Legionella populations in freshwater systems in Germany, Palestine and Israel
Understanding the ecology and virulence of Legionella spp. populations in freshwater systems in Germany, Palestine and Israel
The overall objective of this project is to advance current knowledge on the ecology of legionella in freshwater systems, the environmental factors affecting their occurrence, virulence potential and infectivity and to understand their transmission to humans. We will analyze the major environmental factors regulating the abundance of legionella, such as grazing and assimable dissolved organic carbon, because the occurrence of these heterotrophic bacteria in aquatic habitats is highly dependent on these factors.
We will use an integrated molecular approach based on high-resolution diagnostics of environmental samples and clinical isolates to determine the abundance, activity and virulence potential of Legionella populations in-situ. Combining environmental and molecular epidemiological data, we aim at understanding the link between ecology and population dynamics of legionella and cases of LD. The project will result in a novel understanding of the molecular epidemiology of legionella and provide new surveillance tools and strategies to prevent LD.
Project Leader - Germany
Dr. Priv. Doz. Manfred Höfle
Helmholtz Centre for Infection Research
Dept. Vaccinology and Applied Microbiology
Tel. +49 531-6181-4234
Fax +49 531-6181-4699
Prof. Dr. Dina M. Bitar
Al-Quds University, Faculty of Medicine,
Department of Microbiology and Immunology,
P.O. Box 19356, Jerusalem, Abu Dies, Palestine
Tel: +972 22799203
Fax: +972 22796110
Dr. Malka Halpern
University of Haifa, Faculty of Natural Sciences,
Department of Science Education - Biology,
Oranim, Tivon, Israel, 36006.
Tel.: +972 49838978
Fax: +972 48451644