Molecular Organisation of Cellular Communication in the Immune System
Inter- and intracellular communication is necessary for the appropriate function of the immune system. During the defence against pathogens, cells of the innate and adaptive immune system (granulocytes, macrophages, mesangial cells, dendritic cells, T cells, B cells and epithelial cells) communicate with each other to prevent the expansion and spreading of microbes such as bacteria, viruses or fungi. Alterations of cellular communication can also lead to immunological disorders, for example immunodeficiency, autoimmune disease or allergy. Further, alterations of immune function also affect the ability of the immune system to detect and to eliminate malignant transformed cells.
Leibniz-Institut für Neurobiologie, Magdeburg
Otto von Guericke Universität, Magdeburg