Type III secretion system chaperones and effectors
We are working on several components, effectors and chaperones of the Y. enterocolotica type III and enteropathogenic Escherichia coli (EPEC) secretion systems. For efficient secretion, type III secretion system effectors require specific chaperone proteins that keep the effectors in a partially unfolded state prior to transfer through the injectisome.
After having solved the structure of the YopT chaperone SycT (Büttner et al, 2005) we recently solved the structure of SycD, which is responsible for translocator proteins showing a tetratricopeptide repeat fold (Heinz, 2007, in press) .
- Structure and Function of Proteins - Prof. Wulf Blankenfeldt