Needle-free transdermal vaccination
Traditional vaccination requires an intramuscular injection although it does not deliver the vaccine optimally to the skin antigen-presenting cells, which elicit the immune response. Current strategies of needle-free vaccination via the dermal route reduce the protective stratum corneum barrier for a significant time. Therefore, these strategies are suboptimal for specific applications as for example mass vaccination campaigns in countries with critical hygienic conditions.
A new alternative vaccination system uses nanoparticles for targeting the skin immune system via hair follicles. Since pollen-antigens rapidly cross the sebum-filled follicle and cause an immune response with susceptible persons, we hypothesize that mimicking the delivery strategy of pollen with artificial particulate carriers is a promising strategy for non-invasive vaccination across the intact skin barrier.
- Drug Delivery - Prof. Dr. Claus-Michael Lehr