Microbial Drugs

The majority of the medically important antibiotic drugs (including e.g., penicillins, cephalosporins, erythromycin, vancomycin, and daptomycin) are derived from secondary metabolites, which are produced by bacteria and filamentous fungi. Despite intensive world-wide efforts using alternative approaches based on synthetic chemistry, no other concept could so far surpass the historically successful strategy to exploit biologically active natural products as candidates for anti-infective drugs. The recently observed, increasing resistance of the human pathogens against antibiotics has prompted us to intensify our search for novel lead structures from microorganisms and fungi, which can be used as anti-infective drugs.



  • Thongklang N, Thongbai B, Chamyuang S, Callac P, Chukeatirote E, Hyde KD, Wittstein K, Stadler M (2016) 
    Blazeispirol A, a chemotaxonomic marker from mycelia of the medicinal mushroom Agaricus subrufescens. 
    Chiang Mai J Sc., in press.
  • Wiebach V, Surup F, Kuhnert E, Stadler M (2016)
    Rickicaryophyllane, a caryophyllane from the ascomyceteous fungus Hypoxylon rickii and a 10-norbotryane congener.
    Nat Prod Comm, in press.
  • Richter C, Helaly SE, Thongbai B, Hyde KD, Stadler M (2016)
    Pyristriatins A and B - pyridino-cyathane antibiotics from the basidiomycete Cyathus cf. striatus.
    J Nat Prod, in press (DOI: 10.1021/acs.jnatprod.6b00194).
  • Ariyawansa HA, Hyde KD, Jayasiri SC, Buyck B, Chethana KT, Dai DQ., ... Stadler M, ...& Ghobad-Nejhad, M. (2015).
    Fungal diversity notes 111–252—taxonomic and phylogenetic contributions to fungal taxa.
    Fungal Divers 75: 27-274.
  • Li GJ, Hyde KD, Zhao RL, Hongsanan S, Abdel-Aziz FA, Abdel-Wahab MA.,Kuhnert E, ... Stadler M, ... & Baghela, A. (2016).
    Fungal diversity notes 253–366: taxonomic and phylogenetic contributions to fungal taxa.
    Fungal Diversity, in press (DOI 10.1007/s13225-016-0366-9)
  • Mudalungu CM, Richter C, Wittstein K, Ali Abdalla M, Matasyoh JC, Stadler M, Süssmuth RD (2016)
    Laxitextines A and B, cyathane xylosides from the tropical fungus Laxitextum incrustatum.
    J Nat Prod 79: 894-898.
  • Daranagama DA, Liu XZ, Chamyuang S, Stadler M., Bahkali AH, Hyde KD (2016)
    Towards a natural classification of Sordariomycetes: The genera Frondisphaeria, Immersisphaeria, Lasiobertia, Pulmosphaeria and Yuea (Sordariomycetes incertae sedis).
    Phytotaxa 258: 153-163.
  • Surup F, Wiebach V, Kuhnert E, Stadler M (2016)
    Truncaquinones A and B, asterriquinones from Annulohypoxylon truncatum.
    Tetrahedron Lett. 57: 2183–2185.
  • Otto A, Laub A, Wendt L, Porzel A, Schmidt J, Palfner G Becerra J, Krüger D, Stadler M, Wessjohann L, Westermann B, Arnold N (2016)
    Chilenopeptins A and B, peptaibols from the Chilean Sepedonium aff. chalcipori KSH 883.
    J Nat Prod 79: 929-938.
  • Karwehl S, Jansen R, Huch V, Stadler M (2016)
    Sorazolons, carbazole alkaloids from Sorangium cellulosum strain Soce375.
    J Nat Prod 79: 369-375. (DOI: 10.1021/acs.jnatprod.5b00997).
  • Sir EB, Kuhnert E, Lambert C, Hladki AI, Romero AI, Stadler M (2016)
    New species and reports of Hypoxylon from Argentina recognized by a polyphasic approach.
    Mycol Prog 15: 42.
  • Mohr, KI, Stechling M, Wink, J, Wilharm E, Stadler M (2016)
    Comparison of myxobacterial diversity and evaluation of isolation success in two niches: Kiritimati Island and German compost.
    MicrobiologyOpen 5: 268-278. (DOI: 10.1002/mbo3.325)
  • Daranagama DA, Camporesi E, Liu XZ, Bhat DJ, Chamyuang S, Bahkali AH, Stadler M, Hyde KD (2016)
    Tristratiperidium microsporum gen. et sp. nov. (Xylariales) on dead leaves of Arundo plinii.
    Mycol Progr 15: 8. (DOI: 10.1007/s11557-015-1151-y)


