Cytokine Receptors and Cytokine-Dependent Signal Paths as Therapeutic Target Structures
The collaborative research centre has put the main emphasis on identifying cytokine receptors and cytokine receptor-dependent intracellular signalling molecules as a target for the therapeutical influence of cytokines. The scientific program includes projects on one of the most exiting areas within cytokine research. The short- and medium-term aims include the identification of receptor molecules and signalling peptides as targets for both, positive or negative therapeutic influences of cytokine effects by either natural peptides or chemically produced specific inhibitors. In the long-term the clinical use of the identified inhibitors or stimulators of hematopoiesis is planned in different disorders of e.g. hematopoiesis, malignancies, immunology and defense of infections. As an example for a promising outcome of this therapeutic strategy the successful inhibition of the abl-specific tyrosine kinases in vivo in patients with Philadelphia-chromosome positive CML could be mentioned.
Medizinische Hochschule Hannover
Helmholtz Zentrum für Infektionsforschung