-74.

41. Wenzel, S.C., Kunze, B., Höfle, G., Silakowski, B., Scharfe, M., Blöcker, H. and Müller, R. (2005) Structure and biosynthesis of myxochromides S1-3 in Stigmatella aurantiaca: evidence for an iterative bacterial type I polyktetide synthase and for module skipping in nonribosomal peptide biosynthesis, ChemBioChem, 6 (2): 375-385.

40. Gaitatzis, N., Kunze, B. and Müller, R. (2005) Novel insights into siderophore formation in myxobacteriaChemBioChem, 6 (2): 365-374.

39. Gerth, K. and Müller, R. (2005) Moderately thermophilic myxobacteria: novel potential for the production of natural products isolation and characterization, Environ. Microbiol., 7 (6): 874-880.

38. Mahmud, T., Wenzel, S.C., Wan, E., Wen, K.W., Bode, H.B., Gaitatzis, N. and Müller, R. (2005) A novel biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway, ChemBioChem, 6 (2): 322-330.

37. Bode, H.B., Wenzel, S.C., Irschik, H., Höfle, G. and Müller, R. (2004) Unusual biosynthesis of leupyrrins in the myxobacterium Sorangium cellulosumAngew. Chem. Int. Ed., 43 (32): 4163-4167.

36. Sandmann, A., Sasse, F. and Müller, R. (2004) Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity, Chem. Biol., 11 (8): 1071-1079.

35. Duerfahrt, T., Eppelmann, K., Müller, R. and Marahiel, M.A. (2004) Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis, Chem. Biol., 11 (2): 261-271.

34. Kopp, M., Irschik, H., Gross, F., Perlova, O., Sandmann, S., Gerth, K. and Müller, R. (2004) Critical variations of conjugational DNA transfer into secondary metabolite multiproducing Sorangium cellulosum strains So ce12 and So ce56: development of a mariner-based transposon mutagenesis system, J. Biotechnol., 107 (1): 29-40.

33. Dickschat, J.S., Wenzel, S.C., Bode, H.B., Müller, R. and Schulz, S. (2004) Biosynthesis of volatiles by the myxobacterium Myxococcus xanthusChemBioChem, 5 (6): 778-787.

32. Müller, R. (2004) Don’t classify polyketide synthases, Chem. Biol., 11 (1): 4-6. 27

31. Gerth, K., Pradella, S., Perlova, O., Beyer, S. and Müller, R. (2003) Myxobacteria: proficient producers of novel natural products with various biological activities – past and future biotechnological aspects with the focus on the genus SorangiumJ. Biotechnol., 106 (2-3): 233-253.

30. Weinig, S., Hecht, H.J., Mahmud, T. and Müller, R. (2003) Melithiazol biosynthesis: further insights into Myxobacterial PKS/NRPS systems and evidence for a new subclass of methyl transferases, Chem. Biol., 10 (10): 939-952.

29. Weinig, S., Mahmud, T. and Müller, R. (2003) Markerless mutations in the myxothiazol biosynthetic gene cluster: a delicate megasynthetase with a superfluous nonribosomal peptide synthetase domain, Chem. Biol., 10 (10): 953-960.

28. Bode, H.B., Irschik, H., Wenzel, S.C., Reichenbach, H., Müller, R. and Höfle, G. (2003) The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum, J. Nat. Prod., 66 (9): 1203-1206.

27. Bode, H.B. and Müller, R. (2003) Possibility of bacterial recruitment of plant genes associated with the biosynthesis of secondary metabolites, Plant Physiol.,132 (3): 1153-1161.

26. Bode, H.B., Zeggel, B., Silakowski, B., Wenzel, S.C., Reichenbach, H. and Müller, R. (2003) Steroid biosynthesis in prokaryotes: identification of myxobacterial steroids and cloning of the first bacterial 2,3(S)-oxidosqualene cyclase from the myxobacterium Stigmatella aurantiaca, Mol. Microbiol., 47 (2): 471-481.

25. Franke, D., Lorbach, V., Esser, S., Dose, C., Sprenger, G.A., Halfar, M., Thömmes, J., Müller, R., Takors, R., Müller, M. (2003) (S,S)-2,3-Dihydroxy-2,3-dihydrobenzoic acid: microbial access with engineered cells of Escherichia coli and applicability as starting material in natural-product synthesis, Chemistry, 9 (17): 4188-4196.

24. Mahmud, T., Bode, H.B., Silakowski, B., Kroppenstedt, R.M., Xu, M., Nordhoff, S., Höfle, G. and Müller, R. (2002) A novel biosynthetic pathway providing precursors for fatty acid biosynthesis and secondary metabolite formation in myxobacteriaJ. Biol. Chem., 277 (36): 32768-32774.