  • Thongbai B, Rapior S, Wittstein K, Hyde KD, Stadler M (2015)
    Hericium erinaceus, an amazing medicinal mushroom. 
    Mycol Prog, 14(91):1-23
  • Daranagama DA, Liu X, Chamyuang S, Stadler M, Bahkali AH, Hyde KD (2015)
    Rhopalostroma brevistipitatum sp. nov. from Thailand with an extended generic description for Rhopalostroma
    Phytotaxa 227: 229 - 242
  • Kuhnert E, Surup F, Herrmann J, Huch V, Müller R, Stadler M (2015)
    Rickenyls A – E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota).
    Phytochemistry 118: 68 – 73 
  • Senanayake IC, Maharachchikumbura SSN, Kevin D. Hyde KD, Bhat JD, Jones EBG, McKenzie EH, Dai DQ, Dagaranagama DA, Dayarathne MC, Goonasekara ID, Konta S, Li WL, Shang QJ, Stadler M, Wijayawardene NN, Xiao XP, Norphanphoun C, Li QR, Liu XZ, Bahkali AH, Kang JC, Wang Y, Wen TC, Wendt L, Xu JC, Camporesi E (2015) 
    Towards unraveling relationships in Xylariomycetidae (Sordariomycetes). 
    Fungal Divers 73: 73–144.
  • Mohr KI, Volz C, Jansen R, Wray V, Bernecker S, Wink J, Gerth K, Stadler M, Müller R (2015) 
    Pinensins: The first antifungal lantibiotics. 
    Angew Chem Int Ed Engl 54: 11254-11258.
  • Franke J., Bock M., Dehn R., Fohrer J., Mhaske S.B., Migliorini A., Kanakis A.A., Jansen R., Herrmann J., Müller R., Kirschning A. (2015)
    Total and semi-syntheses of antimicrobial thuggacin derivatives.
    Chemistry - A European Journal, 21 (2015): 4272 – 4284
  • Karwehl S., Mohr K.I., Jansen R., Sood S., Bernecker S., Stadler M. (2015)
    Edonamides, the first secondary metabolites from the recently described myxobacterium Aggregicoccus edonensis.
    Tetrahedron Letters 56: 6402 – 6404
  • Stumpp N, Premnath P, Schmidt T, Ammermann J, Dräger G, Reck M, Jansen R, Stiesch, M, Wagner-Döbler I, Kirschning A (2015)
    Synthesis of new carolacton derivatives and their activity against biofilms of oral bacteria 
    Organic and Biomolecular Chemistry, 13 (20), pp. 5765-5774. (
    DOI: 10.1039/c5ob00460h)
  • Kuhnert E, Surup F, Wiebach V, Bernecker S, Stadler M (2015) 
    Botryane, noreudesmane and abietane terpenoids from the ascomycete Hypoxylon rickiiPhytochemestry 117: 116-122.
  • Surup F, Kuhnert E, Liscinskij E, Stadler M (2015)
    Silphiperfolene-type terpenoids and other metabolites from cultures of the tropical ascomycete Hypoxylon rickii (Xylariaceae). 
    Nat Prod Bioprospect 5: 167-173.
  • Sood S, Awal RP, Wink J, Mohr KI, Rohde M, Stadler M, Kämpfer P, Glaeser S, Schumann P, Garcia R, Müller R (2015) 
    Aggregicoccus edonensis  gen. nov., sp. nov., an unusually aggregating myxobacterium isolated from a soil sample. 
    Int J Syst Evol Microbiol 65:745-753 (doi:10.1099/ijs.0.061176-0)
  • Herkommer D, Thiede S, Wosniok PR, Dreisigacker S, Tian M, Debnar T, Irschik H, Menche D (2015) 
    Stereochemical determination of the leupyrrins and total synthesis of leupyrrin A1
    J Am Chem Soc 137: 4086-4089. 
  • Daranagama DA, Camporesi E, Tian Q, Liu X, Chamyuang S, Stadler M, Hyde KD (2015) 
    Anthostomella is polyphyletic comprising several genera in Xylariaceae. 
    Fungal Divers 73: 203238
  • Surup F, Thongbai B, Kuhnert E, Hyde KD, Stadler M (2015) 
    Deconins A-E –  unprecedented cuparenic and mevalonic or propionic acid conjugates from the basidomycete Deconica sp. 471. 
    J Nat Prod. 78: 934-938
  • Surup F, Medjedovic A, Schroers HJ, Stadler M (2015) 
    Production of obionin A and derivatives by the sooty blotch fungus Microcyclospora malicola. 
    Planta Med 81:1339-1344
  • Stadler M, Hoffmeister D (2015)
    Fungal natural products – the mushroom perspective.
    Front Microbiol 6:127 (doi:10.3389/fmicb.2015.00127).
  • Sir EB, Kuhnert E, Surup F, Hyde KD, Stadler M (2015)
    Discovery of new mitorubrin derivatives from Hypoxylon fulvo-sulphureum sp. nov. (Ascomycota, Xylariales).
    Mycol Progr 14:28, 1-12
  • Liu X, Wang L, Feng Y, Tian J, Xiang M, Sun J, Ding J, Yin W, Stadler M, Che Y (2015)
    Farming of a defensive fungal mutualist by an attelabid weevil.
    ISME Journal 9: 1793-1801
  • Wang X, Zhang X, Liu L, Xiang M, Wang W, Sun X, Che Y, Guo L, Liu G, Guo L, Wang C, Yin WB, Stadler M, Zhang X, Liu X (2015)
    Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products.
    BMC Genomics, 16:28 (doi:10.1186/s12864-014-1190-9)
  • Bruns N, Collisi W, Bernecker S, Stadler M, Richter C, Schwalbe H, Kalesse M (2015)
    Spirangien derivatives from the Myxobacterium Sorangium cellulosum: Isolation, structure elucidation, and biological activity.
    Eur J Org Chem 2015 (4): 847–857.(doi: 10.1002/ejoc.201403353)
  • Kuhnert E, Surup F, Sir E B, Lambert C, Hyde K D, Hladki A I, Romero A I, Stadler M (2015)
    Lenormandins A-G, new azaphilones from Hypoxylon lenormandii and Hypoxylon jaklitschii sp. nov., recognized by chemotaxonomic data.
    Fungal Divers 71:165-184 (doi: 10.1007/s13225-014-0318-1)
  • Richter C, Wittstein K, Kirk PM, Stadler M (2015) 
    An assessment of the taxonomy and chemotaxonomy of Ganoderma
    Fungal Divers 17: 1-15 (doi: 10.1007/s13225-014-0313-6)


  • Müller R, Raju R, Mohr KI, Bernecker S, Herrmann J (2014)
    Cystodienoic acid: A new diterpene isolated from the myxobacterium, Cystobacter sp..".
    Journal of Antibiotics, article accepted
  • Hamm R, Sugimoto Y, Steinmetz H, Efferth T (2014)
    Resistance mechanisms of cancer cells to the novel vacuolar H+-ATPase inhibitor archazolid B. 
    Investigational New Drugs, article in Press (doi: 10.1007/s10637-014-0134-1)
  • Hofle G, Reinecke S, Laude U, Spitzner D (2014)
    Amethystin, the coloring principle of Stentor amethystinus.
    Journal of Natural Products 77: 1383 – 1389 (doi: 10.1021/np5001363)
  • Pesic A, Steinhaus B, Kemper S, Nachtigall J, Kutzner HJ, Hofle G, Sussmuth RD (2014)
    Isolation and structure elucidation of the nucleoside antibiotic strepturidin from Streptomyces albus DSM 40763.
    Journal of Antibiotics 67: 471 – 477 (doi: 10.1038/ja.2014.16)
  • Poblete-Castro I, Rodriguez AL, Chi Lam CM, Kessler W (2014)
    Improved production of medium-chain-length polyhydroxyalkanoates in glucose-based fed-batch cultivations of metabolically engineered Pseudomonas putida strains
    Journal of Microbiology and Biotechnlogy 24: 59 – 69.
  • Fruth M, Plaza A, Hinsberger S, Sahner JH, Haupenthal J, Bischoff M, Jansen R, Müller R and Hartmann RW (2014)
    Binding mode characterization of novel RNA polymerase inhibitors using a combined biochemical and NMR approach.
    ACS Chemical Biology 9 (11): 2656-2663 (doi: 10.1021/cb5005433)
  • Reker D, Perna A, Rodrigues T, Schneider P, Reutlinger M, Mönch B, Koeberle A, Lamers C, Gabler M, Steinmetz H, Müller R, Schubert-Zsilavecz M, Werz O and Schneider G (2014)
    Revealing the macromolecular targets of complex natural products.
    Nature Chemistry 6 (12), 1072-1078 (doi:10.1038/nchem.2095)
  • Scherer O, Steinmetz H, Kaether C, Weinigel C, Barz D, Kleinert H, Menche D, Müller R, Pergola C and Werz O (2014)
    Targeting V-ATPase in primary human monocytes by archazolid potently represses the classical secretion of cytokines due to accumulation at the endoplasmic reticulum.
    Biochemical Pharmacology 91 (4), 490-500. (doi: 10.1016/j.bcp.2014.07.028)
  • Held J, Gebru T, Kalesse M, Jansen R, Gerth K, Müller R and Mordmüller B (2014)
    Antimalarial activity of the myxobacterial macrolide chlorotonil A.
    Antimicrobial Agents and Chemotherapy, 58 (11), 6378-6384. (doi: 10.1128/AAC.03326-14)
  • Müller S, Rachid S, Hoffmann T, Surup F, Volz C, Zaburannyi N and Müller R (2014)
    Biosynthesis of crocacin involves an unprecedented hydrolytic release domain showing similarity to condensation domains.
    Chemistry & Biology 21 (7), 855-865. (doi:10.1016/j.chembiol.2014.05.012)
  • Wensing A, Gernold M, Jock S, Jansen R, Geider K (2014)
    Identification and genetics of 6thioguanine secreted by Erwinia species and its interference with the growth of other bacteria.
    Mol Genet Genomics 289: 215–223. (doi: 10.1007/s00438-013-0805-1)
  • Wensing A, Gernold M, Jock S, Jelkmann W, Geider K, Beck A, Jansen R (2014)
    6-Thioguanine biosynthesis in Erwinia species.

