Improving predictability of preclinical data
To increase predictability of the success rates of vaccine and drug candidates transferred into the clinic, advanced animals models are being established that would allow a cost-efficient screening, selection and prioritization of different candidates and formulations.
The goal of this project is to create small animal models based on humanized mice for testing vaccines and drugs against pathogens with tropism for human cells. Specifically, we aim to generate mice with a functional human immune system (HIS), functional human liver cells (HuHep) or harboring both tissues (HIS-HuHep). These three humanized mouse models will allow us to identify vaccine and drug candidates against lymphotropic (e.g., HIV) and hepatotropic (e.g. HCV, HBV) pathogens. The humanized animals would represent a valuable technology platform not only for a robust preclinical evaluation of the immunogenicity, efficacy and safety of products aimed at treating diseases with highly predictive value for humans, but also for the generation of human monoclonal antibodies (mAbs) that can be used for therapeutic and diagnostic purposes.
- Vaccinology - Prof. Dr. Carlos A. Guzmán