23. Gaitatzis, N., Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G. and Müller, R. (2002) The biosynthesis of the aromatic myxobacterial electron transport inhibitor stigmatellin is directed by a novel type of modular polyketide synthase, J. Biol. Chem., 277 (15): 13082-13090.

22. Arakawa, K., Müller, R., Mahmud, T., Yu, T.W. and Floss, H.G. (2002) Characterization of the early stage aminoshikimate pathway in the formation of 3-amino-5-hydroxybenzoic acid: the RifN protein specifically converts kanosamine into kanosamine 6-phosphate, J. Am. Chem. Soc., 124 (36): 10644-10655.

21. Gaitatzis, N., Hans, A., Müller, R. and Beyer, S(2001) The mtaA gene of the myxothiazol biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1 encodes a phosphopantetheinyl transferase that activates polyketide synthases and polypeptide synthetases, J. Biochem., 129 (1): 119-124.

20. Gaitatzis, N., Kunze, B. and Müller, R. (2001) In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: biochemical characterisation of a reductive release mechanism from nonribosomal peptide synthetases, Proc. Natl. Acad. Sci. U.S.A., 98 (20): 11136-11141. 28

19. Silakowski, B., Nordsiek, G., Kunze, B., Blöcker, H. and Müller, R. (2001) Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sg a15, Chem. Biol., 8 (1): 59-69.

18. Yu, T., Müller, R., Müller, M., Zhang, X., Dräger, G., Kim, C.G., Leistner, E. and Floss, H.G. (2001) Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in Amycolatopsis mediterranei S699., J. Biol. Chem., 276 (16): 12546-12555.

17. Silakowski, B., Kunze, B. and Müller, R. (2001) Multiple hybrid polyketide synthase/non-ribosomal peptide synthetase gene clusters the myxobacterium Stigmatella aurantiaca, Gene, 275 (2): 233-240.

16. Buss, K., Müller, R., Dahm, C., Gaitatzis, N., Skrypczak-Pietrszek, E., Lohmann, S., Gassen, M. and Leistner, E. (2001) Clustering of isochorismate synthase genes menF and entC and channeling of isochorismate in Escherichia coliBiochim. Biophys. Acta, 1522 (3): 151-157.

15. Müller, R., Gerth, K., Brandt, P., Blöcker, H. and Beyer, S. (2000) Identification of an L-dopa decarboxylase gene from Sorangium cellulosum So ce90, Arch. Microbiol. 173 (4): 303-306.

14. Silakowski, B., Kunze, B. and Müller, R. (2000) Stigmatella aurantiaca Sg a15 carries genes encoding type I and type II 3-deoxy-D-arabino-heptulosonate-7-phosphate synthases: involvement of a type II synthase in aurachin biosynthesis, Arch. Microbiol., 173 (5-6): 403-411.

13. Silakowski, B., Kunze, B., Nordsiek, G., Blöcker, H., Höfle, G. and Müller, R. (2000) The myxochelin iron transport regulon of the myxobacterium Stigmatella aurantiaca Sg a15, Eur. J. Biochem., 267 (21): 6476-6485.

12. Chen, S., von Bamberg, D., Hale, V., Breuer, M., Hardt, B., Müller, R., Floss, H.G., Reynolds, K.A. and Leistner, E. (1999) Biosynthesis of ansatrienin (mycotrienin) and naphtomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus TÜ 1892, Eur. J. Biochem., 261 (1): 98-107.

11. Beyer, S., Kunze, B., Silakowski, B. and Müller, R. (1999) Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilon producing strain Sorangium cellulosum So ce90, Biochim. Biophys. Acta,1445 (2): 185-195.

10. Silakowski, B., Schairer, H.U., Ehret, H., Kunze, B., Weinig, S., Norsiek, G., Blöcker, H., Höfle, G., Beyer, S. and Müller, R. (1999) New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1, J. Biol. Chem., 274 (52): 37391-37399.

9. Dahm, C., Müller, R., Schulte, G., Schmidt, K. and Leistner, E. (1998) The role of isochorismate hydroxymutase genes entC aned menF in enterobactin and menaquinone biosynthesis in Escherichia coliBiochim. Biophys. Acta, 1425 (2): 377-386.

8. August, P.R., Tang, L., Yoon, Y.J., Ning, S., Müller, R., Yu, T.W., Taylor, M., Hoffmann, D., Kim, C.G., Zhang, X., Hutchinson, C.R. and Floss, H.G. (1998) Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699, Chem. Biol., 5 (2): 69-79. 29

7. Müller, M., Müller, R., Yu, T. and Floss, H.G. (1998) Synthesis of (-)-3-amino-3-deoxyquinic acid, J. Org. Chem., 63: 9753-9755.

6. Ledüc, C., Birgel, I., Müller, R. and Leistner, E. (1997) Isochorismate hydroxymutase from a cell-suspension culture of Galium mollugo L., Planta, 202 (2): 206-210.

