Investigation of the influence of the sequence and load of infections and vaccinations during childhood on the development of the immunesystem
Within the birth cohort study LöwenKIDS, we want to investigate the influence of the sequence and load of infections and vaccinations during childhood on the development of the immune system. At birth, the immune system is not yet fully developed. It needs to get in contact with infectious agents to be able to develop adequate defense mechanisms against them. That is one reason for children being more likely to get sick than adults. Vaccines can stimulate the immune system to develop defense mechanisms against certain diseases without suffering from the actual disease.
However, the immune system does not always develop in the optimal way. For example, in case of an allergy the immune system responds to rather harmless substances like pollen, cat fur or peanuts and mistakes them for harmful pathogens. Sometimes the immune system even attacks cells of the own body, for example at certain forms of diabetes mellitus. Those diseases often become apparent at adulthood, but their origin can be found in the patient’s childhood. We want to investigate the influence these research questions within LöwenKIDS in greater detail.
For further information about the LöwenKIDS study click here.
Prof Dr Rafael Mikolajczyk
Head of the research group Epidemiological and statistical methods
+49 531 6181-3110
- Epidemiological and statistical methods - Prof. Dr. Rafael Mikolajczyk
- Vaccinology - Prof. Dr. Carlos A. Guzmán
Dr. Evelyn Dorendorf und Heike Raupach-Rosin
HZI - Helmholtz Centre for Infection Research