LöwenKIDS

Investigation of the influence of the sequence and load of infections and vaccinations during childhood on the development of the immunesystem

Within the birth cohort study LöwenKIDS, we want to investigate the influence of the sequence and load of infections and vaccinations during childhood on the development of the immune system. At birth, the immune system is not yet fully developed.

It needs to get in contact with infectious agents to be able to develop adequate defense mechanisms against them. That is one reason for children being more likely to get sick than adults. Vaccines can stimulate the immune system to develop defense mechanisms against certain diseases without suffering from the actual disease.

However, the immune system does not always develop in the optimal way. For example, in case of an allergy the immune system responds to rather harmless substances like pollen, cat fur or peanuts and mistakes them for harmful pathogens. Sometimes the immune system even attacks cells of the own body, for example at certain forms of diabetes mellitus.

Those diseases often become apparent at adulthood, but their origin can be found in the patient’s childhood. We want to investigate the influence these research questions within LöwenKIDS in greater detail.

For further information about the LöwenKIDS study click here.

Partners

Day nurseries Braunschweig

Local health authority of Lower Saxony, Hannover

Research group Microbial Interactions and Processes, Helmholtz-Centre for Infection Research, Braunschweig

Research group Microbial Communication, Helmholtz-Centre for Infection Research, Braunschweig

BaBi-Team of the Bielefeld University

Research group Vaccinology, Helmholtz-Centre for Infection Research, Braunschweig

Leader

  • Prof Dr Rafael Mikolajczyk

    Rafael Mikolajczyk

    Head of the research group Epidemiological and statistical methods

    +49 531 6181-3110

    Contact

    CV and Publications

Groups

Coordinator

Dr. Evelyn Dorendorf und Heike Raupach-Rosin

Homepage

http://loewenkids.helmholtz-hzi.de/de/

Funding Agency

HZI - Helmholtz Centre for Infection Research