Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.

Leader

Team

Christian Richter

PhD Student

Curriculum Vitae

Since 01/2013   
PhD student in the department of Prof. Dr. Marc Stadler, Helmholtz Centre for Infection Research, Braunschweig, Germany
2012                 
master thesis in the working group of Prof. Dr. Dominik Begerow Title: “Investigation of antimicrobial metabolites from epiphyllic yeasts on maize”
2005-2012       
study of biology at the Ruhr-University Bochum (focus on biodiversity)

 

Abstract
Basidiomycetes have been known to produce bioactive compounds for a long time, mutilins and strobilurins being examples for lead compounds that have even gained great commercial success. However, discovery of novel antibiotics and other useful compounds has so far been mainly restricted to the fruitbody-forming “macrofungi”. Over 90% of the Basidiomycetes remain unexploited for bioactive metabolites. My project targets the Ustilaginomycotina, a hyperdiverse subdivision of the basidiomycetes that has already yielded unique compounds like glycolipids in the past.

Mycology

Microbiology

Natural Product Chemistry

Fermentation

Microbial Strain Collection

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