Renal cell carcinoma
Characterization of the human kinome in renal cell carcinoma
This project comprises the most extensive systematic kinome analysis based on chemical and quantitative proteomics that targets kinases and their phosphorylations in ex-vivo RCC tissues and their healthy counterparts. The regulated kinase subset comprises both proof-of-concept kinases that were already linked to RCC and, importantly, also novel candidates as well as kinases of other cancer-relevant processes. This study therefore hints at prospective therapeutic approaches, by complementing our knowledge and understanding of RCC, i.e. its development and specific signal networks.