IFN-mediated control of chronic CMV infection

Type I interferons exert strong inhibitory effects on the de novo infection of cells by MCMV. This is in line with the fact that MCMV infection induces the production of large amounts of type I IFNs.

However, the contribution of type I IFNs to latency and reactivation of chronically infected animals remains unclear: IFNs might have controlling effects. Alternatively, the induction and/or function of type I IFNs could be suppressed by viral evasion mechanisms in chronicity. The planned experiments are carried out in (transgenic) mice and in a newly developed in vitro latency model.


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