PQS quorum sensing communication system
Development of molecules that interfere with the PQS quorum sensing communication system in Pseudomonas aeruginosa
The department is also working on the development of compounds interfering with a PQS quorum sensing cell-cell-communication system in Pseudomonas aeruginosa. Lung infections resulting from this opportunistic pathogen are regarded as one of the major causes of morbidity and mortality in patients with cystic fibrosis. Resistance to generally applied antibiotics is often associated with biofilm formation.
Both the formation of biofilms as well as the production of virulence factors is regulated by a complex quorum sensing communication network. Within this network, bacteria coordinate population behaviour and density. In addition to the quorum sensing networks LasR and RhlR, which are present in numerous bacteria, P. aeruginosa uses a third communication system. This system is regulated by PQS (Pseudomonas Quinoline Signal, 2-heptyl-3-hydroxy-4-quinolone) as an intercellular signal molecule.
The overall aim of the project is to develop compounds for the treatment of P. aeruginosa infections. These compounds interfere with PQS quorum sensing communication in order to prevent biofilm formation and to reduce the production of multiple quorum sensing-regulated virulence factors without affecting bacterial viability.
- Drug Design and Optimization - Prof. Dr. Hirsch / Prof. Dr. Hartmann