    Acta Horticulturae 1056: 165-167. (ISBN: 978-94-62610-46-0)
  • Surup F, Viehrig K, Mohr KI, Herrmann J, Jansen R, Müller R (2014)
    Disciformycins A and B: 12-Membered Macrolide Glycoside Antibiotics from the Myxobacterium Pyxidicoccus fallax Active against Multiresistant Staphylococci.
    Angew Chem Int Ed 53: 13588 -13591 (doi: 10.1002/anie.201406973)
  • Zhang Y, Degen D, Ho M X, Sineva E, Ebright K Y, Ebright Y W, Mekler V, Vahedian-Movahed V, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, Arnold E, Ebright R H (2014) 
    GE23077 binds to the RNA polymerase ‘i’ and ‘i+1’ sites and prevents the binding of initiating nucleotides.

    eLife 2014;3:e02450. (doi: 10.7554/eLife.02450)
  • Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr K I, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014)
    Cystobactamids: Myxobacterial Topoisomerase Inhibitors Exhibiting Potent Antibacterial Activity.
    Angew Chem Int Ed 53: 14605-14609 (doi: 10.1002/anie.201409964)
  • Richter C, Wittstein K, Kirk PM, Stadler M (2014) 
    An assessment of the taxonomy and chemotaxonomy of Ganoderma. 
    Fungal Divers, in press (doi: 10.1007/s13225-014-0313-6)
  • Bills GF, Stadler M (2014) 
    Discovery, distribution and biosynthesis of fungal secondary metabolites. 
    Editorial to Special issue, Mycol Int J Fungal Biol 5(3): 99-101. (doi:10.1080/21501203.2014.943929)
  • Shen T, Hof LM, Hausmann H, Stadler M, Zorn H (2014) 
    Development of an enzyme linked immunosorbent assay for detection of cyathane diterpenoids. 
    BMC Biotechnology 2014, 14(1):98. (doi:10.1186/s12896-014-0098-4)
  • Jansen R, Sood S, Mohr K, Kunze B, Irschik H, Stadler M , Müller R (2014) 
    Nannozinones and Sorazinones, four unprecedented pyrazinones from Myxobacteria. 
    J Nat Prod 77: 2545-2552. (doi: 10.1021/np500632c)
  • Daranagama DA, Liu X, Chamyuang S, Stadler M, Hyde KD (2014) 
    A multiple gene genealogy reveals phylogenetic placement of Rhopalostroma lekae. 
    Phytotaxa 186: 177-187. (doi:10.11646/phytotaxa.186.4.1)
  • Sood S, Steinmetz H, Beims H, Mohr KI, Stadler M, Djukic M, von der Ohe W, Steinert M,, Daniel R, Müller R (2014) 
    Paenilarvins, iturin family lipopeptides from the honey bee pathogen Paenibacillus larvae. 
    ChemBioChem 15(13): 1947–1955. (doi: 10.1002/cbic.201402139)
  • Okanya P, Mohr K, Gerth K, Kessler W, Jansen R, Stadler M, Müller R (2014) 
    Hyafurones, hyapyrrolines and hyapyrones: Polyketides from Hyalangium minutum. 
    J Nat Prod 77: 1420-1429. (doi: 10.1021/np500145f)
  • Surup F, Kuhnert E, Lehmann E, Heitkämper S, Hyde KD, Fournier J, Stadler M (2014)
    Sporothriolide derivatives as chemotaxonomic markers for Hypoxylon monticulosum. 
    Mycol Int J Fungal Biol 5: 110-119. (doi:10.1080/21501203.2014.929600)
  • Stadler M, Hawksworth DL, Fournier J (2014) 
    The application of the name Xylaria hypoxylon, based on Clavaria hypoxylon of Linnaeus. 
    IMA Fungus 5: 57-66.
  • Surup F, Medjedović A, Szczygielski M, Schroers HJ, Stadler M (2014)
    Production of trichothecenes by the apple sooty blotch fungus Microcyclospora tardicrescens. 
    J Agric Food Chem 62: 3525–3530 (DOI: 10.1021/jf500153d).
  • Jansen R, Mohr KI, Bernecker S, Stadler M, Müller R (2014)
    Indothiazinone, an indolyl-thiazolyl-ketone from a novel mxobacterium belonging to the Sorangiineae. 
    J Nat Prod 77:1054-1060 (DOI: 10.1021/np500144t).
  • J. Niggemann, P. Bozko, N. Bruns, A. Wodtke, M.T. Gieseler, K. Thomas, C. Jahns, M. Nimtz, I. Reupke, T. Brueser, G. Auling, N. Malek, M. Kalesse (2014)
    Baceridin, a Cyclic Hexapeptide from an Epiphytic Bacillus Strain, Inhibits the Proteasome,
    ChemBioChem 2014, 7, 1021-1029.
  • Chomnunti P, Hongsanan S, Aguirre–Hudson B, Qing T, Peršoh D, Dhami MK, Alias SA, Xu J, Liu J, Stadler M, Hyde KD (2014) 
    The sooty moulds. 
    Fungal Divers 66: 1–36. (doi: 10.1007/s13225-014-0278 -5)
  • Halecker S, Surup F, Kuhnert E, Mohr KI, Brock NL, Dickschat JS, Junker C, Schulz B, Stadler M (2014)
    Hymenosetin, a 3-decalinoyltetramic acid antibiotic from cultures of the ash dieback pathogen, Hymenoscyphus pseudoalbidus
    Phytochemistry, 100: 86-91.
  • Jansen R, Sood S, Huch V, Kunze B, Stadler M, Müller R (2014) 
    Pyrronazols, metabolites from the mxobacteria Nannocystis pusilla and N. exedens are unusual chlorinated pyrone-oxazole-pyrroles. 
    J. Nat. Prod. 77: 320-326. (doi: 10.1021/np400877r)
  • Kirk PM, Stalpers JA, Braun U, Crous PW, Hansen K, Hawksworth DL, Hyde KD, Lücking R, Lumbsch HT, Rossman AY, Seifert KA, Stadler M (2013)
    A without-prejudice list of generic names of fungi for protection under the International Code of Nomenclature for algae, fungi, and plants

