Drug Delivery

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Drug Delivery” on techniques for the correct distribution of novel drugs.

Leader

Publications

Full publications list of Claus-Michael Lehr (PDF)

DDEL publications  from 2010 to date (PDF)

Claus-Michael Lehr - 10 most cited papers (PDF)

Selected highly cited papers

Graef F, Vukosavljevic B, Michel JP, Wirth M, Ries O, De Rossi C, Windbergs M, Rosilio V, Ducho C, Gordon S & Lehr CM (2016) The bacterial cell envelope as delimiter of anti-infective bioavailability – An in vitro permeation model of the Gram-negative bacterial inner membrane. Journal of Controlled Release 243: 214–224

Kuehn A, Kletting S, Souza Carvalho-Wodarz C de, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N & Lehr C-M (2016) Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. ALTEX 33: 251–260

Menina S, Labouta HI, Geyer R, Krause T, Gordon S, Dersch P & Lehr CM (2016) Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infective drugs. RSC Advances 6: 41622–41629

Serr I, Furst RW, Ott VB, Scherm MG, Nikolaev A, Gokmen F, Kalin S, Zillmer S, Bunk M, Weigmann B, Kunschke N, Loretz B, Lehr C-M, Kirchner B, Haase B, Pfaffl M, Waisman A, Willis RA, Ziegler A-G & Daniel C (2016) miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity. Proceedings of the National Academy of Sciences of the United States of America 113: E6659-E6668

Susewind J, Souza Carvalho-Wodarz C de, Repnik U, Collnot E-M, Schneider-Daum N, Griffiths GW & Lehr C-M (2016) A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa for safety testing of nanomaterials. Nanotoxicology 10: 53–62

Lehr CM, Labouta HI, Gordon S, Castoldi A, Menina S, Geyer R, Kochut A & Dersch P. Lehr CM, Labouta HI, Gordon S, Castoldi A, Menina S, Geyer R, Kochut A & Dersch P (2015) Methods and compositions of carrier systems for the purpose of intracellular drug targeting

Labouta HI, Menina S, Kochut A, Gordon S, Geyer R, Dersch P & Lehr CM (2015) Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery. Journal of Controlled Release 220: 414–424

Mahiny AJ, Dewerth A, Mays LE, Alkhaled M, Mothes B, Malaeksefat E, Loretz B, Rottenberger J, Brosch DM, Reautschnig P, Surapolchai P, Zeyer F, Schams A, Carevic M, Bakele M, Griese M, Schwab M, Nurnberg B, Beer-Hammer S & Handgretinger R et al (2015) In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nature biotechnology 33: 584–586

Mittal A, Schulze K, Ebensen T, Weissmann S, Hansen S, Guzmán CA & Lehr CM (2015) Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination. Journal of Controlled Release 206: 140–152

Mittal A, Schulze K, Ebensen T, Weißmann S, Hansen S, Lehr CM & Guzmán CA (2015) Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation. Nanomedicine: Nanotechnology, Biology, and Medicine 11: 147–154

Raber AS, Mittal A, Schäfer J, Bakowsky U, Reichrath J, Vogt T, Schaefer UF, Hansen S & Lehr CM (2014) Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm. Journal of Controlled Release 179: 25–32

Herd H, Daum N, Jones AT, Huwer H, Ghandehari H & Lehr CM (2013) Nanoparticle geometry and surface orientation influence mode of cellular uptake. ACS Nano 7: 1961–1973

News

Bachelor & Master
Are you interested in a bachelor or master thesis? We are looking forward to your request!

Video

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Kleine Teile – große Wirkung: Pharmazeuten des HIPS schleusen Medikamente zielsicher durch den Körper Wie kommt ein Medikament dahin, wo es wirken soll? Das ist eine der zentralen Fragen bei der Entwicklung neuer Wirkstoffe. Denn es reicht nicht, ein tolles neues Medikament gegen Darminfektionen im Reagenzglas zu haben – es muss auch dort hin gelangen, wo die Krankheit stattfindet. Mit Transportmolekülen schleusen die Pharmazeuten des HZI diese Wirkstoffe durch unseren Körper – über Barrieren, durch passende Lücken und an gefährlichen Stellen vorbei. Besuchen Sie Claus-Michael Lehr und Brigitta Loretz am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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