Drug Delivery

This group is located at the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)

While considering the confusing flood of drugs in the pharmacies it is hard to believe in a lack of medication. But there are still many infectious diseases and also cancer that cannot be treated sufficiently. During a medical treatment it is essential that the drug arrives at the envisaged body region. Read more about the research of the department “Drug Delivery” on techniques for the correct distribution of novel drugs.

Leader

Publications

Complete List of Publications of Claus-Michael Lehr's Group

Download the complete List of Publications

Selected highly cited papers

Barthold, S.; Kletting, S.; Taffner, J.; De Souza Carvalho-Wodarz, C.; Lepeltier, E.; Loretz, B.; Lehr, C. M. (2016): Preparation of nanosized coacervates of positive and negative starch derivatives intended for pulmonary deliveryof proteins. In: Journal of Materials Chemistry B 4 (13), S. 2377-2386. DOI: 10.1039/c6tb00178e.

Graef, Florian; Vukosavljevic, Branko; Michel, Jean Philippe; Wirth, Marius; Ries, Oliver; De Rossi, Chiara et al.(2016): The bacterial cell envelope as delimiter of anti-infective bioavailability - An in vitro permeation model ofthe Gram-negative bacterial inner membrane. In: Journal of Controlled Release 243, S. 214-224. DOI:10.1016/j.jconrel.2016.10.018.

Kanber, Erdem; Yamada, Hiroe; Loretz, Brigitta; Lepeltier, Elise; Lehr, Claus-Michael (2016): Design of PolyamineGraftedStarches for Nucleotide Analogue Delivery: In Vitro Evaluation of the Anticancer Activity. In: Bioconjugatechemistry. DOI: 10.1021/acs.bioconjchem.6b00396.

Kuehn, Anna; Kletting, Stephanie; Souza Carvalho-Wodarz, Cristiane de; Repnik, Urska; Griffiths, Gareth; Fischer,Ulrike et al. (2016): Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. In:ALTEX 33 (3), S. 251-260. DOI: 10.14573/altex.1511131.

Mathes, C.; Melero, A.; Conrad, P.; Vogt, T.; Rigo, L.; Selzer, D. et al. (2016): Nanocarriers for optimizing the balancebetween interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverseeffects. In: Journal of Controlled Release 223, S. 207-214. DOI: 10.1016/j.jconrel.2015.12.010.

Menina, Sara; Labouta, Hagar Ibrahim; Geyer, Rebecca; Krause, Tanja; Gordon, Sarah; Dersch, Petra; Lehr, ClausMichael (2016): Invasin-functionalized liposome nanocarriers improve the intracellular delivery of anti-infectivedrugs. In: RSC Advances 6 (47), S. 41622-41629. DOI: 10.1039/c6ra02988d.

Murgia, Xabier; Pawelzyk, Paul; Schaefer, Ulrich F.; Wagner, Christian; Willenbacher, Norbert; Lehr, Claus Michael(2016): Size-Limited Penetration of Nanoparticles into Porcine Respiratory Mucus after Aerosol Deposition. In:Biomacromolecules 17 (4), S. 1536-1542. DOI: 10.1021/acs.biomac.6b00164.

Serr, Isabelle; Furst, Rainer W.; Ott, Verena B.; Scherm, Martin G.; Nikolaev, Alexei; Gokmen, Fusun et al. (2016):miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors inT1D islet autoimmunity. In: Proceedings of the National Academy of Sciences of the United States of America 113(43), E6659-E6668. DOI: 10.1073/pnas.1606646113.

Susewind, Julia; Souza Carvalho-Wodarz, Cristiane de; Repnik, Urska; Collnot, Eva-Maria; Schneider-Daum, Nicole;Griffiths, Gareth Wyn; Lehr, Claus-Michael (2016): A 3D co-culture of three human cell lines to model the inflamedintestinal mucosa for safety testing of nanomaterials. In: Nanotoxicology 10 (1), S. 53-62. DOI:10.3109/17435390.2015.1008065.

Labouta, Hagar Ibrahim; Menina, Sara; Kochut, Annika; Gordon, Sarah; Geyer, Rebecca; Dersch, Petra; Lehr, ClausMichael (2015): Bacteriomimetic invasin-functionalized nanocarriers for intracellular delivery. In: Journal ofControlled Release 220, S. 414-424. DOI: 10.1016/j.jconrel.2015.10.052.

Mahiny, Azita J.; Dewerth, Alexander; Mays, Lauren E.; Alkhaled, Mohammed; Mothes, Benedikt; Malaeksefat, Emadet al. (2015): In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency. In: Naturebiotechnology 33 (6), S. 584-586. DOI: 10.1038/nbt.3241.

Mittal, Ankit; Schulze, Kai; Ebensen, Thomas; Weissmann, Sebastian; Hansen, Steffi; Guzmán, Carlos A.; Lehr, ClausMichael (2015): Inverse micellar sugar glass (IMSG) nanoparticles for transfollicular vaccination. In: Journal ofControlled Release 206, S. 140-152. DOI: 10.1016/j.jconrel.2015.03.017.

Raesch, Simon Sebastian; Tenzer, Stefan; Storck, Wiebke; Rurainski, Alexander; Selzer, Dominik; Ruge, ChristianArnold et al. (2015): Proteomic and Lipidomic Analysis of Nanoparticle Corona upon Contact with Lung SurfactantReveals Differences in Protein, but Not Lipid Composition. In: ACS Nano 9 (12), S. 11872-11885. DOI:10.1021/acsnano.5b04215.

Kirch, J.; Schneider, A.; Abou, B.; Hopf, A.; Schaefer, U. F.; Schneider, M. et al. (2012): Optical tweezers revealrelationship between microstructure and nanoparticle penetration of pulmonary mucus. In: Proceedings of theNational Academy of Sciences of the United States of America 109 (45), S. 18355-18360. DOI:10.1073/pnas.1214066109.

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Video

  • HIPS Infofilm (English)

    Resistance to antibiotics has become one of the major global challenges regarding infectious diseases. This is specifically the issue that is being tackled by the new Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS).

Audio Podcast

  • Kleine Teile – große Wirkung: Pharmazeuten des HIPS schleusen Medikamente zielsicher durch den Körper Wie kommt ein Medikament dahin, wo es wirken soll? Das ist eine der zentralen Fragen bei der Entwicklung neuer Wirkstoffe. Denn es reicht nicht, ein tolles neues Medikament gegen Darminfektionen im Reagenzglas zu haben – es muss auch dort hin gelangen, wo die Krankheit stattfindet. Mit Transportmolekülen schleusen die Pharmazeuten des HZI diese Wirkstoffe durch unseren Körper – über Barrieren, durch passende Lücken und an gefährlichen Stellen vorbei. Besuchen Sie Claus-Michael Lehr und Brigitta Loretz am Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)…
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