    IMA Fungus 4, 381-443.
  • Kuhnert E, Heitkämper S, Fournier J, Surup F, Stadler M (2014)
    Hypoxyvermelhotins A – C, novel pigments from Hypoxylon lechatii sp. nov.

    Fungal Biol. 118: 242-252.
  • Kuhnert E, Fournier J, Peršoh D, Luangsa-ard JJD, Stadler M (2014)
    New Hypoxylon species from Martinique and new evidence on the molecular phylogeny of Hypoxylon based on ITS rDNA and β-tubulin data

    Fungal Divers, 64: 181-203. (doi: 10.1007/s13225-013-0264-3).
  • Stadler M, Læssøe T, Fournier J, Decock C, Schmieschek B, Tichy HV, Peršoh D (2014)
    A polyphasic taxonomy of Daldinia (Xylariaceae)

    Stud Mycol, 77: 1-143 (doi: 10.3114/sim0016).



  • De Silva DD, Rapior S, Sudarman E, Stadler M, Xu J, Aisyah Alias S, Hyde KD (2013)
    Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

    Fungal Divers 61: 1-40.
  • Thongbai B, Surup F, Mohr K, Kuhnert E, Hyde KD, Stadler M (2013)
    Gymnopalynes A and B – Chloropropynyl-isocoumarin antibiotics from cultures of the basidiomycete Gymnopus sp.

    J. Nat. Prod., 2013, 76 (11), 2141–2144.
  • Daniel P. Canterbury, Kristen E. N. Scott, Ozora Kubo, Rolf Jansen, John L. Cleveland, and Glenn C. Micalizio (2013)
    Synthesis of C11-Desmethoxy Soraphen A1α: A Natural Product Analogue That Inhibits Acetyl-CoA Carboxylase

    ACS Med. Chem. Lett., 2013, 4 (12), 1244–1248.
  • Viehrig K, Surup F, Harmrolfs K, Jansen R, Kunze B, Müller R (2013)
    Concerted Action of P450 Plus Helper Protein to Form the Amino-hydroxy-piperidone Moiety of the Potent Protease Inhibitor Crocapeptin

    J. Am. Chem. Soc. 135, 16885-16894.
  • Martinez, J.P., Hinkelmann, B., Fleta-Soriano, E., Steinmetz, H., Jansen, R., Diez, J., Frank, R., Sasse, F., Meyerhans, A. (2013)
    Identification of myxobacteria-derived HIV inhibitors by a high-throughput two-step infectivity assay

    Microbial Cell Factories 12 (1), art. no. 85.
  • Martinez, J.P., Perez-Vilaro, G., Muthukumar, Y., Scheller, N., Hirsch, T., Diestel, R., Steinmetz, H., Jansen, R., Frank, R., Sasse, F., Meyerhans, A., Diez, J. (2013)
    Screening of small molecules affecting mammalian P-body assembly uncovers links with diverse intracellular processes and organelle physiology

    RNA Biology 10 (11), 1661-1669.
  • Rambold G, Stadler M, Begerow D (2013)
    Mycology should be recognized as a field in biology at eye level with other major disciplines – a memorandum

    Mycol Progr 12: 455–463.
  • Surup F, Mohr KI, Jansen R, Stadler M (2013)
    Cohaerins G - K, azaphilone pigments from Annulohypoxylon cohaerens and absolute stereochemistry of cohaerins C – K

    Phytochemistry 95: 252-258.
  • Pažoutová S, Follert S, Bitzer J, Keck M, Surup F, Šrůtka P, Holuša J, Stadler M (2013)
    A new endophytic insect-associated Daldinia species, recognised from a comparison of secondary metabolite profiles and molecular phylogeny

    Fungal Divers 60: 107–123.
  • Stadler,M., Kuhnert,E., Persoh,D., & Fournier,J. (2013)
    The Xylariaceae as model example for a unified nomenclature following the "One Fungus-One Name" (1F1N) concept

    Mycology 4, 5-21.
  • Stadler,M. & Hyde,K.D. (2013)
    Editorial comment - Volume 60 of Fungal diversity: Special issue dedicated to the COST Action FA1103, "endophytes in Biotechnology and Agriculture"

    Fungal Diversity 60, 1-4.
  • Irschik,H., Washausen,P., Sasse,F., Fohrer,J., Huch,V., Müller,R., & Prusov,E.V. (2013)
    Isolation, structure elucidation, and biological activity of maltepolides: remarkable macrolides from myxobacteria

    Angewandte Chemie International Edition 52, 5402-5405.
  • Hernández-Restrepo M, Castañeda-Ruíz RF, Gené J, Guarro J, Minter DW, Stadler M (2013)
    Microfungi from Portugal: Minimelanolocus manifestus sp. nov. and Vermiculariopsiella pediculata comb. nov.

    Mycotaxon 122: 135-143.
  • Da Cruz,A.C.R., Gusmao,L.F.P., Castaneda-Ruiz,R.F., Stadler,M., & Minter,D.W. (2013)
    Zelodactylaria, an interesting new genus from semi-arid northeast Brazil

    Mycotaxon 119, 241-248.
  • Castaneda-Ruiz,R.F., Heredia,G., Arias-Mota,R.M., Stadler,M., Saikawa,M., & McKenzie, E.H.C. (2013)
    Two new fungi from Mexico: Anaseptoidium gen. nov. and Cylindrosympodium sosae sp. nov.

    Mycotaxon 119, 141-148.
  • Altendorfer,M., Raja,A., Sasse,F., Irschik,H., & Menche,D. (2013)
    Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes

    Organic and Biomolecular Chemistry 11, 2116-2139.



