PQS quorum sensing communication system
Development of molecules that interfere with the PQS quorum sensing communication system in Pseudomonas aeruginosa
Both the formation of biofilms as well as the production of virulence factors is regulated by a complex quorum sensing communication network. Within this network, bacteria coordinate population behaviour and density. In addition to the quorum sensing networks LasR and RhlR, which are present in numerous bacteria, P. aeruginosa uses a third communication system. This system is regulated by PQS (Pseudomonas Quinoline Signal, 2-heptyl-3-hydroxy-4-quinolone) as an intercellular signal molecule.
The overall aim of the project is to develop compounds for the treatment of P. aeruginosa infections. These compounds interfere with PQS quorum sensing communication in order to prevent biofilm formation and to reduce the production of multiple quorum sensing-regulated virulence factors without affecting bacterial viability.
- Drug Design and Optimization - Prof. Dr. Rolf W. Hartmann