Compound Profiling und Screening
The skin and mucosa of all humans are colonized by a large number of different microorganisms. Among them are opportunistic pathogens, which switch from harmless commensal organisms into life-threatening pathogens in particular when the immune system is compromised, e.g. as consequence of a severe disease or of therapeutic interventions, such as chemotherapies or antibiotic treatment. Thus, these infections frequently develop on top of another severe disease causing complications and extended stays in critical care units of hospitals. To avoid the outbreak of those infections, antibiotics are prophylactically applied, which supports the emergence of antibiotic resistance. Hence, new therapeutic approaches are urgently needed.