The European Mouse Disease Clinic: A distributed phenotyping resource for studiying human disease

As a first step towards a comprehensive functional annotation of the mouse genome, EUMODIC will undertake a primary phenotype assessment of up to 650 mouse mutant lines. In addition, a number of the mutant lines will be subject to a more in depth secondary phenotype assessment.
The EUMODIC consortium is made up of 18 laboratories across Europe who are experts in the field of mouse functional genomics and phenotyping and have a track record of successful collaborative research in EUMORPHIA. The EUMODIC consortium will build on the work in the EUMORPHIA project that delivered a comprehensive database ' EMPReSS - of Standard Operating Procedures (SOPs) that can be used to determine the phenotype of a mouse. EUMODIC has developed a selection of these screens, EMPReSSslim, which is structured for comprehensive, primary, high throughput phenotyping of large numbers of mice.
We will also adopt innovative approaches to the generation and assessment of cohorts of age-matched mutants and controls for phenotyping. Primary phenotype assessment using EMPReSSslim will be undertaken in four large-scale phenotyping centres at the GSF, Germany; ICS, France; MRC Harwell, UK and the Sanger Institute, UK. Mutant lines will be made available from another EU initiative, the EUCOMM (European Conditional Mouse Mutagenesis) project which aims to produce conditional mutations in 20,000 mouse genes.
A distributed network of centres with in depth expertise in a number of phenotyping domains will undertake more complex, secondary phenotyping screens and apply them to a subset of the mice which have shown interesting phenotypes in the primary screen. The partners will also develop technologies to refine EMPReSSslim and improve throughput of mouse phenotyping. A key element will be the continued development of bioinformatics resources to store the phenotype information and link them to existing database resources.


MRC Harwell, UK

Institut Clinique de la Souris, France

Helmholtz Zentrum München, Germany

The Wellcome Trust Sanger Institute, UK

Helmholtz-Centre for Infection Research, Germany

National Research Council, Italy

University of Manchester, UK

European Molecular Biology Laboratory Monterotondo, Italy

Spanish National Cancer Research Centre, Spain

Ani.Rhone-Alpes, France

Tel Aviv University, Israel

Autonomous University of Barcelona, Spain

Center for Integrative Genomics, Switzerland

Institut De Transgenose, France

University of Cambridge, UK

Telethon Institute of Genetics and Medicine, Italy

Research Centre "Alexander Fleming", Greece



Andreas Lengeling


MRC Mammalian Genetics Unit (UK)


Funding Agency