Drug Delivery

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Drug Delivery” on techniques for the correct distribution of novel drugs.



Complete List of Publications of Claus-Michael Lehr's Group

Download the complete List of Publications

Selected highly cited papers

Lehr, C.-M., Bouwstra, J.A., Schacht, E.H., Junginger, H.E., In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers, Int. J. Pharm., 78 (1992) 43-48. Cited 725 times.

Ravi Kumar, M.N.V., Bakowsky, U., Lehr, C.M., Preparation and characterization of cationic PLGA nanospheres as DNA carriers, Biomaterials, 25 (2004) 1771-1777. Cited 314 times.

Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H., Lehr, C.-M., A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro, Bioconjugate Chem., 11 (2000) 926-932. Cited 243 times.

Lamprecht, A., Schäfer, U., Lehr, C.-M., Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa, Pharm. Res., 18 (2001) 788-793. Cited 216 times.

Nafee, N., Taetz, S., Schneider, M., Schaefer, U.F., Lehr, C.-M., Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides, Nanomedicine: NBM, 3 (2007) 173-183. Cited 124 times.

Collnot, E.-M., Baldes, C., Wempe, M.F., Kappl, R., Hüttermann, J., Hyatt, J.A., Edgar, K.J., Schaefer, U.F., Lehr, C.-M., Mechanism of inhibition of P-glycoprotein mediated efflux by vitamin E TPGS: Influence on ATPase activity and membrane fluidity, Mol. Pharmaceutics, 4 (2007) 465-474. Cited 117 times.


Selected Recent Papers

Kuehn, A., Kletting, S., de Souza Carvalho-Wodarz, C., Repnik, U., Griffiths, G., Fischer, U., Meese, E., Huwer, H., Wirth, D., May, T., Schneider-Daum, N., Lehr, C.-M.: Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. ALTEX. 33, 251–260 (2016).

Susewind, J. et al. A 3D co-culture of three human cell lines to model the inflamed intestinal mucosa. for safety testing of nanomaterials. Nanotoxicology. 10, 53–62 (2016).

Murgia, X., Pawelzyk, P., Schaefer, U.F., Wagner, C., Willenbacher, N., Lehr, C.-M.: Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition. Biomacromolecules. 17, 1536–1542 (2016).

Menina, S., Labouta, H.I., Geyer, R., Krause, T., Gordon, S., Dersch, P., Lehr, C.-M.: Invasin-functionalized liposome nanocarriers improve intracellular delivery of anti-infective drugs. RSC Adv. 6, 41622–29 (2016).

Mittal, A. et al. Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination. J. Control. Rel. 206, 140–152 (2015).

Labouta, H.I., Menina, S., Kochut, A., Gordon, S., Geyer, R., Dersch, P., Lehr, C.-M.: Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery. J. Control. Rel. 220, 414–424 (2015).

Mittal, A. et al. Efficient nanoparticle-mediated needle-free transcutaneous vaccination via hair follicles requires adjuvantation. Nanomedicine NBM 11, 147–154 (2015).

Raesch, S.S., Tenzer, S., Storck, W., Rurainski, A., Selzer, D., Ruge, C.A., Perez-Gil, J., Schaefer, U.F., Lehr, C.-M.: Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung Surfactant Reveals Differences in Protein, but Not Lipid Composition. ACS Nano. 9, 11872–11885 (2015).

Mahiny, A.J., Dewerth, A., Mays, L.E., ..Malaeksefat, E., Loretz, B…Lehr, C.-M., Kormann, M.S.D.: In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. Nature Biotechnology. 33, 584–586 (2015).


Bachelor & Master
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  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Kleine Teile – große Wirkung: Pharmazeuten des HIPS schleusen Medikamente zielsicher durch den Körper Wie kommt ein Medikament dahin, wo es wirken soll? Das ist eine der zentralen Fragen bei der Entwicklung neuer Wirkstoffe. Denn es reicht nicht, ein tolles neues Medikament gegen Darminfektionen im Reagenzglas zu haben – es muss auch dort hin gelangen, wo die Krankheit stattfindet. Mit Transportmolekülen schleusen die Pharmazeuten des HZI diese Wirkstoffe durch unseren Körper – über Barrieren, durch passende Lücken und an gefährlichen Stellen vorbei. Besuchen Sie Claus-Michael Lehr und Brigitta Loretz am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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