Microtubule-dependent motor protein dynamics in HSV-infection
Many pathogens, such as the herpes simplex viruses (HSV), use the cellular microtubule network and its associated motor proteins for intracellular movement. The recruitment of molecular motors to microtubules depends on the tyrosination status of microtubules, thus the tubulin-tyrosin-ligase (TTL) might influence intracellular transport of pathogens like HSV. In this project, we characterize the interactome of microtubules and their associated motor proteins in wild type and TTL-deficient cells, and furthermore aim to validate and functionally characterize novel TTL- and HSV-dependent motor and adapter proteins.
- Cellular Proteome Research - Prof. Dr. Lothar Jänsch
Björn Bulitta (Helmholtz-Zentrum für Infektionsforscher)