  • Reboll, M., Nourbakhsh, M., Niggemann, J., Gerth, K., Steinmetz, H., Frank, R. (2012)
    Use of spirangiens for the treatment or prevention of IL-8 or IL-6 mediated inflammatory disorders

    Eur. Pat. Appl. (2012), EP 2520292 A1 20121107.
  • Jaklitsch, W.M., Stadler, M., Voglmayr, H. (2012)
    Blue pigment in Hypocrea caerulescens sp. Nov. And two additional new species in sect. Trichoderma

    Mycologia 104 (4), 925-941.
  • Reboll, M.R., Ritter, B., Sasse, F., Niggemann, J., Frank, R., Nourbakhsh, M. (2012)
    The myxobacterial compounds spirangien a and spirangien M522 are potent inhibitors of IL-8 expression
    ChemBioChem, 13 (3), 409-415.
  • Hoffmann, N., Keck, M., Neuweger, H., Wilhelm, M., Högy, P., Niehaus, K., Stoye, J. (2012)
    Combining peak- and chromatogram-based retention time alignment algorithms for multiple chromatography-mass spectrometry datasets.
    BMC Bioinformatics, 13: 214.
  • Zander,W., Irschik,H., Augustiniak,H., Herrmann,M., Jansen,R., Steinmetz,H., Gerth,K., Kessler,W., Kalesse,M., Hofle,G., & Müller,R. (2012)
    Sulfangolids, macrolide sulfate esters from Sorangium cellulosum

    Chemistry 18, 6264-6271.
  • Xiao,Y., Gerth,K., Müller,R., & Wall,D. (2012)
    Myxobacterium-produced antibiotic TA (Myxovirescin) inhibits type II signal peptidase

    Antimicrobial Agents and Chemotherapy 56, 2014-2021.
  • Svilar,L., Stankov-Jovanovic,V., Stadler,M., Nedev,H., & Tabet,J.C. (2012)
    Distinctive gas-phase fragmentation pathway of the mitorubramines, novel secondary metabolites from Hypoxylon fragiforme

    Rapid Communications in Mass Spectrometry 26, 2612-2618.
  • Steinmetz,H., Mohr,K.I., Zander,W., Jansen,R., Gerth,K., & Müller,R. (2012)
    Indiacens A and B: Prenyl Indoles from the myxobacterium Sandaracinus amylolyticus

    Journal of Natural Products 75, 1803-1805.
  • Altendorfer,M., Irschik,H., & Menche,D. (2012)
    Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien
    Bioorganic and Medicinal Chemistry Letters 22, 5731-5734.
  • Barbier,J., Gerth,K., Jansen,R., & Kirschning,A. (2012)
    Total synthesis of noricumazole B establishes d-arabinose as glycan unit

    Organic and Biomolecular Chemistry 10, 8298-8307.
  • Barbier,J., Jansen,R., Irschik,H., Benson,S., Gerth,K., Bohlendorf,B., Hofle,G., Reichenbach,H., Wegner,J., Zeilinger,C., Kirschning,A., & Müller,R. (2012)
    Isolation and total synthesis of icumazoles and noricumazoles-antifungal antibiotics and kation-channel blockers from Sorangium cellulosum

    Angewandte Chemie International Edition 51, 1256-1260.
  • Bielecki,P., Lukat,P., Husecken,K., Dotsch,A., Steinmetz,H., Hartmann,R.W., Müller,R., & Häußler,S. (2012)
    Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosa

    ChemBioChem 13, 2339-2345.
  • Bills,G.F., Gonzalez-Menendez,V., Martin,J., Platas,G., Fournier,J., Persoh,D., & Stadler,M. (2012)
    Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte

    PLoS ONE 7, e46687.
  • Castaneda-Ruiz,R.F., Granados,M.M., Mardones,M., Stadler,M., Minter,D.W., Hernandez-Restrepo,M., Gene,J., & Guarro,J. (2012)
    A microfungus from Costa Rica: Ticosynnema gen. nov.

    Mycotaxon 122, 255-259.
  • Chakraborty,A., Wang,D., Ebright,Y.W., Korlann,Y., Kortkhonjia,E., Kim,T., Chowdhury,S., Wigneshweraraj,S., Irschik,H., Jansen,R., Nixon,B.T., Knight,J., Weiss,S., & Ebright,R.H. (2012)
    Opening and closing of the bacterial RNA polymerase clamp

    Science 337, 591-595.
  • Gams,W., Baral,H.O., Jaklitsch,W.M., Kirschner,R., & Stadler,M. (2012)
    Clarifications needed concerning the new Article 59 dealing with pleomorphic fungi

    IMA Fungus 3, 175-177.
  • Gams,W., Humber,R.A., Jaklitsch,W., Kirschner,R., & Stadler,M. (2012)
    Minimizing the chaos following the loss of Article 59: Suggestions for a discussion

    Mycotaxon 119, 495-507.
  • Steinmetz,H., Zander,W., Shushni,M.A., Jansen,R., Gerth,K., Dehn,R., Drager,G., Kirschning,A., & Müller,R. (2012)
    Precursor-directed syntheses and biological evaluation of new elansolid derivatives

    ChemBioChem 13, 1813-1817.
  • Plaza,A., Garcia,R., Bifulco,G., Martinez,J.P., Huttel,S., Sasse,F., Meyerhans,A., Stadler,M., & Müller,R. (2012)
    Aetheramides A and B, potent HIV-inhibitory depsipeptides from a myxobacterium of the new genus "Aetherobacter"

    Organic Letters 14, 2854-2857.
  • Osteresch,C., Bender,T., Grond,S., von,Z.P., Kunze,B., Jansen,R., Huss,M., & Wieczorek,H. (2012)
    The binding site of the V-ATPase inhibitor apicularen is in the vicinity of those for bafilomycin and archazolid

    Journal of Biological Chemistry 287, 31866-31876.
  • Okanya,P.W., Mohr,K.I., Gerth,K., Steinmetz,H., Huch,V., Jansen,R., & Müller,R. (2012)
    Hyaladione, an S-methyl cyclohexadiene-dione from Hyalangium minutum

    Journal of Natural Products 75, 768-770.
  • Mohr,K.I., Garcia,R.O., Gerth,K., Irschik,H., & Müller,R. (2012)
    Sandaracinus amylolyticus gen. nov., sp. nov., a starch-degrading soil myxobacterium, and description of Sandaracinaceae fam. nov.

