Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.

Leader

Team

Dr Sabrina Karwehl

PostDoc

Curriculum Vitae

Since 05/2013
PhD thesis in the working group of Prof. Dr. Marc Stadler
Title: “Novel antibacterial metabolites from gliding bacteria – isolation, structure elucidation, biosynthesis, biological characterization and applicability”

04/2013
master thesis in the working group of Prof. Dr. Marc Stadler
Title: “Isolation and structure elucidation of secondary metabolites from gliding bacteria

10/2007-04/2013
study of chemistry at the Technische Universität Braunschweig (with focus on biological chemistry and structure elucidation)

Abstract
Gliding bacteria – including Myxobacteria – have been established as acknowledged producers of valuable bioactive secondary metabolites that cannot be found from commonly screened sources like Actinobacteria. Our biological and chemical screening project of gliding bacteria continues to discover unknown potential drugs. The aim of my project is the isolation and chemical and biological characterization of these secondary metabolites and to study their potential applicability as antibiotics.

 

 

Mycology

Microbiology

Natural Product Chemistry

Fermentation

Microbial Strain Collection

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Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

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