Met signaling pathway
Phosphoproteome analysis of the Met signaling pathway
The human Met signaling pathway plays a crucial role in the cellular response to growth factors. Once stimulated by its physiological ligand hepatocyte growth factor (HGF), the Met receptor initiates a signaling cascade via phosphorylations, which leads to proliferation, motility and cell survival. In cancer, this pathway is overexpressed and causes metastasis formation. The surface protein internalin B of Listeria monocytogenes is also able to bind and activate Met, which leads to the pathogen’s invasion into the host cell.
The aim of this project is to shed more light on the pathways downstream of the Met receptor and to understand the influence of L. monocytogenes on the signaling using phosphoproteomics.