    International Journal of Systematic and Evolutionary Microbiology 62, 1191-1198.
  • Jahns,C., Hoffmann,T., Muller,S., Gerth,K., Washausen,P., Hofle,G., Reichenbach,H., Kalesse,M., & Müller,R. (2012)
    Pellasoren: Structure elucidation, biosynthesis, and total synthesis of a cytotoxic secondary metabolite from Sorangium cellulosum

    Angewandte Chemie International Edition 51, 5239-5243.
  • Huo,L., Rachid,S., Stadler,M., Wenzel,S.C., & Müller,R. (2012)
    Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis

    Chemistry and Biology 19, 1278-1287.
  • Höfle,G., Gerth,K., Reichenbach,H., Kunze,B., Sasse,F., Forche,E., & Prusov,E.V. (2012)
    Isolation, biological activity evaluation, structure elucidation, and total synthesis of eliamid: a novel complex i inhibitor

    Chemistry 18, 11362-11370.
  • Herrmann,J., Elnakady,Y.A., Wiedmann,R.M., Ullrich,A., Rohde,M., Kazmaier,U., Vollmar,A.M., & Müller,R. (2012)
    Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy

    PLoS ONE 7, e37416.
  • Hernandez-Restrepo,M., Castaneda-Ruiz,R.F., Gene,J., Guarro,J., Minter,D.W., & Stadler,M. (2012)
    Microfungi from Portugal: Minimelanolocus manifestus sp. nov. and Vermiculariopsiella pediculata comb. nov.

    Mycotaxon 122, 135-143.        



  • Abdel-Basset, R., Friedl, T., Mohr, K.I., Rybalka, N., Martin, W. (2011)
    High growth rate, photosynthesis rate and increased hydrogen(ases) in manganese deprived cells of a newly isolated Nostoc-like cyanobacterium 
    International Journal of Hydrogen Energy, 36, 12200-12210. 
  • Anderl, T., Nicolas, L., Münkemer, J., Baro, A., Sasse, F., Steinmetz, H., Jansen, R., Höfle, G., Taylor, R.E., Laschat, S. (2011)
    Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (Part II): Total synthesis of gephyronic acid

    Angewandte Chemie - International Edition, 50, 942-945.
  • Capell, A., Liebscher, S., Fellerer, K., Brouwers, N., Willem, M., Lammich, S., Gijselinck, I., Bittner, T., Carlson, A.M., Sasse, F., Kunze, B., Steinmetz, H., Jansen, R., Dormann, D., Sleegers, K., Cruts, M., Herms, J., Van Broeckhoven, C., Haass, C. (2011)
    Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase
    Journal of Neuroscience, 31, 1885-1894.                  
  • Dehn, R., Katsuyama, Y., Weber, A., Gerth, K., Jansen, R., Steinmetz, H., Höfle, G., Müller, R., Kirschning, A. (2011)
    Molecular basis of elansolid biosynthesis: Evidence for an unprecedented quinone methide initiated intramolecular diels-alder cycloaddition/ macrolactonization
    Angewandte Chemie – International Edition, 50, 3882-3887.
  • Frank, S., Keck, M., Sagasser, M., Niehaus, K., Weisshaar, B., Stracke, R. (2011)
    Two differentially expressed MATE factor genes from apple complement the Arabidopsis transparent testa12 mutant

    Plant Biology, 13, 42-50. 
  • Garcia, R., Pistorius, D., Stadler, M., Müller, R. (2011)
    Fatty acid-related phylogeny of myxobacteria as an approach to discover polyunsaturated omega-3/6 fatty acids
    Journal of Bacteriology, 193, 1930-1942.
  • Gentzsch, J., Hinkelmann, B., Kaderali, L., Irschik, H., Jansen, R., Sasse, F., Frank, R., Pietschmann, T. (2011)
    Hepatitis C virus complete life cycle screen for identification of small molecules with pro- or antiviral activity

    Antiviral Research, 89 (2), 136-148.
  • Jansen, R., Gerth, K., Steinmetz, H., Reinecke, S., Kessler, W., Kirschning, A., Müller, R. (2011)
    Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti
    Chemistry - A European Journal, 17, 7739-7744.
  • Keck, M., Gisch, N., Moll, H., Vorhölter, F.-J., Gerth, K., Kahmann, U., Lissel, M., Lindner, B., Niehaus, K., Holst, O. (2011)
    Unusual outer membrane lipid composition of the gram-negative, lipopolysaccharide-lacking myxobacterium sorangium cellulosum so ce56
    Journal of Biological Chemistry, 286, 12850-12859.
  • Kopp, M., Irschik, H., Gemperlein, K., Buntin, K., Meiser, P., Weissman, K.J., Bode, H.B., Müller, R. (2011)
    Insights into the complex biosynthesis of the leupyrrins in Sorangium cellulosum so ce690
    Molecular BioSystems, 7, 1549-1563.
  • Li, Z., Kessler, W., Van Den Heuvel, J., Rinas, U. (2011)
    Simple defined autoinduction medium for high-level recombinant protein production using T7-based Escherichia coli expression systems
    Applied Microbiology and Biotechnology, 91, 1203-1213.
  • Nicolas, L., Anderl, T., Sasse, F., Steinmetz, H., Jansen, R., Höfle, G., Laschat, S., Taylor, R.E. (2011)
    Gephyronic acid, a missing link between polyketide inhibitors of eukaryotic protein synthesis (Part I): Structural revision and stereochemical assignment of gephyronic acid
    Angewandte Chemie - International Edition, 50, 938-941.
  • Okanya, P.W., Mohr, K.I., Gerth, K., Jansen, R., Müller, R. (2011)
    Marinoquinolines A-F, pyrroloquinolines from ohtaekwangia kribbensis (Bacteroidetes)
    Journal of Natural Products, 74, 603-608.
  • Rachid, S., Huo, L., Herrmann, J., Stadler, M., Köpcke, B., Bitzer, J., Müller, R. (2011)
    Mining the Cinnabaramide Biosynthetic Pathway to Generate Novel Proteasome Inhibitors
    ChemBioChem, 12, 922-931.
  • Steinmetz, H., Gerth, K., Jansen, R., Dehn, R., Reinecke, S., Kirschning, A., Müller, R. (2011)
    Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti Isolated as Two Stable Atropisomers

    Angewandte Chemie - International Edition, 50, 532-536.
  • Srivastava, A., Talaue, M., Liu, S., Degen, D., Ebright, R.Y., Sineva, E., Chakraborty, A., Druzhinin, S.Y., Chatterjee, S., Mukhopadhyay, J., Ebright, Y.W., Zozula, A., Shen, J., Sengupta, S., Niedfeldt, R.R., Xin, C., Kaneko, T., Irschik, H., Jansen, R., Donadio, S., Connell, N., Ebright, R.H. (2011)
    New target for inhibition of bacterial RNA polymerase: 'switch region'
    Current Opinion in Microbiology, 14, 532-543.
  • Zander, W., Gerth, K., Mohr, K.I., Kessler, W., Jansen, R., Müller, R. (2011)
    Roimatacene: An antibiotic against gram-negative bacteria isolated from cystobacter ferrugineus Cb G35 (Myxobacteria)
    Chemistry - A European Journal, 17, 7875-7881.
  • Zander, W., Mohr, K.I., Gerth, K., Jansen, R., Müller, R. (2011)
    P-hydroxyacetophenone amides from cystobacter ferrugineus, strain Cb G35
    Journal of Natural Products, 74, 1358-1363.



