Development of mouse mutant resources for functional analyses of human diseases - Enhancing the translation of research into innovation

The increasing demand of the biomedical researchers for systemic phenotyping, archiving and distribution of mouse models cannot be accommodated with the capacities currently existing in Europe. The Infrafrontier Project is funded by the European Commission to set the stage for the implementation of an infrastructure that addresses these needs.

The objective of the project is to build a world-class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function in human disease. The Infrafrontier project brings together partners from twelve European countries and Canada. Our scientific partners are the leading research facilities in the field of systemic phenotyping, archiving and distribution of mouse models. Our administrative partners represent national research ministries and funding agencies.

Establishing the distributed Infrafrontier Research Infrastructure comprises two phases: the Preparatory Phase from 2008 to 2012 and the Implementation and Operation Phase from 2011 onwards. The Infrafrontier Research Infrastructure will consist of the National Infrafrontier Partners, i.e. the participating facilities operating the national research infrastructures and a central coordination unit (Infrafrontier ERIC).

Coordinator: Prof. Dr. Martin Hrabé de Angelis

This project is funded by the European Commission.

The EC funded INFRAFRONTIER-I3 project offers a comprehensive phenotype analysis for 22 mouse lines free of charge for researchers in eligible European countries. The access unit consists of a comprehensive first line phenotyping of a mutant line with appropriate control.