SPP 1150

Signal Pathways to the Cytoskeleton and Bacterial Pathogenesis

The Priority Programme investigates the cytoskeleton as a "signal-responsive subcompartment" involved in various cellular processes, including signal transduction by extracellular stimuli and especially as a target of pathogen-host interactions. Dynamic changes of the cytoskeleton play pivotal roles in the interaction of microbial pathogens with their eukaryotic host cells and are prerequisites of infection biological processes (cellular microbiology). 
In the Priority Programme, cellular receptors, regulatory proteins and signal pathways are studied, which are involved in rapid, temporally and spatially regulated cytoskeleton changes. Dynamic protein-protein interactions of cytoskeleton components are investigated and structure-functions analyses of signaling molecules involved are studied. Of particular interest are signal proteins and molecular switches of the family of low-molecular-mass GTPases (e.g. Rho proteins) and their various effectors, including direct regulators of actin dynamics. Of interest are also signal pathways and regulatory proteins, which are involved inpathogen-host cell-interactions and which are modified and/or modulated by bacterial effectors and protein toxins. The experimental approach is multi- and interdisciplinary and covers methods from cell biology, microbiology and structural biology, including modern protein interaction analysis, protein structure analysis and genetic approaches. 
Aim of the Priority Programme is to define the precise pathways of signal/receptor-mediated changes in the cytoskeleton and to understand the dynamics of the cytoskeleton in pathogen-host interactions.

Partners

Ludwig-Maximilians-Universität München

Medizinische Fakultät, Universitätsklinikum Magdeburg A. ö. R.

Westfälische Wilhelms-Universität Münster

Medizinische Hochschule Hannover

Lehrstuhl Zellbiologie, Universität Konstanz

Universitätsklinikum Erlangen

Institut für Medizinische Strahlenkunde und Zellforschung
der Universität Würzburg

Leibniz-Institut für Neurobiologie Magdeburg

Helmholtz Zentrum für Infektionsforschung

 

 

Coordinator

Prof. Dr. Dr. Klaus Aktories (Albert-Ludwigs-Universität Freiburg)

Homepage

www.spp1150.uni-freiburg.de

Funding Agency

DFG - German Research Foundation