  • Jansen, R., Irschik, H., Huch, V., Schummer, D., Steinmetz, H., Bock, M., Schmidt, T., Kirschning, A., and Müller, R. 2010.
    Carolacton -a macrolide ketocarbonic acid reducing biofilm by the caries- and endocarditis-associated bacterium Streptococcus mutans.

    European Journal of Organic Chemistry: 1284.
  • Buntin, K., Irschik, H., Weissman, K. J., Luxenburger, E., Blöcker, H., and Müller, R. 2010.
    Biosynthesis of Thuggacins in Myxobacteria: Comparative Cluster Analysis Reveals Basis for Natural Product Structural Diversity.
    Chemistry & Biology 17: 342.
  • Irschik, H., Kopp, M., Weissman, K. J., Buntin, K., Piel, J., and Müller, R. 2010.
    Analysis of the sorangicin  gene cluster reinforces the utitlity of a combined hylogenetic/retrobiosynthetic analysis for deciphering natural product assembly by transATPKS.
    ChemBioChem 11: 1840.
  • Nawrath, T., Gerth, K., Müller, R., and Schulz, S. 2010.
    The biosynthesis of the aroma volatile 2-methyltetrahydrothiophen-3-one in the bacterium Chitinophaga Fx 7914.
    ChemBioChem 11: 1014.
  • Menche, D., and Irschik, H. 2010.
    Design, synthesis and biological evaluation of simplified analogues of the RNA polymerase inhibitor etnangien.
    Bioorganic & Medicinal Chemistry Letters 20: 939.
  • Bülow, L., Nickeleit, I., Girbig, A.-K., Brodmann, T., Rentsch, A., Eggert, U., Sasse, F., Steinmetz, H., Frank, R., Carlomagno, T., Malek, N.P., Kalesse, M. 2010.
    Synthesis and biological characterization of argyrin F.
    ChemMedChem, 5: 832.
  • Nawrath, T., Gerth, K., Müller, R., and Schulz, S. 2010.
    Volatile Methyl Esters of Medium Chain Length from the Bacterium Chitinophaga Fx7914.
    Chemistry & Biodiversity: 7: 2228



  • Jensen, N. A., Gerth, K., Grotjohann, T., Kapp, D., Kecek, M., and Niehaus, K. 2009.
    Establishment of a high content assay for the identification anc characterization of bioactivities in crude bacterial extracts that interfere with the eukaryotic cell cycle.
    Journal of Biotechnology 140 (1-2), pp. 124-134
  • Rachid, S., Gerth, K., and Müller, R. 2009.
    NtcA-A Negative Regualtor of Secondary Metabolite Biosynthesis in Sorangium cellulosum.
    J. Biotechnology  140 (1-2), pp. 135-142
  • Perlova O., Gerth K., Kuhlmann S., Zhang Y., Müller R. (2009).
    Novel Expression Hosts for Complex Secondary Metabolite Megasynthetases: Production of Myxochromide in the Thermophilic Isolate Corallococcus GT-2 macrosporus.
    Microbial cell factories: 2009, 8:1  doi:10.1186/1475-2859-8-1
  • Hagelueken G., Albrecht S. C., Steinmetz H., Jansen R., Heinz D. W., Kalesse M., Schubert W.-D. (2009).
    The Absolute Configuration of Rhizopodin and Its Inhibition of Actin Polymerization by Dimerization.
    Angew. Chem. Int. Ed.: 48, 595 – 598.



  • Rachid S., Gerth K., Müller R. (2008).
    NtcA - A Negative Regulator of Secondary Metabolite Biosynthesis in Sorangium cellulosum.
    J. Biotech. 2009 Mar 10;140(1-2):135-42.
  • Jensen, N. A., K. Gerth, T. Grotjohann, D. Kapp, M. Keck, K. Niehaus. (2008). Establishment of a High Content Assay for the Identification and Characterization of Bioactivities in Crude Bacterial Extracts that Interfere with the Eukaryotic Cell Cycle.
    J. Biotech. 2009 Mar 10;140(1-2):124-34. 
  • Mukhopadhyay J., Das K., Ismail S., Koppstein D., Jang M., Hudson B., Sarafianos S., Tuske S., Patel J., Jansen R., Irschik H., Arnold E., Ebright R. H. (2008).
    The RNA Polymerase "Switch Region" is a Target for Inhibitors.
    Cell: 135, 295 – 307.
  • Menche D., Arikan F., Perlova O., Horstmann N., Ahlbrecht W., Wenzel S.C., Jansen R., Irschik H., Müller R. (2008).
    Stereochemical Determination and Complex Biosynthetic Assembly of Etnangien, a Highly Potent RNA Polymerase Inhibitor from the Myxobacterium Sorangium cellulosum.
    J. Am. Chem. Soc., 130, 14234 – 14243.
  • Feklistov A., Mekler V., Jiang Q., Westblade L. F., Irschik H., Jansen R., Mustaev A., Ebright R. H., Darst S. A. (2008).
    Rifamycins Do Not Function by Allosteric Modulation of Binding of Mg2+ to the RNA Polymerase Active Center.
    PNAS: 105, 14820 – 14825.
  • Bock M., Buntin K., Müller R., Kirschning A. (2008).
    Stereochemical Determination of Thuggacins A – C, Highly Active Antibiotics from the Myxobacterium Sorangium cellulosum.
    Angew. Chem. Int. Ed.: 47, 2308 – 2311.
  • Gerth K., Steinmetz H., Höfle G., Jansen R. (2008).
    Chlorotonil A, a Macrolide with a Unique gem-Dichloro-1,3-dione Functionality from Sorangium cellulosum, So ce1525.

    Angew. Chem.120, 610 – 613. Angew. Chem. Int. Ed.: 47, 600 – 602.
  • Höfle G., Irschik H. (2008).
    Isolation and Biosynthesis of Aurachin P and 5-Nitroresorcinol from Stigmatella erecta.
    J. Nat. Prod.: 71, 1946 – 1948.
  • Dwivedi D., Jansen R., Molinari G., Nimtz M., Johri B. N., Wray V. (2008). 
    Antimycobacterial Serratamolides and Diacyl Peptoglucosamine Derivatives from Serratia sp..

