Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.

Team

    Sandra Halecker

    Sandra Halecker

    PhD Student

    +49 531 6181-4244

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    Curriculum Vitae

    Since 09/2013 
    PhD student in the group of Prof. Marc Stadler, Helmholtz Centre for Infection Research, Braunschweig, Germany

    10/2012 - 06/2013            
    Diploma thesis in the department of Prof. Dr. Marc Stadler,  Helmholtz Centre for Infection Research, Braunschweig, Germany Title: “Charakterisierung der Sekundärmetabolitbildung des pathogenen Ascomyceten Hymenoscyphus pseudoalbidus und der endophytischen Mycobiota seines Wirtsbaumes Fraxinus excelsior”  

    2003 - 2013                     
    study of biotechnology at the Technical University of Braunschweig (focus on bioprocess engineering)

    Abstract 
    The ascomycete Hymenoscyphus pseudoalbidus was proven to be the causal agent of ash dieback in extended parts of Europe, however, virulence factors responsible for the pathogenicity of this fungus are hitherto unknown. My project will focus on the novel antimicrobially active natural product from H. pseudoalbidus that was recently isolated by me and my colleagues in preliminary work and furthermore on the exploitation of new secondary metabolites of the pathogen by using antagonistic assays as well as chemical-epigenetic methods to induce changes in fungal secondary metabolism. The cultures (from fermentations in solid and liquid media) of several strains of H. pseudoalbidus and of promising antagonists will be screened by HPLC/DAD-MS profiling and antimicrobial assays and the most promising biologically active compounds will be isolated using bioassay-guided isolation procedures using preparative chromatography and identified by NMR and MS.    

Mycology

  • Clara Chepkirui

    Clara Chepkirui

    PhD Student

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  • Sandra Halecker

    Sandra Halecker

    PhD Student

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    CV and Publications

  • Wilawan Kuephadungphan

    Wilawan Kuephadungphan

    PhD Student

    +49 531 6181-4225

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  • Juan Sebastian Lopez

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    Visiting PhD Student

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  • Sarah Raouia Noumeur

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    Visiting PhD Student

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  • Christian Richter

    Christian Richter

    PhD Student

    +49 531 6181-4235

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    CV and Publications

  • Lucile Wendt

    Lucile Wendt

    PhD Student

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  • Simone Heitkämper

    Simone Heitkaemper

    Research Assistant

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  • Kathrin Pommerehne

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    Master Student

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  • Jennifer Weber

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    Bachelor Student

    + 49 531 6181-4224

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  • Jan-Peer Wennrich

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    Bachelor Student

    + 49 531 6181-4253

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  • Anke Skiba

    Anke Skiba

    Technical Assistant

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  • Christopher Lambert

    Christopher Lambert

    Student Assistant

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  • Anne Weiß

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    Student assistant

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Microbiology

Natural Product Chemistry

Fermentation

  • Dr Stephan Hüttel

    Stephan Huettel

    Scientist

    +49 531 6181-4237

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  • Dipl.-Ing. Steffen Bernecker

    Steffen Bernecker

    Engineer

    +49 531 6181-4246

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  • Amelie Beckmann

    Amelie Beckmann

    PhD Student

    +49 531 6181-4263

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  • Zeljka Rupcic

    Zeljka Rupcic

    PhD Student

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  • Burkhard Ebert

    Technical Assistant

    +49 531 6181-4249

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  • Andrew Perreth

    Andrew Perreth

    Technical Assistant

    +49 531 6181-4243

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  • Axel Schulz

    Axel Schulz

    Technical Assistant

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  • Cäcilia Schwager

    Caecilia Schwager

    Technical Assistent

    +49 531 6181-4224

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  • Reinhard Sterlinski

    Reinhard Sterlinski

    Technical Assistant

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  • Lisa Hoffmann

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    Bachelor Student

    + 49 531 6181-4263

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  • Steve Möller

    Bachelor Student

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Microbial Strain Collection

To the team page

Guests and Former Members

  • Dr Klaus Gerth

    Klaus Gerth

    Scientist

    +49 531 6181-4261

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  • Dr Ignacio Poblete-Castro

    Ignacio Poblete-Castro

    Scientist

    + 49 531 6181-4261

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  • Dipl.-Ing. Wolfgang Kessler

    Wolfgang Kessler

    Engineer

    +49 531 6181-4237

    +49 531 6181-9499

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  • Vincent Wiebach

    +49 531 6181-4225

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  • Benjarong Thonbai (Zine)

    Benjarong Thongbai

    PhD Student

    +49 531 6181-4225

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  • Dr Andre Luis Rodrigues

    Andre Luis Rodrigues

    Postdoc

    +49 531 6181-4238

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  • Dr Kathrin Bohle

    Kathrin Bohle

    Scientist

    +49 531 6181-4237

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  • Dr Smita Bhuyan

    Scientist

    +49 531 6181-4244

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  • Samad Ashrafi

    PhD of JKI

    0531 6181-4235

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  • Pia Philine Wotsch

    Pia Philine Wotsch

    Technical Assistant

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  • Dr Eric Kuhnert

    PostDoc

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  • Nadine Wurzler

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    Bachelor Student

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Leader

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