Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.

Leader

Team

Dr Eric Kuhnert

PostDoc

Curriculum Vitae

Since 04/2012       
PhD student in the group of Prof. Dr. Marc Stadler, Helmholtz Centre for Infection Research, Braunschweig, Germany

2011
Master thesis in the working group of Prof. Dr. Gerhard Rambold Title: “New neotropical species of the fungal genus Hypoxylon (Xylariaceae) – A comparative analysis based on morphological, chemotaxonomic and phylogenetic data”

2006-2011  
    
studies in biology at the TU Bayreuth (focus on molecular ecology)

Abstract
Xylariaceae are ascomycetes showing an extraordinary diversity both in terms of metabolic and biological diversity. My project focuses on the exploitation of the secondary metabolomes of various new or hitherto unexploited species from tropical and subtropical regions. The cultures (from fermentations in solid and liquid media) and fruiting bodies of these fungi are screened by HPLC/DAD-MS profiling and antimicrobial assays. The most promising bioactive compounds are isolated by using bioassay-guided isolation procedures and preparative chromatography. Structure elucidation is done by NMR and MS in collaboration with our skilled chemists.

Mycology

Microbiology

Natural Product Chemistry

Fermentation

Microbial Strain Collection

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