5. Müller, R., Dahm, C., Schulte, G. and Leistner, E. (1996) An isochorismate hydroxymutase isogene in Escherichia coliFEBS Lett., 378 (2): 131-134.

4. Müller, R., Kuttler, E., Lanz, C., Drewke, C. and Schmidt, K. (1996) Isolation of a gene encoding cysteine synthase from Flavobacterium K3-15, FEMS Microbiol. Lett.,136 (3): 305-308.

3. Müller, R., Breuer, M., Wagener, A., Schmidt, K. and Leistner, E. (1996) Bacterial production of transdihydroxycyclohexadiene carboxylates by metabolic pathway engineering, Microbiology, 142 (4): 1005-1012.

2. Drewke, C., Klein, M., Clade, D., Arenz, A., Müller, R. and Leistner, E. (1996) 4-O-Phosphoryl-L-threonine, a substrate of the pdxC (serC) gene product involved in vitamin B6 biosynthesis, FEBS Lett., 390 (2): 179-182.

1. Müller, R., Wagener, A., Schmidt, K. and Leistner, E. (1995) Microbial production of specifically ring-13C-labelled 4-hydroxybenzoic acid, Appl. Microbiol. Biotechnol., 43 (6): 985-988. 30

Review articles in other journals

17. Hüttel, S., Herrmann, J. and Müller, R. (2013) Schätze aus dem Boden: innovative Prozesse zur Wirkstofffindung, BIOspektrum, 19 (5): 520-522.

16. Bian, X., Fu, J., Plaza, A., Stewart, A.F. and Müller, R. (2013) Novel recombineering method facilitates cryptic natural product discovery Planta Medica 10 (2013) Annual Meeting of the American Society of Pharmacognosy, St. Louis, USA

15. Hüttel, S. and Müller, R. (2012) Application of gas analyzers in process automation and production optimization of secondary metabolites from myxobacteriaThe BlueSens Report No. 2, 6-7.

14. Wenzel, S.C. and Müller, R. (2011) Naturstoffbiotechnologie des Myxobakteriums Chondromyces crocatusBiospektrum, 5 (11): 580-582.

13. Müller, R. and Gerth, K. (2009) Von Mega-Genomen und Mikro-Chemikern: Neue Perspektiven für die Wirkstoffproduktion in Myxobakterien. Forschungsbericht 2008/2009, Helmholtz Zentrum für Infektionsforschung, Braunschweig, 22-29.

12. Müller, R. (2008) Plant biochemistry and biotechnology lecture, SWISS PHARMA, 10: 10-11.

11. Mulzer, J., Altmann, K.H., Höfle, G., Müller, R. and Prantz, K. (2008) Epothilones - A fascinating family of microtubule stabilizing antitumor agents, C. R. Chimie, 11 (11-12): 1336-1368.

10. Perlova, O., Gerth, K. and Müller R. (2008) Analyse des größten bekannten Bakteriengenoms: Neue Perspektiven für die Wirkstoff-Produktion in Sorangium cellulosumGenomXpress, 1.08: 4-7.

9. Müller, R. (2008) Neue Therapeutika aus Myxobakterie, magazin forschung, 1: 9-13.

8. Frank, B. and Müller, R. (2007) Fachgruppen Workshop Biologie Naturstoff-produzierender Bakterien, Biospektrum, 7: 784.

7. Frank, B. and Müller, R. (2007) Neue Wirkstoffe aus Myxobakterien: Wie Mikro-organismen den Krebs bekämpfen helfen, Pharmazeutische Zeitung, 50: 64-67.

6. Müller, R. (2006) Exploiting microbial diversity and bacterial genomics to find novel antibiotics, Int J Med Microbiol, 296S3 (42): 138-9.

5. Wenzel, S.C. and Müller, R. (2005) Heterologe Expression von komplexen myxobakteriellen Naturstoff-Biosynthesewegen in PseudomonadenBiospektrum, 11 (5): 628-631.

4. Beyer, S. and Müller, R. (2001) Molecular biology of Secondary Metabolites in Myxobacteria, Annual Report 2001 (GBF - German Research Centre for Biotechnology Ltd.), 108-110.

3. Müller, R. (2000) Irseer Naturstofftage: Aktuelle Entwicklungen in der Naturstoff-Forschung, transcript 6, 4, 32-34.

2. Müller, R. and Beyer, S. (2000) Genetics of Secondary Metabolism in Myxobacteria, Annual Report 1999/2000 (GBF - German Research Centre for Biotechnology Ltd.), 105-106. 31

1. Beyer, S. and Müller, R. (1999) Molecular Biology of Secondary Metabolism in Myxobacteria, Scientific Annual Report 1998 (GBF - Gesellschaft für Biotechnologische Forschung), 31-33. 

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