Infection challenge - Secondary phenotyping of mouse mutant lines
This project is performed in the context of Infrafrontier, a large European infrastructure, to perform systematic functional studies of genes using mouse knock-out models. In collaboration with the German Mouse Clinic at the HMGU in Munich, we will investigate a larger number of mouse knock-out mutants for their susceptibility to infections. Both bacterial and viral pathogens will be used. Close interactions will be maintained with international consortia for large scale phenotyping, especially the IMPC (International Mouse Phenotyping Consortium). In our laboratory about 5 – 10 mouse lines will be studied per year.