    J. Nat. Prod.: 71, 637 – 641.
  • Jansen R., Steinmetz H., Sasse F., Schubert W.-D., Hagelüken G., Albrecht S. C., Müller R. (2008).
    Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria).
    Tetrahedron Lett.: 49, 5796 – 5799.
  • Nickeleit I., Zender S., Sasse F., Geffers R., Brandes G., Sörensen I., Steinmetz H., Kubicka S., Carlomagno T., Menche D., Gütgemann I., Buer J., Gossler A., Manns M.P., Kalesse M., Frank R., Malek N.P. (2008).
    Argyrin A Reveals a Critical Role for the Tumor Suppressor Protein p27kip1 in Mediating Antitumor Activities in Response to Proteasome Inhibition.
    Cancer Cell, 14, 23 – 35.
  • Knauber T., Doss S.D., Gerth K., Perlova O., Müller R., Treuner-Lange A. (2008).
    Mutation in the rel Gene of Sorangium cellulosum Affects Morphological and Physiological Differentiation.
    Mol. Microbiol.: 69, 254 – 266.



  • Schneiker S., Perlova O., Kaiser O., Gerth K., Alici A., Altmeyer M. O., Bartels D., Bekel T., Beyer S., Bode E., Bode H. B., Bolten C. J., Choudhuri J. V., Doss S., Elnakady Y. A., Frank B., Gaigalat L., Goesmann A., Groeger C., Gross F., Jelsbak L., Jelsbak L., Kalinowski J., Kegler C., Knauber T., Konietzny S., Kopp M., Krause L., Krug D., Linke B., Mahmud T., Martinez-Arias R., McHardy A.C., Merai M., Meyer F., Mormann S., Muoz-Dorado J., Perez J., Pradella S., Rachid S., Raddatz G., Rosenau F., Rückert C., Sasse F., Scharfe M., Schuster S. C., Suen G., Treuner-Lange A., Velicer G. J., Vorhölter F.-J., Weissmann K. J., Welch R. D., Wenzel S. C., Whithworth D. E., Wilhelm S., Wittmann C., Blöcker H., Pühler A., Müller R. (2007).
    Complete Genome Sequence of the Myxobacterium Sorangium cellulosum.
    Nature Biotechnology:  25, 1281 – 1289
  • Kopp M., Rupprath C., Irschik H., Bechthold A., Elling L., Müller R. (2007).
    SorF: A Glycosyltransferase with Promiscuous Donor Substrate Specifity in vitro.
    ChemBioChem: 8, 813 – 819.
  • H. Irschik, H. Reichenbach, G. Höfle, R. Jansen (2007).
    The Thuggacins, Novel Antibacterial Macrolides from Sorangium cellulosum Acting against Selected Gram-positive Bacteria: Production, Antimicrobial Activity and Mechanism of Action.
    J. Antibiot.: 60, 733 – 738.
  • Steinmetz H., Irschik H., Kunze B., Reichenbach H., Höfle G., Jansen R. (2007).
    Thuggacins, Macrolide Antibiotics Active against Mycobacterium tuberculosis: Isolation from Myxobacteria, Structure Elucidation, Conformation Analysis and Biosynthesis.
    Chem. Eur. J.: 13, 5822 – 5832.
  • Janssen D., Albert D., Jansen R., Müller R., Kalesse M. (2007).
    Chivosazole A - Elucidation of the Absolute and Relative Configuration.
    Angew. Chem.: 119, 4985 – 4988. Angew. Chem. Int. Ed.: 46, 4898 – 4901.
  • Irschik H., Schummer D., Höfle G., Reichenbach H., Steinmetz H., Jansen R. (2007).
    Etnangien, a Macrolide-Polyene Antibiotic from Sorangium cellulosum That Inhibits Nucleic Acid Polymerases.
    J. Nat. Prod.: 70, 941 – 947.
  • Zainuddin E. N., Mentel R., Wray V., Jansen R., Nimtz M., Lalk M., Mundt S. (2007). 
    Cyclic Depsipeptides, Ichthyopeptins A and B, from Microcystis ichthyoblabe.

    J. Nat. Prod.: 70, 1084 – 1088.
  • Sharma A., Jansen R., Nimtz M., Johri B. N., Wray V. (2007).
    Rhamnolipids from the Rhizosphere Bacterium Pseudomonas sp. GRP3 That Reduces Damping-off Disease in Chilli and Tomato Nurseries.
    J. Nat. Prod.: 70, 941 – 947.
  • Bui H. T. N., Jansen R., Pham H. T. L., Mundt S. (2007).
    Carbamidocyclophanes A - E, Chlorinated Paracyclophanes with Cytotoxic and Antibiotic Activity from the Vietnamese Cyanobacterium Nostoc sp..
    J. Nat. Prod.: 70, 499 – 503.
  • Rachid, S., Gerth, K., Kochems, I., Müller, R. (2007). 
    Deciphering Regulatory Mechanisms for Secondary Metabolite Production in the Myxobacterium Sorangium cellulosum So ce56.
    Mol. Microbiol.: 63, 1783 – 1796. 
  • Gerth, K., Perlova, O., Müller, R. (2007).
    Sorangium cellulosum (Ch. 20) in: Multicellularity and Differentiation Among the Myxobacteria and Their Neighbors
    HB Kaplan & D Whitworth, editors. American Society for Microbiology Press, Washington, DC.
  • Gerth K., Irschik H., Jansen R., Kunze B., Müller R., Sasse F. (2007).
    Myxobakterien, vom Aussenseiter zum Geheimfavoriten,
    in Vorbild Natur, G. Kreysa, D. Sell (Eds.) Dechema e.V., Frankfurt am Main, 64 – 71. 
  • Menche, D., Hassfeld, J., Steinmetz, H., Huss, M., Wieczorek, H., Sasse, F. (2007).
    Archazolid-7-O-α-D-glucopyranoside - Isolation, Structural Elucidation and Solution Conformation of a Novel V-ATPase Inhibitor from the Myxobacterium Cystobacter violaceus.
    Eur. J. Org. Chem.: (7), 1196 – 1202.
  • Menche, D., Hassfeld, J., Steinmetz, H., Huss, M., Wieczorek, H., Sasse, F. (2007).
    The First Hydroxylated Archazolid from the Myxobacterium Cystobacter violaceus: Isolation, Structural Elucidation and V-ATPase Inhibition.
    J. Antibiot.: 60, 328 – 331.
  • Frank, B., Knauber, J., Steinmetz, H., Scharfe, M., Blöcker, H., Beyer, S., Müller, R. (2007). 
    Spiroketal Polyketide Formation in Sorangium: Identification and Analysis of the Biosynthetic Gene Cluster for the Highly Cytotoxic Spirangienes.

    Chemistry & Biology: 14, 221 – 233.





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