IFN-mediated control of chronic CMV infection
However, the contribution of type I IFNs to latency and reactivation of chronically infected animals remains unclear: IFNs might have controlling effects. Alternatively, the induction and/or function of type I IFNs could be suppressed by viral evasion mechanisms in chronicity. The planned experiments are carried out in (transgenic) mice and in a newly developed in vitro latency model.
- Immune Aging and Chronic Infections - Prof. Dr. Dr. Luka Cicin-Sain