DZIF: Gastrointestinal Infections

TTU 06.801: Identification of novel inhibitors targeting coloisation and virulence of gastrointestinal pathogens

Treatment of most bacterial infections of the GI tract with antibiotics is either (i) ineffective with respect to clinical course and duration of shedding, (ii) hampered by widespread resistance, or (iii) even associated with an increased risk of complications (EHEC). One likely reason for this situation is the activity of antibiotics against members of the normal GI microbiota. The objective of this project is the development of new treatments against GI infections (Campylobacter, H. pylori, E. coli, including EHEC), by targeting pathogen-specific functions, such as virulence-associated type three secretion systems, flagellar motility, or toxin function, while preserving the microbiota and limiting the emergence of antimicrobial resistance.



Prof. Dr. Sebastian Suerbaum


Prof. Dr. Ingo Autenrieth